7 unknown, 6 completed, 4 recruiting, 1 active not recruiting. 12 Not applicable, 2 Phase 3, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 12 | Completed 6, Recruiting 3, Unknown 2, Not yet recruiting 1 |
| Phase 3 | 2 | Unknown 2 |
| Early Phase 1 | 1 | Unknown 1 |
Follow ICSI: new trials by email Literature Review of ICSI trials Research Report on ICSI
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Dual Trigger VS HCG Trigger for Final Oocyte Maturation in Normal Responders Dual trigger (human chorionic gonadotropin plus GnRH-agonist), hCG trigger - ICSI, IVF | Not applicable | Recruiting | Al-Azhar University | 100 | 2026-09-01 | 2026-10-06 |
| Comparison of Two Types of Calcium (Ca²⁺) Ionophore Treatments for Oocyte Activation in Cases of Suboptimal Fertilization Potential Group 1: Oocyte Activation (OA) CultActive, Group 2: Oocyte Activation (OA) Ionomycin, Group 3: Control - ICSI, Testicular Sperm Extraction in Azoospermic Patients | Not applicable | Not yet recruiting | ART Fertility Clinics LLC | 20 | 2026-04-30 | 2026-05-11 |
| Development of an AI Platform for the Analysis of Sperm and Prediction of Their Clinical Potential Swim-up, Density gradient centrifugation, HyperSperm - Infertility (IVF Patients), ICSI | Recruiting | Fecundis Lab SL | 500 | 2026-03-18 | 2026-06-12 | |
| Impact of Dry vs Humidified Culture Conditions on Blastocyst Development and Aneuploidy: A Time-lapse Sibling Oocyte Study K- system incubator - Incubator Stay, Total Blastulation | Not applicable | Recruiting | ART Fertility Clinics LLC | 60 | 2026-02-10 | 2026-05-07 |
| Evaluating the Utility of Implementing Microfluids for Sperm Preparation Compared to Conventional Method of Density Gradient Centrifugation in a PGT-A Program: a Sibling Oocyte Study FERTILE Plus - Semen Analysis, ICSI | Not applicable | Recruiting | ART Fertility Clinics LLC | 100 | 2025-09-12 | 2025-10-02 |
| Embryo Transfer Catheter Rotation Effect on Pregnancy Rate Embryo Transfer Catheter Withdrawal Technique - ICSI, Embryo Transfer | Not applicable | Completed | Kafrelsheikh University | 310 | 2024-07-12 | 2026-08-12 |
| The Effect of Pretreatment With Dydrogesterone Vs Combined Estradiol Valerate and Dydrogestrone on Clinical Pregnancy Outcome of ICSI in PCOS Patients" dydrogesterone 20 mg /d (Duphaston, Abott Healthcare , Egypt), estradiol valerate 2 mg /d (white tablets of cycloprognova, Bayer Shering, Germany) - PCOS, ICSI | Early Phase 1 | Unknown | Sohag University | 500 | 2022-05-01 | 2022-04-14 |
| Comparison of ICSI Outcomes in Cycles Using Testicular and Ejaculate Sperm From Couples With High SDF Testicular biopsy - Oligospermia, DNA Damage | Not applicable | Completed | Fundación IVI | 22 | 2020-10-01 | 2025-03-13 |
| Noninvasive Preimplantation Genetic Testing for Aneuploidy NiPGT-A - Preimplantation Genetic Testing (PGT), ICSI | Unknown | Mỹ Đức Hospital | 218 | 2020-08-15 | 2020-09-22 | |
| Cytokines Supplementation to Culture Media and ICSI Outcome A single step culture medium - ICSI | Not applicable | Completed | Mansoura Integrated Fertility Center | 700 | 2020-02-01 | 2023-06-18 |
| Sperm Selection and Embryo Development: Comparison of the Density Gradient Centrifugation and Microfluidic Chip Sperm Preparation Methods Sperm Selection and Embryo Development: Comparison of the Density Gradient Centrifugation and Microfluidic Chip Sperm Preparation Methods Microfluidic sperm sorting chip, Density gradient - Reduced Sperm Motility, IVF | Not applicable | Completed | Maltepe University | 22 | 2020-01-05 | 2021-07-14 |
| Priority to Cryopreservation Strategy (PCS) in IVF-ICSI Cycles Priority to freeze, Fresh embryo transfer - Infertility, IVF | Not applicable | Unknown | Tanta University | 1000 | 2019-05-01 | 2023-07-18 |
| Luteal Phase Support With Estradiol In Poor Responders Undergoing In Vitro Fertilization Estradiol Valerate, Placebo Oral Tablet - ICSI | Phase 3 | Unknown | Ain Shams University | 170 | 2018-04-01 | 2018-12-27 |
| Effect of Magnesium Supplement in Early Pregnancy After ICSI Magnesium Oxide, Placebo Oral Tablet - ICSI | Phase 3 | Unknown | Ain Shams University | 180 | 2017-06-01 | 2018-01-12 |
| Retrieval Versus Mid-luteal Endometrial Scratching (ES) for Intra Cytoplasmic Sperm Injection (ICSI) Endometrial scratching - ICSI | Not applicable | Unknown | Mansoura University | 100 | 2017-01-01 | 2018-03-19 |
| Acrosome Reaction Induction Prior to ICSI Acrosome Reaction induction, capacitation in incubation medium prior to ICSI - Assisted Reproductive Technique, ICSI | Not applicable | Completed | Assistance Publique - Hôpitaux de Paris | 111 | 2014-12-13 | 2026-05-20 |
| Comparison Between the Role of Follicular Output Rate and Preovulatory Count in the Prediction of Pregnancy in Women With Polycystic Ovarian Syndrome Undergoing Intra Cytoplasmic Sperm Injection (ICSI) Polycystic Ovarian Syndrome, Subfertility | Unknown | Cairo University | 300 | 2014-07-01 | 2017-01-23 | |
| Randomized Prospective Trial on the Use of Laser Assisted Hatching (LAH) for Transfer of Frozen/Thawed Embryos in Human IVF/ICSI laser assisted hatching - IVF, ICSI | Not applicable | Completed | University Hospital, Ghent | 293 | 2007-12-01 | 2014-01-27 |
| Reproductive Outcomes After Intracytoplasmic Sperm Injection (ICSI) With Surgically Retrieved Sperm. IVF/ICSI - Reproductive Technology, Assisted, IVF Outcomes | Active not recruiting | Karolinska Institutet | 200000 | 2007-01-01 | 2025-04-30 |
Infertility (4) · Infertility, Male (2) · Asthenozoospermia (1) · Helping Behavior (1) · Hypersensitivity (1) · Long Qt Syndrome 3 (1) · Oligospermia (1) · Polycystic Ovary Syndrome (1)
Genital Diseases (7) · Urogenital Diseases (7) · Genital Diseases, Male (4) · Male Urogenital Diseases (4) · Infertility (3) · Infertility, Male (2) · Adnexal Diseases (1) · Behavior (1) · Cysts (1) · Endocrine System Diseases (1) · Female Urogenital Diseases (1) · Female Urogenital Diseases and Pregnancy Complications (1) · Genital Diseases, Female (1) · Gonadal Disorders (1) · Immune System Diseases (1)
Centrifugation, Density Gradient (2) · Estradiol (2) · Chorionic Gonadotropin (1) · Dydrogesterone (1) · Gonadotropin-Releasing Hormone (1) · Ionomycin (1) · Magnesium (1) · Magnesium Oxide (1) · Tablets (1) · Triptorelin Pamoate (1)
ART Fertility Clinics LLC (3) · Ain Shams University (2) · Al-Azhar University (1) · Assistance Publique - Hôpitaux de Paris (1) · Cairo University (1) · Fecundis Lab SL (1) · Fundación IVI (1) · Kafrelsheikh University (1) · Karolinska Institutet (1) · Maltepe University (1) · Mansoura Integrated Fertility Center (1) · Mansoura University (1) · Mỹ Đức Hospital (1) · Sohag University (1) · Tanta University (1)
Egypt (8) · Spain (2) · United Arab Emirates (2) · Belgium (1) · France (1) · Sweden (1) · Turkey (Türkiye) (1) · Vietnam (1)
AbdelGany MA Hassan, MRCOG, MD (1) · Abdelghaffar Dawood, MD (1) · Abdelhady A Zayed, Ass. prof. (1) · Ahmed Abbas, MD (1) · Ahmed Elhalwagy, MD (1) · Ahmed Elkhyat, MD (1) · Ahmed Elsawaf, MD (1) · Ahmed Saber, MD (1) · Amr Abdelrahman (1) · Barbara Lawrenz (1) · Ehab HM Hasanin, Professor (1) · Emad M Sedeek, MS (1)
PMID 12215343, PMID 18983750, PMID 22417664, PMID 25596904, PMID 25602996, PMID 26277587, PMID 26346057, PMID 26658129, PMID 27278231, PMID 27734719, PMID 28651960, PMID 29108881, PMID 29177244, PMID 29392515, PMID 29606300, PMID 29620419, PMID 29758560, PMID 30826994, PMID 31133387, PMID 31709844, PMID 31710194, PMID 31994001, PMID 32083189, PMID 32285298, PMID 32298520, PMID 33227188, PMID 33751461, PMID 35261925, PMID 35811802, PMID 37133689, PMID 37747409, PMID 39704318
2025 (1)