18 completed. 18 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 18 | Completed 18 |
| Phase 2 | 3 | Completed 3 |
Follow Vancomycin: new trials by email Literature Review of Vancomycin trials Research Report on Vancomycin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Vancomycin Dose Optimization in Obesity Vancomycin (IV) - Pharmacokinetics and Pharmacodynamics | Phase 1 | Completed | University of Michigan | 35 | 2025-04-01 | 2026-05-22 |
| A Phase 1b Trial to Evaluate the Safety of MB310 in Patients With Active, Mild-to-Moderate Ulcerative Colitis MB310, Placebo, Vancomycin - Ulcerative Colitis | Phase 1 | Completed | Microbiotica Ltd | 29 | 2024-09-27 | 2026-06-15 |
| Vancomycin Tissue Concentrations by Bier Block or Intravenous Administration Systemic IV Vancomycin, Bier Block, Vancomycin - Infection, Hand Injury Wrist | Phase 1 | Completed | Mayo Clinic | 20 | 2021-08-26 | 2022-10-07 |
| Microbiome Effect of Omadacycline on Healthy Volunteers Omadacycline, Vancomycin Pill, Moxifloxacin - Healthy Volunteers | Phase 1 | Completed | University of Houston | 32 | 2020-10-12 | 2025-03-25 |
| Study of VE800 and Nivolumab in Patients With Selected Types of Advanced or Metastatic Cancer VE800, Nivolumab, Vancomycin Oral Capsule - Metastatic Cancer, Melanoma | Phase 1 / Phase 2 | Completed | Vedanta Biosciences, Inc. | 56 | 2020-01-23 | 2025-10-27 |
| Vancomycin for the Treatment of NAAT(+)/Toxin(-) C. Difficile Vancomycin Oral Capsule, Placebo Oral Capsule - Clostridium Difficile Infection | Phase 1 | Completed | Medical College of Wisconsin | 7 | 2019-07-17 | 2021-10-20 |
| Vancomycin Pharmacokinetics in Patients on Peritoneal Dialysis Vancomycin - Peritoneal Dialysis-associated Peritonitis | Phase 1 | Completed | Thomas Jefferson University | 4 | 2018-11-15 | 2022-03-03 |
| Topical Antibiotics in Chronic Rhinosinusitis Mupirocin, Tobramycin, Levofloxacin - Chronic Rhinosinusitis (Diagnosis) | Phase 1 / Phase 2 | Completed | Mayo Clinic | 19 | 2018-09-26 | 2022-04-20 |
| Evaluate the Effects of the Environmental Change in Intestine by Antibiotics on the Pharmacokinetic Characteristics of Simvastatin in Healthy Male Volunteers Vancomycin 250Mg Capsule - Simvastatin Pharmacokinetics and Gut Microbiome | Phase 1 | Completed | Seoul National University Hospital | 6 | 2017-12-06 | 2018-01-19 |
| First-in-human Study of VE303 in Healthy Adult Volunteers VE303, Oral Vancomycin - Healthy Volunteers | Phase 1 | Completed | Vedanta Biosciences, Inc. | 39 | 2017-11-28 | 2020-01-27 |
| MET-2 Clinical Study for Recurrent Clostridium Difficile Infection (CDI) MET-2, Vancomycin - Clostridium Difficile Infection | Phase 1 | Completed | NuBiyota | 19 | 2017-10-27 | 2020-08-11 |
| Optimal Fecal Microbiota Transplant Dosing for Mild to Moderate Ulcerative Colitis Fecal Microbiota Transplantation (FMT), OpenBiome, pretreatment antibiotics - Ulcerative Colitis | Phase 1 | Completed | Najwa Elnachef | 30 | 2017-03-02 | 2021-04-28 |
| A Pilot Study to Characterize Bile Acid Metabolism and Dysbiosis in Primary Sclerosing Cholangitis Vancomycin - Primary Sclerosing Cholangitis, Inflammatory Bowel Disease | Phase 1 | Completed | University of Minnesota | 8 | 2015-07-01 | 2020-07-17 |
| Beneficial Bacteria Treatment for Autism oral Vancomycin, MoviPrep, Prilosec - Gastrointestinal Problems, Autism Spectrum Disorders | Phase 1 / Phase 2 | Completed | Arizona State University | 18 | 2014-07-01 | 2025-09-12 |
| Cystatin-C C-guided Vancomycin Dosing in Critically Ill Patients: A Quality Improvement Project Vancomycin, Cystatin C dosing algorithm, Creatine clearance dosing algorithm - Methicillin-resistant Staphylococcus Aureus, Sepsis | Phase 1 | Completed | Mayo Clinic | 399 | 2014-04-01 | 2023-10-10 |
| Inhaled Vancomycin Tolerability, Safety and Pharmacokinetics AeroVanc, IV vancomycin hydrochloride - Healthy, Cystic Fibrosis | Phase 1 | Completed | Savara Inc. | 25 | 2011-11-01 | 2014-03-31 |
| A Pilot Study of Vancomycin or Metronidazole in Patients With Primary Sclerosing Cholangitis Vancomycin, Metronidazole - Primary Sclerosing Cholangitis | Phase 1 | Completed | Mayo Clinic | 35 | 2010-02-01 | 2013-09-19 |
| Gastrointestinal Microbiota in Primary Sclerosing Cholangitis and Biliary Atresia With Vancomycin Vancomycin - Primary Sclerosing Cholangitis, Biliary Atresia | Phase 1 | Completed | Stanford University | 32 | 2007-05-01 | 2016-05-18 |
Cholangitis, Sclerosing (3) · Clostridium Infections (2) · Colitis, Ulcerative (2) · Disease (2) · Autism Spectrum Disorder (1) · Biliary Atresia (1) · Colorectal Neoplasms (1) · Critical Illness (1) · Cystic Fibrosis (1) · Hand Injuries (1) · Infections (1) · Inflammatory Bowel Diseases (1) · Melanoma (1) · Neoplasm Metastasis (1) · Obesity (1)
Mayo Clinic (4) · Vedanta Biosciences, Inc. (2) · Arizona State University (1) · Medical College of Wisconsin (1) · Microbiotica Ltd (1) · Najwa Elnachef (1) · NuBiyota (1) · Savara Inc. (1) · Seoul National University Hospital (1) · Stanford University (1) · Thomas Jefferson University (1) · University of Houston (1) · University of Michigan (1) · University of Minnesota (1)
United States (11) · Australia (1) · Austria (1) · Bulgaria (1) · Canada (1) · Poland (1) · South Korea (1) · Spain (1) · United Kingdom (1)
Byron P Vaughn, MD (1) · Dina Kao, MD (1) · Erin Frazee, PharmD, RPh (1) · Garret W Choby, MD (1) · James B Adams, PhD (1) · Jayant A Talwalkar, MD (1) · Judy Wang, MD (1) · Kenneth L Cox, MD (1) · Kevin Renfree, MD (1) · Kevin W Garey (1) · SeungHwan Lee, MD, PhD (1) · Silvia Munoz-Price, M.D., Ph.D. (1) · Walter K Kraft, MD (1)
PMID 23054338, PMID 23384404, PMID 28122648, PMID 30967657, PMID 32633158, PMID 33087514, PMID 33631102, PMID 34755479, PMID 35365713, PMID 38051631, PMID 39819014, PMID 41081530
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