17 recruiting, 13 active not recruiting, 12 completed, 6 not yet recruiting. 24 Not applicable, 16 Phase 2, 5 Phase 3, 2 Phase 1, 1 Early Phase 1.
Follow Breast Cancer Stage II: new trials by email Literature Review of Breast Cancer Stage II trials Research Report on Breast Cancer Stage II
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of the TheraBionic P1 Device in Breast Cancer TheraBionic P1 Device - Breast Cancer Stage I, Breast Cancer Stage II | Not applicable | Recruiting | Barbara Ann Karmanos Cancer Institute | 24 | 2026-10-01 | 2026-04-21 |
| Herbs & Supplements in Breast Cancer Usage, Impact, and Personalized Approaches for Diverse Populations No intervention - Breast Cancer, Breast Cancer Stage I | Not yet recruiting | Case Comprehensive Cancer Center | 240 | 2026-10-01 | 2026-08-28 | |
| Capecitabine in ER+/HER2-negative Breast Cancer Capecitabine - ER-positive, HER2-negative Breast Cancer, Breast Cancer Stage I | Phase 2 | Recruiting | University Health Network, Toronto | 15 | 2026-07-29 | 2026-08-18 |
| Effect of Meal Timing During Cancer Treatment in Patients in Alaska: A Randomized Clinical Trial Time-restricted eating, Questionnaire Administration, Biospecimen Collection - Rectal Cancer Stage II, Rectal Cancer Stage III | Not applicable | Recruiting | Fred Hutchinson Cancer Center | 100 | 2026-07-23 | 2026-07-29 |
| Pembrolizumab Adjuvant in Patients With Early-stage Triple Negative Breast Cancer With Residual Disease After Neoadjuvant Pembrolizumab Plus Chemotherapy Standard of care plus pembrolizumab, Standard of care (capecitabine or olaparib) - Triple Negative Breast Cancer (TNBC), Early Setting, Early Stage Triple-Negative Breast Carcinoma | Phase 3 | Not yet recruiting | The Netherlands Cancer Institute | 1000 | 2026-04-01 | 2026-03-20 |
| Neoadjuvant, SBRT With Intratumoural Pembrolizumab Followed by Neoadjuvant Chemotherapy in Breast Cancer Radiation, Pembrolizumab (KEYTRUDA®) - Breast Cancer, Breast Cancer Stage II | Phase 2 | Recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 40 | 2026-01-19 | 2026-02-11 |
| Study Assessing the Efficacy and Safety of cANnabidiol Oral Solution for Joint Pain of Adjuvant enDOcrine theRApy in Patients With Early Breast Cancer CBD oil, Placebo - Breast Cancer Stage I, Breast Cancer Stage II | Phase 3 | Not yet recruiting | Gustave Roussy, Cancer Campus, Grand Paris | 130 | 2025-12-01 | 2025-12-02 |
| CARE (Chemotherapy Alopecia REduction) Scalp Cooling by DigniCap - Breast Cancer, Breast - Female | Not applicable | Active not recruiting | George Washington University | 30 | 2025-09-24 | 2025-10-01 |
| Role of Triggering Receptor Expressed on Myeloid Cells (TREM-1) as a Novel Biomarker in Human Epidermal Growth Factor Receptor -2 (HER-2) Negative Breast Cancer: a Molecular and Clinical Study Breast Cancer Stage I, Breast Cancer Stage II | Not yet recruiting | Rahma Esam Salama Esawi | 1 | 2025-09-15 | 2025-04-30 | |
| Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer Memantine, Placebo medication, Exercise Intervention - Breast Cancer, Locally Advanced Breast Cancer | Phase 2 | Recruiting | UNC Lineberger Comprehensive Cancer Center | 90 | 2025-08-19 | 2026-05-06 |
| A Phase Ib/II Study to Evaluate Multiple Combination Therapies of FWD1802 in Patients With ER+/HER2- BC FWD1802, Palbociclib 125mg, Ribociclib 200Mg Oral Tablet - Metastatic Breast Cancer, Breast Cancer Stage I | Phase 1 / Phase 2 | Recruiting | Forward Pharmaceuticals Co., Ltd. | 196 | 2025-06-01 | 2026-01-07 |
| The Efficacy and Safety of CDK4/6 Inhibitors in Combination with Endocrine Therapy in the Neoadjuvant Treatment Ribociclib; abemaciclib; palbociclib; Dalpiciclib - Breast Cancer Stage III, Breast Cancer Stage II | Not applicable | Not yet recruiting | Hongmei Zheng, PhD | 40 | 2025-04-01 | 2025-03-17 |
| Abbreviated MBCT for Depression in Older Black or African American Breast Cancer Survivors MBCT - Breast Cancer, Breast Cancer Female | Not applicable | Active not recruiting | Case Comprehensive Cancer Center | 23 | 2025-03-21 | 2026-09-15 |
| EFFECT OF KINESIO TAPING AND LASER THERAPY IN PATIENT WITH LYMPHEDEMA ON GIRTH MEASUREMENT Low Level Laser Therapy, kinesio taping - Lymphedema, Breast Cancer Stage II | Not applicable | Completed | Beni-Suef University | 90 | 2025-02-01 | 2026-05-12 |
| A New Tool to Promote Patient's Engagement in Their Healthcare Process Healthcare professionals, Patients PDA group, Patients control group - Breast Carcinoma, Breast Cancer Stage I | Recruiting | European Institute of Oncology | 180 | 2025-01-22 | 2025-11-28 | |
| A Study of Language Interpretation Solutions for People With Breast Cancer Remote Simultaneous Medical Interpreting/RSMI, Remote Consecutive Medical Interpreting/RCMI, Remote Consecutive Video Medical Interpreting/RCVI - Breast Cancer, Breast Cancer Stage II | Not applicable | Recruiting | Memorial Sloan Kettering Cancer Center | 700 | 2024-12-02 | 2026-09-25 |
| Improvement of Quality of Life Through Supportive Treatments for Hormone Therapy - Related Symptoms in Patients With Early Breast Cancer Duloxetine 60 MG, Furosemide 40 mg, Booklet for healthy behaviors - ER+ Breast Cancer, HER2-negative Breast Cancer | Phase 3 | Not yet recruiting | European Organisation for Research and Treatment of Cancer - EORTC | 399 | 2024-12-01 | 2024-11-05 |
| Predicting Response to Neoadjuvant Endocrine Therapy (Neo-PREDICT) Neoadjuvant endocrine therapy - Breast Cancer Stage I, Breast Cancer Stage II | Phase 2 | Recruiting | George Washington University | 90 | 2024-10-01 | 2026-03-03 |
| Tart Cherry Juice as a Dietary Supplement for the Prevention of Paclitaxel-Induced Neuropathy Tart Cherry Juice - Breast Cancer, Breast Cancer Stage I | Phase 2 | Recruiting | University of California, Davis | 86 | 2024-08-15 | 2026-03-04 |
| Optimizing Surgical Decisions in Young Adults With Breast Cancer CONSYDER decision aid - Breast Cancer Stage 0, Breast Cancer Stage I | Not applicable | Recruiting | Weill Medical College of Cornell University | 800 | 2024-03-13 | 2026-08-19 |
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Breast Neoplasms (55) · Breast Carcinoma In Situ (5) · Triple Negative Breast Neoplasms (5) · Lymphedema (2) · Motor Activity (2) · Alopecia (1) · Breast Cancer Lymphedema (1) · Breast Neoplasms, Male (1) · Carcinoma (1) · Cardiotoxicity (1) · Cognitive Dysfunction (1) · Colorectal Neoplasms (1) · Drug-Related Side Effects and Adverse Reactions (1) · Head and Neck Neoplasms (1) · Intermittent Fasting (1)
Breast Diseases (55) · Neoplasms by Site (55) · Skin Diseases (55) · Skin and Connective Tissue Diseases (55) · Neoplasms (54) · Neoplasms by Histologic Type (6) · Neoplasms, Glandular and Epithelial (6) · Carcinoma (5) · Carcinoma in Situ (5) · Pathological Conditions, Signs and Symptoms (5) · Behavior (3) · Hemic and Lymphatic Diseases (3) · Lymphatic Diseases (3) · Pathologic Processes (3) · Chemically-Induced Disorders (2)
Capecitabine (3) · Letrozole (3) · Paclitaxel (3) · Trastuzumab (3) · palbociclib (3) · pembrolizumab (3) · ribociclib (3) · Carboplatin (2) · Docetaxel (2) · Gonadotropin-Releasing Hormone (2) · Tamoxifen (2) · abemaciclib (2) · pertuzumab (2) · AC protocol (1) · Acupuncture Therapy (1)
Dana-Farber Cancer Institute (5) · Memorial Sloan Kettering Cancer Center (4) · Alliance for Clinical Trials in Oncology (2) · Case Comprehensive Cancer Center (2) · European Organisation for Research and Treatment of Cancer - EORTC (2) · George Washington University (2) · Massachusetts General Hospital (2) · University Health Network, Toronto (2) · University of Chicago (2) · Affiliated Hospital of Jiangnan University (1) · Barbara Ann Karmanos Cancer Institute (1) · Baylor Breast Care Center (1) · Beni-Suef University (1) · Branch Office of "Hadassah Medical Ltd" (1) · Brust-Zentrum AG (1)
United States (29) · Canada (4) · China (3) · France (3) · Spain (3) · Egypt (2) · Italy (2) · Nigeria (2) · Portugal (2) · Belgium (1) · Czechia (1) · Germany (1) · Guam (1) · Jordan (1) · Netherlands (1)
Rachel Jimenez, MD (2) · Agnes Jager, MD, PhD (1) · Aleix Prat, MD (1) · Alina Markova, MD (1) · Alla Kartasheva, PhD (1) · Ana Garrido-Castro, MD (1) · Anthony Yu, MD (1) · Barbara Andersen (1) · Christina M Dieli-Conwright, PhD (1) · Chunjing Yu (1) · Einsley Janowski, MD, PhD (1) · Elizabeth Stone, MD (1) · Eve Rodler, MD (1) · Francesca Gany, MD, MS (1) · Gabe Sonke, MD, PhD (1)
PMID 18487249, PMID 29285038, PMID 30762400, PMID 31144265, PMID 32628583, PMID 34275766, PMID 34956864, PMID 34989765, PMID 36396308, PMID 36696330, PMID 37923529, PMID 39320397, PMID 40382452, PMID 41734922, PMID 42128956, PMID 42602220, PMID 42831611
2023 (1), 2025 (1), K23AG086604 (1), P01CA261669 (1), P30CA138292 (1), P50CA285275 (1), R01CA256877 (1), UG1CA189823 (1)