38 completed, 10 recruiting, 9 active not recruiting, 7 terminated. 70 Phase 1, 30 Phase 2.
Follow Tmz: new trials by email Literature Review of Tmz trials Research Report on Tmz
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combination ADI-PEG 20, TMZ, and RT for Treatment of Newly Diagnosed High-grade Glioma (HGG) ADI-PEG 20 (Arginine deiminase pegylated), Temozolomide (TMZ), Standard of Care Radiation Therapy (RT) - Glioblastoma, High-Grade Glioma (WHO III-IV) | Phase 1 / Phase 2 | Not yet recruiting | Sabine Mueller, MD, PhD | 97 | 2027-06-01 | 2026-09-15 |
| Liothyronine in Combination With BIT Regimen for Medulloblastoma With or Without Minimal Residual Disease Liothyronine (L-T3), Bevacizumab, Irinotecan - Medulloblastoma, Medulloblastoma, Childhood | Phase 1 / Phase 2 | Recruiting | Sabine Mueller, MD, PhD | 69 | 2026-08-21 | 2026-09-28 |
| A Rollover Study of NBM-BMX in Combination With Temozolomide in Patients With Newly Diagnosed Glioblastoma NBM-BMX Capsule, Temozolomide - Malignant Neoplasm of Brain | Phase 1 / Phase 2 | Recruiting | Novelwise Pharmaceutical Corporation | 15 | 2026-04-20 | 2026-05-06 |
| STARLITE for Unresectable High-Grade Gliomas Magnetic Resonance (MR)-guided Laser Interstitial Thermal Therapy (LITT), Abacavir, Lamivudine - High Grade Glioma | Phase 1 | Recruiting | University of Miami | 24 | 2025-04-15 | 2026-06-25 |
| Triapine in Combination With Temozolomide for the Treatment of Patients With Recurrent Glioblastoma Biospecimen Collection, Magnetic Resonance Imaging, Questionnaire Administration - Recurrent Glioblastoma, IDH-Wildtype, Recurrent WHO Grade 2 Glioma | Phase 1 | Recruiting | Northwestern University | 22 | 2024-07-23 | 2026-09-09 |
| Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness Biopsy Procedure, Biospecimen Collection, Computed Tomography - Advanced Malignant Solid Neoplasm, Advanced Microsatellite Stable Colorectal Carcinoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 42 | 2023-09-28 | 2026-07-31 |
| Evaluation of Eflornithine Plus Temozolomide in Patients With Newly Diagnosed Glioblastoma or Astrocytoma Eflornithine (Dose Level 1), Eflornithine (Dose Level 2), Eflornithine (Dose Level -1) - Glioblastoma, IDH-wildtype, Glioblastoma | Phase 1 | Recruiting | Orbus Therapeutics, Inc. | 66 | 2023-07-24 | 2025-06-25 |
| B7-H3 CAR-T for Recurrent or Refractory Glioblastoma Temozolomide, B7-H3 CAR-T - Recurrent Glioblastoma, Refractory Glioblastoma | Phase 1 / Phase 2 | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 40 | 2023-06-01 | 2022-12-28 |
| Preoperative Radiosurgery for the Treatment of High Grade Glioma, NeoGlioma Trial Radiation Therapy, Radiosurgery, Stereotactic Biopsy - Malignant Glioma | Phase 1 | Recruiting | Mayo Clinic | 28 | 2023-05-23 | 2026-09-30 |
| Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment Biospecimen Collection, Magnetic Resonance Imaging, Placebo Administration - Recurrent Glioblastoma, IDH-Wildtype, Recurrent MGMT-Methylated Glioblastoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 97 | 2023-03-20 | 2026-11-06 |
| Natural Killer Cell Therapy (UD TGFbetai NK Cells) and Temozolomide for the Treatment of Stage IV Melanoma Metastatic to the Brain Natural Killer Cell Therapy, Temozolomide - Clinical Stage IV Cutaneous Melanoma AJCC v8, Metastatic Malignant Neoplasm in the Brain | Phase 1 / Phase 2 | Recruiting | Kari Kendra | 24 | 2023-03-01 | 2026-06-11 |
| LITT Combined With Early Use of Temozolomide for Recurrent Glioblastomas Laser interstitial thermal therapy, Temozolomide - Recurrent Glioblastoma | Phase 1 / Phase 2 | Unknown | Beijing Tiantan Hospital | 10 | 2022-12-01 | 2022-12-23 |
| Mycophenolate Mofetil in Combination With Standard of Care for the Treatment of Glioblastoma Mycophenolate Mofetil, Quality-of-Life Assessment, Radiation Therapy - Astrocytoma, Glioblastoma | Phase 1 | Active not recruiting | Northwestern University | 86 | 2022-08-08 | 2026-08-26 |
| A Study of Maprotiline in Combination With Tamoxifen and Temozolomide for Recurrent Glioblastoma Temozolomide, Tamoxifen, Maprotiline - Glioblastoma, Brain Tumor | Phase 1 | Withdrawn | University of Rochester | 2022-06-01 | 2022-08-22 | |
| Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors VAL-413, Temozolomide - Solid Tumors, Neuroblastoma | Phase 1 | Active not recruiting | Valent Technologies, LLC | 20 | 2021-10-25 | 2026-07-30 |
| Partial Brain RT, Temozolomide, Chloroquine, and TTF Therapy for the Treatment of Newly Diagnosed Glioblastoma 3-Dimensional Conformal Radiation Therapy, Intensity-Modulated Radiation Therapy (IMRT), Temozolomide - Glioblastoma, Gliosarcoma | Phase 1 | Terminated | Barbara Ann Karmanos Cancer Institute | 2 | 2021-08-12 | 2025-01-15 |
| Safety and Efficacy of L19TNF Plus Temozolomide Chemoradiotherapy in Patients With Newly Diagnosed Glioblastoma Onfekafusp alfa, Temozolomide - Glioblastoma | Phase 1 / Phase 2 | Recruiting | Philogen S.p.A. | 226 | 2021-01-20 | 2023-10-10 |
| Clinical Study of an Dendritic and Glioma Cells Fusion Vaccine With IL-12 for Treatment-naïve GBM Patients. Dendritic Cell/Tumor Fusion Vaccine, Interleukin-12, Temozolomide - Glioblastoma, Glioma | Phase 1 / Phase 2 | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 10 | 2020-12-01 | 2020-06-09 |
| Phase I Trial of DNA-PK Inhibitor (PEPOSERTIB ) in Combination With Radiation and Adjuvant Temozolomide in Newly Diagnosed MGMT Unmethylated and Recurrent Glioblastoma Peposertib, Radiation Therapy, Resection - Glioblastoma, Gliosarcoma | Phase 1 | Active not recruiting | M.D. Anderson Cancer Center | 29 | 2020-09-20 | 2026-10-16 |
| Mycophenolate Mofetil Combined With Radiation Therapy in Glioblastoma Mycophenolate Mofetil, Radiation Therapy, Re-resection (as part of standard of care) - Recurrent Glioblastoma, Recurrent Gliosarcoma | Phase 1 | Active not recruiting | University of Michigan Rogel Cancer Center | 68 | 2020-08-05 | 2026-05-14 |
Showing 20 of 70. Sign in to see all of them.
Glioblastoma (39) · Gliosarcoma (19) · Glioma (14) · Astrocytoma (13) · Brain Neoplasms (12) · Oligodendroglioma (8) · Central Nervous System Neoplasms (7) · Medulloblastoma (7) · Familial ependymoma (4) · Melanoma (4) · Choroid Plexus Neoplasms (3) · Neoplasm Metastasis (3) · Neoplasms (3) · Optic Nerve Glioma (3) · Breast Neoplasms (2)
National Cancer Institute (NCI) (20) · Northwestern University (5) · Children's Oncology Group (2) · Jonsson Comprehensive Cancer Center (2) · M.D. Anderson Cancer Center (2) · Sabine Mueller, MD, PhD (2) · Second Affiliated Hospital, Zhejiang University, School of Medicine (2) · AbbVie (1) · Barbara Ann Karmanos Cancer Institute (1) · BeiGene (1) · BeiGene USA, Inc. (1) · Beijing Tiantan Hospital (1) · BioMimetix JV, LLC (1) · Brown University (1) · Candel Therapeutics, Inc. (1)
United States (60) · Canada (3) · China (3) · Switzerland (3) · Australia (2) · France (2) · Spain (2) · Bosnia and Herzegovina (1) · Bulgaria (1) · Georgia (1) · Netherlands (1) · Taiwan (1) · United Kingdom (1)
Timothy Cloughesy (2) · Aerang Kim, M.D. (1) · Alok Kothari, M.D. (1) · Amar Gajjar (1) · Ashish Shah, MD (1) · Bhardwaj Desai, MD (1) · Bryan Oronsky (1) · Dabiao Zhou, MD (1) · Daniel M. Trifiletti, MD (1) · Eric S Schafer (1) · Erin Trovillion, M.D. (1) · Eudocia Q Lee (1) · Evanthia Galanis (1)
PMID 22517399, PMID 23554030, PMID 24101040, PMID 24552317, PMID 24991840, PMID 27098749, PMID 28497258, PMID 29490632, PMID 31386061, PMID 31724813, PMID 32270710, PMID 32652442, PMID 33284237, PMID 35031547, PMID 35468680, PMID 36274161, PMID 36705597, PMID 38874333, PMID 38970256, PMID 39487711, PMID 40120123, PMID 40875628, PMID 40906325, PMID 41041559, PMID 41544350, PMID 42189896
P30CA060553 (3), U01CA062399 (3), U01CA097452 (3), UM1CA097452 (3), 2017 (2), U01CA062475 (2), U01CA081457 (2), U01CA137443 (2), U10CA025224 (2), UM1CA137443 (2), 2018 (1), N01CM00071 (1), N01CM62201 (1), N01CM62209 (1), P30CA006973 (1)