7 active not recruiting, 7 recruiting, 5 completed, 4 terminated. 18 Phase 2, 11 Phase 1, 3 Phase 3, 2 Not applicable.
Follow Extensive Stage Lung Small Cell Carcinoma: new trials by email Literature Review of Extensive Stage Lung Small Cell Carcinoma trials Research Report on Extensive Stage Lung Small Cell Carcinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tarlatamab for the Treatment of Extensive Stage Small-cell Lung Cancer Biopsy Procedure, Biospecimen Collection, Computed Tomography - Extensive Stage Lung Small Cell Carcinoma | Phase 2 | Recruiting | Asrar Alahmadi | 39 | 2026-03-20 | 2026-07-06 |
| Using Biomarker Tests to Select and Test New, Personalized Treatments for Extensive Stage Small Cell Lung Cancer, PRISM Study Biospecimen Collection, Ceralasertib, Computed Tomography - Extensive Stage Lung Small Cell Carcinoma, Lung Small Cell Carcinoma, A Subtype | Phase 2 | Recruiting | SWOG Cancer Research Network | 900 | 2025-11-06 | 2026-03-30 |
| Testing the Combination of an Anti-cancer Drug, Iadademstat, With Other Anti-cancer Drugs (Atezolizumab or Durvalumab) at Improving Outcomes for Small Cell Lung Cancer Atezolizumab, Biopsy Procedure, Biospecimen Collection - Extensive Stage Lung Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8 | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 45 | 2025-04-08 | 2026-10-29 |
| Adebrelimab Combined with Chemotherapy and Thoracic Radiotherapy for First-line Treatment of ES-SCLC Adebrelimab, Radiation Therapy - Extensive Stage Lung Small Cell Carcinoma | Phase 3 | Not yet recruiting | Jinming Yu | 524 | 2024-12-01 | 2024-11-05 |
| Phase I/II Trial in ES-SCLC to Enhance Response to Atezolizumab Plus Chemotherapy With Total Body Irradiation Carboplatin, Atezolizumab, Etoposide - Extensive Stage Lung Small Cell Carcinoma, Stage IV Lung Cancer | Phase 1 / Phase 2 | Recruiting | Vanderbilt-Ingram Cancer Center | 18 | 2024-04-24 | 2024-06-20 |
| Hypofractionated Radiation Therapy After Durvalumab and Chemotherapy for the Treatment of Stage IV Extensive Stage Small Cell Lung Cancer, CASPIAN-RT Trial Carboplatin, Cisplatin, Durvalumab - Extensive Stage Lung Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8 | Phase 2 | Withdrawn | University of Washington | 2023-10-19 | 2023-10-18 | |
| Testing of Tazemetostat in Combination With Topotecan and Pembrolizumab in Patients With Recurrent Small Cell Lung Cancer Biopsy Procedure, Biospecimen Collection, Computed Tomography - Extensive Stage Lung Small Cell Carcinoma, Limited Stage Lung Small Cell Carcinoma | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 18 | 2022-07-27 | 2026-05-13 |
| Palliative Radiotherapy With Lurbinectedin in Patients With Extensive Stage Small Cell Lung Cancer Lurbinectedin, Palliative Radiation Therapy - Extensive Stage Lung Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8 | Phase 1 | Recruiting | Emory University | 22 | 2022-07-27 | 2025-10-31 |
| Supportive Care Intervention (ROAR-LCT) for Patients With Stage IIIA, IIIB, and IV Lung Cancer, ROAR-LCT Trial Best Practice, Exercise Intervention, Physical Therapy - Advanced Lung Non-Small Cell Carcinoma, Advanced Lung Small Cell Carcinoma | Not applicable | Completed | Ohio State University Comprehensive Cancer Center | 100 | 2022-04-14 | 2025-11-21 |
| Bomedemstat and Maintenance Immunotherapy for Treatment of Newly Diagnosed Extensive Stage Small Cell Lung Cancer Bomedemstat, Atezolizumab - Extensive Stage Lung Small Cell Carcinoma, Limited Stage Lung Small Cell Carcinoma | Phase 1 / Phase 2 | Terminated | University of Washington | 3 | 2022-04-11 | 2024-09-26 |
| Temozolomide and Atezolizumab for Subsequent Line for the Treatment of Metastatic or Recurrent Small Cell Lung Cancer Atezolizumab, Temozolomide - Extensive Stage Lung Small Cell Carcinoma, Metastatic Lung Small Cell Carcinoma | Phase 2 | Recruiting | Dwight Owen | 56 | 2022-01-26 | 2026-04-08 |
| Lamivudine in Combination With Chemoimmunotherapy for the Treatment of Extensive Stage Small Cell Lung Cancer Atezolizumab, Carboplatin, Etoposide - Extensive Stage Lung Small Cell Carcinoma | Phase 2 | Recruiting | Roswell Park Cancer Institute | 28 | 2021-07-02 | 2025-12-15 |
| LB-100, Carboplatin, Etoposide, and Atezolizumab for the Treatment of Untreated Extensive-Stage Small Cell Lung Cancer Atezolizumab, Carboplatin, Etoposide - Extensive Stage Lung Small Cell Carcinoma | Phase 1 | Active not recruiting | City of Hope Medical Center | 3 | 2021-05-28 | 2026-04-07 |
| Testing the Addition of an Anti-cancer Drug, Entinostat, to the Usual Chemotherapy and Immunotherapy Treatment (Atezolizumab, Carboplatin and Etoposide) for Previously Untreated Aggressive Lung Cancer That Has Spread Atezolizumab, Carboplatin, Entinostat - Extensive Stage Lung Small Cell Carcinoma, Malignant Solid Neoplasm | Phase 1 | Completed | National Cancer Institute (NCI) | 3 | 2021-04-27 | 2025-10-03 |
| Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial Atezolizumab, Biospecimen Collection, Computed Tomography - Extensive Stage Lung Small Cell Carcinoma | Phase 2 / Phase 3 | Suspended | National Cancer Institute (NCI) | 138 | 2021-01-07 | 2026-10-29 |
| Olaparib and Durvalumab With Carboplatin, Etoposide, and/or Radiation Therapy for the Treatment of Extensive-Stage Small Cell Lung Cancer, PRIO Trial Carboplatin, Durvalumab, Etoposide - Extensive Stage Lung Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8 | Phase 1 / Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 63 | 2021-01-05 | 2026-06-11 |
| Testing Maintenance Therapy for Small Cell Lung Cancer in Patients With SLFN11 Positive Biomarker Atezolizumab, Biopsy Procedure, Biospecimen Collection - Extensive Stage Lung Small Cell Carcinoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 103 | 2020-07-20 | 2026-06-05 |
| S1827 (MAVERICK) Testing Whether the Use of Brain Scans Alone Instead of Brain Scans Plus Preventive Brain Radiation Affects Lifespan in Patients With Small Cell Lung Cancer Magnetic Resonance Imaging, Prophylactic Cranial Irradiation - Extensive Stage Lung Small Cell Carcinoma, Limited Stage Lung Small Cell Carcinoma | Phase 3 | Active not recruiting | SWOG Cancer Research Network | 668 | 2020-05-04 | 2026-06-11 |
| Resiliency Among Older Adults Receiving Lung Cancer Treatment Physical Therapy, Quality-of-Life Assessment, Questionnaire Administration - Advanced Lung Carcinoma, Extensive Stage Lung Small Cell Carcinoma | Not applicable | Completed | Ohio State University Comprehensive Cancer Center | 18 | 2020-01-22 | 2023-11-15 |
| Randomized Trial of Topotecan With M6620, an ATR Kinase Inhibitor, in Small Cell Lung Cancers and Small Cell Cancers Outside of the Lungs Berzosertib, Biopsy Procedure, Biospecimen Collection - Extensive Stage Lung Small Cell Carcinoma, Extrapulmonary Small Cell Neuroendocrine Carcinoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 104 | 2019-12-30 | 2026-07-31 |
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Lung Neoplasms (10) · Small Cell Lung Carcinoma (10) · Brain Neoplasms (2) · Breast Neoplasms (1) · Breast Neoplasms, Male (1) · Carcinoma, Non-Small-Cell Lung (1) · Melanoma (1)
Neoplasms (19) · Neoplasms by Site (19) · Lung Diseases (18) · Respiratory Tract Diseases (18) · Respiratory Tract Neoplasms (18) · Thoracic Neoplasms (18) · Bronchial Neoplasms (10) · Carcinoma, Bronchogenic (10) · Lung Neoplasms (8) · Brain Diseases (2) · Central Nervous System Diseases (2) · Central Nervous System Neoplasms (2) · Nervous System Diseases (2) · Nervous System Neoplasms (2) · Breast Diseases (1)
Etoposide (10) · atezolizumab (10) · Carboplatin (9) · Magnetic Resonance Spectroscopy (7) · Specimen Handling (7) · Biopsy (5) · Disulfides (5) · Immunoglobulin G (5) · 1,2-diaminocyclohexaneplatinum II citrate (4) · Cisplatin (4) · Platinum (4) · Radiation (4) · durvalumab (4) · Radiotherapy (3) · Physical Therapy Modalities (2)
National Cancer Institute (NCI) (10) · Ohio State University Comprehensive Cancer Center (2) · SWOG Cancer Research Network (2) · University of Washington (2) · Asrar Alahmadi (1) · City of Hope Medical Center (1) · Dwight Owen (1) · Emory University (1) · Jinming Yu (1) · Jonsson Comprehensive Cancer Center (1) · M.D. Anderson Cancer Center (1) · OHSU Knight Cancer Institute (1) · Roswell Park Cancer Institute (1) · Vanderbilt-Ingram Cancer Center (1)
United States (25) · Canada (1) · Chile (1) · Colombia (1) · Mexico (1) · Saudi Arabia (1) · South Korea (1)
Anish Thomas (1) · Anne C Chiang (1) · Arun Rajan (1) · Asrar AlAhmadi, MBBS (1) · Carolyn J Presley, MD (1) · Carolyn J Presley, MD, MHS (1) · Chad G Rusthoven (1) · Charles M Rudin (1) · Dwight Owen (1) · Evan Osmundson, MD, PhD (1) · Grace K Dy (1) · Jacob Sands (1) · Jing Zeng (1) · Jonathan W Goldman (1) · Kristin Higgins, MD (1)
PMID 25732163, PMID 33509647, PMID 36184621, PMID 37555284, PMID 37584370, PMID 37824137, PMID 38932511, PMID 39113428, PMID 39146945, PMID 41671459, PMID 42820295
U10CA180888 (3), UM1CA186691 (2), K76AG074923 (1), N01CM00039 (1), P30CA016672 (1), P30CA033572 (1), P30CA138292 (1), P50CA228944 (1), R03AG064374 (1), U01CA062461 (1), U01CA069852 (1), U01CA076576 (1), U10CA031946 (1), U10CA180820 (1), U10CA180821 (1)