13 completed, 2 terminated, 1 not yet recruiting, 1 recruiting. 19 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 19 | Completed 13, Terminated 2, Not yet recruiting 1, Recruiting 1, Unknown 1, Withdrawn 1 |
Follow Valacyclovir: new trials by email Literature Review of Valacyclovir trials Research Report on Valacyclovir
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Aciclovir Versus Placebo for HSV-2 Meningitis Acyclovir 50 MG/ML, Placebo - Herpes Simplex 2, Meningitis, Viral | Phase 4 | Not yet recruiting | Jacob Bodilsen | 150 | 2027-01-01 | 2026-10-28 |
| Valacyclovir Monotherapy in Pain Management of Acute Periapical Abscesses After Emergency Chamber Opening Valacyclovir 500 mg, Naproxen Sodium 550mg - Acute Apical Abscess | Phase 4 | Unknown | Dow University of Health Sciences | 82 | 2024-03-27 | 2024-04-10 |
| VZV in the Enteric Nervous System: Pathogenesis and Consequences ValACYclovir 1000 MG, Shingrix - Achalasia | Phase 4 | Recruiting | Vanderbilt University Medical Center | 40 | 2023-03-27 | 2026-10-05 |
| Impact of Metformin and Polysorbate 80 on Drug Absorption and Disposition pravastatin and chenodeoxycholic acid, after metformin and placebo, valacyclovir, chenodeoxycholic acid, and enalaprilat, after polysorbate 80 and placebo - Bile Salt Export Pump (BSEP) Transporter, Polysorbate 80 | Phase 4 | Completed | University of Maryland, Baltimore | 18 | 2021-04-01 | 2024-07-16 |
| Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily, oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily + topical corticosteroid eye drops - Herpes Simplex Virus Keratitis | Phase 4 | Withdrawn | NYU Langone Health | 2019-12-10 | 2022-01-14 | |
| Zoster Eye Disease Study Masked Placebo, Masked Oral Valacyclovir - Herpes Zoster Ophthalmicus | Phase 4 | Completed | NYU Langone Health | 527 | 2017-08-23 | 2025-03-07 |
| Palatability Testing of a New Paediatric Formulation of Valacyclovir Valacyclovir - Varicella Zoster Virus Infection, Herpes Simplex Virus Infection | Phase 4 | Completed | Radboud University Medical Center | 41 | 2012-09-01 | 2020-12-07 |
| Valacyclovir vs. Acyclovir as HSV-2 Suppressive Therapy: Effect on Plasma HIV-1 Levels Among HIV-1/HSV-2 Co-infected Persons acyclovir, valacyclovir - HSV Infection, HIV Infection | Phase 4 | Completed | University of Washington | 32 | 2010-02-01 | 2014-04-08 |
| In UTERO Treatment of Cytomegalovirus Congenital Infection With Valacyclovir Valacyclovir (ZELITREX), Placebo - Viral Disease, Cytomegalovirus Infection | Phase 4 | Terminated | Assistance Publique - Hôpitaux de Paris | 6 | 2009-09-01 | 2012-10-15 |
| Randomized Trial to Evaluate Suppressive Effect of High-Dose Valacyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2 valacyclovir, Valacyclovir - Genital Herpes | Phase 4 | Completed | University of Washington | 50 | 2008-11-01 | 2017-03-09 |
| Trial to Study the Effect of Dose of Herpes Simplex Virus-2 (HSV-2) Suppressive Therapy on HSV and HIV valacyclovir, acyclovir - Genital Herpes, HIV Infection | Phase 4 | Completed | University of Washington | 28 | 2007-12-01 | 2018-06-07 |
| Randomized Trial to Evaluate Suppressive Effect of High-Dose Acyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2 acyclovir, valacyclovir - Genital Herpes | Phase 4 | Completed | University of Washington | 31 | 2006-09-01 | 2021-11-18 |
| VALTREX(Valacyclovir) Once Daily for Viral Shedding In Subjects Newly Diagnosed With HSV-2 valacyclovir - Herpes Labialis | Phase 4 | Completed | GlaxoSmithKline | 70 | 2006-02-20 | 2018-03-23 |
| Pharmacokinetic Study Of Valaciclovir Hydrochloride Tablets Valaciclovir Hydrochloride - Virus Diseases | Phase 4 | Completed | GlaxoSmithKline | 18 | 2005-07-01 | 2015-04-14 |
| VALTREX Once Daily For Viral Shedding In Herpes Simplex Virus 2 (HSV-2) Seropositive Subjects. VALTREX® Tablet is a Trademark of GlaxoSmithKline Group of Companies. Valaciclovir, Placebo - Infections, Herpesviridae | Phase 4 | Completed | GlaxoSmithKline | 73 | 2005-03-29 | 2018-02-12 |
| A Study Comparing Daily Treatment With Valaciclovir To Placebo For Suppression Of Herpes Simplex Virus HSV-2 Genital Herpes In Newly Diagnosed Patients. VALTREX® Tablet is a Trademark of the GlaxoSmithKline Group of Companies. Valaciclovir, Placebo - Herpes Genitalis | Phase 4 | Completed | GlaxoSmithKline | 384 | 2004-06-21 | 2019-02-15 |
| A Clinical Research Study For The Suppression And Treatment Of Genital Herpes Infection In HIV-Infected Persons valacyclovir hydrochloride - Herpes Genitalis | Phase 4 | Terminated | GlaxoSmithKline | 7 | 2004-03-12 | 2020-11-24 |
| A Study of Valacyclovir to Suppress HSV and HIV Shedding in Coinfected Persons valacyclovir, placebo - Herpes Simplex, HIV Infections | Phase 4 | Completed | University of Washington | 60 | 2003-03-01 | 2008-01-10 |
| Scandinavian Bell's Palsy Study Prednisolone + placebo, Valaciclovir + placebo, Prednisolone + valaciclovir - Bell's Palsy | Phase 4 | Completed | Uppsala University Hospital | 839 | 2001-05-01 | 2008-06-04 |
Herpes Genitalis (7) · Herpes Simplex (5) · HIV Infections (3) · Herpes Zoster (2) · Virus Diseases (2) · Acquired Immunodeficiency Syndrome (1) · Bell Palsy (1) · Chickenpox (1) · Cholestasis, progressive familial intrahepatic 2 (1) · Cytomegalovirus Infections (1) · Esophageal Achalasia (1) · Herpes Labialis (1) · Herpes Zoster Ophthalmicus (1) · Herpesviridae Infections (1) · Meningitis (1)
GlaxoSmithKline (5) · University of Washington (5) · NYU Langone Health (2) · Assistance Publique - Hôpitaux de Paris (1) · Dow University of Health Sciences (1) · Jacob Bodilsen (1) · Radboud University Medical Center (1) · University of Maryland, Baltimore (1) · Uppsala University Hospital (1) · Vanderbilt University Medical Center (1)
United States (12) · Canada (2) · Argentina (1) · Australia (1) · Brazil (1) · Chile (1) · France (1) · Hong Kong (1) · Kenya (1) · Netherlands (1) · Pakistan (1)
Anna Wald, MD, MPH (2) · Christine Johnston, MD (1) · Christine Johnston, MD, MPH (1) · Connie Celum, MD, MPH (1) · David Burger (1) · Dr. Yumna Shaheen Ali (1) · Elisabeth Cohen, MD (1) · Jared Baeten, MD, PhD (1) · Lars Jonsson, M.D., Ph.D. (1) · Mats Engstrom, M.D., Ph.D. (1) · Michael Vaezi, MD (1)
PMID 22225814, PMID 18849193, PMID 21998479, PMID 22652942, PMID 28800385, PMID 35090154, PMID 38411973, PMID 40048183, PMID 40048191, PMID 42593809, PMID 42635062
P01AI030731 (1), U10EY026869 (1)