The Relationship Between Serum Levels of Angiogenin, bFGF, VEGF and Ocular Involvement in Patients With Behçet's Disease

NCT01720628 — Completed, 86 participants, Turkish Ophthalmology Society

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Registry	NCT01720628
Status	Completed
Study type	Observational
Enrollment	86 (Actual)
Sponsor	Turkish Ophthalmology Society (Other)
Conditions	Behçet's Disease
Interventions	serum levels of angiogenin, bFGF, VEGF (Other)
Dates	start 2011-11-01, primary completion 2011-11-01, completion 2012-02-01, first posted 2012-11-02, last updated 2012-11-02
Locations	1 site in Turkey (Türkiye)

-Summary

Objectives: Behçet's disease (BD) is a systemic vasculitis. Since vascular endothelial dysfunction plays a prominent role in the pathogenesis of the disease, we considered angiogenic cytokines as an interesting target for investigation in BD. The aim of this study was to investigate the possible role of angiogenin, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in the pathogenesis of BD.

Design and Methods: Sixty five patients with BD and 21 healthy control subjects were included in the study. Serum angiogenin, bFGF and VEGF concentrations were determined by using in vitro enzyme immunoassay (ELISA) kits according to the manufacturer's instructions.

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+Arms and interventions

Arm	Type	Interventions	Description
Behçet's patients		Other: serum levels of angiogenin, bFGF, VEGF	Serum levels of angiogenin, bFGF, VEGF levels in Behçet's patients with ocular involvement group, without ocular involvement group and control group

serum levels of angiogenin, bFGF, VEGF (Other): Behçet's patients

+Outcome measures

Primary outcomes

Serum levels of angiogenin in Behçet's patients with or without ocular involvement [1 year]: The median serum angiogenin level was significantly higher in all patients with BD than controls (P=0.001). However there was no statistically significant difference between all patients and patients with or without ocular involvement. The mean serum bFGF and the median serum VEGF levels were higher in patients with ocular involvement than all patients, patients without ocular involvement and controls. But these differences did not reach statistical significance.

Secondary outcomes

Serum levels of bFGF in Behçet's patients with or without ocular involvement [1 year]

Other outcomes

Serum levels of VEGF in Behçet's patients with or without ocular involvement [1 year]

+Eligibility

Sex: All, ages: 18 Years to 65 Years, accepts healthy volunteers

Inclusion Criteria:

* age between 18-65
* fulfilling the international diagnostic criteria for Behçet's disease

Exclusion Criteria:

* to have another systemic disease

+Locations (1)

Facility	City	Country	Status
Ankara University, Faculty of Medicine, Department of Ophthalmology	Ankara	Turkey (Türkiye)

+Investigators

ali yalçındağ, Study director, * Dışkapı Yıldırım Beyazıt Training and Research Hospital, Department of Clinical Biochemistry