7 completed, 6 unknown, 3 terminated, 2 not yet recruiting. 21 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 21 | Completed 7, Unknown 6, Terminated 3, Not yet recruiting 2, Recruiting 2, Suspended 1 |
Follow Leukemia, B-Cell: new trials by email Literature Review of Leukemia, B-Cell trials Research Report on Leukemia, B-Cell
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Immune Profiling of CLL/SLL Treated With First-Line Pirtobrutinib Pirtobrutinib - Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL) | Early Phase 1 | Recruiting | National Heart, Lung, and Blood Institute (NHLBI) | 30 | 2026-03-11 | 2026-10-22 |
| Safety and Feasibility of CD19 CAR T Cells Using CliniMACS Prodigy for Relapsed/Refractory CD19 Positive ALL and NHL CD19 specific Chimeric Antigen Receptor T Cell - Acute Lymphoblastic Leukemia, in Relapse, Non-Hodgkin's Lymphoma, Relapsed | Early Phase 1 | Not yet recruiting | Nationwide Children's Hospital | 12 | 2025-10-01 | 2025-08-15 |
| A Clinical Study Evaluating the Safety and Efficacy of GT801 Injection in Adult Patients With Relapsed/Refractory CD19-positive B-cell Hematologic Malignancies and Autoimmune Hemolytic Anemia GT801 Injection - B-cell Acute Lymphoblastic Leukemia (B-ALL), Chronic Lymphocytic Leukemia (CLL) | Early Phase 1 | Recruiting | Grit Biotechnology | 28 | 2025-09-26 | 2026-07-20 |
| 64Cu-LLP2A for Imaging Hematologic Malignancies 64Cu-LLP2A, PET/CT - Multiple Myeloma, Low-Grade Lymphoma | Early Phase 1 | Terminated | Washington University School of Medicine | 21 | 2025-03-20 | 2026-10-16 |
| Effects of a Strength Physical Exercise Program in Chronic Lymphocytic Leukemia Patients Exercise, Home exercise - Chronic Lymphocytic Leukemia, Exercise | Early Phase 1 | Not yet recruiting | University of Salamanca | 40 | 2025-03-10 | 2025-02-19 |
| Universal CAR-T Cells (REVO-UWD-19) for Refractory and Relapsed B-Cell Tumors Single dose injection of certain dose of UWD-19, MMF Immunosuppression - B Cell Lymphoma, B Cell Leukemia | Early Phase 1 | Suspended | Wondercel Biotech (ShenZhen) | 30 | 2024-10-24 | 2026-05-07 |
| Safety and Efficacy of Allogenic CD19-CAR-NK Cells in Treatmenting r/r B-cell Hematologic Malignancies allogenic CD19-CAR-NK cells - Acute Lymphoblastic Leukemia, B-cell Lymphoma | Early Phase 1 | Unknown | Xuzhou Medical University | 12 | 2023-03-01 | 2023-02-22 |
| Safety and Efficacy of CT125A Cells for Treatment of Relapsed/Refractory CD5+ Hematopoietic Malignancies CT125A cells, Cyclophosphamide, fludarabine - CD5+ Relapsed/Refractory Hematopoietic Malignancies, Chronic Lymphocytic Leukemia (CLL) | Early Phase 1 | Unknown | Huazhong University of Science and Technology | 18 | 2021-03-01 | 2021-02-23 |
| γδT Cell Infusion to Prevent Relapsed/Refractory Leukemia Rescue Relapse γδT Cell infusion agent - Leukemia, B-cell | Early Phase 1 | Unknown | PersonGen BioTherapeutics (Suzhou) Co., Ltd. | 5 | 2020-05-01 | 2021-01-06 |
| γδT Cells Immunotherapy in Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma (NHL) Autologous γδT cells - Non-Hodgkin's Lymphoma, Relapsed or Refractory B Cell Non-Hodgkin's Lymphoma | Early Phase 1 | Unknown | Institute of Hematology & Blood Diseases Hospital, China | 6 | 2019-10-01 | 2019-09-26 |
| Serologic Response to SHINGRIX Vaccine in Patients With CLL and WM Treated With BTK Inhibitors Shingrix vaccine - Chronic Lymphocytic Leukemia (CLL), Waldenstrom Macroglobulinemia (WM) | Early Phase 1 | Completed | University of Rochester | 33 | 2019-02-01 | 2024-03-15 |
| CD20-CD19 Compound CAR (cCAR) T Cells for Patients With Relapsed /Refractory B Cell Malignancies CD20-CD19 cCAR T cells - B Cell Lymphoma, B Cell Leukemia | Early Phase 1 | Unknown | iCell Gene Therapeutics | 12 | 2018-08-01 | 2019-11-12 |
| CD19 CARvac T Cells for Patients With Relapsed / Refractory B Cell Malignancies CD19 CARvac T cells - B Cell Lymphoma, B Cell Leukemia | Early Phase 1 | Unknown | iCell Gene Therapeutics | 20 | 2018-02-01 | 2019-11-12 |
| Pilot Trial Of Autologous T Cells Engineered To Express Anti-CD19 Chimeric Antigen Receptor (CART19)In Combination With Ibrutinib In Patients With Relapsed Or Refractory CD19+ Chronic Lymphocytic Leukemia (CLL)Or Small Lymphocytic Lymphoma (SLL) CART 19 - LYMPHOCYTIC LEUKEMIA (CLL) OR SMALL LYMPHOCYTIC LYMPHOMA (SLL) | Early Phase 1 | Terminated | University of Pennsylvania | 20 | 2016-01-29 | 2023-06-22 |
| Intra-Osseous Co-Transplant of UCB and hMSC cyclophosphamide, fludarabine phosphate, total-body irradiation - Acute Lymphoblastic Leukemia, Acute Myelogenous Leukemia | Early Phase 1 | Completed | Case Comprehensive Cancer Center | 6 | 2015-07-22 | 2020-12-04 |
| Pretreatment With Valproate Prior to Immunotherapy Targeting Cluster of Differentiation Antigen 20 in Chronic Lymphocytic Leukemia Valproate - Chronic Lymphocytic Leukemia | Early Phase 1 | Completed | Lund University Hospital | 4 | 2015-01-01 | 2017-03-03 |
| Dose Monitoring of Busulfan and Combination Chemotherapy in Hodgkin or Non-Hodgkin Lymphoma Undergoing Stem Cell Transplant busulfan, etoposide, cyclophosphamide - Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma | Early Phase 1 | Completed | Case Comprehensive Cancer Center | 33 | 2014-03-01 | 2015-08-13 |
| A Study of the Effect of Vinca Alkaloids on c-Jun N-terminal Kinase (JNK) Phosphorylation in Patients With Chronic Lymphocytic Leukemia (CLL) vincristine - Chronic Lymphocytic Leukemia (CLL) | Early Phase 1 | Terminated | Dartmouth-Hitchcock Medical Center | 11 | 2012-10-01 | 2015-05-12 |
| Vaccine Therapy With or Without Cryosurgery in Treating Patients With Residual, Relapsed, or Refractory B-Cell Non-Hodgkin Lymphoma dendritic cell vaccine therapy, cryotherapy, pneumococcal polyvalent vaccine - Cutaneous B-cell Non-Hodgkin Lymphoma, Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Early Phase 1 | Completed | Mayo Clinic | 16 | 2010-11-01 | 2020-01-14 |
| Pemetrexed Disodium in the Cerebrospinal Fluid of Patients With Leptomeningeal Metastases Pemetrexed - Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders | Early Phase 1 | Completed | Northwestern University | 15 | 2007-01-01 | 2021-09-08 |
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Leukemia, Lymphocytic, Chronic, B-Cell (16) · Lymphoma, B-Cell (8) · Lymphoma, Non-Hodgkin (8) · Lymphoma, Follicular (6) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (6) · Lymphoma, B-Cell, Marginal Zone (5) · Lymphoma, Mantle-Cell (5) · Lymphoma, Large B-Cell, Diffuse (4) · Waldenstrom Macroglobulinemia (4) · Burkitt Lymphoma (3) · Hodgkin Disease (3) · Leukemia (3) · Lymphoma (3) · Lymphoma, Large-Cell, Immunoblastic (3)
Hematologic Diseases (21) · Hemic and Lymphatic Diseases (21) · Immune System Diseases (21) · Immunoproliferative Disorders (21) · Lymphatic Diseases (21) · Neoplasms by Histologic Type (21) · Leukemia, Lymphoid (20) · Lymphoproliferative Disorders (20) · Neoplasms (20) · Leukemia (18) · Disease Attributes (17) · Pathologic Processes (17) · Pathological Conditions, Signs and Symptoms (17) · Chronic Disease (16)
Cyclophosphamide (3) · Peripheral Blood Stem Cell Transplantation (2) · 23-valent pneumococcal capsular polysaccharide vaccine (1) · Busulfan (1) · CF regimen (1) · Cord Blood Stem Cell Transplantation (1) · Cryotherapy (1) · Cyclosporine (1) · Etoposide (1) · Exercise (1) · Filgrastim (1) · Granulocyte Colony-Stimulating Factor (1) · Immunoenzyme Techniques (1) · Immunohistochemistry (1) · Mesenchymal Stem Cell Transplantation (1)
Case Comprehensive Cancer Center (2) · iCell Gene Therapeutics (2) · Dartmouth-Hitchcock Medical Center (1) · Grit Biotechnology (1) · Huazhong University of Science and Technology (1) · Institute of Hematology & Blood Diseases Hospital, China (1) · Lund University Hospital (1) · Mayo Clinic (1) · National Cancer Institute (NCI) (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · Nationwide Children's Hospital (1) · Northwestern University (1) · PersonGen BioTherapeutics (Suzhou) Co., Ltd. (1) · University of Pennsylvania (1) · University of Rochester (1)
United States (11) · China (7) · Sweden (1)
Fang Liu, MD, PhD (2) · Hongyu Zhang, MD, PhD (2) · Alexey V Danilov, MD (1) · Brian Hill, MD (1) · Carlos Martin Sanchez, PhD (1) · Dehui Zou, Dr. (1) · Farrokh Dehdashti, M.D. (1) · Jeffrey J. Raizer, MD (1) · Jianfeng Zhou, PhD, MD (1) · Jonathan Friedberg, MD (1) · Kailin Xu, M.D., Ph.D. (1) · Kristina Drott, MD, PhD (1) · Laura S Samples, M.D. (1) · Leland Metheny, MD (1) · Lode Swinnen (1)
PMID 32298202, PMID 32840736, PMID 35349631, PMID 38143760, PMID 40129522, PMID 41633358
P30CA043703 (2), R42CA257797 (1)