7 completed, 2 terminated, 1 recruiting, 1 withdrawn. 6 Not applicable, 2 Phase 1, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 6 | Completed 3, Recruiting 1, Terminated 1, Withdrawn 1 |
| Phase 1 | 2 | Completed 2 |
| Phase 4 | 2 | Completed 1, Terminated 1 |
Follow Insulin Secretion: new trials by email Literature Review of Insulin Secretion trials Research Report on Insulin Secretion
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Glucose-Independent Effects of Exogenous Glucagon on Insulin Secretion and Cognitive Function in Healthy Subjects Glucagon Infusion, Glucose clamp - Glucose Metabolism, Insulin Secretion | Not applicable | Completed | Nicolai Jacob Wewer Albrechtsen | 15 | 2024-11-08 | 2026-04-29 |
| Effect of Spinal Cord Stimulation (SCS) on Insulin Secretion in Humans BurstDR stimulation, Tonic stimulation, No stimulation - Spinal Cord Stimulation, Insulin Secretion | Not applicable | Withdrawn | University Hospital Tuebingen | 2023-03-16 | 2024-05-10 | |
| Intermittent Fasting to Improve Insulin Secretion Intermittent fasting, Control diet - PreDiabetes, Diabetes type2 | Not applicable | Recruiting | University Hospital Tuebingen | 200 | 2021-04-08 | 2026-04-21 |
| Effect of Taking a Single Tablet of Iron on Insulin Secretion Ferrous sulphate - Insulin Secretion | Not applicable | Completed | Christian Medical College, Vellore, India | 15 | 2020-10-10 | 2022-03-02 |
| Effect of Serum LDL Cholesterol Concentration on Pancreatic Insulin Secretion Lowering cholesterol concentrations by PCSK-9 inhibitor - Hypercholesterolemia, Insulin Resistance | Not applicable | Terminated | University Hospital Tuebingen | 9 | 2020-07-28 | 2024-05-16 |
| Glucagon Regulation of Glucose Metabolism Glucagon - Insulin Secretion | Phase 1 | Completed | David D'Alessio, M.D. | 19 | 2019-09-24 | 2021-05-14 |
| Regulation of Insulin Secretion by the GLP-1 Receptor Exendin (9-39), Dexamethasone, Hyperglycemic Clamp - Insulin Secretion | Phase 4 | Terminated | VA Office of Research and Development | 6 | 2018-07-01 | 2024-12-12 |
| Influence of Central Nervous Insulin Sensitivity on Insulin Secretion intranasal insulin, Placebo - Insulin Secretion | Not applicable | Completed | University Hospital Tuebingen | 15 | 2016-08-01 | 2018-05-08 |
| Incretin Action in Physiology and Diabetes GIP infusion, GLP-1 infusion, Ex-9 infusion - Insulin Secretion | Phase 1 | Completed | David D'Alessio, M.D. | 39 | 2016-04-21 | 2023-11-18 |
| Contribution of Pancreatic αcells Function to Blood Glucose Regulation in Chinese Type 2 Diabetics- the Effect of Sitagliptin on Glucagon Secretion, Insulin Secretion and Insulin Resistance in Chinese Type 2 Diabetics Sitagliptin - Insulin Secretion, Insulin Resistance | Phase 4 | Completed | Guangwei Li | 85 | 2012-10-01 | 2017-05-11 |
| Maternal GDM in Hispanic Youth: Risk for Obesity Diabetes, Gestational, Obesity | Completed | University of Southern California | 240 | 2010-08-01 | 2019-04-16 |
Insulin Resistance (4) · Diabetes Mellitus (2) · Diabetes, Gestational (1) · Glucose Intolerance (1) · Hypercholesterolemia (1) · Intermittent Fasting (1) · Obesity (1) · Pediatric Obesity (1) · Prediabetic State (1)
Glucose Metabolism Disorders (6) · Metabolic Diseases (6) · Nutritional and Metabolic Diseases (6) · Endocrine System Diseases (4) · Hyperinsulinism (4) · Diabetes Mellitus (2) · Behavior (1) · Body Weight (1) · Dyslipidemias (1) · Fasting (1) · Feeding Behavior (1) · Female Urogenital Diseases and Pregnancy Complications (1) · Hyperglycemia (1) · Hyperlipidemias (1) · Lipid Metabolism Disorders (1)
exendin (9-39) (2) · Dexamethasone (1) · Glucagon (1) · Glucose Clamp Technique (1) · Sitagliptin Phosphate (1) · ferrous sulfate (1)
University Hospital Tuebingen (4) · David D'Alessio, M.D. (2) · Christian Medical College, Vellore, India (1) · Guangwei Li (1) · Nicolai Jacob Wewer Albrechtsen (1) · University of Southern California (1) · VA Office of Research and Development (1)
Germany (4) · United States (3) · China (1) · Denmark (1) · India (1)
David D'Alessio, MD (2) · Joe Varghese, M.D.,PhD (1) · Kathleen Page, MD (1) · Martin Heni, MD (1) · Matthias Morgalla, Prof. (1) · Nicolai J Wewer Albrecthsen, MD PhD (1) · Padmanaban Venkatesan, M.D. (1)
PMID 31689708, PMID 36000222, PMID 37870928
R01DK101991 (2)