18 completed, 6 unknown, 1 recruiting, 1 terminated. 10 Phase 4, 6 Not applicable, 5 Phase 2, 5 Phase 3, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 10 | Completed 5, Unknown 4, Recruiting 1 |
| Not applicable | 6 | Completed 6 |
| Phase 2 | 5 | Completed 2, Unknown 2, Withdrawn 1 |
| Phase 3 | 5 | Completed 3, Terminated 1, Unknown 1 |
| Phase 1 | 2 | Completed 2 |
Follow Tramadol hydrochloride: new trials by email Literature Review of Tramadol hydrochloride trials Research Report on Tramadol hydrochloride
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Canadá Association in the Treatment of Chronic Pain Canadá, Canadá placebo, Dipyrone - Pain, Chronic | Phase 2 | Withdrawn | EMS | 2026-09-01 | 2023-09-08 | |
| Analgesic Efficacy and Obstetric Effects of Tramadol, Paracetamol and Placebo in Active Labor Tramadol Hydrochloride, Paracetamol (acetaminophen), Placebo (Saline Solution) - Labor Pain | Phase 4 | Recruiting | Universidad Nacional Autonoma de Honduras | 300 | 2026-02-15 | 2026-02-27 |
| Comparison of Tramadol, Pethidine and Morphine in the Treatment of Pain After Thoracic Surgery Tramadol hydrochloride, Aldolan, Morphine hydrochloride - Thoracic Diseases, Analgesia | Phase 4 | Unknown | Baskent University | 45 | 2023-12-31 | 2023-12-15 |
| Intravenous Paracetamol Versus Intramuscular Tramadol in Shortening the Duration of Labour. paracetamol, Tramadol hydrochloride - Labour Duration | Not applicable | Completed | Federal Teaching Hospital Abakaliki | 189 | 2022-11-01 | 2026-02-06 |
| A Clinical Trial Evaluating the Efficacy and Safety of HSK21542 in Patients for Postoperative Pain Treatment HSK21542 Injection, Tramadol hydrochloride, placebo - Postoperative Analgesia | Phase 3 | Completed | Haisco Pharmaceutical Group Co., Ltd. | 387 | 2022-06-08 | 2023-04-04 |
| Use of Tramadol Intraligamentary Injections Tramadol hydrochloride, Lidocaine Hydrochloride - Pulpitis | Not applicable | Completed | Jamia Millia Islamia | 105 | 2022-04-01 | 2022-12-19 |
| Effect of Tramadol on Postoperative Sore Throat After General Anesthesia Tramadol hydrochloride, Normal Saline - Post-operative Sore Throat, Intubation Intratracheal | Phase 4 | Unknown | Affiliated Cancer Hospital of Shantou University Medical College | 168 | 2021-09-10 | 2024-05-13 |
| Lidocaine Spray for Pain Control in Rib Fractures Lidocaine topical - Rib Fractures, Analgesia | Phase 4 | Completed | Ankara City Hospital Bilkent | 48 | 2021-06-01 | 2022-08-17 |
| Continuous Erector Spinae Block for Post Analgesia in Pediatric Patients Bupivacaine Hydrochloride, Tramadol hydrochloride - Pediatric Cancer | Phase 3 | Completed | Assiut University | 60 | 2020-11-20 | 2023-02-03 |
| Effect of Tramadol Versus Morphine on PD1 and PD1-ligand in Patients With Chronic Cancer Pain Tramadol Hydrochloride - Chronic Pain | Phase 2 / Phase 3 | Unknown | Assiut University | 15 | 2020-04-16 | 2021-01-14 |
| Oral Use of Dexketoprofen/Tramadol for Acute Postoperative Pain in Total Hip Replacement With a Direct Anterior Approach. Dexketoprofen/tramadol (27mg/75mg), Tramadol hydrochloride, Paracetamol - Postoperative Pain, Pain, Acute | Phase 2 | Completed | KAT General Hospital | 226 | 2019-01-10 | 2019-11-26 |
| Drug-Drug Interaction Study of "CG100650" in Healthy Volunteers Polmacoxib and Tramadol combination, Polmacoxib, Tramadol hydrochloride - Healthy | Phase 1 | Completed | CrystalGenomics, Inc. | 41 | 2018-12-01 | 2022-05-27 |
| Oral Tramadol Versus Oral Celecoxib for Post-perineal Repair Analgesia Tramadol Hydrochloride, Celecoxib 200mg - Perineal Pain | Phase 4 | Unknown | Cairo University | 200 | 2018-10-10 | 2018-10-03 |
| Tramadol Simultaneously With Sciatic Nerve Block for Calcaneus Fracture Osteosynthesis Tramadol Hydrochloride, Placebo - Foot Fracture, Pain, Acute | Phase 4 | Completed | Medical University of Warsaw | 40 | 2017-06-15 | 2021-10-28 |
| Tramadol for Labor Analgesia: a Placebo Controlled Randomised Control Trial Tramadol Hydrochloride, Distilled Water - Tramadol for Labor Analgesia | Phase 2 | Unknown | Maulana Azad Medical College | 86 | 2016-12-01 | 2016-12-23 |
| Quadratus Lumborum Block in Pediatric Patients Tramadol Hydrochloride, Morphine Sulfate - Postoperative Pain | Not applicable | Completed | Bakirkoy Dr. Sadi Konuk Research and Training Hospital | 40 | 2016-05-15 | 2018-10-04 |
| Transversus Abdominis Plane Block and Quadratus Lumborum Block in Pediatric Patients Tramadol hydrochloride - Pain, Postoperative | Not applicable | Completed | Bakirkoy Dr. Sadi Konuk Research and Training Hospital | 40 | 2016-05-01 | 2020-01-13 |
| To Compare the Efficacy and Patients' Satisfaction for the Treatment of Post Cesarean Pain of Two Protocols: Oral Medications in Fixed Time Interval Administration Versus Spinal Morphine Tramadol hydrochloride, Morphine, Paracetamol - Post Cesarean Pain Management | Not applicable | Completed | HaEmek Medical Center, Israel | 200 | 2015-07-01 | 2017-05-09 |
| Dexamethasone Versus Local Infiltration Technique for Tonsillectomy in Children dexamethasone, Local anesthetic infiltration, General anesthesia - Postoperative Nausea and Vomiting | Not applicable | Completed | Makassed General Hospital | 129 | 2015-01-01 | 2015-08-21 |
| Intraoperative Use of Dexketoprofen Trometamol, Pethidine Hcl, Tramadol Hcl and Their Combinations for Postoperative Pain Management in Laparoscopic Nissen Fundoplication dexketoprofen trometamol, tramadol hydrochloride, pethidine hydrochloride - Laparoscopic Nissen Fundoplication | Phase 4 | Unknown | Kavaklıdere Umut Hospital | 72 | 2012-03-01 | 2012-03-23 |
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Pain, Postoperative (6) · Agnosia (4) · Pain (4) · Acute Pain (2) · Chronic Pain (2) · Fibromyalgia (1) · Labor Pain (1) · Neoplasms (1) · Parkinson Disease 4, Autosomal Dominant Lewy Body (1) · Postoperative Nausea and Vomiting (1) · Premature Ejaculation (1) · Pulpitis (1) · Rib Fractures (1) · Thoracic Diseases (1) · Tonsillitis (1)
Assiut University (2) · Bakirkoy Dr. Sadi Konuk Research and Training Hospital (2) · Affiliated Cancer Hospital of Shantou University Medical College (1) · Ankara City Hospital Bilkent (1) · Baskent University (1) · Bausch Health Americas, Inc. (1) · Cairo University (1) · Children's Hospitals and Clinics of Minnesota (1) · CrystalGenomics, Inc. (1) · EMS (1) · Federal Teaching Hospital Abakaliki (1) · HaEmek Medical Center, Israel (1) · Haisco Pharmaceutical Group Co., Ltd. (1) · Jamia Millia Islamia (1) · Janssen Pharmaceutical K.K. (1)
Turkey (Türkiye) (4) · China (3) · Poland (3) · Egypt (2) · Hungary (2) · Bulgaria (1) · Czechia (1) · Germany (1) · Greece (1) · Honduras (1) · India (1) · Israel (1) · Italy (1) · Japan (1) · Lebanon (1)
Ahmet Burak Erdem, M.D. (1) · Assumpta N Nweke (1) · Cosme Gay-Escoda, Professor (1) · Janusz Trzebicki, Dr hab. (1) · Kyung-Sang Yu, Ph.D. (1) · Peter Nyiradi, MD (1) · R Andrew Moore, Professor (1) · Shereen M Kamal, Associate Professor (1) · Stefan J Friedrichsdorf, M.D. (1) · XiaoFeng Shen, MD (1)
PMID 19122548, PMID 21889833, PMID 26123824, PMID 28012528, PMID 34463805, PMID 38204364, PMID 40413233, PMID 41430574, PMID 41874970