29 completed, 8 recruiting, 3 active not recruiting, 3 terminated. 21 Phase 2, 16 Phase 1, 6 Not applicable, 4 Phase 3, 1 Phase 4.
Follow Juvenile Myelomonocytic Leukemia: new trials by email Literature Review of Juvenile Myelomonocytic Leukemia trials Research Report on Juvenile Myelomonocytic Leukemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Alpha/Beta T Cell and CD19+ B Cell Depletion in Allogeneic Stem Cell Transplantation in Patients With Malignant Diseases Miltenyi CliniMACS Prodigy ® system - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Phase 2 | Recruiting | University of Florida | 20 | 2024-05-03 | 2026-06-04 |
| MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies Fludarabine, Busulfan, Melphalan - Hematologic Malignancy, Acute Leukemia | Phase 2 | Recruiting | Masonic Cancer Center, University of Minnesota | 70 | 2023-05-11 | 2026-04-06 |
| Preventing of GVHD With Post-transplantation Cyclophosphamide, Abatacept, Vedolizumab and Calcineurin Inhibitor at Patients With Hemoblastosis GVHD prevention: post-transplantation cyclophosphamide, abatacept, vedolizumab, calcineurin inhibitor - Acute Lymphoblastic Leukemia, Myeloblastic Leukemia | Phase 3 | Active not recruiting | Federal Research Institute of Pediatric Hematology, Oncology and Immunology | 56 | 2022-08-23 | 2023-09-28 |
| The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study Biospecimen Collection - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Phase 1 / Phase 2 | Recruiting | PedAL BCU, LLC | 960 | 2022-04-18 | 2026-08-25 |
| A Phase 1 Trial of CIML NK Cell Infusion for Myeloid Disease Relapse After Hematopoietic Cell Transplantation CIML NK, Fludarabine, Cyclophosphamide - Acute Myeloid Leukemia, Myelodysplastic Syndromes | Phase 1 | Recruiting | Dana-Farber Cancer Institute | 50 | 2019-08-31 | 2026-06-17 |
| Vorinostat Dose-escalation After Allogeneic Hematopoietic Cell Transplantation Vorinostat, Azacitidine Injection - Acute Myeloid Leukemia, Myelodysplastic Syndromes | Phase 1 | Active not recruiting | Johns Hopkins All Children's Hospital | 15 | 2019-05-01 | 2026-07-15 |
| CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post TCRαβ/CD19 Depleted HSCT CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Depleted Peripheral Stem Cell Addback - Acute Leukemia, Acute Myeloid Leukemia | Not applicable | Recruiting | Children's Hospital of Philadelphia | 50 | 2019-03-01 | 2026-07-08 |
| Trametinib in Treating Patients With Relapsed or Refractory Juvenile Myelomonocytic Leukemia Bone Marrow Aspiration and Biopsy, Trametinib - Juvenile Myelomonocytic Leukemia, Neurofibromatosis Type 1 | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 10 | 2018-09-09 | 2026-07-20 |
| Myeloablative Allo HSCT With Related or Unrelated Donor for Heme Disorders HSCT with TBI Regimen, HSCT with Non-TBI Regimen - Acute Leukemia, Acute Myeloid Leukemia | Phase 2 | Recruiting | Masonic Cancer Center, University of Minnesota | 300 | 2018-03-30 | 2026-06-25 |
| HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant CD8+ and CD4+ Donor Memory T-cells-expressing HA1-Specific TCR, Bone Marrow Aspiration, Biospecimen Collection - Juvenile Myelomonocytic Leukemia, Recurrent Acute Biphenotypic Leukemia | Phase 1 | Recruiting | Fred Hutchinson Cancer Center | 24 | 2018-02-23 | 2026-05-18 |
| Pacritinib in Combination With Low Dose Decitabine in Intermediate-High Risk Myelofibrosis or Myeloproliferative Neoplasm (MPN)/Myelodysplastic Syndrome (MDS) Pacritinib, Decitabine - Chronic Myelomonocytic Leukemia, Juvenile Myelomonocytic Leukemia | Phase 1 | Withdrawn | Washington University School of Medicine | 2017-06-01 | 2017-05-08 | |
| Yttrium-90 Anti CD66 Monoclonal Antibody in Childhood Relapsed/Refractory Leukaemia Yttrium-90 labelled monoclonal antibody against CD66 - Acute Myeloblastic Leukemia, Acute Lymphoblastic Leukemia | Phase 1 | Completed | Great Ormond Street Hospital for Children NHS Foundation Trust | 9 | 2016-05-01 | 2021-06-25 |
| Donor Lymphocyte Infusion With Azacitidine to Prevent Hematologic Malignancy Relapse After Stem Cell Transplantation azacitidine, donor lymphocyte infusion - Acute Myelogenous Leukemia, Acute Lymphoid Leukemia | Phase 2 | Completed | University of California, San Francisco | 17 | 2015-06-02 | 2020-10-12 |
| Natural History and Biology of Long-Term Late Effects Following Hematopoietic Cell Transplant for Childhood Hematologic Malignancies Acute Lymphoblastic Leukemia/Lymphoma, Myelodysplasia | Unknown | Center for International Blood and Marrow Transplant Research | 340 | 2015-03-01 | 2023-02-08 | |
| Busulfan, Cyclophosphamide, and Melphalan or Busulfan and Fludarabine Phosphate Before Donor Hematopoietic Cell Transplant in Treating Younger Patients With Juvenile Myelomonocytic Leukemia Allogeneic Hematopoietic Stem Cell Transplantation, Busulfan, Cyclophosphamide - Juvenile Myelomonocytic Leukemia | Phase 2 | Completed | Children's Oncology Group | 30 | 2013-06-24 | 2018-12-05 |
| T-Cell Replete Haploidentical Donor Hematopoietic Stem Cell Plus Natural Killer (NK) Cell Transplantation in Patients With Hematologic Malignancies Relapsed or Refractory Despite Previous Allogeneic Transplant clofarabine, cytarabine, busulfan - Acute Lymphoblastic Leukemia, Acute Myelocytic Leukemia | Phase 2 | Terminated | St. Jude Children's Research Hospital | 34 | 2012-08-01 | 2017-02-20 |
| Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies fludarabine phosphate, melphalan, total-body irradiation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Roswell Park Cancer Institute | 94 | 2012-02-28 | 2019-09-24 |
| A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies Fludarabine, Busulfan, Total Body Irradiation (TBI) - Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 40 | 2011-08-04 | 2026-04-15 |
| Busulfan and Cyclophosphamide Instead of Total Boby Irradiation (TBI) and Cyclophosphamide for Hematological Malignancies Hematocrit (HCT) Busulfan/Cyclophosphamide - Acute Leukemias, Chronic Leukemias | Phase 4 | Unknown | Tel-Aviv Sourasky Medical Center | 10 | 2011-06-01 | 2011-04-21 |
| Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant supersaturated calcium phosphate rinse, placebo, questionnaire administration - Childhood Acute Lymphoblastic Leukemia in Remission, Childhood Acute Myeloid Leukemia in Remission | Phase 3 | Completed | Children's Oncology Group | 226 | 2011-03-01 | 2019-09-17 |
Showing 20 of 46. Sign in to see all of them.
Leukemia, Myelomonocytic, Juvenile (46) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (35) · Leukemia, Myeloid, Acute (29) · Myelodysplastic Syndromes (19) · Burkitt Lymphoma (17) · Leukemia, Myelomonocytic, Chronic (17) · Lymphoma, Non-Hodgkin (16) · Myeloproliferative Disorders (16) · Recurrence (16) · Leukemia, Lymphocytic, Chronic, B-Cell (15) · Dendritic Cell Sarcoma, Interdigitating (14) · Lymphoma, B-Cell, Marginal Zone (13) · Lymphoma, Follicular (13) · Lymphoma, Large B-Cell, Diffuse (13) · Mycosis Fungoides (13)
Bone Marrow Diseases (46) · Hematologic Diseases (46) · Hemic and Lymphatic Diseases (46) · Leukemia, Myeloid (46) · Myelodysplastic-Myeloproliferative Diseases (46) · Neoplasms by Histologic Type (46) · Neoplasms (45) · Leukemia (41) · Immune System Diseases (36) · Immunoproliferative Disorders (36) · Leukemia, Lymphoid (36) · Lymphatic Diseases (36) · Lymphoproliferative Disorders (36) · Pathologic Processes (31) · Pathological Conditions, Signs and Symptoms (31)
Cyclophosphamide (11) · Mycophenolic Acid (11) · fludarabine phosphate (11) · Busulfan (8) · Whole-Body Irradiation (8) · Peripheral Blood Stem Cell Transplantation (7) · thymoglobulin (7) · Cyclosporine (6) · Tacrolimus (6) · Antilymphocyte Serum (4) · Melphalan (4) · fludarabine (4) · Clofarabine (3) · Isotretinoin (3) · Methotrexate (3)
Fred Hutchinson Cancer Center (8) · Children's Oncology Group (5) · National Cancer Institute (NCI) (5) · St. Jude Children's Research Hospital (4) · Masonic Cancer Center, University of Minnesota (3) · Roswell Park Cancer Institute (2) · University of California, San Francisco (2) · Case Comprehensive Cancer Center (1) · Center for International Blood and Marrow Transplant Research (1) · Children's Hospital of Philadelphia (1) · Columbia University (1) · Dana-Farber Cancer Institute (1) · Federal Research Institute of Pediatric Hematology, Oncology and Immunology (1) · Great Ormond Street Hospital for Children NHS Foundation Trust (1) · Johns Hopkins All Children's Hospital (1)
United States (41) · Canada (7) · Australia (4) · Italy (4) · Germany (3) · New Zealand (3) · Puerto Rico (2) · Russia (1) · Switzerland (1) · United Kingdom (1)
Brenda Sandmaier (2) · David Maloney (2) · George Chen (2) · Gregory Hale, M.D. (2) · Maryam Fouladi (2) · Paul Martin (2) · Ann Woolfrey (1) · Biljana Horn, M.D. (1) · Brandon M. Triplett, MD (1) · Brenda Cooper, MD (1) · Brigitte C Widemann (1) · Camille Abboud, M.D. (1) · Cassandra Josephson, MD (1) · Charlotte M. Niemeyer, M.D. (1) · Christine Duncan, MD (1)
PMID 32499241, PMID 18698002, PMID 20802024, PMID 24162791, PMID 24786393, PMID 25425683, PMID 25644958, PMID 28817727, PMID 33728588, PMID 34893945, PMID 35349491, PMID 37584291, PMID 37944074, PMID 38683966, PMID 38867349, PMID 40554414
P30CA015704 (5), U10CA098543 (5), P01CA018029 (3), U10CA180886 (3), U01CA097452 (2), P01CA078902 (1), U10CA095861 (1), U54CA196519 (1), UG1CA189958 (1)