Most Influential NATURE MEDICINE Papers (2026-03 Version)
Nature Medicine is a monthly peer-reviewed medical journal publishing research articles, reviews, news and commentaries in the biomedical area, including both basic research and early-phase clinical research covering all aspects of medicine. Paper Digest Team analyze all papers published on NATURE MEDICINE in the past years, and presents the 10 most influential papers for each year (based on when the paper became available online). This ranking list is automatically constructed based upon citations from both research papers and granted patents, and will be frequently updated to reflect the most recent changes. To find the most influential papers from other conferences/journals, visit Best Paper Digest page. Note: the most influential papers may or may not include the papers that won the best paper awards. (Version: 2026-03)
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TABLE 1: Most Influential NATURE MEDICINE Papers (2026-03 Version)
| Year | Rank | Paper | Author(s) |
|---|---|---|---|
| 2026 | 1 | Extracorporeal Liver Cross-circulation Using Transgenic Xenogeneic Pig Livers with Brain-dead Human Decedents IF:4 Related Papers Related Patents Related Grants Related Venues Related Experts View Save |
ABRAHAM SHAKED et. al. |
| 2026 | 2 | The Science of Psychedelic Medicine IF:4 Related Papers Related Patents Related Grants Related Venues Related Experts View Save |
Joshua S. Siegel; Conor Liston; Ginger E. Nicol; Robin L. Carhart-Harris; Michael P. Bogenschutz; |
| 2025 | 1 | Toward Expert-level Medical Question Answering with Large Language Models IF:7 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Large language models (LLMs) have shown promise in medical question answering, with Med-PaLM being the first to exceed a ‘passing’ score in United States Medical Licensing … |
KARAN SINGHAL et. al. |
| 2025 | 2 | Global Patterns and Trends in Breast Cancer Incidence and Mortality Across 185 Countries IF:6 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Updates of current and projected estimates of the burden are critical to monitoring the success of ongoing efforts in breast cancer control, such as the World Health Organization … |
JOANNE KIM et. al. |
| 2025 | 3 | Bioaccumulation of Microplastics in Decedent Human Brains IF:6 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Rising global concentrations of environmental microplastics and nanoplastics (MNPs) drive concerns for human exposure and health outcomes. Complementary methods for the robust … |
ALEXANDER J NIHART et. al. |
| 2025 | 4 | The TRIPOD-LLM Reporting Guideline for Studies Using Large Language Models IF:4 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Large language models (LLMs) are rapidly being adopted in healthcare, necessitating standardized reporting guidelines. We present transparent reporting of a multivariable model … |
JACK GALLIFANT et. al. |
| 2025 | 5 | Artificial Intelligence in Drug Development IF:4 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Drug development is a complex and time-consuming endeavor that traditionally relies on the experience of drug developers and trial-and-error experimentation. The advent of … |
KANG ZHANG et. al. |
| 2025 | 6 | Mapping The Effectiveness and Risks of GLP-1 Receptor Agonists IF:4 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Glucagon-like peptide 1 receptor agonists (GLP-1RAs) are increasingly being used to treat diabetes and obesity. However, their effectiveness and risks have not yet been … |
Yan Xie; Taeyoung Choi; Ziyad Al-Aly; |
| 2025 | 7 | A Generalist Medical Language Model for Disease Diagnosis Assistance IF:4 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: The delivery of accurate diagnoses is crucial in healthcare and represents the gateway to appropriate and timely treatment. Although recent large language models (LLMs) have … |
XIAOHONG LIU et. al. |
| 2025 | 8 | Medical Large Language Models Are Vulnerable to Data-poisoning Attacks IF:4 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: The adoption of large language models (LLMs) in healthcare demands a careful analysis of their potential to spread false medical knowledge. Because LLMs ingest massive volumes of … |
DANIEL ALEXANDER ALBER et. al. |
| 2025 | 9 | An Evaluation Framework for Clinical Use of Large Language Models in Patient Interaction Tasks IF:4 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: The integration of large language models (LLMs) into clinical diagnostics has the potential to transform doctor-patient interactions. However, the readiness of these models for … |
SHREYA JOHRI et. al. |
| 2025 | 10 | CONSORT 2025 Statement: Updated Guideline for Reporting Randomized Trials IF:4 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Well-designed and properly executed randomized trials are considered the most reliable evidence on the benefits of healthcare interventions. However, there is overwhelming … |
SALLY HOPEWELL et. al. |
| 2024 | 1 | Towards A General-purpose Foundation Model for Computational Pathology IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Quantitative evaluation of tissue images is crucial for computational pathology (CPath) tasks, requiring the objective characterization of histopathological entities from … |
RICHARD J CHEN et. al. |
| 2024 | 2 | A Visual-language Foundation Model for Computational Pathology IF:7 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: The accelerated adoption of digital pathology and advances in deep learning have enabled the development of robust models for various pathology tasks across a diverse array of … |
MING Y LU et. al. |
| 2024 | 3 | Adapted Large Language Models Can Outperform Medical Experts in Clinical Text Summarization IF:7 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Analyzing vast textual data and summarizing key information from electronic health records imposes a substantial burden on how clinicians allocate their time. Although large … |
DAVE VAN VEEN et. al. |
| 2024 | 4 | Evaluation and Mitigation of The Limitations of Large Language Models in Clinical Decision-making IF:6 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Clinical decision-making is one of the most impactful parts of a physician’s responsibilities and stands to benefit greatly from artificial intelligence solutions and large … |
PAUL HAGER et. al. |
| 2024 | 5 | A Foundation Model for Clinical-grade Computational Pathology and Rare Cancers Detection IF:6 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: The analysis of histopathology images with artificial intelligence aims to enable clinical decision support systems and precision medicine. The success of such applications … |
EUGENE VORONTSOV et. al. |
| 2024 | 6 | A Generalist Vision-language Foundation Model for Diverse Biomedical Tasks IF:6 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Traditional biomedical artificial intelligence (AI) models, designed for specific tasks or modalities, often exhibit limited flexibility in real-world deployment and struggle to … |
KAI ZHANG et. al. |
| 2024 | 7 | Highly Accurate Blood Test for Alzheimer’s Disease Is Similar or Superior to Clinical Cerebrospinal Fluid Tests IF:6 Related Papers Related Patents Related Grants Related Venues Related Experts View Save |
NICOLAS R. BARTHÉLEMY et. al. |
| 2024 | 8 | Safety, Efficacy and Determinants of Response of Allogeneic CD19-specific CAR-NK Cells in CD19+ B Cell Tumors: A Phase 1/2 Trial IF:5 Related Papers Related Patents Related Grants Related Venues Related Experts View Save |
DAVID MARIN et. al. |
| 2024 | 9 | Long COVID Science, Research and Policy IF:5 Related Papers Related Patents Related Grants Related Venues Related Experts View Save Highlight: Addressing the challenge of long COVID requires an ambitious and coordinated-but so far absent-global research and policy response strategy. In this interdisciplinary review, we provide a synthesis of the state of scientific evidence on long COVID, assess the impacts of long COVID on human health, health systems, the economy and global health metrics, and provide a forward-looking research and policy roadmap. |
ZIYAD AL-ALY et. al. |
| 2024 | 10 | Sustained Human Outbreak of A New MPXV Clade I Lineage in The Eastern Democratic Republic of The Congo IF:5 Related Papers Related Patents Related Grants Related Venues Related Experts View Save |
E. H. VAKANIAKI et. al. |
| 2023 | 1 | Large Language Models in Medicine IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Large language models (LLMs) can respond to free-text queries without being specifically trained in the task in question, causing excitement and concern about their use in … |
ARUN JAMES THIRUNAVUKARASU et. al. |
| 2023 | 2 | A Visual–language Foundation Model for Pathology Image Analysis Using Medical Twitter IF:7 Related Papers Related Patents Related Grants Related Venues Related Experts View Save |
Zhi Huang; Federico Bianchi; Mert Yuksekgonul; T. Montine; J. Zou; |
| 2023 | 3 | A Visual-language Foundation Model for Pathology Image Analysis Using Medical Twitter IF:7 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: The lack of annotated publicly available medical images is a major barrier for computational research and education innovations. At the same time, many de-identified images and … |
Zhi Huang; Federico Bianchi; Mert Yuksekgonul; Thomas J Montine; James Zou; |
| 2023 | 4 | Heat-related Mortality in Europe During The Summer of 2022 IF:7 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Over 70,000 excess deaths occurred in Europe during the summer of 2003. The resulting societal awareness led to the design and implementation of adaptation strategies to protect … |
JOAN BALLESTER et. al. |
| 2023 | 5 | An Integrated Cell Atlas of The Lung in Health and Disease IF:6 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Single-cell technologies have transformed our understanding of human tissues. Yet, studies typically capture only a limited number of donors and disagree on cell type definitions. … |
LISA SIKKEMA et. al. |
| 2023 | 6 | Zolbetuximab Plus CAPOX in CLDN18.2-positive Gastric or Gastroesophageal Junction Adenocarcinoma: The Randomized, Phase 3 GLOW Trial IF:6 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: There is an urgent need for first-line treatment options for patients with human epidermal growth factor receptor 2 (HER2)-negative, locally advanced unresectable or metastatic … |
MANISH A SHAH et. al. |
| 2023 | 7 | Elranatamab in Relapsed or Refractory Multiple Myeloma: Phase 2 MagnetisMM-3 Trial Results IF:6 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Elranatamab is a humanized B-cell maturation antigen (BCMA)-CD3 bispecific antibody. In the ongoing phase 2 MagnetisMM-3 trial, patients with relapsed or refractory multiple … |
ALEXANDER M LESOKHIN et. al. |
| 2023 | 8 | The Next Generation of Evidence-based Medicine IF:6 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Recently, advances in wearable technologies, data science and machine learning have begun to transform evidence-based medicine, offering a tantalizing glimpse into a future of … |
Vivek Subbiah; |
| 2023 | 9 | Heterogeneous Aging Across Multiple Organ Systems and Prediction of Chronic Disease and Mortality IF:6 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Biological aging of human organ systems reflects the interplay of age, chronic disease, lifestyle and genetic risk. Using longitudinal brain imaging and physiological phenotypes … |
YE ELLA TIAN et. al. |
| 2023 | 10 | Molecular Residual Disease and Efficacy of Adjuvant Chemotherapy in Patients with Colorectal Cancer IF:6 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Despite standard-of-care treatment, more than 30% of patients with resectable colorectal cancer (CRC) relapse. Circulating tumor DNA (ctDNA) analysis may enable postsurgical risk … |
DAISUKE KOTANI et. al. |
| 2022 | 1 | AI in Health and Medicine IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Artificial intelligence (AI) is poised to broadly reshape medicine, potentially improving the experiences of both clinicians and patients. We discuss key findings from a 2-year … |
Pranav Rajpurkar; Emma Chen; Oishi Banerjee; Eric J Topol; |
| 2022 | 2 | Long-term Cardiovascular Outcomes of COVID-19 IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: The cardiovascular complications of acute coronavirus disease 2019 (COVID-19) are well described, but the post-acute cardiovascular manifestations of COVID-19 have not yet been … |
Yan Xie; Evan Xu; Benjamin Bowe; Ziyad Al-Aly; |
| 2022 | 3 | Multimodal Biomedical AI IF:7 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: The increasing availability of biomedical data from large biobanks, electronic health records, medical imaging, wearable and ambient biosensors, and the lower cost of genome and … |
Julián N Acosta; Guido J Falcone; Pranav Rajpurkar; Eric J Topol; |
| 2022 | 4 | Symptoms and Risk Factors for Long COVID in Non-hospitalized Adults IF:7 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is associated with a range of persistent symptoms impacting everyday functioning, known as post-COVID-19 … |
ANURADHAA SUBRAMANIAN et. al. |
| 2022 | 5 | Cellular Senescence and Senolytics: The Path to The Clinic IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Interlinked and fundamental aging processes appear to be a root-cause contributor to many disorders and diseases. One such process is cellular senescence, which entails a state of … |
Selim Chaib; Tamar Tchkonia; James L Kirkland; |
| 2022 | 6 | Anti-CD19 CAR T Cell Therapy for Refractory Systemic Lupus Erythematosus IF:7 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Systemic lupus erythematosus (SLE) is a life-threatening autoimmune disease characterized by adaptive immune system activation, formation of double-stranded DNA autoantibodies and … |
ANDREAS MACKENSEN et. al. |
| 2022 | 7 | Long COVID After Breakthrough SARS-CoV-2 Infection IF:7 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: The post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-also referred to as Long COVID-have been described, but whether breakthrough … |
Ziyad Al-Aly; Benjamin Bowe; Yan Xie; |
| 2022 | 8 | Phylogenomic Characterization and Signs of Microevolution in The 2022 Multi-country Outbreak of Monkeypox Virus IF:7 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: The largest monkeypox virus (MPXV) outbreak described so far in non-endemic countries was identified in May 2022 (refs. ). In this study, shotgun metagenomics allowed the rapid … |
JOANA ISIDRO et. al. |
| 2022 | 9 | The SGLT2 Inhibitor Empagliflozin in Patients Hospitalized for Acute Heart Failure: A Multinational Randomized Trial IF:7 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: The sodium-glucose cotransporter 2 inhibitor empagliflozin reduces the risk of cardiovascular death or heart failure hospitalization in patients with chronic heart failure, but … |
ADRIAAN A VOORS et. al. |
| 2022 | 10 | The Global Burden of Disease Study at 30 Years IF:7 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: The Global Burden of Disease Study (GBD) began 30 years ago with the goal of providing timely, valid and relevant assessments of critical health outcomes. Over this period, the … |
Christopher J L Murray; |
| 2021 | 1 | Post-acute COVID-19 Syndrome IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic, which has resulted in global … |
ANI NALBANDIAN et. al. |
| 2021 | 2 | Neutralizing Antibody Levels Are Highly Predictive of Immune Protection from Symptomatic SARS-CoV-2 Infection IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Predictive models of immune protection from COVID-19 are urgently needed to identify correlates of protection to assist in the future deployment of vaccines. To address this, we … |
DAVID S KHOURY et. al. |
| 2021 | 3 | Attributes and Predictors of Long COVID IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Reports of long-lasting coronavirus disease 2019 (COVID-19) symptoms, the so-called ‘long COVID’, are rising but little is known about prevalence, risk factors or whether it is … |
CAROLE H SUDRE et. al. |
| 2021 | 4 | SARS-CoV-2 501Y.V2 Escapes Neutralization By South African COVID-19 Donor Plasma IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: SARS-CoV-2 501Y.V2 (B.1.351), a novel lineage of coronavirus causing COVID-19, contains substitutions in two immunodominant domains of the spike protein. Here, we show that … |
CONSTANTINOS KURT WIBMER et. al. |
| 2021 | 5 | Correlates of Protection Against Symptomatic and Asymptomatic SARS-CoV-2 Infection IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: The global supply of COVID-19 vaccines remains limited. An understanding of the immune response that is predictive of protection could facilitate rapid licensure of new vaccines. … |
SHUO FENG et. al. |
| 2021 | 6 | Health Systems Resilience in Managing The COVID-19 Pandemic: Lessons from 28 Countries IF:7 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Health systems resilience is key to learning lessons from country responses to crises such as coronavirus disease 2019 (COVID-19). In this perspective, we review COVID-19 … |
VICTORIA HALDANE et. al. |
| 2021 | 7 | COVID-19 Vaccine Acceptance and Hesitancy in Low- and Middle-income Countries IF:7 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Widespread acceptance of COVID-19 vaccines is crucial for achieving sufficient immunization coverage to end the global pandemic, yet few studies have investigated COVID-19 … |
JULIO S SOLÍS ARCE et. al. |
| 2021 | 8 | Resistance of SARS-CoV-2 Variants to Neutralization By Monoclonal and Serum-derived Polyclonal Antibodies IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the global COVID-19 pandemic. Rapidly spreading SARS-CoV-2 variants may jeopardize newly introduced … |
RITA E CHEN et. al. |
| 2021 | 9 | Toward Personalized Treatment Approaches for Non-small-cell Lung Cancer IF:7 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Worldwide, lung cancer is the most common cause of cancer-related deaths. Molecular targeted therapies and immunotherapies for non-small-cell lung cancer (NSCLC) have improved … |
Meina Wang; Roy S Herbst; Chris Boshoff; |
| 2021 | 10 | Targeting Metastatic Cancer IF:7 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Despite recent therapeutic advances in cancer treatment, metastasis remains the principal cause of cancer death. Recent work has uncovered the unique biology of … |
Karuna Ganesh; Joan Massagué; |
| 2020 | 1 | The Proximal Origin of SARS-CoV-2 IF:9 Related Papers Related Patents Related Grants Related Venues Related Experts View Save |
Kristian G Andersen; Andrew Rambaut; W Ian Lipkin; Edward C Holmes; Robert F Garry; |
| 2020 | 2 | Temporal Dynamics in Viral Shedding and Transmissibility of COVID-19 IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: We report temporal patterns of viral shedding in 94 patients with laboratory-confirmed COVID-19 and modeled COVID-19 infectiousness profiles from a separate sample of 77 … |
XI HE et. al. |
| 2020 | 3 | SARS-CoV-2 Entry Factors Are Highly Expressed in Nasal Epithelial Cells Together with Innate Immune Genes IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human … |
WARADON SUNGNAK et. al. |
| 2020 | 4 | Extrapulmonary Manifestations of COVID-19 IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Although COVID-19 is most well known for causing substantial respiratory pathology, it can also result in several extrapulmonary manifestations. These conditions include … |
AAKRITI GUPTA et. al. |
| 2020 | 5 | Antibody Responses to SARS-CoV-2 in Patients with COVID-19 IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within 19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G … |
QUAN-XIN LONG et. al. |
| 2020 | 6 | Clinical and Immunological Assessment of Asymptomatic SARS-CoV-2 Infections IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: The clinical features and immune responses of asymptomatic individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have not been well described. We … |
QUAN-XIN LONG et. al. |
| 2020 | 7 | A Global Survey of Potential Acceptance of A COVID-19 Vaccine IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Several coronavirus disease 2019 (COVID-19) vaccines are currently in human trials. In June 2020, we surveyed 13,426 people in 19 countries to determine potential acceptance rates … |
JEFFREY V LAZARUS et. al. |
| 2020 | 8 | Single-cell Landscape of Bronchoalveolar Immune Cells in Patients with COVID-19 IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells … |
MINGFENG LIAO et. al. |
| 2020 | 9 | An Inflammatory Cytokine Signature Predicts COVID-19 Severity and Survival IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Several studies have revealed that the hyper-inflammatory response induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major cause of disease severity and … |
DIANE MARIE DEL VALLE et. al. |
| 2020 | 10 | Respiratory Virus Shedding in Exhaled Breath and Efficacy of Face Masks IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: We identified seasonal human coronaviruses, influenza viruses and rhinoviruses in exhaled breath and coughs of children and adults with acute respiratory illness. Surgical face … |
NANCY H L LEUNG et. al. |
| 2019 | 1 | High-performance Medicine: The Convergence of Human and Artificial Intelligence IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: The use of artificial intelligence, and the deep-learning subtype in particular, has been enabled by the use of labeled big data, along with markedly enhanced computing power and … |
Eric J Topol; |
| 2019 | 2 | A Guide to Deep Learning in Healthcare IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Here we present deep-learning techniques for healthcare, centering our discussion on deep learning in computer vision, natural language processing, reinforcement learning, and … |
ANDRE ESTEVA et. al. |
| 2019 | 3 | Chronic Inflammation in The Etiology of Disease Across The Life Span IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and … |
DAVID FURMAN et. al. |
| 2019 | 4 | Cardiologist-level Arrhythmia Detection and Classification in Ambulatory Electrocardiograms Using A Deep Neural Network IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Computerized electrocardiogram (ECG) interpretation plays a critical role in the clinical ECG workflow . Widely available digital ECG data and the algorithmic paradigm of deep … |
AWNI Y HANNUN et. al. |
| 2019 | 5 | Clinical-grade Computational Pathology Using Weakly Supervised Deep Learning on Whole Slide Images IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: The development of decision support systems for pathology and their deployment in clinical practice have been hindered by the need for large manually annotated datasets. To … |
GABRIELE CAMPANELLA et. al. |
| 2019 | 6 | Supplementation with Akkermansia Muciniphila in Overweight and Obese Human Volunteers: A Proof-of-concept Exploratory Study IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Metabolic syndrome is characterized by a constellation of comorbidities that predispose individuals to an increased risk of developing cardiovascular pathologies as well as type 2 … |
CLARA DEPOMMIER et. al. |
| 2019 | 7 | The Practical Implementation of Artificial Intelligence Technologies in Medicine IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: The development of artificial intelligence (AI)-based technologies in medicine is advancing rapidly, but real-world clinical implementation has not yet become a reality. Here we … |
JIANXING HE et. al. |
| 2019 | 8 | End-to-end Lung Cancer Screening with Three-dimensional Deep Learning on Low-dose Chest Computed Tomography IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: With an estimated 160,000 deaths in 2018, lung cancer is the most common cause of cancer death in the United States . Lung cancer screening using low-dose computed tomography has … |
DIEGO ARDILA et. al. |
| 2019 | 9 | Blood-brain Barrier Breakdown Is An Early Biomarker of Human Cognitive Dysfunction IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Vascular contributions to cognitive impairment are increasingly recognized as shown by neuropathological , neuroimaging , and cerebrospinal fluid biomarker studies. Moreover, … |
DANIEL A NATION et. al. |
| 2019 | 10 | Adult Hippocampal Neurogenesis Is Abundant in Neurologically Healthy Subjects and Drops Sharply in Patients with Alzheimer’s Disease IF:8 Related Papers Related Patents Related Grants Related Venues Related Experts View Save |
E. P. MORENO-JIMÉNEZ et. al. |
| 2018 | 1 | Understanding The Tumor Immune Microenvironment (TIME) for Effective Therapy IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: The clinical successes in immunotherapy have been both astounding and at the same time unsatisfactory. Countless patients with varied tumor types have seen pronounced clinical … |
MIKHAIL BINNEWIES et. al. |
| 2018 | 2 | Signatures of T Cell Dysfunction and Exclusion Predict Cancer Immunotherapy Response IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Cancer treatment by immune checkpoint blockade (ICB) can bring long-lasting clinical benefits, but only a fraction of patients respond to treatment. To predict ICB response, we … |
PENG JIANG et. al. |
| 2018 | 3 | Mechanisms Of NAFLD Development And Therapeutic Strategies IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: There has been a rise in the prevalence of nonalcoholic fatty liver disease (NAFLD), paralleling a worldwide increase in diabetes and metabolic syndrome. NAFLD, a continuum of … |
Scott L Friedman; Brent A Neuschwander-Tetri; Mary Rinella; Arun J Sanyal; |
| 2018 | 4 | Classification and Mutation Prediction from Non-small Cell Lung Cancer Histopathology Images Using Deep Learning IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Visual inspection of histopathology slides is one of the main methods used by pathologists to assess the stage, type and subtype of lung tumors. Adenocarcinoma (LUAD) and squamous … |
NICOLAS COUDRAY et. al. |
| 2018 | 5 | Classification and Mutation Prediction from Non–small Cell Lung Cancer Histopathology Images Using Deep Learning IF:8 Related Papers Related Patents Related Grants Related Venues Related Experts View Save |
N. COUDRAY et. al. |
| 2018 | 6 | Clinically Applicable Deep Learning for Diagnosis and Referral in Retinal Disease IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: The volume and complexity of diagnostic imaging is increasing at a pace faster than the availability of human expertise to interpret it. Artificial intelligence has shown great … |
JEFFREY DE FAUW et. al. |
| 2018 | 7 | Senolytics Improve Physical Function and Increase Lifespan in Old Age IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Physical function declines in old age, portending disability, increased health expenditures, and mortality. Cellular senescence, leading to tissue dysfunction, may contribute to … |
MING XU et. al. |
| 2018 | 8 | Molecular Subtypes of Diffuse Large B Cell Lymphoma Are Associated with Distinct Pathogenic Mechanisms and Outcomes IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Diffuse large B cell lymphoma (DLBCL), the most common lymphoid malignancy in adults, is a clinically and genetically heterogeneous disease that is further classified into … |
BJOERN CHAPUY et. al. |
| 2018 | 9 | Determinants of Response and Resistance to CD19 Chimeric Antigen Receptor (CAR) T Cell Therapy of Chronic Lymphocytic Leukemia IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Tolerance to self-antigens prevents the elimination of cancer by the immune system . We used synthetic chimeric antigen receptors (CARs) to overcome immunological tolerance and … |
JOSEPH A FRAIETTA et. al. |
| 2018 | 10 | Comprehensive Molecular Characterization Of Clinical Responses To PD-1 Inhibition In Metastatic Gastric Cancer IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Clinical studies support the efficacy of programmed cell death 1 (PD-1) targeted therapy in a subset of patients with metastatic gastric cancer (mGC). With the goal of identifying … |
SEUNG TAE KIM et. al. |
| 2017 | 1 | Mutational Landscape of Metastatic Cancer Revealed from Prospective Clinical Sequencing of 10,000 Patients IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Tumor molecular profiling is a fundamental component of precision oncology, enabling the identification of genomic alterations in genes and pathways that can be targeted … |
AHMET ZEHIR et. al. |
| 2017 | 2 | Cancer Stem Cells Revisited IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: The cancer stem cell (CSC) concept was proposed four decades ago, and states that tumor growth, analogous to the renewal of healthy tissues, is fueled by small numbers of … |
Eduard Batlle; Hans Clevers; |
| 2017 | 3 | CD22-targeted CAR T Cells Induce Remission in B-ALL That Is Naive or Resistant to CD19-targeted CAR Immunotherapy IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Chimeric antigen receptor (CAR) T cells targeting CD19 mediate potent effects in relapsed and/or refractory pre-B cell acute lymphoblastic leukemia (B-ALL), but antigen loss is a … |
TERRY J FRY et. al. |
| 2017 | 4 | Metformin Alters The Gut Microbiome Of Individuals With Treatment-naive Type 2 Diabetes, Contributing To The Therapeutic Effects Of The Drug IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Metformin is widely used in the treatment of type 2 diabetes (T2D), but its mechanism of action is poorly defined. Recent evidence implicates the gut microbiota as a site of … |
HAO WU et. al. |
| 2017 | 5 | Local Clearance Of Senescent Cells Attenuates The Development Of Post-traumatic Osteoarthritis And Creates A Pro-regenerative Environment IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Senescent cells (SnCs) accumulate in many vertebrate tissues with age and contribute to age-related pathologies, presumably through their secretion of factors contributing to the … |
OK HEE JEON et. al. |
| 2017 | 6 | Gut Microbiome And Serum Metabolome Alterations In Obesity And After Weight-loss Intervention IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Emerging evidence has linked the gut microbiome to human obesity. We performed a metagenome-wide association study and serum metabolomics profiling in a cohort of lean and obese, … |
RUIXIN LIU et. al. |
| 2017 | 7 | Human Primary Liver Cancer -derived Organoid Cultures for Disease Modelling and Drug Screening IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Human liver cancer research currently lacks in vitro models that can faithfully recapitulate the pathophysiology of the original tumor. We recently described a novel, … |
LAURA BROUTIER et. al. |
| 2017 | 8 | CD22-CAR T Cells Induce Remissions in CD19-CAR Naïve and Resistant B-ALL IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Chimeric antigen receptor (CAR) T-cells targeting CD19 mediate potent effects in relapsed/refractory pre-B cell acute lymphoblastic leukemia (B-ALL) but antigen loss is a frequent … |
TERRY J. FRY et. al. |
| 2017 | 9 | Targeting Cellular Senescence Prevents Age-related Bone Loss in Mice IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Aging is associated with increased cellular senescence, which is hypothesized to drive the eventual development of multiple comorbidities. Here we investigate a role for senescent … |
JOSHUA N FARR et. al. |
| 2017 | 10 | HRDetect Is A Predictor of BRCA1 and BRCA2 Deficiency Based on Mutational Signatures IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Approximately 1-5% of breast cancers are attributed to inherited mutations in BRCA1 or BRCA2 and are selectively sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. In … |
HELEN DAVIES et. al. |
| 2016 | 1 | Resting-state Connectivity Biomarkers Define Neurophysiological Subtypes Of Depression IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Biomarkers have transformed modern medicine but remain largely elusive in psychiatry, partly because there is a weak correspondence between diagnostic labels and their … |
ANDREW T DRYSDALE et. al. |
| 2016 | 2 | A Purified Membrane Protein From Akkermansia Muciniphila Or The Pasteurized Bacterium Improves Metabolism In Obese And Diabetic Mice IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Obesity and type 2 diabetes are associated with low-grade inflammation and specific changes in gut microbiota composition. We previously demonstrated that administration of … |
HUBERT PLOVIER et. al. |
| 2016 | 3 | Neutrophil Extracellular Traps Enriched in Oxidized Mitochondrial DNA Are Interferogenic and Contribute to Lupus-like Disease IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Neutrophil extracellular traps (NETs) are implicated in autoimmunity, but how they are generated and their roles in sterile inflammation remain unclear. Ribonucleoprotein immune … |
CHRISTIAN LOOD et. al. |
| 2016 | 4 | Microglia Emerge As Central Players In Brain Disease IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: There has been an explosion of new findings recently giving us insights into the involvement of microglia in central nervous system (CNS) disorders. A host of new molecular tools … |
Michael W Salter; Beth Stevens; |
| 2016 | 5 | Divergent Clonal Evolution of Castration Resistant Neuroendocrine Prostate Cancer IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: An increasingly recognized resistance mechanism to androgen receptor (AR)-directed therapy in prostate cancer involves epithelial plasticity, in which tumor cells demonstrate low … |
HIMISHA BELTRAN et. al. |
| 2016 | 6 | CARD9 Impacts Colitis By Altering Gut Microbiota Metabolism of Tryptophan Into Aryl Hydrocarbon Receptor Ligands IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Complex interactions between the host and the gut microbiota govern intestinal homeostasis but remain poorly understood. Here we reveal a relationship between gut microbiota and … |
BRUNO LAMAS et. al. |
| 2016 | 7 | Signals From The Gut Microbiota To Distant Organs In Physiology And Disease IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: The ecosystem of the human gut consists of trillions of bacteria forming a bioreactor that is fueled by dietary macronutrients to produce bioactive compounds. These … |
Bjoern O Schroeder; Fredrik Bäckhed; |
| 2016 | 8 | An Emerging Role For Neutrophil Extracellular Traps In Noninfectious Disease IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: The production of neutrophil extracellular traps (NETs) is a process that enables neutrophils to help catch and kill bacteria. However, increasing evidence suggests that this … |
Selina K Jorch; Paul Kubes; |
| 2016 | 9 | Insulin Action and Resistance in Obesity and Type 2 Diabetes IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Nutritional excess is a major forerunner of type 2 diabetes. It enhances the secretion of insulin, but attenuates insulin’s metabolic actions in the liver, skeletal muscle and … |
Michael P Czech; |
| 2016 | 10 | Type I Interferons and Microbial Metabolites of Tryptophan Modulate Astrocyte Activity and CNS Inflammation Via The Aryl Hydrocarbon Receptor IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Astrocytes have important roles in the central nervous system (CNS) during health and disease. Through genome-wide analyses we detected a transcriptional response to type I … |
VEIT ROTHHAMMER et. al. |
| 2015 | 1 | The Consensus Molecular Subtypes of Colorectal Cancer IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Colorectal cancer (CRC) is a frequently lethal disease with heterogeneous outcomes and drug responses. To resolve inconsistencies among the reported gene expression-based CRC … |
JUSTIN GUINNEY et. al. |
| 2015 | 2 | The Prognostic Landscape of Genes and Infiltrating Immune Cells Across Human Cancers IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Molecular profiles of tumors and tumor-associated cells hold great promise as biomarkers of clinical outcomes. However, existing data sets are fragmented and difficult to analyze … |
ANDREW J GENTLES et. al. |
| 2015 | 3 | Inflammasomes: Mechanism Of Action, Role In Disease, And Therapeutics IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: The inflammasomes are innate immune system receptors and sensors that regulate the activation of caspase-1 and induce inflammation in response to infectious microbes and molecules … |
Haitao Guo; Justin B Callaway; Jenny P-Y Ting; |
| 2015 | 4 | The Emerging Role Of LncRNAs In Cancer IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: It is increasingly evident that many of the genomic mutations in cancer reside inside regions that do not encode proteins. However, these regions are often transcribed into long … |
Maite Huarte; |
| 2015 | 5 | A Small-molecule Inhibitor of The NLRP3 Inflammasome for The Treatment of Inflammatory Diseases IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: The NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inflammasome is a component of the inflammatory process, and its aberrant activation is pathogenic in … |
REBECCA C COLL et. al. |
| 2015 | 6 | Cellular Senescence In Aging And Age-related Disease: From Mechanisms To Therapy IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Cellular senescence, a process that imposes permanent proliferative arrest on cells in response to various stressors, has emerged as a potentially important contributor to aging … |
Bennett G Childs; Matej Durik; Darren J Baker; Jan M van Deursen; |
| 2015 | 7 | Molecular Analysis Of Gastric Cancer Identifies Subtypes Associated With Distinct Clinical Outcomes IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Gastric cancer, a leading cause of cancer-related deaths, is a heterogeneous disease. We aim to establish clinically relevant molecular subtypes that would encompass this … |
RAZVAN CRISTESCU et. al. |
| 2015 | 8 | 4-1BB Costimulation Ameliorates T Cell Exhaustion Induced By Tonic Signaling Of Chimeric Antigen Receptors IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Chimeric antigen receptors (CARs) targeting CD19 have mediated dramatic antitumor responses in hematologic malignancies, but tumor regression has rarely occurred using CARs … |
ADRIENNE H LONG et. al. |
| 2015 | 9 | Clearance Of Senescent Cells By ABT263 Rejuvenates Aged Hematopoietic Stem Cells In Mice IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Senescent cells (SCs) accumulate with age and after genotoxic stress, such as total-body irradiation (TBI). Clearance of SCs in a progeroid mouse model using a transgenic approach … |
JIANHUI CHANG et. al. |
| 2015 | 10 | Ketone Body Β-hydroxybutyrate Blocks The NLRP3 Inflammasome-mediated Inflammatory Disease IF:8 Related Papers Related Patents Related Grants Related Venues Related Experts View Save |
Y. YOUM et. al. |
| 2014 | 1 | Gut Microbiota Metabolism of Dietary Fiber Influences Allergic Airway Disease and Hematopoiesis IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Metabolites from intestinal microbiota are key determinants of host-microbe mutualism and, consequently, the health or disease of the intestinal tract. However, whether such … |
AURÉLIEN TROMPETTE et. al. |
| 2014 | 2 | An Ultrasensitive Method for Quantitating Circulating Tumor DNA with Broad Patient Coverage IF:10 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Circulating tumor DNA (ctDNA) is a promising biomarker for noninvasive assessment of cancer burden, but existing ctDNA detection methods have insufficient sensitivity or patient … |
AARON M NEWMAN et. al. |
| 2014 | 3 | Defective Fatty Acid Oxidation in Renal Tubular Epithelial Cells Has A Key Role in Kidney Fibrosis Development IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Renal fibrosis is the histological manifestation of a progressive, usually irreversible process causing chronic and end-stage kidney disease. We performed genome-wide … |
HYUN MI KANG et. al. |
| 2014 | 4 | Age-related Cancer Mutations Associated with Clonal Hematopoietic Expansion IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Several genetic alterations characteristic of leukemia and lymphoma have been detected in the blood of individuals without apparent hematological malignancies. The Cancer Genome … |
MINGCHAO XIE et. al. |
| 2014 | 5 | Ubiquitination in Disease Pathogenesis and Treatment IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Ubiquitination is crucial for a plethora of physiological processes, including cell survival and differentiation and innate and adaptive immunity. In recent years, considerable … |
Doris Popovic; Domagoj Vucic; Ivan Dikic; |
| 2014 | 6 | Young Blood Reverses Age-related Impairments in Cognitive Function and Synaptic Plasticity in Mice IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: As human lifespan increases, a greater fraction of the population is suffering from age-related cognitive impairments, making it important to elucidate a means to combat the … |
SAUL A VILLEDA et. al. |
| 2014 | 7 | Multiplexed Ion Beam Imaging of Human Breast Tumors IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Immunohistochemistry (IHC) is a tool for visualizing protein expression that is employed as part of the diagnostic workup for the majority of solid tissue malignancies. Existing … |
MICHAEL ANGELO et. al. |
| 2014 | 8 | Plasma Phospholipids Identify Antecedent Memory Impairment in Older Adults IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Alzheimer’s disease causes a progressive dementia that currently affects over 35 million individuals worldwide and is expected to affect 115 million by 2050 (ref. 1). There are no … |
MARK MAPSTONE et. al. |
| 2014 | 9 | Cancer Cell-autonomous Contribution of Type I Interferon Signaling to The Efficacy of Chemotherapy IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Some of the anti-neoplastic effects of anthracyclines in mice originate from the induction of innate and T cell-mediated anticancer immune responses. Here we demonstrate that … |
ANTONELLA SISTIGU et. al. |
| 2014 | 10 | Cancer Cell–autonomous Contribution of Type I Interferon Signaling to The Efficacy of Chemotherapy IF:7 Related Papers Related Patents Related Grants Related Venues Related Experts View Save |
A. SISTIGU et. al. |
| 2013 | 1 | Microenvironmental Regulation of Tumor Progression and Metastasis IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Cancers develop in complex tissue environments, which they depend on for sustained growth, invasion and metastasis. Unlike tumor cells, stromal cell types within the tumor … |
Daniela F Quail; Johanna A Joyce; |
| 2013 | 2 | Intestinal Microbiota Metabolism of L-carnitine, A Nutrient in Red Meat, Promotes Atherosclerosis IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trimethylamine-N-oxide … |
ROBERT A KOETH et. al. |
| 2013 | 3 | ABT-199, A Potent and Selective BCL-2 Inhibitor, Achieves Antitumor Activity While Sparing Platelets IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are key regulators of the apoptotic process. This family comprises proapoptotic and prosurvival proteins, and shifting the … |
ANDREW J SOUERS et. al. |
| 2013 | 4 | CSF-1R Inhibition Alters Macrophage Polarization and Blocks Glioma Progression IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Glioblastoma multiforme (GBM) comprises several molecular subtypes, including proneural GBM. Most therapeutic approaches targeting glioma cells have failed. An alternative … |
STEPHANIE M PYONTECK et. al. |
| 2013 | 5 | Brown and Beige Fat: Development, Function and Therapeutic Potential IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Adipose tissue, best known for its role in fat storage, can also suppress weight gain and metabolic disease through the action of specialized, heat-producing adipocytes. Brown … |
Matthew Harms; Patrick Seale; |
| 2013 | 6 | Development, Maintenance and Disruption of The Blood-brain Barrier IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: The interface between the blood circulation and the neural tissue features unique characteristics that are encompassed by the term ‘blood-brain barrier’ (BBB). The main functions … |
Birgit Obermeier; Richard Daneman; Richard M Ransohoff; |
| 2013 | 7 | WNT Signaling in Bone Homeostasis and Disease: from Human Mutations to Treatments IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Low bone mass and strength lead to fragility fractures, for example, in elderly individuals affected by osteoporosis or children with osteogenesis imperfecta. A decade ago, rare … |
Roland Baron; Michaela Kneissel; |
| 2013 | 8 | The Role of Autophagy in Neurodegenerative Disease IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Autophagy is a lysosomal degradative process used to recycle obsolete cellular constituents and eliminate damaged organelles and protein aggregates. These substrates reach … |
Ralph A Nixon; |
| 2013 | 9 | PPARγ Signaling and Metabolism: The Good, The Bad and The Future IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Thiazolidinediones (TZDs) are potent insulin sensitizers that act through the nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ) and are highly effective oral … |
MARYAM AHMADIAN et. al. |
| 2013 | 10 | Key Roles of Adjuvants in Modern Vaccines IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Vaccines containing novel adjuvant formulations are increasingly reaching advanced development and licensing stages, providing new tools to fill previously unmet clinical needs. … |
Steven G Reed; Mark T Orr; Christopher B Fox; |
| 2012 | 1 | Melanoma Exosomes Educate Bone Marrow Progenitor Cells Toward A Pro-metastatic Phenotype Through MET IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Tumor-derived exosomes are emerging mediators of tumorigenesis. We explored the function of melanoma-derived exosomes in the formation of primary tumors and metastases in mice and … |
HÉCTOR PEINADO et. al. |
| 2012 | 2 | Mechanisms of Fibrosis: Therapeutic Translation for Fibrotic Disease IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Fibrosis is a pathological feature of most chronic inflammatory diseases. Fibrosis, or scarring, is defined by the accumulation of excess extracellular matrix components. If … |
Thomas A Wynn; Thirumalai R Ramalingam; |
| 2012 | 3 | Asthma Phenotypes: The Evolution from Clinical to Molecular Approaches IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Although asthma has been considered as a single disease for years, recent studies have increasingly focused on its heterogeneity. The characterization of this heterogeneity has … |
Sally E Wenzel; |
| 2012 | 4 | Identification of The Molecular Basis of Doxorubicin-induced Cardiotoxicity IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Doxorubicin is believed to cause dose-dependent cardiotoxicity through redox cycling and the generation of reactive oxygen species (ROS). Here we show that cardiomyocyte-specific … |
SUI ZHANG et. al. |
| 2012 | 5 | IgE and Mast Cells in Allergic Disease IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Immunoglobulin E (IgE) antibodies and mast cells have been so convincingly linked to the pathophysiology of anaphylaxis and other acute allergic reactions that it can be difficult … |
Stephen J Galli; Mindy Tsai; |
| 2012 | 6 | The Cellular and Signaling Networks Linking The Immune System and Metabolism in Disease IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: It is now recognized that obesity is driving the type 2 diabetes epidemic in Western countries. Obesity-associated chronic tissue inflammation is a key contributing factor to type … |
Olivia Osborn; Jerrold M Olefsky; |
| 2012 | 7 | RET, ROS1 and ALK Fusions in Lung Cancer IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Through an integrated molecular- and histopathology-based screening system, we performed a screening for fusions of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1, receptor … |
KENGO TAKEUCHI et. al. |
| 2012 | 8 | Mitochondrial Transfer from Bone-marrow-derived Stromal Cells to Pulmonary Alveoli Protects Against Acute Lung Injury IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Bone marrow-derived stromal cells (BMSCs) protect against acute lung injury (ALI). To determine the role of BMSC mitochondria in this protection, we airway-instilled mice first … |
MOHAMMAD NAIMUL ISLAM et. al. |
| 2012 | 9 | Mitochondrial Transfer from Bone-marrow–derived Stromal Cells to Pulmonary Alveoli Protects Against Acute Lung Injury IF:8 Related Papers Related Patents Related Grants Related Venues Related Experts View Save |
M. N. ISLAM et. al. |
| 2012 | 10 | In Vivo Photodynamic Therapy Using Upconversion Nanoparticles As Remote-controlled Nanotransducers IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Conventional photodynamic therapy (PDT) is limited by the penetration depth of visible light needed for its activation. Here we used mesoporous-silica-coated upconversion … |
NIAGARA MUHAMMAD IDRIS et. al. |
| 2011 | 1 | Ischemia and Reperfusion—from Mechanism to Translation IF:8 Related Papers Related Patents Related Grants Related Venues Related Experts View Save |
H. Eltzschig; T. Eckle; |
| 2011 | 2 | Metabolite Profiles And The Risk Of Developing Diabetes IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Emerging technologies allow the high-throughput profiling of metabolic status from a blood specimen (metabolomics). We investigated whether metabolite profiles could predict the … |
THOMAS J WANG et. al. |
| 2011 | 3 | The Immunology Of Stroke: From Mechanisms To Translation IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Immunity and inflammation are key elements of the pathobiology of stroke, a devastating illness second only to cardiac ischemia as a cause of death worldwide. The immune system … |
Costantino Iadecola; Josef Anrather; |
| 2011 | 4 | Atherosclerosis: Current Pathogenesis and Therapeutic Options IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Coronary artery disease (CAD) arising from atherosclerosis is a leading cause of death and morbidity worldwide. The underlying pathogenesis involves an imbalanced lipid metabolism … |
Christian Weber; Heidi Noels; |
| 2011 | 5 | Adipocytes Promote Ovarian Cancer Metastasis and Provide Energy for Rapid Tumor Growth IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Intra-abdominal tumors, such as ovarian cancer, have a clear predilection for metastasis to the omentum, an organ primarily composed of adipocytes. Currently, it is unclear why … |
KRISTIN M NIEMAN et. al. |
| 2011 | 6 | The Cancer Stem Cell: Premises, Promises And Challenges IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Over the last decade, the notion that tumors are maintained by their own stem cells, the so-called cancer stem cells, has created great excitement in the research community. This … |
Hans Clevers; |
| 2011 | 7 | A Human Memory T-cell Subset with Stem Cell-like Properties IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Immunological memory is thought to depend on a stem cell–like, self-renewing population of lymphocytes capable of differentiating into effector cells in response to antigen … |
LUCA GATTINONI et. al. |
| 2011 | 8 | The MicroRNA MiR-34a Inhibits Prostate Cancer Stem Cells And Metastasis By Directly Repressing CD44 IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Cancer stem cells (CSCs), or tumor-initiating cells, are involved in tumor progression and metastasis. MicroRNAs (miRNAs) regulate both normal stem cells and CSCs, and … |
CAN LIU et. al. |
| 2011 | 9 | Evidence For Osteocyte Regulation Of Bone Homeostasis Through RANKL Expression IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Osteocytes embedded in bone have been postulated to orchestrate bone homeostasis by regulating both bone-forming osteoblasts and bone-resorbing osteoclasts. We find here that … |
TOMOKI NAKASHIMA et. al. |
| 2011 | 10 | Tumor Angiogenesis: Molecular Pathways and Therapeutic Targets IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: As angiogenesis is essential for tumor growth and metastasis, controlling tumor-associated angiogenesis is a promising tactic in limiting cancer progression. The tumor … |
Sara M Weis; David A Cheresh; |
| 2010 | 1 | Organ Reengineering Through Development Of A Transplantable Recellularized Liver Graft Using Decellularized Liver Matrix IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Orthotopic liver transplantation is the only available treatment for severe liver failure, but it is currently limited by organ shortage. One technical challenge that has thus far … |
BASAK E UYGUN et. al. |
| 2010 | 2 | Epithelial Cell Cycle Arrest In G2/M Mediates Kidney Fibrosis After Injury IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Fibrosis is responsible for chronic progressive kidney failure, which is present in a large number of adults in the developed world. It is increasingly appreciated that acute … |
Li Yang; Tatiana Y Besschetnova; Craig R Brooks; Jagesh V Shah; Joseph V Bonventre; |
| 2010 | 3 | Reciprocal Coupling Of Coagulation And Innate Immunity Via Neutrophil Serine Proteases IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Blood neutrophils provide the first line of defense against pathogens but have also been implicated in thrombotic processes. This dual function of neutrophils could reflect an … |
STEFFEN MASSBERG et. al. |
| 2010 | 4 | Recognition Of Peptidoglycan From The Microbiota By Nod1 Enhances Systemic Innate Immunity IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Humans are colonized by a large and diverse bacterial flora (the microbiota) essential for the development of the gut immune system. A broader role for the microbiota as a major … |
THOMAS B CLARKE et. al. |
| 2010 | 5 | Regeneration And Orthotopic Transplantation Of A Bioartificial Lung IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: About 2,000 patients now await a donor lung in the United States. Worldwide, 50 million individuals are living with end-stage lung disease. Creation of a bioartificial lung … |
HARALD C OTT et. al. |
| 2010 | 6 | Receptor-mediated Activation Of Ceramidase Activity Initiates The Pleiotropic Actions Of Adiponectin IF:7 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: The adipocyte-derived secretory factor adiponectin promotes insulin sensitivity, decreases inflammation and promotes cell survival. No unifying mechanism has yet explained how … |
WILLIAM L HOLLAND et. al. |
| 2010 | 7 | NOD2 Stimulation Induces Autophagy in Dendritic Cells Influencing Bacterial Handling and Antigen Presentation IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Nucleotide-binding oligomerization domain–containing-2 (NOD2) acts as a bacterial sensor in dendritic cells (DCs), but it is not clear how bacterial recognition links with antigen … |
RACHEL COONEY et. al. |
| 2010 | 8 | Real-time Imaging Reveals The Single Steps of Brain Metastasis Formation IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Brain metastasis frequently occurs in individuals with cancer and is often fatal. We used multiphoton laser scanning microscopy to image the single steps of metastasis formation … |
YVONNE KIENAST et. al. |
| 2010 | 9 | Toll-like Receptor 4 And High-mobility Group Box-1 Are Involved In Ictogenesis And Can Be Targeted To Reduce Seizures IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Brain inflammation is a major factor in epilepsy, but the impact of specific inflammatory mediators on neuronal excitability is incompletely understood. Using models of acute and … |
MATTIA MAROSO et. al. |
| 2010 | 10 | Notch-mediated Expansion Of Human Cord Blood Progenitor Cells Capable Of Rapid Myeloid Reconstitution IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Save Abstract: Delayed myeloid engraftment after cord blood transplantation (CBT) is thought to result from inadequate numbers of progenitor cells in the graft and is associated with increased … |
COLLEEN DELANEY et. al. |