9 recruiting, 7 not yet recruiting, 2 active not recruiting, 2 completed. 7 Phase 1, 6 Phase 2, 4 Not applicable, 3 Phase 4.
Follow HIV -1 Infection: new trials by email Literature Review of HIV -1 Infection trials Research Report on HIV -1 Infection
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Integrating iSYV Within HIV Clinical Care for Youth Living With HIV in Tanzania iSYV (integrated Sauti ya Vijana; The Voice of Youth), mHealth, eSOC - HIV -1 Infection, Mental Health Issue | Not applicable | Not yet recruiting | Duke University | 5000 | 2027-01-10 | 2026-06-02 |
| Early Neutralizing Antibodies in Infants Living With HIV to Enhance Their Life Broadly neutralizing antibody (bNAb) ePGT121v1-LS, Saline (0.9% NaCl) - HIV -1 Infection | Phase 1 / Phase 2 | Not yet recruiting | Hospital Universitario 12 de Octubre | 87 | 2027-01-01 | 2026-08-20 |
| Early Neutralizing Antibodies in Infants Living With HIV to Enhance Their Life (2) Broadly neutralizing antibody (bNAb) ePGT121v1-LS, Saline (0.9% NaCl), Broadly neutralizing antibody (bNAb) VRC07-523-LS - HIV -1 Infection | Phase 1 / Phase 2 | Not yet recruiting | Hospital Universitario 12 de Octubre | 73 | 2027-01-01 | 2026-08-20 |
| Short-term Effects of Methamphetamine on Residual Latent HIV Disease Study Oral Methamphetamine, Placebo oral capsule - HIV -1 Infection, Methamphetamine Use | Phase 4 | Not yet recruiting | University of California, San Francisco | 20 | 2026-10-01 | 2026-08-17 |
| Cabotegravir & Rilpivirine Antiretroviral Therapy in Pregnancy Every 4-week long-acting injectable cabotegravir and rilpivirine - HIV -1 Infection | Phase 4 | Recruiting | International Maternal Pediatric Adolescent AIDS Clinical Trials Group | 40 | 2026-10-01 | 2026-11-03 |
| Study of Combined GARP:TGF-β1/PD-1 Blockade as a Shock-and-kill Strategy in HIV-1 Cure blood drawn - HIV -1 Infection | Not applicable | Not yet recruiting | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | 100 | 2026-08-31 | 2026-07-09 |
| A Clinical Trial to Look at the Safety and Immune Responses of the RNA-based Vaccine BNT168 in Adults Living With or Without HIV BNT168, Placebo - HIV -1 Infection | Phase 1 | Recruiting | BioNTech SE | 126 | 2026-08-04 | 2026-10-14 |
| Study of GS-0415 and How It Works in People With HIV GS-0415, GS-0415 Placebo - HIV -1 Infection | Phase 1 | Recruiting | Gilead Sciences | 112 | 2026-07-22 | 2026-09-23 |
| REINItiation of Antiretroviral Therapy Using Oral bicTegravir, emtrIcitAbine and Tenofovir alafenamidE Bictegravir, emtricitabine, and tenofovir alafenamide - HIV -1 Infection, HIV (Human Immunodeficiency Virus) | Phase 4 | Recruiting | CAN Community Health | 200 | 2026-06-17 | 2026-09-03 |
| Combining Latency Reversing Agents to Address the HIV Reservoir Pyrimethamine (PYR), Lenalidomide, Topiramate (drug) - HIV (Human Immunodeficiency Virus), HIV -1 Infection | Phase 1 / Phase 2 | Not yet recruiting | Erasmus Medical Center | 30 | 2026-04-01 | 2026-02-03 |
| A Clinical Trial Investigating the Safety and Biological Activity of the Antibody BNT351 in Adults Living Without and With HIV BNT351, Placebo - HIV -1 Infection | Phase 1 | Recruiting | BioNTech SE | 67 | 2026-02-09 | 2026-09-01 |
| HIV-1 Virologic Suppression With TMB-365 and TMB-380 Antibodies Study TMB-365, TMB-380, Baseline ART - HIV -1 Infection | Phase 2 | Active not recruiting | TaiMed Biologics Inc. | 88 | 2025-12-16 | 2026-08-06 |
| Safety Study of MucoCept-CVN Live Biotherapeutic Product L. jensenii 1153-1666, Placebo - HIV -1 Infection | Phase 1 | Recruiting | Craig Cohen, MD, MPH | 12 | 2025-10-06 | 2026-10-16 |
| Impacts of HIV Treatment Regimens on Archived Drug Resistance HIV -1 Infection, Antiretroviral Therapy | Recruiting | Chinese University of Hong Kong | 420 | 2025-10-01 | 2026-06-12 | |
| PERSON-CENTERED APPROACHES TO VIREMIA: CONNECTION, RAPPORT, AND ENGAGEMENT STUDY Interventions will be developed in aim 2 of the study. - HIV Viremia, HIV -1 Infection | Not applicable | Active not recruiting | Centre for Infectious Disease Research in Zambia | 3000 | 2025-04-01 | 2026-08-10 |
| Establishment of a Database of HIV Subjects Initiating or Simplifying Dual Therapy With Dolutegravir/Lamivudine Blood sampling for evaluation of biomarkers - HIV -1 Infection | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 1220 | 2024-10-30 | 2024-10-15 | |
| Prevention ICONA Dedicated Ensemble PrEP, PrEP Adherence Monitoring | Recruiting | Fondazione ICONA | 5000 | 2024-09-09 | 2025-09-22 | |
| Analyses of Newly Diagnosed HIV Infection in Hong Kong HIV -1 Infection | Recruiting | Chinese University of Hong Kong | 720 | 2024-08-01 | 2026-07-24 | |
| Resistance Profile to Antiretroviral Medications in Individuals Living With HIV Who Failed a First-Line Regimen With Tenofovir / Lamivudina and Dolutegravir in Brasil TL+D antiretroviral - HIV, HIV -1 Infection | Not applicable | Completed | Federal University of São Paulo | 777 | 2022-04-13 | 2026-06-10 |
| Treatment With Probiotics (Saccharomyces Boulardii) and Its Role in Bacterial Translocation and Immune Reconstitution in VIH Infection. Probiotic., Placebo - HIV -1 Infection | Phase 2 | Unknown | Parc de Salut Mar | 44 | 2012-08-01 | 2016-11-15 |
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Acquired Immunodeficiency Syndrome (3) · HIV Infections (3) · Inflammation (1) · Sexually Transmitted Diseases (1)
Communicable Diseases (6) · Genital Diseases (6) · Infections (6) · Urogenital Diseases (6) · Blood-Borne Infections (5) · Immune System Diseases (5) · Immunologic Deficiency Syndromes (5) · Lentivirus Infections (5) · RNA Virus Infections (5) · Retroviridae Infections (5) · Sexually Transmitted Diseases (5) · Sexually Transmitted Diseases, Viral (5) · Virus Diseases (5) · Slow Virus Diseases (3) · HIV Infections (2)
Broadly Neutralizing Antibodies (2) · Sodium Chloride (2) · Association (1) · Blood Specimen Collection (1) · Lenalidomide (1) · Methamphetamine (1) · Pharmaceutical Preparations (1) · Probiotics (1) · Pyrimethamine (1) · Rilpivirine (1) · Telemedicine (1) · Topiramate (1) · bictegravir, emtricitabine, tenofovir alafenamide, drug combination (1) · leronlimab (1)
BioNTech SE (2) · Chinese University of Hong Kong (2) · Hospital Universitario 12 de Octubre (2) · CAN Community Health (1) · Centre for Infectious Disease Research in Zambia (1) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (1) · Craig Cohen, MD, MPH (1) · CytoDyn, Inc. (1) · Duke University (1) · Erasmus Medical Center (1) · Federal University of São Paulo (1) · Fondazione ICONA (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Gilead Sciences (1) · International Maternal Pediatric Adolescent AIDS Clinical Trials Group (1)
United States (9) · Belgium (1) · Brazil (1) · China (1) · Germany (1) · Hong Kong (1) · Italy (1) · Netherlands (1) · South Africa (1) · Spain (1) · Tanzania (1) · Zambia (1)
Casper Rokx, MD PhD (1) · Craig Cohen, MD, MPH (1) · Dorothy Dow, MD, MSc (1) · Dr Aaloke Mody (1) · Hector Bolivar, MD (1) · Jean Cyr Yombi, MD (1) · Jessica Altamirano, MD (1) · Kombatende Sikombe (1) · Rachel Scott, MD, MPH (1) · Shui Shan Lee, MD (1) · Shui Shan S Lee, MD (1) · Simona Di Giambenedetto (1)
PMID 20377413, PMID 25469528, PMID 42325270
2025 (1), RM1DA063218 (1), U01AI186333 (1), UM1AI068616 (1), UM1AI068632 (1), UM1AI106716 (1)