5 completed, 1 terminated. 6 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 6 | Completed 5, Terminated 1 |
Follow Childhood Central Nervous System Teratoma: new trials by email Literature Review of Childhood Central Nervous System Teratoma trials Research Report on Childhood Central Nervous System Teratoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia gamma-secretase/Notch signalling pathway inhibitor RO4929097, diagnostic laboratory biomarker analysis, pharmacological study - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Choriocarcinoma | Phase 1 | Terminated | National Cancer Institute (NCI) | 129 | 2010-03-01 | 2014-11-05 |
| Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors vorinostat, temozolomide, diagnostic laboratory biomarker analysis - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Choriocarcinoma | Phase 1 | Completed | National Cancer Institute (NCI) | 27 | 2010-02-01 | 2013-05-03 |
| Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma vorinostat, bortezomib, pharmacological study - Childhood Burkitt Lymphoma, Childhood Central Nervous System Choriocarcinoma | Phase 1 | Completed | National Cancer Institute (NCI) | 20 | 2009-08-01 | 2013-07-02 |
| Pazopanib Hydrochloride in Treating Young Patients With Solid Tumors That Have Relapsed or Not Responded to Treatment pazopanib hydrochloride, pharmacological study - Childhood Central Nervous System Choriocarcinoma, Childhood Central Nervous System Embryonal Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 55 | 2009-06-01 | 2013-09-30 |
| Sunitinib in Treating Young Patients With Refractory Solid Tumors sunitinib malate, pharmacological study, dynamic contrast-enhanced magnetic resonance imaging - Central Nervous System Metastases, Childhood Central Nervous System Choriocarcinoma | Phase 1 | Completed | National Cancer Institute (NCI) | 35 | 2006-10-01 | 2014-01-28 |
| Combination Chemotherapy in Treating Young Patients With Advanced Solid Tumors oxaliplatin, fluorouracil, leucovorin calcium - Childhood Central Nervous System Choriocarcinoma, Childhood Central Nervous System Embryonal Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 42 | 2005-09-01 | 2013-05-03 |
Optic Nerve Glioma (4) · Astrocytoma (3) · Choroid Plexus Neoplasms (3) · Familial ependymoma (3) · Medulloblastoma (3) · Oligodendroglioma (3) · Burkitt Lymphoma (2) · Dendritic Cell Sarcoma, Interdigitating (2) · Lymphoma, Large-Cell, Anaplastic (2) · Recurrence (2) · Rhabdoid Tumor (2) · Spinal Cord Neoplasms (2) · Adenoma, Acidophil (1) · Adenoma, Basophil (1) · Adenoma, Chromophobe (1)
Cranial Nerve Diseases (4) · Cranial Nerve Neoplasms (4) · Eye Diseases (4) · Glioma (4) · Neoplasms (4) · Neoplasms by Histologic Type (4) · Neoplasms by Site (4) · Neoplasms, Germ Cell and Embryonal (4) · Neoplasms, Glandular and Epithelial (4) · Neoplasms, Nerve Tissue (4) · Neoplasms, Neuroepithelial (4) · Nervous System Diseases (4) · Nervous System Neoplasms (4) · Neuroectodermal Tumors (4) · Optic Nerve Diseases (4)
Vorinostat (2) · 2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide (1) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (1) · Bortezomib (1) · Calcium Dobesilate (1) · Dexamethasone (1) · Fluorouracil (1) · Leucovorin (1) · Magnetic Resonance Spectroscopy (1) · Oxaliplatin (1) · Sunitinib (1) · Temozolomide (1) · pazopanib (1)
National Cancer Institute (NCI) (6)
United States (6) · Canada (3)
Jodi Muscal (1) · Julia Glade-Bender (1) · Lia Gore (1) · Najat Daw (1) · Steven DuBois (1) · Trent Hummel (1)
PMID 23554030, PMID 23857966, PMID 32623479, PMID 33852135
U01CA097452 (5)