6 completed, 3 recruiting, 2 terminated, 1 unknown. 5 Phase 2, 5 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Recruiting 2, Terminated 2, Completed 1 |
| Phase 3 | 5 | Completed 3, Recruiting 1, Unknown 1 |
| Phase 1 | 1 | Completed 1 |
Follow Mitotane: new trials by email Literature Review of Mitotane trials Research Report on Mitotane
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase II Study of PD-1 Inhibitor Combined With Apatinib and Mitotane in the Treatment of Advanced Adrenal Cortical Carcinoma Camrelizumab, Apatinib, mitotane - Adrenal Cortical Carcinoma, Adrenal Cortical Cancer | Phase 2 | Recruiting | West China Hospital | 28 | 2025-03-15 | 2025-06-03 |
| A Phase II Study to Evaluate the Efficacy and Safety of Pembrolizumab in Combination With Mitotane in Patients With Advanced Adrenocortical Carcinoma Mitotane, Pembrolizumab - Adrenocortical Carcinoma | Phase 2 | Terminated | M.D. Anderson Cancer Center | 3 | 2023-03-23 | 2025-06-19 |
| Evaluation of the Efficacy of Addition of Progesterone to Standard Chemotherapy in Adrenocortical Carcinoma (ACC) Etoposide, doxorubicin, cisplatin and Mitotane plus Megestrol Acetate 160 MG, Etoposide, doxorubicin, cisplatin and Mitotane plus Placebo - Adrenocortical Carcinoma | Phase 2 | Recruiting | Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia | 80 | 2022-06-08 | 2024-08-01 |
| The Impact of Mitotane Therapy on Serum Free Proteins in Patients With Adrenocortical Carcinoma Mitotane - Adrenocortical Carcinoma | Completed | King's College Hospital NHS Trust | 35 | 2022-04-11 | 2023-03-08 | |
| Mitotane With or Without Cisplatin and Etoposide After Surgery in Treating Patients With Stage I-III Adrenocortical Cancer With High Risk of Recurrence Cisplatin, Etoposide, Mitotane - ENSAT Stage I Adrenal Cortex Carcinoma, ENSAT Stage II Adrenal Cortex Carcinoma | Phase 3 | Recruiting | M.D. Anderson Cancer Center | 240 | 2018-08-20 | 2026-07-16 |
| Adjuvant Chemotherapy vs. Observation/Mitotane After Primary Surgical Resection of Localized Adrenocortical CarcInoma Cisplatin plus Etoposide, Observation or Mitotane - Adrenocortical Carcinoma | Phase 3 | Completed | Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia | 40 | 2018-07-20 | 2024-08-01 |
| A Safety and Feasibility Study of Mitotane in Prostate Cancer Mitotane - Prostate Cancer | Phase 1 | Completed | University Health Network, Toronto | 1 | 2013-09-01 | 2015-12-17 |
| IMC-A12 With Mitotane vs Mitotane Alone in Recurrent, Metastatic, or Primary ACC That Cannot Be Removed by Surgery IMC-A12, mitotane - Recurrent Adrenocortical Carcinoma, Stage III Adrenocortical Carcinoma | Phase 2 | Terminated | National Cancer Institute (NCI) | 20 | 2008-12-01 | 2014-04-29 |
| Efficacy of Adjuvant Mitotane Treatment (ADIUVO) MITOTANE - Adrenocortical Carcinoma | Phase 3 | Unknown | University of Turin, Italy | 200 | 2008-04-01 | 2017-05-08 |
| Cisplatin-Based Chemotherapy and/or Surgery in Treating Young Patients With Adrenocortical Tumor Cisplatin, Conventional Surgery, Doxorubicin Hydrochloride - Stage I Adrenal Cortical Carcinoma AJCC v7, Stage II Adrenal Cortical Carcinoma AJCC v7 | Phase 3 | Completed | Children's Oncology Group | 78 | 2007-05-03 | 2024-02-28 |
| Trial in Locally Advanced and Metastatic Adrenocortical Carcinoma Treatment (FIRM-ACT) Etoposide, Doxorubicin, Cisplatin - Carcinoma, Adrenal Cortical | Phase 3 | Completed | Collaborative Group for Adrenocortical Carcinoma Treatment | 304 | 2004-06-01 | 2016-09-21 |
| A Study of Combination Chemotherapy and Surgical Resection in the Treatment of Adrenocortical Carcinoma: Continuous Infusion Doxorubicin, Vincristine and Etoposide With Daily Mitotane Before and After Surgical Resection doxorubicin, vincristine, and etoposide with mitotane - Adrenal Cortical Carcinoma | Phase 2 | Completed | National Cancer Institute (NCI) | 42 | 1993-08-01 | 2008-03-04 |
Adrenocortical Carcinoma (10) · Adrenal Gland Neoplasms (1) · Prostatic Neoplasms (1)
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (2) · M.D. Anderson Cancer Center (2) · National Cancer Institute (NCI) (2) · Children's Oncology Group (1) · Collaborative Group for Adrenocortical Carcinoma Treatment (1) · King's College Hospital NHS Trust (1) · University Health Network, Toronto (1) · University of Turin, Italy (1) · West China Hospital (1)
United States (7) · Italy (4) · Canada (3) · France (3) · Germany (3) · Australia (2) · Netherlands (2) · Sweden (2) · United Kingdom (2) · Austria (1) · Brazil (1) · China (1) · Poland (1)
Alfredo Berruti, MD (2) · Martin Fassnacht, MD (2) · Alfredo Berruti (1) · Britt Skogseid, MD (1) · Carlos Rodriguez-Galindo (1) · Eric Baudin, MD (1) · Gary Hammer (1) · Harm Haak, MD (1) · Jeena Varghese (1) · Massimo Terzolo, MD (1) · Mouhammed Habra, MD (1)
PMID 22551107, PMID 11762335, PMID 15867769, PMID 16680602, PMID 17554118, PMID 18506026, PMID 18824557, PMID 19494162, PMID 19851811, PMID 20580485, PMID 21470991, PMID 22997446, PMID 23150683, PMID 23704714, PMID 23970019, PMID 25559399, PMID 27626976, PMID 30299884, PMID 30367443, PMID 32861807, PMID 33981288, PMID 34675114, PMID 37619579, PMID 9716042, PMID 9827725
N01CM00038 (1), N01CM00099 (1), N01CM00100 (1), N01CM62201 (1), N01CM62204 (1), N01CM62205 (1), N01CM62207 (1), U10CA098543 (1), U10CA180886 (1)