12 completed, 2 unknown, 1 recruiting, 1 terminated. 8 Phase 2, 5 Phase 3, 3 Phase 4, 2 Not applicable, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Completed 5, Recruiting 1, Terminated 1, Unknown 1 |
| Phase 3 | 5 | Completed 2, Unknown 2, Terminated 1 |
| Phase 4 | 3 | Completed 3 |
| Not applicable | 2 | Completed 2 |
| Phase 1 | 2 | Completed 2 |
Follow Sorbitol: new trials by email Literature Review of Sorbitol trials Research Report on Sorbitol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intranasal and Intravenous Oxytocin for Analgesia to Noxious Heat Pain Intravenous oxytocin, Intravenous placebo, Intranasal oxytocin - Pain, Acute | Phase 2 | Completed | Wake Forest University Health Sciences | 24 | 2025-11-05 | 2026-06-30 |
| Safety and Efficacy Study of Sorbitol With Neoadjuvant Chemotherapy Combined With Tirellizumab (PD-1 Inhibitor) in Patients With Locally Advanced Gastric Cancer Sorbitol + PD-1 inhibitor + SOX chemotherapy, PD-1 inhibitor + SOX chemotherapy - Gastric Junction Adenocarcinoma, Gastric Cancer | Phase 2 | Recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 86 | 2024-11-01 | 2026-08-18 |
| A Study to Evaluate the Effect of Activated Charcoal With Sorbitol on the Single-dose of Mavacamten in Healthy Participants Mavacamten, Activated Charcoal with Sorbitol - Healthy Participants | Phase 1 | Completed | Bristol-Myers Squibb | 45 | 2022-04-15 | 2022-11-08 |
| A Study to Assess the Efficacy and Safety of PXT3003 in Charcot-Marie-Tooth Type 1A PXT3003, PXT3003 placebo - Charcot-Marie-Tooth Type 1A | Phase 3 | Completed | Tasly GeneNet Pharmaceuticals Co., Ltd | 176 | 2021-09-28 | 2025-01-09 |
| Phase III Trial Assessing the Efficacy and Safety of PXT3003 in CMT1A Patients (RS)-baclofen, naltrexone hydrochloride and D-sorbitol, Placebo - Charcot-Marie-Tooth Disease | Phase 3 | Unknown | Pharnext S.C.A. | 350 | 2021-03-30 | 2024-04-03 |
| Metabolic Cofactor Supplementation and Hydroxychloroquine Combination in Covid-19 Patients Hydroxychloroquine + Metabolic cofactor supplementation, Hydroxychloroquine + Sorbitol - COVID-19 | Phase 2 / Phase 3 | Terminated | ScandiBio Therapeutics AB | 100 | 2020-09-21 | 2025-02-10 |
| Metabolic Cofactor Supplementation in Alzheimer's Disease (AD) and Parkinson's Disease (PD) Patients Metabolic Cofactor Supplementation, Sorbitol - Alzheimer Disease, Parkinson Disease | Phase 2 | Completed | Istanbul Medipol University Hospital | 120 | 2019-12-02 | 2022-08-08 |
| Metabolic Cofactor Supplementation in Obese Patients With Non-Alcoholic Fatty Liver Disease Metabolic Cofactor Supplementation, Sorbitol - Non-alcoholic Fatty Liver Disease (NAFLD) | Phase 2 | Completed | ScandiBio Therapeutics AB | 32 | 2019-07-20 | 2025-02-10 |
| A Nicotine Pharmacokinetics and Smoking Behaviour Study Examining Cigarette Ingredients Reference cigarette, Cigarette with carob bean extract, Cigarette with cocoa powder - Healthy Volunteers, Smoking | Not applicable | Completed | British American Tobacco (Investments) Limited | 40 | 2017-09-12 | 2022-12-07 |
| Effect of Treatment of Low Anterior Resection Syndrome After Rectal Cancer Surgery Transanal irrigation, Medication - Low Anterior Resection Syndrome | Not applicable | Completed | Mirna Abraham-Nordling | 45 | 2017-05-15 | 2023-03-09 |
| A Phase IV, Open Label, 4-period Cross-over Study to Investigate a Drug Interaction Between Lamivudine and Sorbitol Oral Solutions in Healthy Volunteers Lamivudine, Sorbitol - Infection, Human Immunodeficiency Virus | Phase 4 | Completed | ViiV Healthcare | 16 | 2016-01-01 | 2017-05-15 |
| Gait Analysis Following Knee Viscosupplementation hyaluronic acid with mannitol, hyaluronic acid with sorbitol, Placebos - Gait, Knee Osteoarthritis | Phase 2 / Phase 3 | Completed | Brigitte Jolles, MD | 22 | 2013-05-01 | 2018-08-17 |
| Effect of Xylitol on Oral Microbiota in Children xylitol, sorbitol - Bacterial Infections | Phase 1 / Phase 2 | Completed | Kuwait University | 122 | 2012-03-01 | 2015-08-10 |
| Effect of Erythritol and Xylitol on Dental Caries Prevention in Children A, erythritol, xylitol, C, sorbitol - Dental Caries | Phase 2 / Phase 3 | Unknown | University of Tartu | 450 | 2008-01-01 | 2010-02-04 |
| Study About Effect of Preoperative Bowel Preparation Versus no Bowel Preparation Before Spinal Surgery Docusate natrium and sorbitol, Bisacodyl - Constipation, Ileus | Phase 4 | Completed | Oslo University Hospital | 45 | 2007-12-01 | 2013-06-18 |
| Bifidobacterium Lactis BB12 and Xylitol Delivered With a Novel Slow-release Pacifier Sorbitol, Xylitol + BB12, Xylitol - Dental Caries, Infectious Diseases | Phase 4 | Completed | University of Turku | 106 | 2004-06-01 | 2013-01-08 |
Dental Caries (2) · Acquired Immunodeficiency Syndrome (1) · Acute Pain (1) · Agnosia (1) · Alzheimer Disease (1) · Anthrax (1) · Bacterial Infections (1) · COVID-19 (1) · Charcot-Marie-Tooth Disease (1) · Communicable Diseases (1) · Constipation (1) · Ileus (1) · Infections (1) · Low Anterior Resection Syndrome (1) · Non-alcoholic Fatty Liver Disease (1)
ScandiBio Therapeutics AB (2) · Brigitte Jolles, MD (1) · Bristol-Myers Squibb (1) · British American Tobacco (Investments) Limited (1) · Istanbul Medipol University Hospital (1) · Kuwait University (1) · Mirna Abraham-Nordling (1) · Oslo University Hospital (1) · Pharnext S.C.A. (1) · Tasly GeneNet Pharmaceuticals Co., Ltd (1) · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (1) · University of Tartu (1) · University of Turku (1) · ViiV Healthcare (1) · Wake Forest University Health Sciences (1)
United States (4) · Turkey (Türkiye) (3) · China (2) · Belgium (1) · Canada (1) · Denmark (1) · Estonia (1) · Finland (1) · France (1) · Germany (1) · Israel (1) · Italy (1) · Kuwait (1) · Norway (1) · Spain (1)
Eino Honkala, PhD (2) · Brigitte Brigitte (1) · Burak Yulug, MD, PhD (1) · Ida T Bjork, MNSc, PhD, (1) · James C Eisenach, MD (1) · Johnston Stewart, MB (1) · Lutfu Hanoglu, MD, PhD (1) · Mare Saag, PhD (1) · Mario Saporta, MD (1) · Mirna Abraham-Nordling, MD.PhD (1)
PMID 22607272, PMID 23571819, PMID 24095985, PMID 24852946, PMID 27806364, PMID 29150845, PMID 30999906, PMID 31024734, PMID 34694070, PMID 36703196, PMID 38926266, PMID 39816194