20 completed, 2 terminated, 2 withdrawn. 24 Phase 2, 4 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 24 | Completed 20, Terminated 2, Withdrawn 2 |
| Phase 1 | 4 | Completed 3, Terminated 1 |
| Phase 3 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison of Captisol-Enabled™ Iohexol and Omnipaque™ in Patients With Impaired Renal Function Undergoing Coronary Angiography CE-Iohexol, Iohexol - Contrast-induced Nephropathy | Phase 2 | Withdrawn | Ligand Pharmaceuticals | 2022-01-01 | 2022-04-11 | |
| A Study of LGD-6972 in Patients With Type 2 Diabetes Mellitus LGD-6972-5 mg, LGD-6972-10 mg, LGD-6972-15 mg - Type 2 Diabetes Mellitus | Phase 2 | Completed | Ligand Pharmaceuticals | 148 | 2016-09-01 | 2018-01-12 |
| Study of MB07811 in Subjects With Hypercholesterolemia MB07811, Placebo - Hypercholesterolemia | Phase 2 | Withdrawn | Ligand Pharmaceuticals | 80 | 2009-04-01 | 2011-08-12 |
| A Study To Evaluate The Dose-Related Efficacy and Safety of PS433540 in Subjects With Hypertension irbesartan, placebo, PS433540 - Hypertension | Phase 2 | Completed | Ligand Pharmaceuticals | 261 | 2008-03-01 | 2011-09-16 |
| The Effects of Aplindore on the Treatment of Signs and Symptoms of Restless Legs Syndrome Aplindore, Placebo - Restless Legs Syndrome | Phase 2 | Completed | Ligand Pharmaceuticals | 24 | 2008-02-01 | 2011-10-03 |
| Compare Captisol-Enabled (CE) Budesonide + Azelastine Nasal Solution and Rhinocort Aqua + Astelin in an Environmental Exposure Chamber (EEC) Study of Allergic Rhinitis Budesonide + Azelastine, Placebo - Seasonal Allergic Rhinitis | Phase 2 | Completed | Ligand Pharmaceuticals | 108 | 2008-02-01 | 2012-10-04 |
| The Effects of Aplindore on the Treatment of Signs and Symptoms of Parkinson's Disease Aplindore, Placebo - Early Stage Parkinson's Disease | Phase 2 | Completed | Ligand Pharmaceuticals | 40 | 2008-01-01 | 2011-10-03 |
| A Trial to Evaluate the Safety and Efficacy of PS433540 to Treat Hypertension PS433540, placebo - Hypertension | Phase 2 | Completed | Ligand Pharmaceuticals | 280 | 2007-08-01 | 2011-09-16 |
| Safety, Tolerability, and Efficacy Study of MB07803 Administered to Patients With Type 2 Diabetes Mellitus MB07803, Placebo - Type 2 Diabetes Mellitus | Phase 2 | Completed | Ligand Pharmaceuticals | 105 | 2007-03-01 | 2011-10-03 |
| Compare CE-Budesonide Nasal Solution & Rhinocort Aqua in an EEC Study of AR Budesonide, Placebo - Seasonal Allergic Rhinitis | Phase 2 | Completed | Ligand Pharmaceuticals | 65 | 2007-02-01 | 2012-10-04 |
| Study of Tarceva and Targretin Oral Capsules in Patients With Advanced Lung Cancer erlotinib and bexarotene - Carcinoma, Non-small-cell Lung | Phase 2 | Completed | Konstantin Dragnev | 42 | 2005-08-01 | 2019-01-08 |
| The Prevention Of Postmenopausal Osteoporosis With Lasofoxifene And Cytokine Evaluation Lasofoxifene, Placebo - Bone Loss | Phase 2 | Completed | Ligand Pharmaceuticals | 51 | 2004-09-01 | 2011-08-10 |
| Dose Response Study of Lasofoxifene in Postmenopausal Women With Osteoporosis - Japanese Asian Dose Evaluation lasofoxifene, Placebo, Lasofoxifene - Osteoporosis | Phase 2 | Completed | Ligand Pharmaceuticals | 497 | 2004-06-01 | 2011-08-10 |
| A Phase I/II Study of Bexarotene in Combination With ZD1839 (IRESSA®) in the Treatment of Non-Small Cell Lung Cancer Bexarotene, Iressa - Lung Cancer | Phase 1 / Phase 2 | Completed | Stanford University | 6 | 2004-04-01 | 2026-06-04 |
| Bexarotene With Narrow-Band UVB for Psoriasis Bexarotene/NBUVB vs placebo NBUVB - Psoriasis | Phase 2 | Completed | University of Medicine and Dentistry of New Jersey | 35 | 2003-11-01 | 2008-08-07 |
| Safety and Tolerability of I.V. Infusion of MB07133 in Patients With Unresectable Hepatocellular Carcinoma MB07133 300mg/m2/day, MB07133 600 mg/m2/day, MB07133 1200 mg/m2/day - Hepatocellular Carcinoma | Phase 1 / Phase 2 | Completed | Ligand Pharmaceuticals | 28 | 2003-09-01 | 2011-08-12 |
| Phase II Randomized Bilateral Comparison of Topical Targretin Gel 1% in Alopecia Areata Targretin Gel 1% - Alopecia Areata | Phase 2 / Phase 3 | Completed | M.D. Anderson Cancer Center | 46 | 2003-05-01 | 2012-08-02 |
| Study of Oral Bexarotene in Combination With Photopheresis for Treatment of Cutaneous T-Cell Lymphoma bexarotene, photopheresis - Cutaneous T-Cell Lymphoma | Phase 1 / Phase 2 | Completed | Boston University | 18 | 2001-12-01 | 2006-03-27 |
| A Study of Paclitaxel and Carboplatin in Combination With Bexarotene Oral Capsules in Patients With Advanced Lung Cancer Bexarotene (targretin) - Carcinoma, Non-small-cell Lung | Phase 1 / Phase 2 | Terminated | Dartmouth-Hitchcock Medical Center | 33 | 2001-08-01 | 2019-03-06 |
| Phase II Trial to Evaluate the Efficacy of Topical Bexarotene Gel in Patients With Parapsoriasis Bexarotene 1% gel - Parapsoriasis | Phase 2 | Terminated | Fox Chase Cancer Center | 8 | 2001-04-01 | 2013-04-16 |
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Lymphoma, T-Cell, Cutaneous (3) · Mycosis Fungoides (3) · Carcinoma (2) · Carcinoma, Non-Small-Cell Lung (2) · Diabetes Mellitus, Type 2 (2) · HIV Infections (2) · Hypertension (2) · Osteoporosis (2) · Rhinitis, Allergic, Seasonal (2) · Sarcoma, Kaposi (2) · Sezary Syndrome (2) · AIDS-Related Opportunistic Infections (1) · Acquired Immunodeficiency Syndrome (1) · Alopecia Areata (1) · Alopecia universalis (1)
Bexarotene (9) · Budesonide (2) · Lasofoxifene (2) · SBE4-beta-cyclodextrin (2) · aplindore fumarate (2) · 2-((3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phenoxy)methyl)-4-(3-chlorophenyl)-2-oxido(1,3,2)dioxaphosphonane (1) · 4-amino-1-(5-O-(2-oxo-4-(4-pyridyl)-1,3,2-dioxaphosphorinan-2-yl)arabinofuranosyl)-2(1H)-pyrimidinone (1) · Alitretinoin (1) · Dexamethasone (1) · Erlotinib Hydrochloride (1) · Gefitinib (1) · Gels (1) · Iohexol (1) · Irbesartan (1) · Photopheresis (1)
United States (17) · Canada (2) · Taiwan (2) · Hong Kong (1) · Japan (1) · South Korea (1) · United Kingdom (1)
Deepen Patel, MD (2) · Charlotte D Jacobs (1) · George D. Demetri, MD (1) · Isabela Niculae, MPH (1) · James R Rigas, MD (1) · Joel M Neutel, MD (1) · Joel Neutel, MD (1) · Keith Marschke, Ph.D. (1) · Keith Marschke, PhD (1) · Konstantin H Dragnev, MD (1) · Madeleine Duvic, MD (1) · Marie-France Demierre, MD (1) · Melissa Magliocco, MD (1) · Rene Belder, MD (1)