23 completed, 9 recruiting, 5 terminated, 4 unknown. 12 Phase 2, 11 Not applicable, 9 Phase 3, 9 Phase 4, 6 Phase 1.
Follow Trimethoprim: new trials by email Literature Review of Trimethoprim trials Research Report on Trimethoprim
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Prophylactic Antibiotics for Outpatient Urethral Bulking Bactrim (800/160 mg), Keflex (500 mg), Cipro (250 mg), or Macrobid (100mg) - Urinary Tract Infections, Stress Urinary Incontinence | Phase 4 | Recruiting | University of Miami | 150 | 2026-08-19 | 2026-10-29 |
| Folate Study in Men With Advanced Prostate Cancer Trimethoprim Tablets - Prostate Cancer | Phase 2 | Not yet recruiting | University of California, San Diego | 50 | 2026-06-01 | 2025-11-12 |
| Clinical Trial Testing Whether Targeted Antibiotic Prophylaxis Can Reduce Infections After Cystectomy Compared to Empiric Prophylaxis Pivmecillinam, Amoxicillin clavulanic acid, Amoxicillin - Cystectomy, Bladder Cancer Requiring Cystectomy | Phase 4 | Recruiting | Copenhagen University Hospital, Rigshospitalet | 248 | 2025-01-07 | 2025-01-09 |
| Efficacy and Safety of Tamsulosin for Children with Posterior Urethral Valve. Tamsulosin, Oxybutynin, Trimethoprim/sulfamethoxazole (TMP/SMZ) - Posterior Urethral Valve | Phase 3 | Recruiting | Mansoura University | 50 | 2024-11-01 | 2024-12-20 |
| Pivmecillinam With Amoxicillin/Clavulanic Acid for Step Down Oral Therapy in ESBL UTIs Pivmecillinam and amoxicillin/clavulanic acid, Standard treatment, ciprofloxacin, trimethoprim/sulfamethoxazole or ertapenem depending on susceptibility - Urinary Tract Infections, Bacteremia | Phase 3 | Recruiting | Lund University | 330 | 2023-05-29 | 2023-08-28 |
| Single Dose Aminoglycosides for Acute Uncomplicated Cystitis in the Emergency Department Setting Gentamicin, Standard of Care - Urinary Tract Infections | Phase 2 | Unknown | Mercy Health Ohio | 160 | 2022-10-01 | 2023-01-27 |
| Oral Antimicrobial Treatment vs. Outpatient Parenteral for Infective Endocarditis Cefaclor, Ciprofloxacin Tablets, Ciprofloxacin Injection - Endocarditis Infective | Phase 4 | Recruiting | Fundacion Clinic per a la Recerca Biomédica | 360 | 2022-08-17 | 2026-07-07 |
| Use of Prophylactic Antibiotics Prior to OnabotulinumtoxinA Nitrofurantoin - Antibiotic Prophylaxis | Phase 4 | Recruiting | Atlantic Health System | 140 | 2022-08-16 | 2024-03-27 |
| MRSA Decolonization in Complicated Carriage doxycycline 200 mg q.d. - rifampicin 600mg b.i.d., trimethoprim 200mg b.i.d. - rifampicin 600mg b.i.d. - MRSA | Not applicable | Recruiting | Leiden University Medical Center | 211 | 2022-07-25 | 2025-03-06 |
| Study of Subretinally Injected ATSN-101 Administered in Patients With Leber Congenital Amaurosis Caused by Biallelic Mutations in GUCY2D ATSN-101, ATSN-101 Diluent Solution, Prednisone - Leber Congenital Amaurosis, LCA | Phase 1 / Phase 2 | Active not recruiting | Atsena Therapeutics Inc. | 15 | 2019-10-22 | 2026-08-03 |
| The Effect of SLC19A3 Inhibition on the Pharmacokinetics of Thiamine Trimethoprim, Metformin, Vitamin B1 - Vitamin B1 Deficiency, Thiamine Deficiency | Phase 4 | Completed | University of California, San Francisco | 7 | 2019-01-28 | 2025-01-03 |
| Does Antibiotic Prophylaxis at Urinary Catheter Removal Prevent Urinary Tract Infections Cefuroxime axetil (trimethoprim/sulfamethoxazole if penicillin allergy) - Urologic Diseases, Urinary Tract Disease | Not applicable | Unknown | Omri Schwarztuch Gildor | 1000 | 2018-08-14 | 2022-10-13 |
| Fluoroquinolone Associated Disability Fluoroquinolone (FQ), Azithromycin (AZ), Sulfamethoxazole/Trimethoprim (ST) Fixed Dose Combination - Bronchitis, Sinusitis | Completed | Janssen Research & Development, LLC | 239306 | 2018-05-17 | 2019-01-29 | |
| Comparison of Topical Therapies in Post op Endoscopic Sinus Surgery Patients Saline Nasal, Budesonide Nasal, Topical Antibacterial (Product) - Chronic Rhinosinusitis (Diagnosis) | Phase 3 | Withdrawn | University of Florida | 2018-04-01 | 2018-03-30 | |
| S. Aureus Decolonization in HPN Patients. Doxycycline, Trimethoprim, Sulfamethoxazole/trimethoprim - Staphylococcus Aureus, Motility Disorder | Not applicable | Terminated | Radboud University Medical Center | 63 | 2018-02-08 | 2022-05-31 |
| Prophylactic Oral Antibiotics on Sinonasal Outcomes Following Endoscopic Transsphenoidal Surgery for Pituitary Lesions Placebo, Oral Antibiotics cefdinir or trimethoprim/sulfamethoxazole - Antibiotics, Pituitary Adenoma | Phase 4 | Recruiting | St. Joseph's Hospital and Medical Center, Phoenix | 116 | 2017-07-01 | 2018-08-15 |
| A Non-Interventional Safety Study of Balsamic Bactrim Guaifenesin, Sulfamethoxazole, Trimethoprim - Bronchitis | Completed | Hoffmann-La Roche | 52 | 2016-11-15 | 2017-11-07 | |
| A Safety Study of Balsamic Bactrim in Pediatric Participants With Acute Bronchitis Guaifenesin, Sulfamethoxazole, Trimethoprim - Bronchitis | Completed | Hoffmann-La Roche | 51 | 2016-11-10 | 2019-12-13 | |
| Methenamine Hippurate Versus Trimethoprim in the Prevention of Recurrent UTIs Trimethoprim, Methenamine hippurate - Urinary Tract Infections, Recurrent | Phase 4 | Completed | Endeavor Health | 92 | 2016-06-01 | 2020-01-14 |
| Drug-drug Interaction Study of GSK1278863 With Pioglitazone, Rosuvastatin and Trimethoprim in Healthy Adult Volunteers GSK1278863 25 mg Tablet, Pioglitazone 15 mg Tablet, Rosuvastatin 10 mg Tablet - Anaemia | Phase 1 | Completed | GlaxoSmithKline | 70 | 2015-02-11 | 2017-11-17 |
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Urinary Tract Infections (10) · Pneumonia, Pneumocystis (5) · Acquired Immunodeficiency Syndrome (4) · HIV Infections (4) · Bronchitis (3) · AIDS-Related Opportunistic Infections (2) · Infections (2) · Multiple Myeloma (2) · Osteomyelitis (2) · Abscess (1) · Anemia (1) · Bacteremia (1) · Beriberi (1) · Blast Crisis (1) · Burkitt Lymphoma (1)
Hoffmann-La Roche (2) · Pfizer (2) · Atlantic Health System (1) · Atsena Therapeutics Inc. (1) · Copenhagen University Hospital, Rigshospitalet (1) · Endeavor Health (1) · Fondazione IRCCS Policlinico San Matteo di Pavia (1) · Fundacion Clinic per a la Recerca Biomédica (1) · Gary Morrow (1) · George Washington University (1) · GlaxoSmithKline (1) · HaEmek Medical Center, Israel (1) · Henrik Enghusen Poulsen (1) · International Maternal Pediatric Adolescent AIDS Clinical Trials Group (1) · Jacobus Pharmaceutical (1)
United States (26) · Israel (4) · Italy (4) · Peru (4) · Canada (3) · Denmark (3) · Germany (3) · Spain (3) · Argentina (2) · Brazil (2) · Bulgaria (2) · Croatia (2) · Czechia (2) · Mexico (2) · Netherlands (2)
Paul Newell, MBBS, MRCP (2) · A. D'jamali, MD, MS (1) · Afsoon Roberts, M.D. (1) · Ahmed Elkashef (1) · Ali K M.Sami, Ph.D. (1) · Andrew Little, MD (1) · Andrew S Greenberg (1) · Ashraf Tarek Hafez (1) · Carolyn Botros, DO (1) · Charles D. Mitchell, MD (1) · Claire Pomeroy, MD (1)
PMID 27313268, PMID 29912399, PMID 30061279, PMID 30221827, PMID 30832720, PMID 32602065, PMID 12095806, PMID 15257060, PMID 15276398, PMID 15840453, PMID 17005949, PMID 18230259, PMID 18702902, PMID 19128645, PMID 19588358, PMID 20607114, PMID 20876410, PMID 21732834, PMID 22311838, PMID 22530208, PMID 22980682, PMID 23438305, PMID 23776108, PMID 24119597, PMID 25832968, PMID 26363164, PMID 26872154, PMID 27440128, PMID 27466854, PMID 27556896, PMID 28124652, PMID 29654388, PMID 29954418, PMID 36041061, PMID 36511181, PMID 36965196, PMID 37660037, PMID 37700689, PMID 39836173, PMID 40024946, PMID 40722189, PMID 4902833, PMID 8948280
R01DK108722 (1), U01AI068632 (1), U10CA037420 (1)