11 completed. 11 Phase 2, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 11 | Completed 11 |
| Phase 1 | 2 | Completed 2 |
Follow Acute Biphenotypic Leukemia: new trials by email Literature Review of Acute Biphenotypic Leukemia trials Research Report on Acute Biphenotypic Leukemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Umbilical Cord Blood Transplant With Added Sugar and Chemotherapy and Radiation Therapy in Treating Patients With Leukemia or Lymphoma Anti-Thymocyte Globulin, Busulfan, Clofarabine - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia | Phase 2 | Completed | M.D. Anderson Cancer Center | 6 | 2017-10-13 | 2023-10-11 |
| Ibrutinib in Preventing Acute Leukemia in Patients After Reduced-Intensity Conditioning and Stem Cell Transplant Ibrutinib, Laboratory Biomarker Analysis - Acute Biphenotypic Leukemia, Acute Lymphoblastic Leukemia | Phase 2 | Completed | Andrew Rezvani | 8 | 2017-09-12 | 2023-08-01 |
| Filgrastim, Cladribine, Cytarabine, and Mitoxantrone With Sorafenib in Treating Patients With Newly-Diagnosed, Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome Cladribine, Cytarabine, Filgrastim - Acute Biphenotypic Leukemia, Acute Myeloid Leukemia | Phase 1 / Phase 2 | Completed | University of Washington | 84 | 2016-12-01 | 2023-07-05 |
| Nivolumab and Azacitidine With or Without Ipilimumab in Treating Patients With Refractory/Relapsed or Newly Diagnosed Acute Myeloid Leukemia Azacitidine, Ipilimumab, Venetoclax - Acute Bilineal Leukemia, Acute Biphenotypic Leukemia | Phase 2 | Completed | M.D. Anderson Cancer Center | 150 | 2015-04-07 | 2025-06-08 |
| Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts From HLA-Matched Related and Unrelated Donors in Preventing GVHD Allogeneic Hematopoietic Stem Cell Transplantation, Cyclophosphamide, Fludarabine Phosphate - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 84 | 2015-03-23 | 2026-06-01 |
| Clofarabine, Idarubicin, Cytarabine, Vincristine Sulfate, and Dexamethasone in Treating Patients With Newly Diagnosed or Relapsed Mixed Phenotype Acute Leukemia Clofarabine, Cytarabine, Dexamethasone - Acute Bilineal Leukemia, Acute Biphenotypic Leukemia | Phase 2 | Completed | M.D. Anderson Cancer Center | 16 | 2014-10-27 | 2024-03-22 |
| Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts in Preventing GVHD in Children Allogeneic Hematopoietic Stem Cell Transplantation, Fludarabine Phosphate, Laboratory Biomarker Analysis - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 20 | 2014-04-10 | 2024-03-12 |
| Filgrastim, Cladribine, Cytarabine, and Mitoxantrone Hydrochloride in Treating Patients With Newly Diagnosed or Relapsed/Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes Cladribine, Cytarabine, Filgrastim - Acute Biphenotypic Leukemia, de Novo Myelodysplastic Syndrome | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 199 | 2014-01-23 | 2020-01-10 |
| Donor Umbilical Cord Blood Transplant With or Without Ex-vivo Expanded Cord Blood Progenitor Cells in Treating Patients With Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myelogenous Leukemia, or Myelodysplastic Syndromes Cyclophosphamide, Cyclosporine, Ex Vivo-Expanded Cord Blood Progenitor Cell Infusion - Acute Biphenotypic Leukemia, Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Nohla Therapeutics, Inc. | 163 | 2012-12-11 | 2021-07-06 |
| Treosulfan, Fludarabine Phosphate, and Total-Body Irradiation in Treating Patients With Hematological Cancer Who Are Undergoing Umbilical Cord Blood Transplant Cyclosporine, Fludarabine Phosphate, Laboratory Biomarker Analysis - Acute Biphenotypic Leukemia, Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Fred Hutchinson Cancer Center | 130 | 2009-02-24 | 2023-02-17 |
| Umbilical Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With Hematologic Disease Cyclophosphamide, Cyclosporine, Double-Unit Umbilical Cord Blood Transplantation - Acute Biphenotypic Leukemia, Acute Lymphoblastic Leukemia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 135 | 2005-11-18 | 2025-03-07 |
Leukemia, Biphenotypic, Acute (11) · Leukemia, Myeloid, Acute (8) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (7) · Myelodysplastic Syndromes (6) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (5) · Leukemia, Myeloid, Accelerated Phase (3) · Anemia, Refractory, with Excess of Blasts (2) · Blast Crisis (2) · Leukemia, Lymphocytic, Chronic, B-Cell (2) · Leukemia, Myeloid, Chronic-Phase (2) · Leukemia, Myelomonocytic, Chronic (2) · Lymphoma, Non-Hodgkin (2) · Anemia, Refractory (1) · Blastic Plasmacytoid Dendritic Cell Neoplasm (1) · Burkitt Lymphoma (1)
Hematologic Diseases (11) · Hemic and Lymphatic Diseases (11) · Immune System Diseases (11) · Immunoproliferative Disorders (11) · Leukemia (11) · Leukemia, Lymphoid (11) · Lymphatic Diseases (11) · Lymphoproliferative Disorders (11) · Neoplasms (11) · Neoplasms by Histologic Type (11) · Leukemia, Myeloid (10) · Bone Marrow Diseases (9) · Chronic Disease (8) · Disease Attributes (8) · Pathologic Processes (8)
Whole-Body Irradiation (6) · Mycophenolic Acid (5) · Cord Blood Stem Cell Transplantation (4) · Cyclophosphamide (4) · Thiotepa (4) · fludarabine phosphate (4) · Cyclosporine (3) · Cytarabine (3) · Filgrastim (3) · Granulocyte Colony-Stimulating Factor (3) · Tacrolimus (3) · CT-P10 (2) · Cladribine (2) · Clofarabine (2) · Cyclosporins (2)
Fred Hutchinson Cancer Center (5) · M.D. Anderson Cancer Center (3) · Andrew Rezvani (1) · Nohla Therapeutics, Inc. (1) · University of Washington (1)
United States (11)
Filippo Milano (2) · Marie Bleakley (2) · Amanda Olson (1) · Andrew Rezvani (1) · Ann E. Dahlberg (1) · Anna Halpern (1) · Elias Jabbour (1) · Naval Daver (1) · Roland Walter (1)
PMID 35007144, PMID 32706891, PMID 34980577, PMID 37339483, PMID 38391202
P30CA015704 (3), P01CA018029 (2), R01HL121568 (2), K23CA154532 (1), P50HL110787 (1)