8 recruiting, 6 completed, 5 active not recruiting, 5 not yet recruiting. 21 Phase 2, 12 Phase 3, 1 Not applicable, 1 Phase 4.
Follow Atypical Endometrial Hyperplasia: new trials by email Literature Review of Atypical Endometrial Hyperplasia trials Research Report on Atypical Endometrial Hyperplasia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SHAPE-ENDO: Pilot Randomized Trial of Multimodal Pre-Surgical Optimization Versus Standard Surgery in Patients With Obesity and Early-Stage Endometrial Cancer GLP-1 Receptor Agonist, Levonorgestrel IUD (Lng-IUD), Oral Progestins - Endometrial Cancer, Endometrial Cancer Stage I | Phase 4 | Not yet recruiting | Hospital Universitari de Bellvitge | 80 | 2027-01-01 | 2026-06-10 |
| Canagliflozin Plus Progestin for Atypical Endometrial Hyperplasia and Early-Stage Endometrial Cancer LNG-IUS: levonorgestrel intrauterine system, Metformin, Canagliflozin - Endometrioid Endometrial Cancer, Atypical Endometrial Hyperplasia | Phase 2 | Not yet recruiting | Wang Yingmei | 102 | 2027-01-01 | 2026-10-22 |
| Mazdutide Plus LNG-IUS for Fertility-Sparing Treatment of AEH or Early Endometrial Cancer Mazdutide(Dual GLP-1R/GCGR Agonist), Placebo, Levonorgestrel-releasing intrauterine system - Obesity, Overweight | Phase 2 | Not yet recruiting | Tongji Hospital | 128 | 2026-11-01 | 2026-08-24 |
| Liquid Biopsy-Based Early Screening for Endometrial Cancer in Regional Chinese Populations Endometrial Cancer, Atypical Endometrial Hyperplasia | Recruiting | Guizhou Provincial People's Hospital | 512 | 2026-08-10 | 2026-10-23 | |
| Orlistat Plus Progestin for Fertility-Sparing Treatment of Endometrial Cancer or Atypical Hyperplasia Orlistat, Progestin - Endometrial Neoplasms, Endometrial Cancer | Phase 2 | Not yet recruiting | Peking University People's Hospital | 48 | 2026-07-01 | 2026-07-20 |
| Endometrial Cancer Vaginal Fluid Specimen Collection Study Abnormal Uterine Bleeding (AUB), Endometrial Cancer | Active not recruiting | Exact Sciences Corporation | 4200 | 2026-03-10 | 2026-10-05 | |
| Intrauterine Injection of Type III Collage in FST of EC/AEH Recombinant Humanized Type III Collagen Lyophilized Fibers + High-dose Progestin, High-dose Progestin - Atypical Endometrial Hyperplasia, Endometrial Cancer | Phase 2 | Recruiting | Wang Jianliu | 30 | 2026-01-30 | 2026-03-30 |
| Ultrasound and Histology in AEH and Early EEC Treated Conservatively Hysteroscopic fertility-sparing surgery and hormonal treatment - Fertility-Sparing Treatment (FST), Atypical Endometrial Hyperplasia | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 50 | 2025-06-11 | 2025-06-19 | |
| Medroxyprogesterone Acetate Plus Atorvastatin in Young Women With Early Endometrial Carcinoma and Atypical Endometrial Hyperplasia Medroxyprogesterone acetate + Atorvastatin - Atypical Endometrial Hyperplasia, Endometrial Carcinoma Stage I | Phase 2 | Unknown | Peking University People's Hospital | 82 | 2023-01-06 | 2024-07-11 |
| GnRHa + Letrozole in Obese Progestin-insensitive Endometrial Cancer Patients GnRH antagonist, Letrozole 2.5mg - Endometrial Neoplasms, Atypical Endometrial Hyperplasia | Phase 2 / Phase 3 | Recruiting | Xiaojun Chen | 29 | 2022-07-13 | 2026-09-10 |
| GnRHa + Letrozole in Obese Progestin-insensitive Endometrial Atypical Hyperplasia Patients GnRH antagonist, Letrozole 2.5mg - Atypical Endometrial Hyperplasia, Progesterone Resistance | Phase 2 / Phase 3 | Active not recruiting | Xiaojun Chen | 29 | 2022-07-13 | 2025-08-11 |
| GnRHa + Letrozole in Non-obese Progestin-insensitive Endometrial Cancer and Atypical Hyperplasia Patients GnRHa, Letrozole 2.5mg, Diane-35 - Endometrial Neoplasms, Atypical Endometrial Hyperplasia | Phase 2 / Phase 3 | Recruiting | Xiaojun Chen | 80 | 2022-07-13 | 2026-09-10 |
| Weight Management Plus LNG-IUS/Megestrol Acetate in Endometrial Atypical Hyperplasia Intensive Lifestyle Intervention (ILI), Megestrol Acetate 160 MG Oral Tablet, Levonorgestrel-Releasing Intrauterine Contraceptive System (Mirena), 52 Mg - Atypical Endometrial Hyperplasia, Fertility Issues | Phase 2 / Phase 3 | Recruiting | Xiaojun Chen | 172 | 2022-06-13 | 2026-06-04 |
| Loxenatide Plus LNG-IUS in Endometrial Atypical Hyperplasia levonorgestrel-releasing intrauterine system, Polyethylene Glycol Loxenatide - Atypical Endometrial Hyperplasia, Obesity | Phase 2 / Phase 3 | Completed | Fudan University | 30 | 2022-01-08 | 2026-03-13 |
| Patient-derived Tumor-like Cell Clusters Predict Progesterone Sensitivity in Patients With Early Endometrial Cancer No intervention - Endometrial Carcinoma Stage I, Atypical Endometrial Hyperplasia | Recruiting | Peking University People's Hospital | 244 | 2021-09-01 | 2025-05-04 | |
| Leveraging Methylated DNA Markers (MDMs) in the Detection of Endometrial Cancer, Ovarian Cancer, and Cervical Cancer Vaginal Fluid Collection, Blood Collection - Endometrial Cancer, Cervical Cancer | Recruiting | Mayo Clinic | 3110 | 2021-08-03 | 2026-09-29 | |
| Liraglutide Plus Megestrol Acetate in Endometrial Atypical Hyperplasia Liraglutide Injection, Megestrol Acetate 160 MG - Atypical Endometrial Hyperplasia, Obese | Phase 2 / Phase 3 | Withdrawn | Xiaojun Chen | 2021-03-20 | 2024-09-26 | |
| Metformin Plus Megestrol Acetate As a Fertility-sparing Treatment in Patients with Atypical Endometrial Hyperplasia Metformin plus Megestrol acetate, Megestrol Acetate - Atypical Endometrial Hyperplasia | Phase 2 / Phase 3 | Terminated | Fudan University | 12 | 2021-01-11 | 2024-09-26 |
| Megestrol Acetate Plus Rosuvastatin in Young Women With Atypical Endometrial Hyperplasia Megestrol Acetate, Rosuvastatin - Atypical Endometrial Hyperplasia | Phase 2 / Phase 3 | Completed | Fudan University | 36 | 2020-09-01 | 2024-01-29 |
| LVN- IUS Versus Oral Megesterol Acetate in Treatment of Atypical Endometrial Hyperplasia levonorgestrel intrauterine system (LNG-IUD), Oral Megesterol 160 mg daily - Atypical Endometrial Hyperplasia | Phase 2 / Phase 3 | Completed | Zagazig University | 143 | 2020-05-20 | 2023-01-03 |
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Endometrial Hyperplasia (29) · Endometrial Neoplasms (16) · Obesity (7) · Infertility (3) · Overweight (3) · Progesterone Resistance (3) · Uterine Cervical Dysplasia (2) · Metrorrhagia (1) · Neoplasms (1) · Ovarian Neoplasms (1) · Papillomavirus Infections (1) · Precancerous Conditions (1) · Uterine Cervical Neoplasms (1)
Female Urogenital Diseases (29) · Female Urogenital Diseases and Pregnancy Complications (29) · Genital Diseases (29) · Genital Diseases, Female (29) · Urogenital Diseases (29) · Uterine Diseases (29) · Genital Neoplasms, Female (16) · Neoplasms (16) · Neoplasms by Site (16) · Urogenital Neoplasms (16) · Uterine Neoplasms (16) · Pathological Conditions, Signs and Symptoms (9) · Body Weight (7) · Nutrition Disorders (7) · Nutritional and Metabolic Diseases (7)
Megestrol Acetate (9) · Letrozole (3) · Medroxyprogesterone Acetate (3) · Progestins (3) · LHRH, Ac-Nal(1)-Cpa(2)-Trp(3)-Arg(6)-Ala(10)- (2) · Metformin (2) · 3,5-dimethoxy-4'-hydroxystilbene (1) · Atorvastatin (1) · Blood Specimen Collection (1) · Canagliflozin (1) · Cyproterone acetate, ethinyl estradiol drug combination (1) · Estrogen Replacement Therapy (1) · Everolimus (1) · Gonadotropin-Releasing Hormone (1) · Hysterectomy (1)
Xiaojun Chen (5) · Fudan University (4) · Peking University People's Hospital (3) · M.D. Anderson Cancer Center (2) · City of Hope Medical Center (1) · Exact Sciences Corporation (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · GOG Foundation (1) · Guizhou Provincial People's Hospital (1) · Hospital Universitari de Bellvitge (1) · IRCCS Burlo Garofolo (1) · Mayo Clinic (1) · NYU Langone Health (1) · Tongji Hospital (1) · University of Southern California (1)
China (16) · United States (7) · Italy (2) · Egypt (1) · Japan (1) · South Korea (1)
Amr Alnemr, M.D. (1) · Antonia Carla Testa (1) · Federica Scrimin, MD (1) · Gang Chen, Principal Investigator (1) · Hytham Atia, M.D. (1) · Jamie N. Bakkum-Gamez, M.D. (1) · Jorge Garcia Fernandez (1) · Lola Marti (1) · Shannon N Westin (1) · Shannon N Westin, MD (1) · Stephanie V Blank, M.D. (1) · Thanh H Dellinger (1) · Xiaojun Chen (1)
PMID 32909630, PMID 18928975, PMID 32805208, PMID 37182434, PMID 38425141
P50CA098258 (2), N01CM62201 (1), P30CA014089 (1), P30CA033572 (1), U10CA101165 (1), UG1CA189867 (1)