11 unknown, 7 completed, 1 terminated, 1 withdrawn. 20 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 20 | Unknown 11, Completed 7, Terminated 1, Withdrawn 1 |
Follow Anemia, Aplastic: new trials by email Literature Review of Anemia, Aplastic trials Research Report on Anemia, Aplastic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Romiplostim for the Treatment of Refractory Transfusion-dependent NSAA Romiplostim - Aplastic Anemia | Phase 4 | Unknown | Peking Union Medical College Hospital | 40 | 2024-08-02 | 2024-08-02 |
| Efficacy and Safety of rhTPO in Combination With Cyclosporine Versus Cyclosporine Alone in the Treatment of TD-NSAA rhTPO, Cyclosporin A - Aplastic Anemia, Transfusion-dependent Anemia | Phase 4 | Unknown | Peking Union Medical College Hospital | 54 | 2024-07-30 | 2024-07-29 |
| Ropustin for Refractory Aplastic Anaemia After Radiotherapy - a Single-centre, Prospective, Open-label, Single-arm Study Romiplostim - Aplastic Anemia | Phase 4 | Unknown | Peking Union Medical College Hospital | 40 | 2024-07-30 | 2024-07-24 |
| A Prospective Study on the Treatment of Recurrent/Refractory/Intolerable NSAA With Lusutrombopag Lusutrombopag - Aplastic Anemia | Phase 4 | Unknown | Peking Union Medical College Hospital | 40 | 2024-06-01 | 2024-05-23 |
| Luspatercept Plus CsA vs CsA for the Treatment of Newly Diagnosed Non-Transfusion-Dependent NSAA Luspatercept, cyclosporine - Aplastic Anemia | Phase 4 | Withdrawn | Peking Union Medical College Hospital | 2024-05-01 | 2026-06-04 | |
| The Optimization of Conditioning Regimen for HLA Matched HSCT in SAA Busulfan, Flu/Cy/ATG or Cy/ATG - Severe Aplastic Anemia | Phase 4 | Unknown | Peking University People's Hospital | 160 | 2023-11-15 | 2023-11-18 |
| CsA+ATG+AVA vs. CsA+AVA for the Treatment of Newly-diagnosed SAA in the Elderly Ciclosporin, Avatrombopag, Anti-Human Thymocyte Immunoglobulin, Rabbit - Aplastic Anemia | Phase 4 | Completed | Peking Union Medical College Hospital | 86 | 2023-09-15 | 2025-04-30 |
| A Prospective, Randomized, Controlled Study of rhTPO in Combination With Herombopag + CsA vs Herombopag + CsA for the Treatment of Primary TD-NSAA Herombopag + CsA, rhTPO combined with Herombopag + CsA - Aplastic Anemia, Drug Effect | Phase 4 | Unknown | Peking Union Medical College Hospital | 90 | 2023-08-01 | 2023-08-22 |
| Efficacy of IST Combined With TPO-RA in the Treatment of AA and Establishment of a Recurrence Prediction System CsA+ATG+Herombopag, CsA+Herombopag - Aplastic Anemia, CSA | Phase 4 | Unknown | Peking Union Medical College Hospital | 210 | 2023-01-20 | 2023-08-24 |
| Combination of Thrombopoietin Mimetic and Immunosuppressive Therapy in Aplastic Anaemia Combination of thrombopoietin mimetic and cyclosporin A - Aplastic Anemia | Phase 4 | Completed | Safaa AA Khaled | 66 | 2019-11-15 | 2021-09-29 |
| A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCT Vitamin D3, Standard Vitamin D3 Supplementation - Vitamin D Deficiency, Stem Cell Transplant Complications | Phase 4 | Completed | Phoenix Children's Hospital | 49 | 2017-11-01 | 2020-11-17 |
| ATG Combined With Cyclophosphamide And Cord Blood Transfusion in Treating Patients With Severe Aplastic Anemia Rabbit ATG, (Genzyme), Cy, CsA - Aplastic Anemia | Phase 4 | Unknown | Jinan Military General Hospital | 130 | 2017-02-01 | 2017-02-01 |
| King's Invasive Aspergillosis Study II Posaconazole - Aplastic Anemia, Leukemia, Myeloid, Acute | Phase 4 | Completed | King's College Hospital NHS Trust | 120 | 2016-12-07 | 2020-04-02 |
| The Efficacy of Immunosuppressive Therapy Combined With Cord Blood Transfusion in Treatment of Severe Aplastic Anemia Thymoglobulin, Cord blood, Cyclosporine Oral Product - Severe Aplastic Anemia | Phase 4 | Completed | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | 60 | 2016-01-01 | 2023-03-17 |
| Safety and Efficacy of Exjade in the Treatment of Transfusion-dependent Iron Overload in Aplastic Anemia Patients ICL670, Chelation, No chelation - Aplastic Anemia | Phase 4 | Terminated | Novartis Pharmaceuticals | 15 | 2014-06-23 | 2019-08-16 |
| Treatment Protocol of Child SAA With the Injection of Mesenchymal Stem Cells（Umbilical Cord Derived） MSC+ATG - Complications of Organ Transplant Stem Cells Umbilical Cord | Phase 4 | Unknown | Chinese Academy of Medical Sciences | 20 | 2013-10-01 | 2014-08-18 |
| Moderate-dose Cyclophosphamide for Childhood Acquired Aplastic Anemia cyclophosphamide,cyclosporine A - Aplastic Anemia | Phase 4 | Unknown | Xiaofan Zhu | 30 | 2012-03-01 | 2013-11-26 |
| Safety and Efficacy of Desferasirox in Chinese Patients With Iron Overload and Aplastic Anemia Desferasirox - Iron Overload | Phase 4 | Completed | Novartis Pharmaceuticals | 64 | 2011-10-01 | 2014-10-28 |
| Different Doses of Anti-thymocyte Globin to Treat Child Severe Aplastic Anemia ATG - Severe Aplastic Anemia | Phase 4 | Unknown | Chinese Academy of Medical Sciences | 100 | 2010-12-01 | 2013-12-03 |
| Magnetic Resonance Imaging (MRI) Assessments of the Heart and Liver Iron Load in Patients With Transfusion Induced Iron Overload deferasirox - Hemoglobinopathies, Myelodysplastic Syndromes | Phase 4 | Completed | Novartis | 118 | 2007-11-01 | 2017-02-23 |
Myelodysplastic Syndromes (3) · Anemia, Diamond-Blackfan (1) · Fibromyalgia (1) · Hematologic Diseases (1) · Hemoglobinopathies (1) · Iron Overload (1) · Leukemia, Myeloid, Acute (1) · Neoplasms (1) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (1) · Recurrence (1) · Vitamin D Deficiency (1)
Anemia (20) · Bone Marrow Diseases (20) · Bone Marrow Failure Disorders (20) · Hemic and Lymphatic Diseases (20) · Hematologic Diseases (19) · Leukemia (2) · Neoplasms by Histologic Type (2) · Nutritional and Metabolic Diseases (2) · Anemia, Hypoplastic, Congenital (1) · Avitaminosis (1) · Congenital Bone Marrow Failure Syndromes (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Deficiency Diseases (1) · Disease Attributes (1)
Cyclosporine (7) · Antilymphocyte Serum (3) · Cyclophosphamide (2) · Deferasirox (2) · romiplostim (2) · thymoglobulin (2) · Busulfan (1) · Chelating Agents (1) · Cholecalciferol (1) · Cyclosporins (1) · avatrombopag (1) · luspatercept (1) · lusutrombopag (1) · posaconazole (1)
Peking Union Medical College Hospital (8) · Chinese Academy of Medical Sciences (2) · Novartis Pharmaceuticals (2) · Jinan Military General Hospital (1) · King's College Hospital NHS Trust (1) · Novartis (1) · Peking University People's Hospital (1) · Phoenix Children's Hospital (1) · Safaa AA Khaled (1) · Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine (1) · Xiaofan Zhu (1)
China (15) · Australia (1) · Egypt (1) · Russia (1) · United Kingdom (1) · United States (1)
Bing Bing, PhD (3) · Bing Han, PhD (2) · Alexander Ngwube, MD (1) · Chun Wang, M.D., Ph. D. (1) · Fang Zhou, MD (1) · Kayla Burgett (1) · Safinaz Hussien, MD (1) · Sawsan A Abdelaal, M.B.B.Ch (1) · Xiaifan Zhu, MD (1) · Xiao-Jun Huang (1) · Xiaofan Zhu, MD (1)
PMID 1090310, PMID 21663651, PMID 24838091, PMID 25932194, PMID 26622526, PMID 26876245, PMID 27537786, PMID 33305842, PMID 33639900, PMID 33875811, PMID 35911824