7 completed, 2 withdrawn. 9 Phase 1, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 9 | Completed 7, Withdrawn 2 |
| Phase 2 | 5 | Completed 4, Withdrawn 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Evaluate Safety, Pharmacokinetic and Pharmacodynamic Dose Escalation and Expansion Study of PXS-5505 in Patients With Primary, Post-polycythemia Vera or Post-essential Thrombocythemia Myelofibrosis PXS-5505 - Myelofibrosis, Primary Myelofibrosis (PMF) | Phase 1 / Phase 2 | Completed | Syntara | 43 | 2021-02-18 | 2026-08-04 |
| A Two-part Pharmacokinetic Study of PXS-5382A in Healthy Adult Males PXS-5382A - Pharmacokinetics | Phase 1 | Completed | Syntara | 18 | 2019-12-20 | 2020-06-25 |
| Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of Inhaled TPI 1100 in Healthy Volunteers TPI 1100 - Chronic Obstructive Pulmonary Disease | Phase 1 | Withdrawn | Syntara | 2009-04-01 | 2012-12-03 | |
| High Dose Inhaled Mannitol Study mannitol - Bronchiectasis | Phase 1 / Phase 2 | Completed | Syntara | 10 | 2009-01-01 | 2010-02-26 |
| Pharmacokinetics of Inhaled Mannitol in Cystic Fibrosis Patients Mannitol - Cystic Fibrosis | Phase 1 | Completed | Syntara | 18 | 2008-12-01 | 2010-02-02 |
| A Pilot Study to Investigate Administration of Mannitol Via a Novel Dry Powder Inhaler Device dry powder inhaled mannitol - Healthy, Bronchiectasis | Phase 1 / Phase 2 | Completed | Syntara | 15 | 2008-08-01 | 2009-09-18 |
| A Pharmacokinetic and Bioavailability Study of Mannitol for Inhalation Using Normal Subjects Mannitol - Healthy Volunteers | Phase 1 | Completed | Syntara | 18 | 2006-10-01 | 2007-03-13 |
| A Pilot Safety Study of Inhaled Dry Powder Mannitol in Acute Exacerbations of COPD mannitol - COPD, Exacerbation | Phase 1 / Phase 2 | Withdrawn | Syntara | 2006-10-01 | 2016-09-28 | |
| Multiple Dose ASM8 in Mild Asthmatics ASM8 - Asthma | Phase 1 / Phase 2 | Completed | Syntara | 15 | 2005-12-01 | 2012-12-03 |
Bronchiectasis (2) · Pulmonary Disease, Chronic Obstructive (2) · Asthma (1) · Cystic Fibrosis (1) · Primary Myelofibrosis (1)
Mannitol (4)
Australia (6) · Canada (1) · South Korea (1) · Taiwan (1) · United Kingdom (1) · United States (1)
Andrew Humberstone (1) · Angela Molga, MBBS (1) · David Barnes, MBBS FRACP (1) · Jana Baskar, MBBS MMedSc MBA (1) · Paul O'Byrne, MD (1)