31 recruiting. 31 Phase 2, 8 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 31 | Recruiting 31 |
| Phase 1 | 8 | Recruiting 8 |
Follow Anemia, Aplastic: new trials by email Literature Review of Anemia, Aplastic trials Research Report on Anemia, Aplastic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pacritinib, a Kinase Inhibitor of CSF1R, IRAK1, JAK2, and FLT3, in Adults and Pediatric Participants 12 Years of Age or Older With Myelodysplastic Syndromes or Myelodysplastic/Myeloproliferative Neoplasms pacritinib - Myelodysplastic Syndromes | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 160 | 2026-11-15 | 2026-11-10 |
| A Phase 1/2 Study to Evaluate the Safety and Efficacy of Dibotatug (DR-01) in Adults With Bone Marrow Failure Syndromes Dibotatug (DR-01) - Bone Marrow Failure Syndromes, Aplastic Anemias | Phase 1 / Phase 2 | Recruiting | Dren Bio | 60 | 2026-08-14 | 2026-11-04 |
| Phase I/II Study of Anti-CD38 Monoclonal Antibody in Refractory Severe Aplastic Anemia Isatuximab - Aplastic Anemia | Phase 1 / Phase 2 | Recruiting | Institute of Hematology & Blood Diseases Hospital, China | 32 | 2026-06-30 | 2026-09-21 |
| Romiplostim Versus rhTPO for Platelet Engraftment After Transplant in MDS and AA Romiplostim, Recombinant Human Thrombopoietin - MDS (Myelodysplastic Syndrome), Aplastic Anemia (AA) | Phase 2 | Recruiting | The First Affiliated Hospital of Soochow University | 66 | 2026-01-31 | 2026-04-15 |
| The Safety and Efficacy of Daratumumab in Patients With Refractory Aplastic Anemia Daratumumab - Aplastic Anemia, Refractory | Phase 1 / Phase 2 | Recruiting | Institute of Hematology & Blood Diseases Hospital, China | 37 | 2025-12-17 | 2026-11-06 |
| Clinical Trial of Upfront Haploidentical or Unrelated Donor BMT to Restore Normal Hematopoiesis in Aplastic Anemia Haploidentical donor bone marrow transplant, Unrelated donor bone marrow transplant - Severe Aplastic Anemia | Phase 2 | Recruiting | Medical College of Wisconsin | 60 | 2025-05-12 | 2026-02-17 |
| Efficacy and Safety of Sirolimus With or Without Cyclosporin A in Chinese Patients With Aplastic Anemia Refractory/Intolerant to Cyclosporin A Sirolimus (Rapamune®), Cyclosporin A (CsA) - Aplastic Anaemia | Phase 2 | Recruiting | Peking Union Medical College Hospital | 40 | 2025-01-25 | 2025-06-04 |
| Indication of HSCT in Patients With Refractory/Relapse AA After First-line Standard Immunosuppressive Therapy Aged More Than 40 Years Allogeneic hematopoietic stem cell transplantation Stem cell source only Bone Marrow - Aplastic Anemia | Phase 2 | Recruiting | Assistance Publique - Hôpitaux de Paris | 52 | 2025-01-24 | 2026-04-28 |
| Afatinib in Patients With Fanconi Anemia (FA) and Advanced Head and Neck Squamous Cell Carcinoma (HNSCC) Afatinib - Fanconi Anemia, Head and Neck Squamous Cell Carcinoma | Phase 1 / Phase 2 | Recruiting | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 25 | 2024-11-08 | 2026-05-27 |
| MT2023-20: Hematopoietic Cell Transplant With Reduced Intensity Conditioning and Post-transplant Cyclophosphamide for Severe Aplastic Anemia and Other Forms of Acquired Bone Marrow Failure. Rituximab, Rabbit ATG, Cyclophosphamide - Severe Aplastic Anemia, Acquired Amegakaryocytic Thrombocytopenia | Phase 2 | Recruiting | Masonic Cancer Center, University of Minnesota | 60 | 2024-06-05 | 2026-06-03 |
| A Study of Emapalumab for Pediatric Aplastic Anemia Emapalumab - Aplastic Anemia, Cytopenia | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 35 | 2024-05-21 | 2025-12-17 |
| Clinical Study on Modified Allogeneic Hematopoietic Stem Cell Transplantation Regimen for Severe Aplastic Anemia Modified transplantation system - Severe Aplastic Anemia | Phase 2 | Recruiting | Hematology department of the 920th hospital | 30 | 2024-03-01 | 2024-04-22 |
| Exercise Training and NR Supplementation Trial to Improve Fitness in AYA HCT Survivors Nicotinamide Riboside, Placebo, Exercise Intervention - Lymphoblastic Leukemia, Cancer Survivors | Phase 2 | Recruiting | Children's Hospital of Philadelphia | 80 | 2023-02-23 | 2025-12-04 |
| Rituximab for Serious Aplastic Anemia With Platelet Transfusion Refractoriness Rituximab - Severe Aplastic Anemia, Platelet Transfusion Refractoriness | Phase 2 | Recruiting | Institute of Hematology & Blood Diseases Hospital, China | 20 | 2023-02-23 | 2024-02-12 |
| Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation With Post-transplant Cyclophosphamide in Patients With Acquired Refractory Aplastic Anemia or in Relapse After Immunosuppression Allogenic transplantation - Refractory Idiopathic Aplastic Anemia, Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation | Phase 2 | Recruiting | Assistance Publique - Hôpitaux de Paris | 31 | 2022-01-06 | 2023-11-24 |
| Depleted Donor Stem Cell Transplant in Children and Adults With Fanconi Anemia After Being Conditioned With a Regimen Containing Briquilimab JSP191, CliniMACS Prodigy System, Depleted Stem Cell Transplant - Fanconi Anemia | Phase 1 / Phase 2 | Recruiting | Porteus, Matthew, MD | 18 | 2021-12-07 | 2026-01-27 |
| Two Step Haplo With Radiation Conditioning Fludarabine, Total-Body Irradiation, Donor Lymphocyte Infusion - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Phase 2 | Recruiting | Thomas Jefferson University | 63 | 2021-10-25 | 2025-10-30 |
| AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell Depletion alpha beta depletion - Acute Leukemia, Severe Aplastic Anemia | Phase 2 | Recruiting | Mitchell Cairo | 20 | 2021-04-01 | 2026-10-23 |
| Haploidentical HCT for Severe Aplastic Anemia Anti-Thymocyte Globulin (Rabbit), Fludarabine, Cyclophosphamide - Aplastic Anemia, Bone Marrow Failure Syndrome | Phase 2 | Recruiting | St. Jude Children's Research Hospital | 21 | 2021-01-21 | 2026-09-16 |
| TCR Alpha Beta T-cell Depleted Haploidentical HCT in the Treatment of Non-Malignant Hematological Disorders in Children Haploidentical Hematopoietic Cell Transplantation - Hemoglobinopathy (Disorder), Severe Aplastic Anemia | Phase 2 | Recruiting | Johns Hopkins All Children's Hospital | 17 | 2020-07-22 | 2026-07-01 |
Showing 20 of 31. Sign in to see all of them.
Myelodysplastic Syndromes (8) · Bone Marrow Failure Disorders (6) · Fanconi Anemia (5) · Anemia, Refractory, with Excess of Blasts (4) · Anemia, Diamond-Blackfan (3) · Anemia, Sickle Cell (3) · Dyskeratosis Congenita (3) · Hemoglobinuria, Paroxysmal (3) · beta-Thalassemia (3) · Cytopenia (2) · Hodgkin Disease (2) · Leukemia, Myeloid, Acute (2) · Lymphoma, Non-Hodgkin (2) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (2)
Hemic and Lymphatic Diseases (31) · Anemia (30) · Bone Marrow Diseases (30) · Hematologic Diseases (30) · Bone Marrow Failure Disorders (25) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (9) · Genetic Diseases, Inborn (9) · Anemia, Hypoplastic, Congenital (8) · Congenital Bone Marrow Failure Syndromes (7) · Anemia, Hemolytic (6) · DNA Repair-Deficiency Disorders (6) · Immune System Diseases (6) · Metabolic Diseases (6) · Nutritional and Metabolic Diseases (6)
fludarabine (10) · Cyclophosphamide (9) · Rituximab (5) · Whole-Body Irradiation (5) · thymoglobulin (5) · Alemtuzumab (4) · Filgrastim (4) · Granulocyte Colony-Stimulating Factor (4) · Melphalan (4) · fludarabine phosphate (4) · Antilymphocyte Serum (3) · Cyclosporine (3) · Mycophenolic Acid (3) · Tacrolimus (3) · Busulfan (2)
National Heart, Lung, and Blood Institute (NHLBI) (4) · Institute of Hematology & Blood Diseases Hospital, China (3) · Assistance Publique - Hôpitaux de Paris (2) · Masonic Cancer Center, University of Minnesota (2) · Paul Szabolcs (2) · Children's Hospital Medical Center, Cincinnati (1) · Children's Hospital of Philadelphia (1) · Dren Bio (1) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (1) · Hematology department of the 920th hospital (1) · Johns Hopkins All Children's Hospital (1) · M.D. Anderson Cancer Center (1) · Medical College of Wisconsin (1) · Memorial Sloan Kettering Cancer Center (1) · Mitchell Cairo (1)
United States (22) · China (6) · France (2) · Germany (1) · Spain (1)
Richard W Childs, M.D. (3) · Paul Szabolcs, MD (2) · Akshay Sharma, MBBS (1) · Amr Qudeimat, MD (1) · Andromachi Scaradavou, MD (1) · Bhavisha A Patel, M.D. (1) · Deepak Chellapandian, MD (1) · Heather J Symons, MD, MHS (1) · Huang Jinbo, MD. (1) · Jun Shi, PhD (1) · Margaret MacMillan, MD, Msc, FRCPC (1) · Melhem Solh, MD (1) · Mitchell S Cairo (1) · Najla El Jurdi, M.D. (1)
PMID 19117511, PMID 22517900, PMID 22796534, PMID 24319166, PMID 24319167, PMID 24842530, PMID 25797174, PMID 26359881, PMID 2889870, PMID 32634238, PMID 32750127, PMID 33159275, PMID 35854224, PMID 40696207, PMID 40859225
R01CA254955 (1)