15 completed, 1 terminated, 1 unknown. 6 Phase 1, 3 Phase 4, 2 Phase 3, 1 Not applicable, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 6 | Completed 5, Terminated 1 |
| Phase 4 | 3 | Completed 3 |
| Phase 3 | 2 | Completed 2 |
| Not applicable | 1 | Completed 1 |
| Phase 2 | 1 | Completed 1 |
Follow Impaired Renal Function: new trials by email Literature Review of Impaired Renal Function trials Research Report on Impaired Renal Function
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Compare Linezolid-Induced Thrombocytopenia in Patients With Normal Renal Function Versus Impaired Renal Function Linezolid (LZD) - Thrombocytopaenia, Impaired Renal Function | Completed | Ain Shams University | 60 | 2024-05-20 | 2025-07-25 | |
| Dapagliflozin Treatment in Type 2 Diabetes Dapagliflozin 10 MG [Farxiga] - Diabetes Mellitus, Type 2, Impaired Renal Function | Phase 4 | Completed | Emerald Clinical Inc. | 17 | 2021-04-20 | 2025-04-24 |
| Study of Aldafermin (NGM282) in Participants With Impaired Renal Function Aldafermin (NGM282) - Impaired Renal Function | Phase 1 | Completed | NGM Biopharmaceuticals, Inc | 48 | 2019-11-08 | 2020-04-27 |
| RI Study to Assess and Compare the Pharmacokinetic Parameters of MD1003 in Renal Impaired Patients and Healthy Subjects MD1003 - Healthy Volunteers, Impaired Renal Function | Phase 1 | Terminated | MedDay Pharmaceuticals SA | 24 | 2019-10-09 | 2020-05-13 |
| A Study to Evaluate the Effects of Renal Impairment on the Pharmacokinetics of ELX-02 ELX-02 - Impaired Renal Function | Phase 1 | Completed | Eloxx Pharmaceuticals, Inc. | 24 | 2019-01-04 | 2021-04-13 |
| A Phase 1 Study of Roxadustat in Subjects With Different Degrees of Renal Function Roxadustat - Normal Renal Function, Impaired Renal Function | Phase 1 | Completed | Astellas Pharma Europe B.V. | 34 | 2016-12-12 | 2020-02-12 |
| Evaluation of Renal Function Impairment on the Pharmacokinetics of LEE011 LEE011 - Normal Renal Function, Impaired Renal Function | Phase 1 | Completed | Novartis Pharmaceuticals | 38 | 2015-10-23 | 2020-12-19 |
| Linagliptin's Effect on CD34+ Stem Cells Linagliptin, Placebo - Type 2 Diabetes, Impaired Renal Function | Phase 4 | Completed | George Washington University | 31 | 2015-04-01 | 2023-01-19 |
| Linezolid Pharmacokinetics In Patients With Impaired Renal Function (PPT6) 600 mg linezolid - Renal Failure, Impaired Renal Function | Not applicable | Completed | Damanhour University | 18 | 2013-10-01 | 2014-03-14 |
| Study of SSP-004184 (FBS0701) in Healthy Adults and Elderly Subjects and in Subjects With Impaired Renal Function SSP-004184 - Impaired Renal Function | Phase 1 | Completed | Shire | 66 | 2012-10-29 | 2021-06-10 |
| Longterm Follow-up After Remote Ischemic Preconditioning for Prevention of Contrast-induced Nephropathy Ischemic preconditioning - Impaired Renal Function | Unknown | University of Cologne | 81 | 2012-07-01 | 2013-01-03 | |
| Effects of Obesity Surgery on Renal Function Impaired Renal Function | Completed | Imperial College London | 9 | 2011-06-01 | 2020-11-19 | |
| Evaluation of Efficacy and Safety of Ferric Carboxymaltose (FCM) in Patients With Iron Deficiency Anemia and Impaired Renal Function Ferric Carboxymaltose (FCM), Iron Sucrose (Venofer) - Iron Deficiency Anemia, Impaired Renal Function | Phase 3 | Completed | American Regent, Inc. | 2561 | 2009-08-01 | 2018-02-20 |
| CNI-free de Novo Protocol in Patients Undergoing Liver Transplantation With Renal Impairment anti-CD 25 mAb, Sirolimus, MMF - End Stage Liver Disease, Impaired Renal Function | Phase 3 | Completed | University of Regensburg | 27 | 2008-12-01 | 2014-12-16 |
| Pharmacokinetics of Lenalidomide (Revlimid®) in Patients With Multiple Myeloma and Impaired Renal Function lenalidomide - Multiple Myeloma, Impaired Renal Function | Phase 2 | Completed | Poitiers University Hospital | 39 | 2008-11-01 | 2016-10-11 |
| Computer Prescribing System and Impaired Renal Function computer-assisted counselling about target drugs - Impaired Renal Function | Completed | Assistance Publique - Hôpitaux de Paris | 12 | 2007-05-01 | 2012-11-19 | |
| Platelet Function in Diabetic Patients With and Without Renal Impairment, and the Effects of Lipid Lowering Treatment Ezetimibe - Diabetes Mellitus, Impaired Renal Function | Phase 4 | Completed | Karolinska Institutet | 39 | 2006-01-01 | 2021-03-01 |
Renal Insufficiency (17) · Diabetes Mellitus, Type 2 (2) · Anemia, Iron-Deficiency (1) · Diabetes Mellitus (1) · End Stage Liver Disease (1) · Multiple Myeloma (1) · Thrombocytopenia (1)
Female Urogenital Diseases (17) · Female Urogenital Diseases and Pregnancy Complications (17) · Kidney Diseases (17) · Male Urogenital Diseases (17) · Urogenital Diseases (17) · Urologic Diseases (17) · Metabolic Diseases (4) · Nutritional and Metabolic Diseases (4) · Endocrine System Diseases (3) · Glucose Metabolism Disorders (3) · Hematologic Diseases (3) · Hemic and Lymphatic Diseases (3) · Diabetes Mellitus (2) · Anemia (1) · Anemia, Hypochromic (1)
Linezolid (2) · 4,5-dihydro-2-(2-hydroxy-3-(3,6,9-trioxadecyloxy)phenyl)-4-methyl-4-thiazolecarboxylic acid (1) · Basiliximab (1) · ELX-02 (1) · Ezetimibe (1) · Ferric Oxide, Saccharated (1) · Ischemic Preconditioning (1) · Lenalidomide (1) · Linagliptin (1) · Mycophenolic Acid (1) · Simvastatin (1) · Sirolimus (1) · aldafermin (1) · dapagliflozin (1) · ferric carboxymaltose (1)
Ain Shams University (1) · American Regent, Inc. (1) · Assistance Publique - Hôpitaux de Paris (1) · Astellas Pharma Europe B.V. (1) · Damanhour University (1) · Eloxx Pharmaceuticals, Inc. (1) · Emerald Clinical Inc. (1) · George Washington University (1) · Imperial College London (1) · Karolinska Institutet (1) · MedDay Pharmaceuticals SA (1) · NGM Biopharmaceuticals, Inc (1) · Novartis Pharmaceuticals (1) · Poitiers University Hospital (1) · Shire (1)
United States (7) · Germany (4) · France (3) · United Kingdom (2) · Bulgaria (1) · Canada (1) · Czechia (1) · Egypt (1) · Hungary (1) · Sweden (1)
Andreas A Schnitzbauer, MD (1) · Carel W le Roux, MBChB, PhD (1) · Fikret Er, MD (1) · Hans J Schlitt, MD (1) · Hiddo JL Heerspink (1) · Marcus N Scherer, MD (1) · Paul Hjemdahl, MD, PhD (1) · Sabyasachi Sen, MD, PhD (1) · Yves Donazzolo, MD (1)
PMID 20840760, PMID 22700717, PMID 22735306, PMID 24720535, PMID 26018348, PMID 30594245, PMID 32493344, PMID 33165773, PMID 36800111, PMID 38018702
2015 (1), 2019 (1)