2 unknown, 1 completed, 1 not yet recruiting. 3 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 3 | Unknown 2, Not yet recruiting 1 |
| Phase 2 | 2 | Completed 1, Not yet recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Evaluate the Safety, Tolerability, and Efficacy of PEP-TISSEEL in Subjects With Chronic Radiation Ulcer PEP-TISSEEL, TISSEEL Fibrin Sealant KIT - Chronic Radiation Ulcer | Phase 1 / Phase 2 | Not yet recruiting | Rion Inc. | 184 | 2025-06-01 | 2025-04-06 |
| Phase 1b Clinical Trial to Evaluate PEP and EUFLEXXA for Knee Osteoarthritis (KOA) PEP/Euflexxa, PEP - Knee Osteoarthritis | Phase 1 | Unknown | Rion Inc. | 24 | 2024-11-01 | 2024-06-17 |
| Phase 2a Multi-Center Prospective, Randomized Trial to Evaluate the Safety & Efficacy of Topical PEP-TISSEEL for Diabetic Foot Ulcers (DFU) PEP (Purified Exosome Product) / TISSEEL - Diabetic Foot Ulcer | Phase 2 | Completed | Rion Inc. | 59 | 2024-02-27 | 2026-07-20 |
| PEP on a Skin Graft Donor Site Wound 10% PEP, TISSEEL, 20% PEP - Skin Graft | Phase 1 | Unknown | Rion Inc. | 8 | 2021-03-16 | 2023-09-08 |
Arthritis (1) · Diabetic Foot (1) · Foot Ulcer (1) · Joint Diseases (1) · Musculoskeletal Diseases (1) · Osteoarthritis (1) · Osteoarthritis, Knee (1) · Rheumatic Diseases (1) · Wounds and Injuries (1)
United States (4)
Michael Sabbah, MD (1) · Patrick Walker, MD (1)