14 recruiting, 12 completed, 5 unknown, 2 active not recruiting. 9 Not applicable, 8 Phase 2, 6 Phase 1, 4 Phase 3.
Follow Acute Lymphoblastic Leukemia, Pediatric: new trials by email Literature Review of Acute Lymphoblastic Leukemia, Pediatric trials Research Report on Acute Lymphoblastic Leukemia, Pediatric
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ph+ ALL in Chinese Children: Diagnosis, Treatment, and Survival Acute Lymphoblastic Leukemia, Pediatric | Recruiting | The Children's Hospital of Zhejiang University School of Medicine | 500 | 2025-08-01 | 2026-09-10 | |
| A Phase I Dose Finding Study of MB-CART2219.1 CAR-T cells targeting CD19 and CD22 - Lymphoma, CLL | Phase 1 | Recruiting | University Hospital Tuebingen | 36 | 2025-06-23 | 2025-08-07 |
| A Prospective, Open-label, Randomized Controlled, Multicenter Clinical Study of Haplo-HSCT Using a TBI or TMLI Conditioning Regimen for Pediatric ALL TMLI, TBI, Cyclophosphamide - Acute Lymphoblastic Leukemia, Pediatric | Phase 2 | Recruiting | The First Affiliated Hospital of Zhengzhou University | 276 | 2025-03-17 | 2025-02-18 |
| A Prospective, Open-label, Randomized Controlled, Multicenter Clinical Study of MSD-HSCT Using a TBI or TMLI Conditioning Regimen for Pediatric ALL TBI, TMLI, Cyclophosphamide - Acute Lymphoblastic Leukemia, Pediatric | Phase 2 | Recruiting | The First Affiliated Hospital of Zhengzhou University | 170 | 2025-03-01 | 2025-02-18 |
| Massage Impact on Sleep in Pediatric Oncology Massage therapy, Standard of care - Cancer, Pediatric Cancer | Not applicable | Recruiting | Children's Hospital of Philadelphia | 70 | 2025-01-23 | 2026-04-15 |
| Behavioral Parenting Skills as a Novel Target for Improving Pediatric Medication Adherence: Study 3 CareMeds Intervention, Usual Care Group - Acute Lymphoblastic Leukemia, Pediatric | Not applicable | Recruiting | Roswell Park Cancer Institute | 100 | 2024-11-07 | 2026-04-23 |
| Treatment of Pediatric Very High-risk Acute Lymphoblastic Leukemia in Korea Dasatinib(Sprycel) arm, Non-Dasatinib(Sprycel) arm - Acute Lymphoblastic Leukemia, Pediatric | Phase 2 | Recruiting | Hyoung Jin Kang | 74 | 2024-10-20 | 2026-07-29 |
| Brain MRF in Children, Adolescents and Young Adults With Acute Leukemia MRF with neurocognative studies - Acute Leukemia, Acute Lymphoblastic Leukemia, Pediatric | Not applicable | Recruiting | Case Comprehensive Cancer Center | 20 | 2024-10-04 | 2026-10-20 |
| Virtual Reality During Lumbar Punctures in Acute Lymphoblastic Leukemia Use of Virtual Reality Headset - Acute Lymphoblastic Leukemia, Pediatric | Not applicable | Recruiting | Children's National Research Institute | 40 | 2024-08-30 | 2024-12-09 |
| CD-19 CAR-T Cell for Pediatric ALL or Lymphoma CAR-T - Lymphoma, B-Cell, Acute Lymphoblastic Leukemia, Pediatric | Not applicable | Recruiting | Hong Kong Children's Hospital | 18 | 2024-05-01 | 2025-03-10 |
| Determining the Mechanisms of Loss of CAR T Cell Persistence Acute Lymphoblastic Leukemia With Failed Remission, Acute Lymphoblastic Leukemia Not Having Achieved Remission | Recruiting | University College, London | 50 | 2023-10-18 | 2026-08-07 | |
| Parental Perception of Their Child's Emotional Quality of Life in Paediatric Oncology Before and After "Magic Massages" Self-report questionnaires (only for parents), Interview (only for parents), Clinical data collection (only concerning Children) - Acute Lymphoblastic Leukemia, Pediatric | Unknown | Centre Leon Berard | 181 | 2023-10-01 | 2023-10-30 | |
| Long Non-coding RNAs and Their Role on Epigenome as Diagnostic Markers in Childhood Acute Lymphoblastic Leukemia of T Cells. lncRNA signature analyses - Acute Lymphoblastic Leukemia, Pediatric | Unknown | IRCCS SYNLAB SDN | 20 | 2023-04-30 | 2024-04-03 | |
| Minimal Residual Disease Quantification by Next-generation Sequencing in Pediatric B-ALL Children Patients Treated With Blinatumomab Consolidation Blinatumomab - Acute Lymphoblastic Leukemia, Pediatric | Unknown | Xiaojun Xu | 20 | 2023-04-01 | 2023-05-01 | |
| Vaccine Immune Recovery After Leukemia Observational only: Serology and flow cytometry for ALL cohort participants, Observational only: Infection rates - Acute Lymphoblastic Leukemia, Pediatric | Completed | Children's Hospital of Philadelphia | 89 | 2022-09-28 | 2026-01-26 | |
| Physical Exercise and Dairy Probiotics in Childhood Cancer Survivors Lacticaseibacillus paracasei subsp. Paracasei CNCMI-1518, Physical exercise - Acute Lymphoblastic Leukemia, Pediatric | Not applicable | Completed | Comenius University | 29 | 2022-04-01 | 2024-01-16 |
| Phase II Study of Anti-CD19 CAR-T Cells Treating Leukemia Children Murine autologous anti-CD19 chimeric antigen receptor T cells - Acute Lymphoblastic Leukemia, Pediatric, Acute Lymphoblastic Leukemia, in Relapse | Phase 2 | Completed | Beijing Boren Hospital | 2 | 2022-03-24 | 2025-05-18 |
| Combined Immuno-chemotherapy for Patients With B-linear Acute Lymphoblastic Leukemia Diagnosed From 0 to 365 Days of Life (ALL-Baby-2021) the risk-adapted choice of therapy and the use of a combination of chemotherapy with immunotherapy and hematopoietic stem cell transplantation for patients with risk factors. - Acute Lymphoblastic Leukemia, Pediatric, ALL, Infants | Phase 3 | Recruiting | Federal Research Institute of Pediatric Hematology, Oncology and Immunology | 80 | 2021-09-23 | 2024-06-28 |
| Safety and Efficacy of Curcumin in Children With Acute Lymphoblastic Leukemia Curcumin, Standard of Care - Acute Lymphoblastic Leukemia, Pediatric | Phase 2 | Completed | Ain Shams University | 30 | 2021-08-22 | 2024-01-08 |
| Palbociclib in Combo w/Chemotherapy in Peds Relapsed/Refractory Acute Lymphoblastic Leukemia Palbociclib, Dexamethasone, Bortezomib - Acute Lymphoblastic Leukemia, Pediatric, Relapsed Acute Lymphoblastic Leukemia | Phase 1 | Completed | Tanja Andrea Gruber | 2 | 2021-07-09 | 2026-04-17 |
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Precursor Cell Lymphoblastic Leukemia-Lymphoma (35) · Lymphoma (3) · Lymphoma, B-Cell (2) · Neoplasms (2) · Anxiety Disorders (1) · Bone Diseases, Metabolic (1) · Depression (1) · Drug-Related Side Effects and Adverse Reactions (1) · Leukemia (1) · Leukemia, Lymphocytic, Chronic, B-Cell (1) · Leukemia, Lymphoid (1) · Leukemia, Myeloid, Acute (1) · Lymphoma, Follicular (1) · Lymphoma, Large B-Cell, Diffuse (1) · Lymphoma, Mantle-Cell (1)
Hematologic Diseases (35) · Hemic and Lymphatic Diseases (35) · Immune System Diseases (35) · Immunoproliferative Disorders (35) · Lymphatic Diseases (35) · Lymphoproliferative Disorders (35) · Neoplasms by Histologic Type (35) · Leukemia (34) · Leukemia, Lymphoid (34) · Neoplasms (33) · Lymphoma, Non-Hodgkin (3) · Nutritional and Metabolic Diseases (3) · Behavior (2) · Lymphoma (2) · Pathological Conditions, Signs and Symptoms (2)
Cyclophosphamide (6) · Dexamethasone (4) · Doxorubicin (3) · Mercaptopurine (3) · Asparaginase (2) · Bortezomib (2) · Calcium Dobesilate (2) · Cytarabine (2) · Etoposide (2) · Methotrexate (2) · Standard of Care (2) · Vincristine (2) · blinatumomab (2) · fludarabine (2) · pegaspargase (2)
The Children's Hospital of Zhejiang University School of Medicine (3) · Children's Hospital of Philadelphia (2) · The First Affiliated Hospital of Zhengzhou University (2) · Ain Shams University (1) · Aristotle University Of Thessaloniki (1) · Beijing Boren Hospital (1) · Cairo University (1) · Case Comprehensive Cancer Center (1) · Centre Leon Berard (1) · Children's National Research Institute (1) · Cipherome, Inc. (1) · Columbia University (1) · Comenius University (1) · Dana-Farber Cancer Institute (1) · Federal Research Institute of Pediatric Hematology, Oncology and Immunology (1)
United States (13) · China (7) · Germany (3) · Egypt (2) · Italy (2) · Slovakia (2) · United Kingdom (2) · Australia (1) · Austria (1) · Canada (1) · Czechia (1) · Denmark (1) · Greece (1) · Hong Kong (1) · Israel (1)
Anupam Verma, MD (1) · Athanassios Evangeliou, Prof (1) · Brian T Fisher, DO MSCE MPH (1) · Elena Ladas, PhD (1) · Elizabeth Bouchard, PhD (1) · Giovanni Smaldone, PhD (1) · Ihab Khairy, M.D (1) · Julie-An Talano, MD (1) · Kara Davis, MD (1) · Kathleen M Sakamoto, MD, PhD (1) · Laura D Bilek, PhD (1) · Martin Schrappe, MD (1) · Melissa Burns, MD (1) · Pamela Lee, MD (1)
PMID 21270794, PMID 23962279, PMID 25624441, PMID 31110096, PMID 33590674, PMID 34933343, PMID 35129146, PMID 36973774, PMID 37481608, PMID 37753808, PMID 38841802, PMID 39192036, PMID 40905823, PMID 41469545, PMID 41671463, PMID 42527400, PMID 42748428
2016 (1), R01CA258337 (1), R01NR019190 (1)