24 completed, 3 terminated, 3 unknown, 3 withdrawn. 37 Phase 2, 9 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 37 | Completed 24, Terminated 3, Unknown 3, Withdrawn 3, Not yet recruiting 2, Recruiting 2 |
| Phase 1 | 9 | Completed 6, Not yet recruiting 1, Terminated 1, Unknown 1 |
| Phase 3 | 2 | Completed 2 |
Follow Kidney Calculi: new trials by email Literature Review of Kidney Calculi trials Research Report on Kidney Calculi
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of TRA16 Administered Orally in Patients With Enteric Hyperoxaluria (EH). TRA16, Placebo - Enteric Hyperoxaluria | Phase 2 | Not yet recruiting | Wuhan Kangfude Urolithiasis Research Institute Co., Ltd. | 30 | 2027-03-01 | 2026-10-13 |
| Study of YOLT-203 in Children and Adults With Primary Hyperoxaluria Type 1 (PH1) YOLT-203, Placebo - Primary Hyperoxaluria Type 1, PH1 | Phase 2 | Recruiting | YolTech Therapeutics Co., Ltd | 36 | 2026-09-16 | 2026-10-09 |
| Sodium Bicarbonate as an Alternative to Potassium Citrate for Kidney Stones Potassium Citrate, Sodium Bicarbonate - Kidney Stones, Urolithiasis, Hypocitraturia, Nephrolithiasis | Phase 1 / Phase 2 | Not yet recruiting | University of California, Los Angeles | 30 | 2026-02-01 | 2026-02-12 |
| A Phase 2a Study of LLX-424 in Patients With a History of Kidney Stones LLX-424 - Kidney Stones | Phase 2 | Completed | Lilac Therapeutics, Inc. | 51 | 2025-03-23 | 2025-10-29 |
| Indapamide and Chlorthalidone to Reduce Urine Supersaturation for Kidney Stone Prevention Indapamide 2.5 MG, Hydrochlorothiazide 50Mg, Chlorthalidone 25mg - Kidney Stone | Phase 2 | Recruiting | Insel Gruppe AG, University Hospital Bern | 99 | 2024-10-01 | 2026-05-06 |
| Erector Spinae Plane Block for Uncomplicated Renal Colic Erector Spinae Plane Block (ESPB), Ropivacaine - Renal Colic, Kidney Stone | Phase 2 | Completed | University of Michigan | 5 | 2023-02-08 | 2025-10-30 |
| Research Project: Pilot Study on Oral Urea Use in Patients at High Risk of Kidney Stone Recurrence Ure-Na - Kidney Stone | Phase 2 | Withdrawn | Centre hospitalier de l'Université de Montréal (CHUM) | 2023-01-15 | 2022-11-28 | |
| Silodosin in Management of Lower Ureteral Stones Silodosin - Stone, Kidney | Phase 1 / Phase 2 | Completed | Syrian Private University | 100 | 2022-10-20 | 2024-04-24 |
| A Study to Evaluate Lumasiran in Adults With Recurrent Calcium Oxalate Kidney Stone Disease and Elevated Urinary Oxalate Levels Lumasiran, Placebo - Recurrent Calcium Oxalate Kidney Stone Disease, Elevated Urinary Oxalate Levels | Phase 2 | Terminated | Alnylam Pharmaceuticals | 2 | 2022-01-27 | 2024-05-22 |
| Impact of the SGLT2 Inhibitor Empagliflozin on Urinary Supersaturations in Kidney Stone Formers Empagliflozin 25 MG, Placebo - Kidney Stone | Phase 2 | Completed | Insel Gruppe AG, University Hospital Bern | 50 | 2021-08-25 | 2023-05-12 |
| Safety, Tolerability, and Pharmacodynamics of NOV-001 in Adult Subjects NOV-001, NB1000S, NB2000P - Healthy Volunteers, Enteric Hyperoxaluria | Phase 1 / Phase 2 | Terminated | Novome Biotechnologies Inc | 153 | 2021-06-02 | 2023-05-17 |
| Perioperative Pregabalin in Ureteroscopy Pregabalin 300mg, Placebo oral tablet - Kidney Stone, Pain, Postoperative | Phase 2 / Phase 3 | Completed | University of Missouri-Columbia | 118 | 2020-06-01 | 2025-11-12 |
| Pramipexole and Morphine for Renal Colic Pramipexole, Morphine, Placebo oral tablet - Renal Colic | Phase 1 / Phase 2 | Completed | East Carolina University | 19 | 2019-10-28 | 2023-03-08 |
| Treatment of Renal Stones With Frankincense (Luban) AKBA-Incense (3-acetyl-11-keto-ß-boswellic acid), Potassium Sodium Hydrogen Citrate - Renal Stones | Phase 1 / Phase 2 | Unknown | Sultan Qaboos University | 100 | 2019-09-01 | 2019-04-29 |
| Efficacy and Safety of Renalof® in the Removal of Calculi Smaller Than 10 mm Located in the Reno-Ureteral Tract Renalof, Placebo - Renal Injury, Kidney Injury | Phase 2 | Completed | Catalysis SL | 155 | 2019-08-01 | 2021-01-06 |
| Study of ALLN-177 in Patients Aged 12 Years or Older With Enteric or Primary Hyperoxaluria and Hyperoxalemia ALLN-177 - Enteric Hyperoxaluria, Primary Hyperoxaluria | Phase 2 | Completed | Allena Pharmaceuticals | 15 | 2018-07-17 | 2020-12-30 |
| Prospective Randomized Controlled Trial for Pain Relief After Office Ureteral Stent Removal Ketorolac, normal saline - Pain, Urinary Stone | Phase 2 | Completed | University of Texas Southwestern Medical Center | 125 | 2018-06-28 | 2024-01-10 |
| Toradol to Reduce Ureteroscopic Symptoms Trial Toradol - Urinary Lithiasis, Kidney Diseases | Phase 2 | Completed | Yale University | 94 | 2017-08-01 | 2021-11-02 |
| Lipoic Acid Supplement for Cystine Stone Alpha lipoic acid, Placebo - Cystinuria | Phase 2 | Completed | Thomas Chi, MD | 50 | 2017-06-19 | 2026-04-15 |
| Evaluate the Effect of ALLN-177 in Reducing Urinary Oxalate in Patients With Secondary Hyperoxaluria and Kidney Stones Over 28 Days ALLN-177, Placebo - Secondary Hyperoxaluria, Nephrolithiasis | Phase 2 | Completed | Allena Pharmaceuticals | 66 | 2015-09-01 | 2017-01-19 |
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Nephrolithiasis (11) · Urolithiasis (8) · Hyperoxaluria (6) · Kidney Diseases (5) · Calculi (3) · Renal Colic (3) · Urinary Calculi (3) · Urologic Diseases (3) · Crohn Disease (2) · Cystinuria (2) · Hyperoxaluria, Primary (2) · Nephrolithiasis, Calcium Oxalate (2) · Pain, Postoperative (2) · Ureteral Calculi (2)
Female Urogenital Diseases (37) · Female Urogenital Diseases and Pregnancy Complications (37) · Male Urogenital Diseases (37) · Pathological Conditions, Anatomical (37) · Pathological Conditions, Signs and Symptoms (37) · Urogenital Diseases (37) · Calculi (34) · Urinary Calculi (34) · Urologic Diseases (34) · Kidney Diseases (32) · Urolithiasis (29) · Nephrolithiasis (26) · Signs and Symptoms (7) · Neurologic Manifestations (6) · Pain (5)
oxalate decarboxylase (4) · reloxaliase (4) · Isoproterenol (2) · Ketorolac Tromethamine (2) · Potassium Citrate (2) · silodosin (2) · Allopurinol (1) · Chlorthalidone (1) · Citrates (1) · Citric Acid (1) · Febuxostat (1) · Frankincense (1) · Hydrochlorothiazide (1) · Indapamide (1) · Ketorolac (1)
Allena Pharmaceuticals (4) · Fredericia Hosptial (2) · Insel Gruppe AG, University Hospital Bern (2) · Mayo Clinic (2) · University of Texas Southwestern Medical Center (2) · Alnylam Pharmaceuticals (1) · Amai Charitable Trust (1) · Catalysis SL (1) · Centre hospitalier de l'Université de Montréal (CHUM) (1) · East Carolina University (1) · Isfahan University of Medical Sciences (1) · Lilac Therapeutics, Inc. (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · Mission Pharmacal (1) · Novome Biotechnologies Inc (1)
United States (23) · Canada (4) · Switzerland (3) · Denmark (2) · United Kingdom (2) · Belgium (1) · Germany (1) · Iceland (1) · India (1) · Iran (1) · Italy (1) · Nicaragua (1) · Oman (1) · Spain (1) · Syria (1)
Annamaria Kausz, MD MS (2) · Chris Fung (1) · Daniel Fuster, MD (1) · Daniel G Fuster, M.D. (1) · David Clark, MD (1) · Davis J Viprakasit, MD (1) · Helene U Jung (1) · Jamshid Roozbeh, MD (1) · John C Lieske, MD (1) · John D Denstedt, MD, FRCSC (1) · Jon I Scheinman, M.D. (1) · Katie Murray, DO (1) · Kori Brewer, PhD (1) · Kymora B Scotland, MD, PhD (1) · Lachy McLean, MB ChB, PhD (1)
PMID 20736987, PMID 21161651, PMID 21419606, PMID 23929928, PMID 30783888, PMID 34569278, PMID 35288397, PMID 39411383, PMID 39747681
P50DK083007 (2), 2005 (1), 2017 (1), P20DK100863 (1), R21AT002534 (1), R21DK072454 (1), R21DK097476 (1), UL1RR024150 (1)