36 completed, 33 active not recruiting, 20 recruiting, 7 terminated. 41 Phase 2, 18 Not applicable, 18 Phase 1, 11 Phase 3, 3 Early Phase 1.
Follow Invasive Breast Carcinoma: new trials by email Literature Review of Invasive Breast Carcinoma trials Research Report on Invasive Breast Carcinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer Biopsy Procedure, Biospecimen Collection, Echocardiography Test - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8 | Phase 1 | Recruiting | National Cancer Institute (NCI) | 36 | 2026-10-06 | 2026-10-16 |
| Imlunestrant and Abemaciclib for the Treatment of Estrogen Receptor Positive Breast Cancer in Patients With Minimal Residual Disease, MIRI Trial Abemaciclib, Biospecimen Collection, Imlunestrant - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Phase 2 | Recruiting | Jonsson Comprehensive Cancer Center | 42 | 2026-05-18 | 2026-08-20 |
| Areola Preservation in NSM With Nipple Involvement Areola-Preserving Nipple-Sparing Mastectomy with Immediate Nipple Reconstruction - Breast Cancer, Ductal Carcinoma In Situ, DCIS | Not applicable | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 40 | 2026-05-01 | 2026-04-22 |
| Individual Factors Associated With Care Pathways Delays in Breast Cancer in Hauts-de-France. Breast Cancer, Invasive Breast Carcinoma | Active not recruiting | University Hospital, Lille | 500 | 2026-04-20 | 2026-05-12 | |
| Tissue- and Serum-Derived Exosomal microRNAs as Predictors of Neoadjuvant Chemotherapy Response in Breast Cancer Breast Cancer, Invasive Breast Carcinoma | Not yet recruiting | Atlas University | 60 | 2026-04-12 | 2026-03-30 | |
| Circulating microRNAs and Response to Neoadjuvant Chemotherapy in Breast Cancer Breast Cancer, Neoadjuvant Therapy | Recruiting | Atlas University | 80 | 2025-12-15 | 2026-03-31 | |
| Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy in IBC SLN identification using technetium-99m, SLN intra-operatory identification with radioguided surgery, Axillary Limph Node Dissection (ALND) - Invasive Breast Carcinoma, Sentinel Lymph Node Biopsy (SLNB) | Not applicable | Recruiting | European Institute of Oncology | 75 | 2025-12-12 | 2026-01-06 |
| Self-Acceptance and Supportive Accountability for Active Living Among Adults Receiving Chemotherapy Acceptance- and Mindfulness-Based Intervention - Invasive Breast Carcinoma, Gynecologic Malignancies | Not applicable | Completed | University of Oklahoma | 42 | 2025-09-10 | 2026-10-21 |
| Testing the Addition of an Investigational Anti-Cancer Drug, ASTX660 (Tolinapant), to a Usual Chemotherapy Treatment (Eribulin) for Treatment of Advanced Triple Negative Breast Cancer Biopsy Procedure, Biospecimen Collection, Computed Tomography - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8 | Phase 1 | Withdrawn | National Cancer Institute (NCI) | 2025-08-04 | 2025-07-03 | |
| NearWave Optical Molecular Monitoring NearWave monitoring - Breast Cancer, HER2-positive Breast Cancer | Not applicable | Recruiting | Indiana University | 15 | 2025-03-07 | 2026-02-17 |
| Metformin for the Treatment of Insulin Resistance in Women With Stage I-III Breast Cancer Completing Chemotherapy Biospecimen Collection, Educational Intervention, Extended Release Metformin Hydrochloride - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Phase 3 | Recruiting | City of Hope Medical Center | 80 | 2025-01-13 | 2026-10-19 |
| Application of Single-Port Robot-Assisted Breast-Conserving Surgery Via Axillary Approach for Breast Cancer. robot-surgery, traditional open surgry - Invasive Breast Carcinoma | Not applicable | Recruiting | Xu Yan | 64 | 2024-12-31 | 2026-08-21 |
| Temporal Immunologic Changes With Hypofractionated Radiation-Induced DNA Damage in Breast Cancer Biopsy, Biospecimen Collection, Radiation Therapy - Breast Carcinoma, Invasive Breast Carcinoma | Recruiting | M.D. Anderson Cancer Center | 36 | 2023-09-15 | 2026-05-06 | |
| Testing the Role of FDG-PET/CT to Predict Response to Therapy Prior to Surgery for HER2-positive Breast Cancer, The DIRECT Trial Chemotherapy, Computed Tomography, Fludeoxyglucose F-18 - Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8 | Phase 2 | Active not recruiting | ECOG-ACRIN Cancer Research Group | 235 | 2023-05-10 | 2026-10-19 |
| Metformin and Nightly Fasting in Women With Early Breast Cancer Biospecimen Collection, Extended Release Metformin Hydrochloride, Monitoring - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 120 | 2023-04-04 | 2026-01-05 |
| Volumetric Specimen Imager Device for the Intraoperative Imaging of Patients With Breast Carcinoma and Breast Ductal Carcinoma In Situ, The VIVID Study Intraoperative Imaging, Lumpectomy - Anatomic Stage 0 Breast Cancer AJCC v8, Bilateral Breast Carcinoma | Phase 2 | Completed | Northwestern University | 113 | 2022-11-28 | 2026-08-19 |
| Comparing Supplemental Topical Agents for the Treatment of Acute Radiation Dermatitis in Patients With Breast Cancer Agent Affecting Integumentary System, Petrolatum-Mineral Oil-Lanolin-Ceresin Ointment, Quality-of-Life Assessment - Breast Ductal Carcinoma In Situ, Invasive Breast Carcinoma | Phase 1 | Active not recruiting | City of Hope Medical Center | 208 | 2022-09-09 | 2026-08-17 |
| Letrozole With and Without Simvastatin for the Treatment of Stage I-III Hormone Receptor Positive, HER2 Negative Breast Cancer Letrozole, Simvastatin - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Early Phase 1 | Recruiting | Emory University | 40 | 2022-09-02 | 2026-07-17 |
| Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection Questionnaire Administration, Biospecimen Collection - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Recruiting | Alliance for Clinical Trials in Oncology | 2000 | 2022-08-18 | 2026-10-02 | |
| Time Restricted Eating for the Improvement of Outcomes in Patients With Stage I-III Breast Cancer Receiving Chemotherapy Before Surgery Short-Term Fasting, Chemotherapy, Biospecimen Collection - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Not applicable | Recruiting | Thomas Jefferson University | 55 | 2022-07-28 | 2026-09-03 |
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Breast Neoplasms (53) · Triple Negative Breast Neoplasms (25) · Carcinoma, Intraductal, Noninfiltrating (24) · Breast Carcinoma In Situ (13) · Carcinoma, Ductal, Breast (3) · Esophageal Neoplasms (3) · Inflammatory Breast Neoplasms (3) · Melanoma (3) · Brain Neoplasms (2) · Carcinoma, Lobular (2) · Carcinoma, Non-Small-Cell Lung (2) · Carcinoma, Renal Cell (2) · Colorectal Neoplasms (2) · Fallopian Tube Neoplasms (2) · Leukemia, Myeloid, Acute (2)
Neoplasms (79) · Neoplasms by Site (71) · Skin Diseases (70) · Skin and Connective Tissue Diseases (70) · Breast Diseases (69) · Neoplasms by Histologic Type (35) · Neoplasms, Glandular and Epithelial (34) · Carcinoma (33) · Adenocarcinoma (28) · Carcinoma in Situ (28) · Neoplasms, Ductal, Lobular, and Medullary (26) · Breast Neoplasms (16) · Breast Carcinoma In Situ (15) · Pathological Conditions, Signs and Symptoms (5) · Head and Neck Neoplasms (4)
Specimen Handling (17) · Paclitaxel (11) · Taxes (11) · Carboplatin (9) · Biopsy (7) · Letrozole (7) · Radiation (7) · Radiotherapy (7) · Magnetic Resonance Spectroscopy (6) · Practice Guidelines as Topic (6) · Standard of Care (6) · Albumin-Bound Paclitaxel (5) · Anastrozole (5) · Cyclophosphamide (5) · Doxorubicin (4)
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PMID 39558017, PMID 24464780, PMID 25913905, PMID 26247543, PMID 27138575, PMID 29789969, PMID 30027292, PMID 30611839, PMID 31276981, PMID 31461380, PMID 32996592, PMID 33305350, PMID 33587350, PMID 33740205, PMID 33992718, PMID 34092112, PMID 34253579, PMID 34616010, PMID 34636255, PMID 34914339, PMID 35507014, PMID 35617923, PMID 35728046, PMID 35736816, PMID 35914239, PMID 36092362, PMID 36216274, PMID 36228112, PMID 36306810, PMID 36759673, PMID 36892847, PMID 37043123, PMID 37061619, PMID 37505106, PMID 37506981, PMID 37547448, PMID 37707811, PMID 37828596, PMID 38236702, PMID 38484209, PMID 38578640, PMID 38828938, PMID 39503605, PMID 39656951, PMID 40073831, PMID 40152443, PMID 40314623, PMID 40332918, PMID 40366003, PMID 40839373
P30CA016672 (4), U10CA180820 (3), U10CA180821 (3), U10CA180888 (3), N01CN00034 (2), P30CA014089 (2), P30CA015083 (2), P30CA015704 (2), P30CA060553 (2), P50CA116201 (2), U10CA180868 (2), UG1CA189823 (2), UM1CA186689 (2), UM1CA186704 (2), UM1CA186712 (2)