7 completed, 6 recruiting, 1 not yet recruiting. 8 Not applicable, 5 Phase 2, 2 Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 8 | Completed 4, Recruiting 3, Not yet recruiting 1 |
| Phase 2 | 5 | Completed 3, Recruiting 2 |
| Phase 1 | 2 | Completed 2 |
| Phase 4 | 1 | Recruiting 1 |
Follow Acute Stress Reaction: new trials by email Literature Review of Acute Stress Reaction trials Research Report on Acute Stress Reaction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Efficacy of Vitamin D Supplementation to Sustain Performance Outcomes Vitamin D3 (Cholecalciferol), Oral Placebo Tablet - Acute Stress Reaction | Not applicable | Recruiting | Walter Reed Army Institute of Research (WRAIR) | 52 | 2026-07-17 | 2026-09-10 |
| Impact of MetaCalm on Stress of Healthy People With Acute Stress 2 chewable tablets of MetaCalm, 4 chewable tablets of MetaCalm - Adults, Acute Stress Reaction | Not applicable | Not yet recruiting | Metagenics, Inc. | 280 | 2026-04-15 | 2026-04-13 |
| Breathwork and Stress: Investigating the Mechanisms of Action and Effectiveness of Breathing Interventions in Modulating the Psychophysiological Response to Acute Stress Test Coherent Breathing (6 bpm), Sham Breathing (15 bpm) - Healthy Adult Participants, Acute Stress Reaction | Not applicable | Completed | Medical University of Bialystok | 100 | 2026-04-07 | 2026-10-21 |
| BXCL501 After Stress to Increase Recovery Success BXCL501 (dexmedetomidine HCl), Placebo - Acute Stress Reaction, Acute Stress Disorder | Phase 2 | Recruiting | University of North Carolina, Chapel Hill | 100 | 2026-02-23 | 2026-04-14 |
| Impact of Repeated Virtual Reality Training on Markers of Stress Active Shooter, Target Practice - Stress, Acute Stress Reaction | Not applicable | Completed | Texas State University | 50 | 2025-10-01 | 2026-08-18 |
| Cannabidiol (CBD) and Stress Response: Psychobiological Mechanisms Stress Intervention - CBD, Cannabidiol | Not applicable | Recruiting | University of Minnesota | 125 | 2025-06-16 | 2026-07-22 |
| The Effects of Propranolol and Hydrocortisone on Military-Relevant Performance Outcomes Propranolol, Hydrocortisone, Placebo (oral) - Fear of Spiders, Acute Stress Reaction | Phase 4 | Recruiting | Walter Reed Army Institute of Research (WRAIR) | 88 | 2025-05-27 | 2026-05-13 |
| Prevention/Reduction of ASRs and PTSD to Sustain Civilian Performance With Sublingual Cyclobenzaprine HCl (TNX-102 SL) Cyclobenzaprine HCl, Placebo - Acute Stress Reaction, Acute Stress Disorder | Phase 2 | Recruiting | University of North Carolina, Chapel Hill | 180 | 2025-03-25 | 2026-10-22 |
| Effect of Transcutaneous Auricular Neurostimulation on Cognitive Performance in a Laboratory Model of Acute Stress Reaction Sparrow Hawk (Active), Sparrow Hawk (Sham) - Acute Stress Reaction, Cognitive Performance | Not applicable | Completed | Spark Biomedical, Inc. | 43 | 2024-11-26 | 2025-08-01 |
| Promoting Improved Functioning Among People Experiencing Stressful Situations iCOVER, Physical Presence with Reassurance - Acute Stress Reaction | Not applicable | Recruiting | University of North Carolina, Chapel Hill | 450 | 2024-08-15 | 2025-12-09 |
| The Effect of Breathing on Cognitive Performance and Stress Box Breathing, Prolonged Exhalation, Normal Breathing - Stress, Acute Stress Reaction | Not applicable | Completed | Texas State University | 66 | 2024-08-01 | 2025-05-22 |
| Neuronal Correlates of Neurexan® Action in Mildly to Moderately Stressed Probands Neurexan, Placebo - Acute Stress Reaction | Phase 2 | Completed | Biologische Heilmittel Heel GmbH | 53 | 2015-08-01 | 2025-06-24 |
| Explorative Open Label Study of Efficacy Profile of Neurexan® in Experimental Acute Stress Setting in Healthy Subjects Neurexan® - Acute Stress Reaction | Phase 1 / Phase 2 | Completed | Biologische Heilmittel Heel GmbH | 65 | 2012-10-01 | 2015-02-11 |
| Explorative Efficacy Profile of Neurexan® in an Experimental Acute Stress Setting in Healthy Subjects Neurexan®, Placebo - Acute Stress Reaction | Phase 1 / Phase 2 | Completed | Biologische Heilmittel Heel GmbH | 66 | 2012-10-01 | 2015-02-11 |
Stress Disorders, Traumatic, Acute (14) · Stress Disorders, Post-Traumatic (2) · Arachnophobia (1) · Dissociative Disorders (1) · Wounds and Injuries (1)
Mental Disorders (14) · Stress Disorders, Traumatic (14) · Trauma and Stressor Related Disorders (14)
neurexan (3) · Cholecalciferol (1) · Crisis Intervention (1) · Dexmedetomidine (1) · Hydrocortisone (1) · Mass Shooting Events (1) · Propranolol (1) · Sugars (1) · cyclobenzaprine (1) · stearic acid (1)
Biologische Heilmittel Heel GmbH (3) · University of North Carolina, Chapel Hill (3) · Texas State University (2) · Walter Reed Army Institute of Research (WRAIR) (2) · Medical University of Bialystok (1) · Metagenics, Inc. (1) · Spark Biomedical, Inc. (1) · University of Minnesota (1)
United States (9) · Germany (3) · Italy (1) · Poland (1)
Manfred Schedlowski, PhD (2) · Samuel McLean, MD (2) · Christopher Jones, MD (1) · Martin Walter, PD Dr Med. (1) · Mieke Van Den Driessche (1) · Navid Khodaparast, PhD (1) · Philip Putnam, PhD (1) · Samuel McLean, MD, MPH (1) · Sergio Davinelli, Professor (1) · Stacey House, MD (1)
PMID 16344363, PMID 18778321, PMID 21763472, PMID 26772822, PMID 28229114, PMID 29486547, PMID 32123197, PMID 32971266, PMID 34729551, PMID 34912250, PMID 35049605, PMID 35213077, PMID 35438535, PMID 36434512, PMID 37628548
2015 (1)