6 completed, 2 recruiting, 2 terminated, 2 unknown. 13 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 13 | Completed 6, Recruiting 2, Terminated 2, Unknown 2, Withdrawn 1 |
| Phase 2 | 4 | Completed 2, Unknown 1, Withdrawn 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Trial to Test Intermittent Deep Brain Stimulation of Nucleus Basalis of Meynert to Treat Alzheimers. Intermittent deep brain stimulation of the nucleus basalis of Meynert - Alzheimer Dementia (AD) | Phase 1 | Recruiting | Augusta University | 12 | 2026-02-01 | 2026-01-07 |
| Chemo-immunotherapy Using Ibrutinib Plus Indoximod for Patients With Pediatric Brain Cancer Indoximod, Ibrutinib, Cyclophosphamide - Ependymoma, Medulloblastoma | Phase 1 | Recruiting | Theodore S. Johnson | 37 | 2022-02-08 | 2026-11-02 |
| Cabozantinib With Pemetrexed in Advanced Non-small Cell Lung Cancer, Urothelial Cancer and Malignant Mesothelioma Cabozantinib, Pemetrexed - Non Small Cell Lung Cancer, Non-squamous Non-small-cell Lung Cancer | Phase 1 | Terminated | Augusta University | 9 | 2020-01-23 | 2022-06-14 |
| Feasibility and Safety Study of Nivolumab With Irinotecan for Small Cell Lung Cancer Nivolumab 10 MG/ML Intravenous Solution [OPDIVO], Irinotecan Injection [Camptosar] - Small-cell Lung Cancer, Small Cell Lung Carcinoma | Phase 1 | Terminated | Augusta University | 10 | 2020-01-06 | 2022-06-14 |
| The Role of Endothelin-1 in Sickle Cell Disease Ambrisentan, Placebo - Sickle Cell Anemia | Phase 1 | Completed | Augusta University | 26 | 2015-09-01 | 2020-04-02 |
| Effects of an Immunosuppressant Mycophenolate Mofetil or MMF on the Urinary Sodium Excretion Response to Mental Stress mycophenolate mofetil (MMF), Placebo - Psychological Stress, Hypertension, Renal | Phase 1 / Phase 2 | Unknown | Augusta University | 50 | 2014-04-22 | 2019-06-20 |
| A Pilot Study of Minocycline in Intracerebral Hemorrhage Patients Minocycline - Intracerebral Hemorrhage | Phase 1 / Phase 2 | Completed | Augusta University | 16 | 2013-02-01 | 2018-04-26 |
| Green Tea Lozenges for the Management of Dry Mouth MighTeaFlow, Xylitol - Xerostomia, Sjogren Syndrome | Phase 1 / Phase 2 | Completed | Augusta University | 60 | 2011-03-01 | 2015-03-18 |
| Mitral Insufficiency Reduction With Biventricular Pacing CRT pacing - Mitral Regurgitation | Phase 1 | Unknown | Trinity Medical Center, Illinois | 50 | 2011-01-01 | 2010-12-02 |
| Prevention of Traumatic Brain Injury in Youth and Adolescents education intervention - Focus of Study: Bicycle Helmet Wearing Compliance | Phase 1 | Completed | Augusta University | 120 | 2010-09-01 | 2013-06-21 |
| Safety and Effectiveness of Cord Blood Stem Cell Infusion for the Treatment of Cerebral Palsy in Children Cord Blood Infusion, Intravenous Sham - Cerebral Palsy | Phase 1 / Phase 2 | Withdrawn | Augusta University | 2010-01-01 | 2022-10-07 | |
| Topical Bethanechol for Improvement of Esophageal Dysmotility Bethanechol - Esophageal Dysmotility | Phase 1 | Completed | Augusta University | 5 | 2009-11-01 | 2015-01-29 |
| Effect of Lubiprostone on Methanogenesis and Bowel Function in Chronic Constipation. Lubiprostone, Lubiprostone Control - Chronic Constipation, Methanogenesis | Phase 1 | Completed | Augusta University | 41 | 2009-02-01 | 2019-01-15 |
Alzheimer Disease (1) · Anemia, Sickle Cell (1) · Brain Neoplasms (1) · Carcinoma, Non-Small-Cell Lung (1) · Carcinoma, Transitional Cell (1) · Cerebral Hemorrhage (1) · Cerebral Palsy (1) · Ependymoma (1) · Esophageal Motility Disorders (1) · Glioblastoma (1) · Hemorrhage (1) · Hemorrhagic Stroke (1) · Hypertension, Renal (1) · Lung Neoplasms (1) · Medulloblastoma (1)
1-methyltryptophan (1) · Aspartame (1) · Bethanechol (1) · Cyclophosphamide (1) · Early Intervention, Educational (1) · Etoposide (1) · Irinotecan (1) · Lubiprostone (1) · Minocycline (1) · Mycophenolic Acid (1) · Nivolumab (1) · Pemetrexed (1) · Sugars (1) · Temozolomide (1) · Xylitol (1)
United States (12)
Nagla A Karim, MD, PhD (2) · Abdullah Kutlar, MD (1) · Adam A Berman, MD (1) · Gregory A Harshfield, PhD (1) · Gregory N Postma, MD (1) · Helbert Acosta, MD (1) · Jagmeet Singh, MD (1) · James E Carroll, M.D. (1) · Jeffrey A Switzer, DO (1) · Patrick Hranitzky, MD (1) · Scott S De Rossi, DMD (1) · Theodore S. Johnson, MD, PhD (1) · Vernon A Barnes, PhD (1)
PMID 23143720, PMID 25240992, PMID 28887388, PMID 37254256
U01HL117684 (1)