12 completed, 2 recruiting, 1 active not recruiting, 1 unknown. 9 Phase 2, 5 Phase 1, 1 Not applicable, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 9 | Completed 7, Active not recruiting 1, Recruiting 1 |
| Phase 1 | 5 | Completed 2, Recruiting 2, Withdrawn 1 |
| Not applicable | 1 | Unknown 1 |
| Phase 3 | 1 | Completed 1 |
Follow Vascular Endothelial Growth Factor A: new trials by email Literature Review of Vascular Endothelial Growth Factor A trials Research Report on Vascular Endothelial Growth Factor A
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Liothyronine in Combination With BIT Regimen for Medulloblastoma With or Without Minimal Residual Disease Liothyronine (L-T3), Bevacizumab, Irinotecan - Medulloblastoma, Medulloblastoma, Childhood | Phase 1 / Phase 2 | Recruiting | Sabine Mueller, MD, PhD | 69 | 2026-08-21 | 2026-09-28 |
| Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer BNT116, Cemiplimab, Docetaxel - Non-Small Cell Lung Cancer | Phase 1 | Recruiting | BioNTech SE | 320 | 2022-06-17 | 2026-07-22 |
| Compare the Efficacy and Safety of HLX04-O with Ranibizumab in Subjects with WAMD HLX04-O，recombinant anti-vascular endothelial growth factor (VEGF) humanized monoclonal antibody ophthalmic injection, Lucentis - Age Related Macular Degeneration | Phase 3 | Completed | Shanghai Henlius Biotech | 407 | 2021-11-01 | 2025-03-24 |
| Evaluate the Safety and Efficacy of HLX04-O in Subjects With wAMD recombinant anti-vascular endothelial growth factor (VEGF) humanized monoclonal antibody ophthalmic injection - Age Related Macular Degeneration | Phase 1 / Phase 2 | Completed | Shanghai Henlius Biotech | 20 | 2021-07-15 | 2023-10-23 |
| Periodontal Health Status in Patients with Systemic Sclerosis periodontal examination's, determination of salivary antioxidants and cytokine levels (VEGF, TGF-β, Il-17) in gingival crevicular fluid, Non-surgical therapy of periodontitis, Activity of antioxidants in unstimulated saliva (GPX, SOD, UA), Total cytokine levels (VEGF, TGF-β, Il-17) in gingival crevicular fluid - Systemic Sclerosis, Periodontitis | Not applicable | Unknown | University of Belgrade | 60 | 2019-02-05 | 2024-09-19 |
| Vascularity Impact on the Treatment Outcome in Malignant Pleural Mesothelioma(VITMPM) marker CD74 and vascular endothelial growth factor VEGF - Malignant Pleural Mesotheliomas | Completed | Ain Shams University | 50 | 2015-10-01 | 2016-06-01 | |
| Pancreatico-biliary Tumor Mutation Profiling in Bile Samples bile sample analysis, biochemical markers, VEGF and MMPs, in bile samples - Cholangiocarcinoma, Cancer of the Head of the Pancreas | Completed | CHU de Reims | 100 | 2015-09-01 | 2016-12-28 | |
| Risk-Adapted Focal Proton Beam Radiation and/or Surgery in Patients With Low, Intermediate and High Risk Rhabdomyosarcoma Receiving Standard or Intensified Chemotherapy Vincristine, Dactinomycin, Cyclophosphamide - Rhabdomyosarcoma | Phase 2 | Active not recruiting | St. Jude Children's Research Hospital | 115 | 2013-12-04 | 2026-06-17 |
| Phase 2 Study of Bevacizumab in Children and Young Adults With NF 2 and Progressive Vestibular Schwannomas Bevacizumab - Neurofibromatosis Type 2, Progressive Vestibular Schwannomas | Phase 2 | Completed | University of Alabama at Birmingham | 22 | 2013-05-15 | 2021-02-12 |
| Salvage Ovarian FANG™ Vaccine + Bevacizumab Vigil™ Vaccine, Bevacizumab - Stage III Ovarian Cancer, Stage IV Ovarian Cancer | Phase 2 | Completed | Gradalis, Inc. | 5 | 2012-03-01 | 2021-10-19 |
| Iplasma IL6, Procalcitonin and VEGF and Dialysate Level in CAPD Patients Measure plasma and dialysate level of IL-6, procalcitonin and VEGF - Chronic Kidney Disease | Completed | Bangkok Metropolitan Administration Medical College and Vajira Hospital | 26 | 2012-03-01 | 2016-08-29 | |
| The Relationship Between Serum Levels of Angiogenin, bFGF, VEGF and Ocular Involvement in Patients With Behçet's Disease serum levels of angiogenin, bFGF, VEGF - Behçet's Disease | Completed | Turkish Ophthalmology Society | 86 | 2011-11-01 | 2012-11-02 | |
| North American Study of Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT) Sterile saline, Bevacizumab, Estriol - Telangiectasia, Hereditary Hemorrhagic, Epistaxis | Phase 2 | Completed | James Gossage | 123 | 2011-08-01 | 2018-10-19 |
| Stem Cell Mobilization and VEGF Gene Transfer for Heart Failure Vascular Endothelial Growth Factor (VEGF1) - Ischemic Congestive Heart Failure (CHF) | Phase 1 | Withdrawn | Losordo, Douglas, M.D. | 2008-07-01 | 2015-04-01 | |
| A Phase II Study of Bevacizumab, Irinotecan and Capecitabine in Patients With Previously Untreated Metastatic Colorectal Cancer Bevacizumab, Irinotecan, Capecitabine - Colorectal Cancer | Phase 2 | Completed | University Health Network, Toronto | 50 | 2006-12-01 | 2019-02-15 |
| Bevacizumab in Treating Patients With Angiosarcoma Bevacizumab - Sarcoma | Phase 2 | Completed | Northwestern University | 32 | 2005-10-01 | 2018-06-25 |
| VEGF Gene Transfer for Diabetic Neuropathy VEGF - Diabetic Neuropathy | Phase 1 / Phase 2 | Completed | Losordo, Douglas, M.D. | 60 | 2002-12-01 | 2010-11-11 |
Macular Degeneration (2) · Behcet Syndrome (1) · Carcinoma, Non-Small-Cell Lung (1) · Carcinoma, Ovarian Epithelial (1) · Cardiomyopathies (1) · Cholangiocarcinoma (1) · Colorectal Neoplasms (1) · Coronary Artery Disease (1) · Diabetes Mellitus (1) · Diabetes Mellitus, Insulin-Dependent, 12 (1) · Diabetic Neuropathies (1) · Epistaxis (1) · Heart Failure (1) · Hemangiosarcoma (1) · Lethal Congenital Contracture Syndrome 2 (1)
Losordo, Douglas, M.D. (2) · Shanghai Henlius Biotech (2) · Ain Shams University (1) · Bangkok Metropolitan Administration Medical College and Vajira Hospital (1) · BioNTech SE (1) · CHU de Reims (1) · Gradalis, Inc. (1) · James Gossage (1) · Northwestern University (1) · Sabine Mueller, MD, PhD (1) · St. Jude Children's Research Hospital (1) · Turkish Ophthalmology Society (1) · University Health Network, Toronto (1) · University of Alabama at Birmingham (1) · University of Belgrade (1)
United States (8) · China (2) · Turkey (Türkiye) (2) · Australia (1) · Canada (1) · Egypt (1) · France (1) · Germany (1) · Hungary (1) · Poland (1) · Serbia (1) · Spain (1) · Thailand (1) · United Kingdom (1)
Allan H Ropper, M.D. (1) · Amr S Saad, MD (1) · Doaa Atef, MD (1) · Dr. Douglas W. Losordo, M.D. (1) · Eric Chen (1) · Hoda Abougabal, MD (1) · James R Gossage, MD (1) · Mahmoud Ellithy, MD (1) · Mark Agulnik, MD (1) · Matthew J. Krasin, MD (1) · Minal Barve, MD (1) · Natasa Nikolic Jakoba, DDS, PhD (1) · Sabine Mueller (1) · Scott Plotkin, MD (1)
PMID 12147798, PMID 22349811, PMID 27599329, PMID 35483358, PMID 36124180
2023 (1)