3 completed, 2 recruiting. 5 Phase 2, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 3, Recruiting 2 |
| Phase 1 | 2 | Completed 2 |
Follow Acute Stress Reaction: new trials by email Literature Review of Acute Stress Reaction trials Research Report on Acute Stress Reaction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| BXCL501 After Stress to Increase Recovery Success BXCL501 (dexmedetomidine HCl), Placebo - Acute Stress Reaction, Acute Stress Disorder | Phase 2 | Recruiting | University of North Carolina, Chapel Hill | 100 | 2026-02-23 | 2026-04-14 |
| Prevention/Reduction of ASRs and PTSD to Sustain Civilian Performance With Sublingual Cyclobenzaprine HCl (TNX-102 SL) Cyclobenzaprine HCl, Placebo - Acute Stress Reaction, Acute Stress Disorder | Phase 2 | Recruiting | University of North Carolina, Chapel Hill | 180 | 2025-03-25 | 2026-10-22 |
| Neuronal Correlates of Neurexan® Action in Mildly to Moderately Stressed Probands Neurexan, Placebo - Acute Stress Reaction | Phase 2 | Completed | Biologische Heilmittel Heel GmbH | 53 | 2015-08-01 | 2025-06-24 |
| Explorative Open Label Study of Efficacy Profile of Neurexan® in Experimental Acute Stress Setting in Healthy Subjects Neurexan® - Acute Stress Reaction | Phase 1 / Phase 2 | Completed | Biologische Heilmittel Heel GmbH | 65 | 2012-10-01 | 2015-02-11 |
| Explorative Efficacy Profile of Neurexan® in an Experimental Acute Stress Setting in Healthy Subjects Neurexan®, Placebo - Acute Stress Reaction | Phase 1 / Phase 2 | Completed | Biologische Heilmittel Heel GmbH | 66 | 2012-10-01 | 2015-02-11 |
Stress Disorders, Traumatic, Acute (5) · Stress Disorders, Post-Traumatic (1)
Mental Disorders (5) · Stress Disorders, Traumatic (5) · Trauma and Stressor Related Disorders (5)
neurexan (3) · Dexmedetomidine (1) · Sugars (1) · cyclobenzaprine (1) · stearic acid (1)
Biologische Heilmittel Heel GmbH (3) · University of North Carolina, Chapel Hill (2)
Germany (3) · United States (2)
Manfred Schedlowski, PhD (2) · Samuel McLean, MD (2) · Christopher Jones, MD (1) · Martin Walter, PD Dr Med. (1) · Stacey House, MD (1)
PMID 26772822, PMID 32123197, PMID 32971266, PMID 34729551, PMID 34912250, PMID 35213077, PMID 35438535, PMID 36434512
2015 (1)