Syntara: Clinical Trials

14 completed, 2 withdrawn, 1 active not recruiting, 1 terminated. 18 Phase 2, 5 Phase 1.

By phase and status

Phase	Trials	Status
Phase 2	18	Completed 14, Withdrawn 2, Active not recruiting 1, Terminated 1
Phase 1	5	Completed 4, Withdrawn 1

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Trials (filtered) newest first · largest first

All 18 trials

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Effect of PXS-4728A on Microglia Activation in Participants With Isolated Rapid Eye Movement Sleep Behaviour Disorder PXS-4728 (A), Matching Placebo (B) - REM Sleep Behavior Disorder	Phase 2	Active not recruiting	Syntara	40	2023-11-08	2026-06-02
Study to Evaluate Safety, Pharmacokinetic and Pharmacodynamic Dose Escalation and Expansion Study of PXS-5505 in Patients With Primary, Post-polycythemia Vera or Post-essential Thrombocythemia Myelofibrosis PXS-5505 - Myelofibrosis, Primary Myelofibrosis (PMF)	Phase 1 / Phase 2	Completed	Syntara	43	2021-02-18	2026-08-04
Crossover Trial Determining the Efficacy of Dry Powder Mannitol to Improve Lung Function in Subjects Aged 6-17 Years Inhaled Mannitol, Inhaled Placebo - Cystic Fibrosis	Phase 2	Completed	Syntara	95	2013-06-01	2015-10-14
A Single Blind Study to Evaluate the Safety, Tolerability and Explore the Efficacy of 8.0 mg ASM8 Inhaled Daily for 14 Days in Severe Asthma ASM8 - Asthma	Phase 2	Withdrawn	Syntara		2011-11-01	2012-12-03
Efficacy of TPI ASM8 During a 14-Day Allergen Challenge TPI ASM8 - Asthma	Phase 2	Completed	Syntara	16	2010-11-01	2013-11-15
Efficacy and Safety of Four Escalating Dose Regimens of TPI ASM8 in Patients With Allergic Asthma TPI ASM8 - Asthma	Phase 2	Completed	Syntara	14	2009-04-01	2013-11-15
High Dose Inhaled Mannitol Study mannitol - Bronchiectasis	Phase 1 / Phase 2	Completed	Syntara	10	2009-01-01	2010-02-26
A Pilot Study to Investigate Administration of Mannitol Via a Novel Dry Powder Inhaler Device dry powder inhaled mannitol - Healthy, Bronchiectasis	Phase 1 / Phase 2	Completed	Syntara	15	2008-08-01	2009-09-18
Study to Evaluate the Safety and Efficacy TPI ASM8 in Subjects With Asthma TPI ASM8, placebo - Allergic Asthma	Phase 2	Completed	Syntara	18	2008-01-01	2013-11-20
Safety, Tolerability and PD Activity of Inhaled TPI 1020 Versus Inhaled Budesonide in COPD Patients TPI 1020, Budesonide, Placebo - Copd Bronchitis	Phase 2	Completed	Syntara	62	2007-11-01	2012-12-03
Safety and Efficacy of Two Dosages of Inhaled TPI ASM8 Compared to Placebo in Mild to Moderate Asthmatic Patients TPI ASM8, ASM8 - Asthma	Phase 2	Terminated	Syntara	10	2007-02-01	2012-12-03
A Pilot Safety Study of Inhaled Dry Powder Mannitol in Acute Exacerbations of COPD mannitol - COPD, Exacerbation	Phase 1 / Phase 2	Withdrawn	Syntara		2006-10-01	2016-09-28
Inhaled TPI-1020 Versus Inhaled Budesonide in Smokers With Mild Reversible Asthma TPI-1020, budesonide - Asthma	Phase 2	Completed	Syntara	27	2006-05-01	2012-12-03
Multiple Dose ASM8 in Mild Asthmatics ASM8 - Asthma	Phase 1 / Phase 2	Completed	Syntara	15	2005-12-01	2012-12-03
Comparison of Inhaled Mannitol and rhDNase in Children With Cystic Fibrosis mannitol, mannitol + pulmozyme, Dornase alpha - Cystic Fibrosis	Phase 2	Completed	Syntara	20	2005-11-01	2010-02-02
Mannitol Dose Response Study in Cystic Fibrosis mannitol - Cystic Fibrosis	Phase 2	Completed	Syntara	48	2005-10-01	2008-08-29
Aridol Challenge as a Tool to Predict Treatment Response to Inhaled Corticosteroids in COPD Dry powder mannitol, Budesonide 400mcg administered via turbuhaler, Ipratropium bromide 80mcg - Lung Diseases, Obstructive	Phase 2	Completed	Syntara	140	2005-07-01	2016-04-20
A Phase 2 Study to Determine the Safety and Efficacy of Inhaled Dry Powder Mannitol in Cystic Fibrosis Inhaled mannitol - Cystic Fibrosis	Phase 2	Completed	Syntara		2004-03-01	2010-02-02

Conditions studied

Asthma (6)  ·  Cystic Fibrosis (4)  ·  Bronchiectasis (2)  ·  Lung Diseases, Obstructive (1)  ·  Primary Myelofibrosis (1)  ·  Pulmonary Disease, Chronic Obstructive (1)  ·  REM Sleep Behavior Disorder (1)

Interventions

Mannitol (5)  ·  TPI ASM8 (4)  ·  Budesonide (3)  ·  NCX 1020 (2)  ·  Albuterol (1)  ·  Inhalation (1)  ·  Ipratropium (1)  ·  dornase alfa (1)

Countries

Australia (7)  ·  Canada (7)  ·  United Kingdom (4)  ·  Argentina (1)  ·  New Zealand (1)  ·  South Korea (1)  ·  Taiwan (1)  ·  United States (1)

Top investigators

Paul O'Byrne, MD (2)  ·  Rene Pageau, M.Sc Pharm (2)  ·  Alan James, MBBS (1)  ·  Alvin Ing, MBBS (1)  ·  Andrew Bush, FRCPCH (1)  ·  Anne Munck, Dr (1)  ·  Brett Charlton (1)  ·  Brett Charlton, MBBS PhD (1)  ·  Brian O'Connor, MD (1)  ·  Chris Steinfort, MBBS (1)  ·  Christiane De Boeck (1)  ·  Colin Wallis, FRCPCH (1)  ·  Dave Singh, MD (1)  ·  David Barnes, MBBS FRACP (1)

Results publications

PMID 17337677, PMID 18244953, PMID 18339790, PMID 18972410, PMID 19880909, PMID 19996349, PMID 33735508, PMID 40241543