5 completed, 2 recruiting, 1 terminated, 1 withdrawn. 9 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 9 | Completed 5, Recruiting 2, Terminated 1, Withdrawn 1 |
| Phase 2 | 1 | Terminated 1 |
Follow Trimethoprim: new trials by email Literature Review of Trimethoprim trials Research Report on Trimethoprim
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Tamsulosin for Children with Posterior Urethral Valve. Tamsulosin, Oxybutynin, Trimethoprim/sulfamethoxazole (TMP/SMZ) - Posterior Urethral Valve | Phase 3 | Recruiting | Mansoura University | 50 | 2024-11-01 | 2024-12-20 |
| Pivmecillinam With Amoxicillin/Clavulanic Acid for Step Down Oral Therapy in ESBL UTIs Pivmecillinam and amoxicillin/clavulanic acid, Standard treatment, ciprofloxacin, trimethoprim/sulfamethoxazole or ertapenem depending on susceptibility - Urinary Tract Infections, Bacteremia | Phase 3 | Recruiting | Lund University | 330 | 2023-05-29 | 2023-08-28 |
| Comparison of Topical Therapies in Post op Endoscopic Sinus Surgery Patients Saline Nasal, Budesonide Nasal, Topical Antibacterial (Product) - Chronic Rhinosinusitis (Diagnosis) | Phase 3 | Withdrawn | University of Florida | 2018-04-01 | 2018-03-30 | |
| Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections) Ceftazidime - Avibactam ( CAZ-AVI), Doripenem, Either switch to oral therapy: 500 mg of Ciprofloxacin (oral) - Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis | Phase 3 | Completed | Pfizer | 598 | 2012-10-01 | 2017-09-06 |
| Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections) Ceftazidime - Avibactam ( CAZ-AVI), Doripenem, Either switch to oral therapy: 500 mg of Ciprofloxacin (oral) - Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis | Phase 3 | Completed | Pfizer | 641 | 2012-10-01 | 2017-09-06 |
| D Mannose in Recurrent Urinary Tract Infections D Mannose, trimethoprim/sulfamethoxazole - Recurrent Urinary Tract Infection | Phase 3 | Completed | Fondazione IRCCS Policlinico San Matteo di Pavia | 60 | 2012-01-01 | 2014-05-21 |
| Influence of Trimethoprim-Sulfamethoxazole for the Recurrence of Ocular Toxoplasmosis Trimethoprim-Sulfamethoxazole - Ocular Toxoplasmosis | Phase 3 | Completed | University of Campinas, Brazil | 141 | 2011-10-01 | 2016-07-12 |
| Daily Isoniazid to Prevent Tuberculosis in Infants Born to Mothers With HIV Isoniazid (INH), Trimethoprim/Sulfamethoxazole (TMP/SMX), Isoniazid Placebo (PL) - HIV Infection, Tuberculosis | Phase 2 / Phase 3 | Terminated | International Maternal Pediatric Adolescent AIDS Clinical Trials Group | 1354 | 2004-02-01 | 2019-02-05 |
| Antibiotic Therapy in Preventing Early Infection in Patients With Multiple Myeloma Who Are Receiving Chemotherapy ciprofloxacin, ofloxacin, 160 mg trimethoprim and 800 mg sulfamethoxazole - Infection, Multiple Myeloma | Phase 3 | Completed | Gary Morrow | 212 | 1997-03-01 | 2015-11-11 |
Urinary Tract Infections (2) · Bacteremia (1) · Chorioretinitis (1) · Cystitis (1) · Disease (1) · HIV Infections (1) · Infections (1) · Multiple Myeloma (1) · Pneumonia, Pneumocystis (1) · Toxoplasmosis, Ocular (1) · Tuberculosis (1)
Pfizer (2) · Fondazione IRCCS Policlinico San Matteo di Pavia (1) · Gary Morrow (1) · International Maternal Pediatric Adolescent AIDS Clinical Trials Group (1) · Lund University (1) · Mansoura University (1) · University of Campinas, Brazil (1) · University of Florida (1)
United States (4) · Argentina (2) · Brazil (2) · Bulgaria (2) · Croatia (2) · Czechia (2) · Germany (2) · Israel (2) · Italy (2) · Mexico (2) · Peru (2) · Poland (2) · Romania (2) · Russia (2) · South Africa (2)
Paul Newell, MBBS, MRCP (2) · Ahmed Elkashef (1) · Ashraf Tarek Hafez (1) · Charles D. Mitchell, MD (1) · Claire Pomeroy, MD (1) · Daniele Porru, MD (1) · Gary R. Morrow, PhD, MS (1) · George McSherry, MD (1) · Jeb Justice, MD (1) · Martin M. Oken, MD (1) · Mohamed Hussiny (1) · Oskar Ljungquist, MD, PhD. (1) · Rodrigo PC Lira, PhD (1) · Shabir Madhi, MD (1)
PMID 27313268, PMID 29912399, PMID 30061279, PMID 30221827, PMID 32602065, PMID 12095806, PMID 18230259, PMID 18702902, PMID 19128645, PMID 20607114, PMID 21732834, PMID 22311838, PMID 22980682, PMID 23776108, PMID 24119597, PMID 25832968, PMID 26363164, PMID 26872154, PMID 27440128, PMID 27466854, PMID 27556896, PMID 28124652, PMID 36041061, PMID 37660037, PMID 37700689
U01AI068632 (1), U10CA037420 (1)