6 completed, 3 active not recruiting, 3 recruiting, 3 unknown. 7 Not applicable, 2 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Active not recruiting 2, Completed 2, Unknown 2, Not yet recruiting 1 |
| Phase 3 | 2 | Recruiting 1, Unknown 1 |
| Phase 2 | 1 | Recruiting 1 |
Follow Achalasia Cardia: new trials by email Literature Review of Achalasia Cardia trials Research Report on Achalasia Cardia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Biological Optimization Versus Standard Care in Post-POEM Achalasia Patients (BIO-POEM) Structured Biological Optimization - Achalasia Cardia, GERD (Gastroesophageal Reflux Disease) | Not applicable | Active not recruiting | Asian Institute of Gastroenterology, India | 166 | 2026-05-20 | 2026-06-02 |
| Artificial Intelligence-Guided Detection of Blood Vessels to Enhance Safety in Third-Space Endoscopic Procedures AI generated segmentation mask for sub-mucosal blood vessels - Achalasia Cardia, Tumor | Not applicable | Completed | Asian Institute of Gastroenterology, India | 40 | 2026-02-10 | 2026-09-22 |
| Comparison of Balloon Dilatation and Per Oral Endoscopic Myotomy in Children With Achalasia Cardia POEM, BALLOON DILATATION - Achalasia Cardia | Not applicable | Not yet recruiting | Asian Institute of Gastroenterology, India | 70 | 2025-09-03 | 2025-09-11 |
| Full-thickness Versus Progressive Myotomy in Peroral Endoscopic Esophageal Myotomy in Achalasia: A Randomized Controlled Trial Full thickness myotomy, Progressive thickness myotomy - Achalasia Cardia, Achalasia | Phase 2 | Recruiting | Cairo University | 70 | 2025-08-01 | 2026-10-15 |
| INCIDENCE, PREVALENCE AND OVERALL RISK OF ESOPHAGEAL CANCER IN ACHALASIA: A PROPENSITY-MATCHED POPULATION-BASED STUDY FROM A LARGE MULTICENTER DATABASE achalasia treatments - Achalasia Cardia, Esophageal Cancer (EsC) | Active not recruiting | IRCCS San Raffaele | 47000 | 2025-06-03 | 2025-07-30 | |
| Electrosurgical Modes for Endoscopic Submucosal Dissection in Peroral Endoscopic Esophageal Myotomy endoscopic submucosal dissection using SPRAY COAG mode, endoscopic submucosal dissection using Precisect mode - Achalasia, Achalasia Cardia | Phase 3 | Recruiting | Cairo University | 52 | 2024-03-16 | 2025-05-13 |
| Endoscopic Versus Robotic Myotomy for Treatment of Achalasia Robotic Heller Myotomy, Peroral Endoscopic Myotomy - Achalasia Cardia | Not applicable | Active not recruiting | Germans Trias i Pujol Hospital | 144 | 2024-01-01 | 2024-03-05 |
| To Investigate the Incidence of Reflux in Patients After Per-oral Endoscopic Myotomy in Achalasia Cardia Patients Peroral endoscopic myotomy - Achalasia Cardia, Gastroesophageal Reflux | Completed | Asian Institute of Gastroenterology, India | 64 | 2021-07-01 | 2023-01-31 | |
| Serum Anti-enteric Neuronal Antibodies in Patients With Achalasia and Their Association With Clinical Profiles peroral endoscopic myotomy (POEM) - Achalasia Cardia | Completed | Peking Union Medical College Hospital | 195 | 2019-02-01 | 2026-03-05 | |
| Nasogastric Tube After Laparoscopic Heller-Dor Myotomy nasogastric tube - Achalasia, Achalasia Cardia | Completed | Federico II University | 79 | 2019-01-01 | 2023-02-15 | |
| Single-Versus Multiple-dose Antimicrobial Prophylaxis for Peroral Endoscopic Myotomy in Achalasia One dose of Cefo-perazone Sulbactum - Achalasia Cardia | Phase 3 | Unknown | Asian Institute of Gastroenterology, India | 40 | 2018-12-01 | 2020-01-18 |
| Randomised Trial Between LHM Alone Vs LHM With Anterior Fundoplication In Achalasia Cardia Laparoscopic Heller's myotomy, Anterior Fundoplication - Achalasia Cardia | Not applicable | Unknown | Govind Ballabh Pant Hospital | 20 | 2018-01-24 | 2022-03-23 |
| Compare the Quality of Life of Patients With Achalasia Cardia (AC) After Laparoscopic and Open Esophagocardiomyotomy. laparoscopic esophagocardiomyotomy, open surgery - Achalasia Cardia, GERD-HRQL Scale | Completed | Osh State University | 38 | 2017-12-01 | 2025-09-16 | |
| Randomized Clinical Trial Comparing Short Versus Long Oesophageal Myotomy in POEM for Achalasia Cardia. Per oral endoscopic myotomy - Achalasia Cardia | Not applicable | Completed | Asian Institute of Gastroenterology, India | 71 | 2017-06-01 | 2019-12-30 |
| POEM Versus Pneumatic Dilatation in Achalasia Cardia Per Oral Endoscopic Myotomy (POEM), Pneumatic Dilatation - Achalasia Cardia | Not applicable | Unknown | Asian Institute of Gastroenterology, India | 140 | 2013-12-01 | 2014-01-01 |
| Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Rare Disorders, Undiagnosed Disorders | Recruiting | Sanford Health | 20000 | 2010-07-01 | 2026-10-28 |
Esophageal Achalasia (16) · Gastroesophageal Reflux (2) · 3-Methylglutaconic Aciduria, Type V (1) · Achalasia Addisonianism Alacrimia syndrome (1) · Acrodysostosis (1) · Activated PI3K-delta Syndrome (1) · Addison Disease (1) · Alagille Syndrome (1) · Alstrom Syndrome (1) · Amnesia, Transient Global (1) · Aniridia (1) · Aniridia and Absent Patella (1) · Aniridia, Partial, with Unilateral Renal Agenesis and Psychomotor Retardation (1) · Ataxia (1) · Ataxia Neuropathy Spectrum (1)
Deglutition Disorders (16) · Digestive System Diseases (16) · Esophageal Diseases (16) · Esophageal Motility Disorders (16) · Gastrointestinal Diseases (16) · Neoplasms (2) · Neoplasms by Site (2) · Pathological Conditions, Signs and Symptoms (2) · Signs and Symptoms (2) · Abnormalities, Multiple (1) · Adrenal Gland Diseases (1) · Adrenal Insufficiency (1) · Amino Acid Metabolism, Inborn Errors (1) · Amino Acid Transport Disorders, Inborn (1) · Amnesia (1)
Conversion to Open Surgery (1) · Enteral Nutrition (1) · Heller Myotomy (1)
Asian Institute of Gastroenterology, India (7) · Cairo University (2) · Federico II University (1) · Germans Trias i Pujol Hospital (1) · Govind Ballabh Pant Hospital (1) · IRCCS San Raffaele (1) · Osh State University (1) · Peking Union Medical College Hospital (1) · Sanford Health (1)
India (7) · Egypt (2) · Italy (2) · China (1) · Kyrgyzstan (1) · Spain (1) · United States (1)
Abhishek Tyagi (1) · Albert Jan Bredenoord, MD, PhD, Prof (1) · Aniruddha P Singh, MBBS,MD,DM (1) · Bakytbek Osmonaliev, PhD (1) · D Nageshwar Reddy, MD (1) · Dr.Mohan Kumar Ramchandani, MD, DM (1) · Giovanni Aprea, professor (1) · Hardik Rughwani, MBBS, MD, DM (1) · Hirdaya H Nag, MS (1) · Mohan Kumar Ramchandani, MD,DM (1) · Mohan Ramchandani (1) · Mohan Ramchandani, MBBS,MD,DM (1) · Nageshwar Reddy, MBBS,MD,DM (1) · Neeraj Singla, MBBS, MD, DM (1) · Pradev Inavolu, MBBS, MD, DM (1)
PMID 11709516, PMID 12010876, PMID 1451966, PMID 15836451, PMID 16538107, PMID 17090769, PMID 19106675, PMID 19453516, PMID 19911238, PMID 20955445, PMID 22562023, PMID 23007004, PMID 36109151, PMID 37142733, PMID 37598862, PMID 39909396, PMID 7590421, PMID 7847301, PMID 7884182, PMID 9219779, PMID 9246028