19 completed. 19 Phase 2, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 19 | Completed 19 |
| Phase 1 | 2 | Completed 2 |
Follow Adrenal Cortex Diseases: new trials by email Literature Review of Adrenal Cortex Diseases trials Research Report on Adrenal Cortex Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cabozantinib in Treating Patients With Locally Advanced or Metastatic Unresectable Adrenocortical Carcinoma Cabozantinib, Pharmacogenomic Study, Pharmacokinetic Study - Metastatic Carcinoma in the Adrenal Cortex, Stage III Adrenal Cortex Carcinoma AJCC v8 | Phase 2 | Completed | M.D. Anderson Cancer Center | 18 | 2018-02-26 | 2024-12-10 |
| Study to Evaluate CORT125134 in Participants With Cushing's Syndrome CORT125134 - Cushing's Syndrome | Phase 2 | Completed | Corcept Therapeutics | 35 | 2016-06-01 | 2019-10-15 |
| Study of Efficacy and Safety of Osilodrostat in Cushing's Syndrome Osilodrostat - Cushing's Syndrome, Ectopic Corticotropin Syndrome | Phase 2 | Completed | Novartis Pharmaceuticals | 9 | 2015-09-24 | 2020-05-06 |
| Medical Safety Follow-up Study for Patients Who Received More Than 28 Days of Total Exposure to BGG492 MRI, CT or ultrasound was permitted if MRI was contraindicated, Dexamethasone Supression Test, Sonogram - Adrenocortical Adenoma, Endometrial Stromal Sarcomas | Phase 2 | Completed | Novartis Pharmaceuticals | 59 | 2014-08-01 | 2016-12-05 |
| Surgery and Heated Chemotherapy for Adrenocortical Carcinoma Cisplatin, Cytoreductive surgery, sodium thiosulfate - Adrenocortical Carcinoma, Peritoneal Carcinomatosis | Phase 2 | Completed | National Cancer Institute (NCI) | 11 | 2013-04-12 | 2019-07-30 |
| Clinical Trial of Dovitinib in First-line Metastatic or Locally Advanced Non-resectable Adrenocortical Carcinoma Dovitinib - Adrenocortical Carcinoma | Phase 2 | Completed | Spanish Oncology Genito-Urinary Group | 17 | 2012-01-01 | 2017-04-25 |
| A Dose Finding Study of TKM-080301 Infusion in Neuroendocrine Tumors (NET) and Adrenocortical Carcinoma (ACC) Patients TKM-080301 - Cancer, Neuroendocrine Tumors | Phase 1 / Phase 2 | Completed | Arbutus Biopharma Corporation | 68 | 2010-12-01 | 2019-01-16 |
| Phase II Study of Axitinib (AG-013736) With Evaluation of the VEGF-Pathway in Metastatic, Recurrent or Primary Unresectable Adrenocortical Cancer Axitinib - Adrenal Cortex Neoplasms | Phase 2 | Completed | National Cancer Institute (NCI) | 13 | 2010-09-01 | 2013-06-27 |
| Gossypol Acetic Acid in Treating Patients With Recurrent, Metastatic, or Primary Adrenocortical Cancer That Cannot Be Removed By Surgery R-(-)-gossypol acetic acid - Recurrent Adrenocortical Carcinoma, Stage III Adrenocortical Carcinoma | Phase 2 | Completed | National Cancer Institute (NCI) | 29 | 2009-02-01 | 2014-05-07 |
| Cixutumumab in Treating Patients With Relapsed or Refractory Solid Tumors cixutumumab, laboratory biomarker analysis - Adult Rhabdomyosarcoma, Adult Synovial Sarcoma | Phase 2 | Completed | National Cancer Institute (NCI) | 116 | 2009-01-01 | 2015-03-30 |
| Sunitinib in Refractory Adrenocortical Carcinoma Sunitinib - Adrenocortical Carcinoma | Phase 2 | Completed | University of Wuerzburg | 39 | 2007-07-01 | 2019-01-31 |
| Evaluation of 123I-Iodometomidate for Adrenal Scintigraphy 123I-Iodometomidate - Adrenal Tumor, Adrenocortical Carcinoma | Phase 1 / Phase 2 | Completed | University of Wuerzburg | 2007-03-01 | 2010-08-18 | |
| Trial With Taxotere and Cisplatin in Non-operable Adrenocortical Carcinoma cisplatin, taxotere - Adrenocortical Carcinoma | Phase 2 | Completed | Copenhagen University Hospital, Rigshospitalet | 19 | 2006-04-01 | 2012-02-22 |
| Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment oxaliplatin - Childhood Central Nervous System Germ Cell Tumor, Childhood Extragonadal Germ Cell Tumor | Phase 2 | Completed | National Cancer Institute (NCI) | 180 | 2004-10-01 | 2013-06-05 |
| Phase II Trial of ZD1839 (Iressa) in Patients With Nonresectable Adrenocortical Carcinoma (ACC) Iressa (ZD1839) - Nonresectable Adrenocortical Carcinoma | Phase 2 | Completed | Dartmouth-Hitchcock Medical Center | 16 | 2004-08-01 | 2018-05-17 |
| Surgery Plus Chemotherapy (Doxorubicin, Vincristine and Etoposide), Mitotane, and Tariquidar to Treat Adrenocortical Cancer XR9576 (Tariquidar) - Adrenal Cortex Neoplasms | Phase 2 | Completed | National Cancer Institute (NCI) | 50 | 2003-10-01 | 2012-09-18 |
| Combination Chemotherapy and Tamoxifen in Treating Patients With Solid Tumors cisplatin, doxorubicin hydrochloride, tamoxifen citrate - Adrenocortical Carcinoma, Brain and Central Nervous System Tumors | Phase 2 | Completed | Ottawa Regional Cancer Centre | 30 | 1994-05-01 | 2013-07-10 |
| A Study of Combination Chemotherapy and Surgical Resection in the Treatment of Adrenocortical Carcinoma: Continuous Infusion Doxorubicin, Vincristine and Etoposide With Daily Mitotane Before and After Surgical Resection doxorubicin, vincristine, and etoposide with mitotane - Adrenal Cortical Carcinoma | Phase 2 | Completed | National Cancer Institute (NCI) | 42 | 1993-08-01 | 2008-03-04 |
| A Study of the Safety and Effects of ADH-1 Given Intravenously as a Single Agent ADH -1 (Exherin™) - Neoplasms | Phase 2 | Completed | Adherex Technologies, Inc. | 2007-08-06 |
Adrenocortical Carcinoma (13) · Adrenal Cortex Neoplasms (6) · ACTH Syndrome, Ectopic (2) · Adrenal Gland Neoplasms (2) · Astrocytoma (2) · Carcinoma, Hepatocellular (2) · Carcinoma, Renal Cell (2) · Cushing Syndrome (2) · Familial ependymoma (2) · Hepatoblastoma (2) · Neoplasms (2) · Neuroblastoma (2) · Optic Nerve Glioma (2) · Osteosarcoma (2) · Sarcoma (2)
Adrenal Gland Diseases (19) · Endocrine System Diseases (19) · Neoplasms by Site (19) · Endocrine Gland Neoplasms (18) · Adrenal Gland Neoplasms (17) · Neoplasms (17) · Neoplasms by Histologic Type (14) · Adenocarcinoma (13) · Adrenal Cortex Neoplasms (13) · Carcinoma (13) · Neoplasms, Glandular and Epithelial (13) · Digestive System Diseases (4) · Digestive System Neoplasms (4) · Female Urogenital Diseases (4)
Cisplatin (3) · Doxorubicin (2) · 4-amino-5-fluoro-3-(5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl)quinolin-2(1H)-one (1) · Axitinib (1) · Biopsy (1) · Cytoreduction Surgical Procedures (1) · Docetaxel (1) · Etoposide (1) · Gefitinib (1) · High-Energy Shock Waves (1) · Magnetic Resonance Spectroscopy (1) · Mitotane (1) · N-Ac-CHAVC-NH2 (1) · Osilodrostat (1) · Oxaliplatin (1)
National Cancer Institute (NCI) (7) · Novartis Pharmaceuticals (2) · University of Wuerzburg (2) · Adherex Technologies, Inc. (1) · Arbutus Biopharma Corporation (1) · Copenhagen University Hospital, Rigshospitalet (1) · Corcept Therapeutics (1) · Dartmouth-Hitchcock Medical Center (1) · M.D. Anderson Cancer Center (1) · Ottawa Regional Cancer Centre (1) · Spanish Oncology Genito-Urinary Group (1)
United States (13) · Canada (3) · Germany (3) · Hungary (2) · Italy (2) · Australia (1) · Denmark (1) · Japan (1) · Netherlands (1) · Slovakia (1) · South Korea (1) · Spain (1) · United Kingdom (1)
Andreas G Moraitis, MD (1) · Antonio Fojo, M.D. (1) · Antonio T Fojo, M.D. (1) · Brenda Weigel, MD (1) · Christoph Reiners, MD (1) · Gedske Daugaard, M.D., DMSc (1) · Jeremy L Davis, M.D. (1) · Mark Kowalski, MD (1) · Martin Fassnacht, MD (1) · Michael Menefee (1) · Mouhammed A Habra (1) · Orren Beaty (1) · Stan Z. Gertler, MD, FRCPC (1)
PMID 22837187, PMID 30463745, PMID 34335465, PMID 35058882, PMID 38608694
U10CA098543 (2), N01CM00038 (1), N01CM00070 (1)