41 completed, 20 active not recruiting, 14 recruiting, 10 unknown. 99 Phase 2, 30 Phase 1, 6 Phase 3.
Follow TMZ: new trials by email Literature Review of TMZ trials Research Report on TMZ
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combination ADI-PEG 20, TMZ, and RT for Treatment of Newly Diagnosed High-grade Glioma (HGG) ADI-PEG 20 (Arginine deiminase pegylated), Temozolomide (TMZ), Standard of Care Radiation Therapy (RT) - Glioblastoma, High-Grade Glioma (WHO III-IV) | Phase 1 / Phase 2 | Not yet recruiting | Sabine Mueller, MD, PhD | 97 | 2027-06-01 | 2026-09-15 |
| Temozolomide and Survivin Long Peptide Vaccine (SurVaxM) for the Treatment of Patients With Progressing Metastatic Neuroendocrine Carcinomas Biospecimen Collection, Computed Tomography, Incomplete Freund''s Adjuvant - Digestive System Neuroendocrine Neoplasm, Lung Neuroendocrine Neoplasm | Phase 2 | Not yet recruiting | Roswell Park Cancer Institute | 60 | 2026-12-15 | 2026-10-20 |
| Temozolomide, With or Without WSD0922-FU, for the Treatment of EGFR-Mutant, IDH-Wildtype Glioblastoma Archive Sample Retrieval, Biospecimen Collection, Chest Radiography - Glioblastoma, IDH-Wildtype | Phase 2 | Recruiting | Mayo Clinic | 60 | 2026-08-28 | 2026-10-26 |
| Liothyronine in Combination With BIT Regimen for Medulloblastoma With or Without Minimal Residual Disease Liothyronine (L-T3), Bevacizumab, Irinotecan - Medulloblastoma, Medulloblastoma, Childhood | Phase 1 / Phase 2 | Recruiting | Sabine Mueller, MD, PhD | 69 | 2026-08-21 | 2026-09-28 |
| Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII silevertinib in combination with temozolomide, temozolomide (TMZ) - Glioblastoma (GBM), Newly Diagnosed Glioblastoma | Phase 2 | Recruiting | Black Diamond Therapeutics, Inc. | 162 | 2026-05-05 | 2026-11-02 |
| A Rollover Study of NBM-BMX in Combination With Temozolomide in Patients With Newly Diagnosed Glioblastoma NBM-BMX Capsule, Temozolomide - Malignant Neoplasm of Brain | Phase 1 / Phase 2 | Recruiting | Novelwise Pharmaceutical Corporation | 15 | 2026-04-20 | 2026-05-06 |
| Trial of Glioblastoma Immunotherapy Advancement With Nivolumab and Relatlimab Nivolumab, Relatlimab, TMZ - Newly Diagnosed Glioblastoma | Phase 2 | Recruiting | Duke University | 92 | 2025-11-28 | 2026-09-17 |
| Study of Senaparib in Combination With Temozolomide in ARID1A Mutation Associated Ovarian Cancer Senaparib, Temozolomide - Ovary Cancer, Fallopian Tube Cancer | Phase 2 | Active not recruiting | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 18 | 2025-02-06 | 2026-10-28 |
| PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma PEP-CMV, Temozolomide, Tetanus Diphtheria Vaccine - High Grade Glioma, Diffuse Intrinsic Pontine Glioma | Phase 2 | Recruiting | Nationwide Children's Hospital | 120 | 2024-07-18 | 2026-08-24 |
| Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness Biopsy Procedure, Biospecimen Collection, Computed Tomography - Advanced Malignant Solid Neoplasm, Advanced Microsatellite Stable Colorectal Carcinoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 42 | 2023-09-28 | 2026-07-31 |
| B7-H3 CAR-T for Recurrent or Refractory Glioblastoma Temozolomide, B7-H3 CAR-T - Recurrent Glioblastoma, Refractory Glioblastoma | Phase 1 / Phase 2 | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 40 | 2023-06-01 | 2022-12-28 |
| Testing Olaparib and Temozolomide Versus the Usual Treatment for Uterine Leiomyosarcoma After Chemotherapy Has Stopped Working Biospecimen Collection, Bone Scan, Computed Tomography - Locally Advanced Uterine Corpus Leiomyosarcoma, Metastatic Uterine Corpus Leiomyosarcoma | Phase 2 / Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 74 | 2023-03-30 | 2026-10-01 |
| Short Course Radiotherapy for the Treatment of Patients With Glioblastoma, SAGA Study Accelerated Hypofractionated Radiation Therapy, Computed Tomography, Fluorodopa F 18 - Glioblastoma | Phase 2 | Active not recruiting | Mayo Clinic | 170 | 2023-03-23 | 2026-07-30 |
| Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment Biospecimen Collection, Magnetic Resonance Imaging, Placebo Administration - Recurrent Glioblastoma, IDH-Wildtype, Recurrent MGMT-Methylated Glioblastoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 97 | 2023-03-20 | 2026-11-06 |
| Natural Killer Cell Therapy (UD TGFbetai NK Cells) and Temozolomide for the Treatment of Stage IV Melanoma Metastatic to the Brain Natural Killer Cell Therapy, Temozolomide - Clinical Stage IV Cutaneous Melanoma AJCC v8, Metastatic Malignant Neoplasm in the Brain | Phase 1 / Phase 2 | Recruiting | Kari Kendra | 24 | 2023-03-01 | 2026-06-11 |
| hSTAR GBM (Hematopoetic Stem Cell (HPC) Rescue for GBM) P140K-MGMT, O6-benzylguanine, Photon Based Radiotherapy - Glioblastoma Multiforme, Glioblastoma Multiforme, Adult | Phase 2 | Recruiting | Leland Metheny | 16 | 2023-01-20 | 2026-09-10 |
| LITT Combined With Early Use of Temozolomide for Recurrent Glioblastomas Laser interstitial thermal therapy, Temozolomide - Recurrent Glioblastoma | Phase 1 / Phase 2 | Unknown | Beijing Tiantan Hospital | 10 | 2022-12-01 | 2022-12-23 |
| Testing the Combination of Anti-Cancer Drugs Talazoparib and Temozolomide in Patients With Advanced Stage Rare Cancers, RARE 2 Trial Biopsy Procedure, Biospecimen Collection, Computed Tomography - Malignant Solid Neoplasm | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 14 | 2022-07-11 | 2026-10-14 |
| Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors Capecitabine, Temozolomide - Metastatic Malignant Neoplasm in the Liver, Pancreatic Neuroendocrine Tumor | Phase 2 | Recruiting | SWOG Cancer Research Network | 141 | 2022-05-05 | 2025-12-15 |
| Temozolomide and Atezolizumab for Subsequent Line for the Treatment of Metastatic or Recurrent Small Cell Lung Cancer Atezolizumab, Temozolomide - Extensive Stage Lung Small Cell Carcinoma, Metastatic Lung Small Cell Carcinoma | Phase 2 | Recruiting | Dwight Owen | 56 | 2022-01-26 | 2026-04-08 |
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Glioblastoma (48) · Brain Neoplasms (17) · Gliosarcoma (17) · Glioma (16) · Astrocytoma (11) · Central Nervous System Neoplasms (7) · Melanoma (6) · Medulloblastoma (5) · Oligodendroglioma (5) · Neoplasms (4) · Neuroblastoma (3) · Small Cell Lung Carcinoma (3) · Adenoma, Islet Cell (2) · Breast Neoplasms (2) · Carcinoma, Islet Cell (2)
National Cancer Institute (NCI) (22) · Mayo Clinic (5) · Children's Oncology Group (4) · Jonsson Comprehensive Cancer Center (3) · M.D. Anderson Cancer Center (3) · Memorial Sloan Kettering Cancer Center (3) · NRG Oncology (3) · Northwestern University (3) · Second Affiliated Hospital, Zhejiang University, School of Medicine (3) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (3) · Mustafa Khasraw, MBChB, MD, FRCP, FRACP (2) · Peking Union Medical College Hospital (2) · Sabine Mueller, MD, PhD (2) · AbbVie (1) · Annick Desjardins, MD (1)
United States (81) · Canada (11) · China (10) · Australia (9) · Puerto Rico (6) · France (5) · New Zealand (5) · Switzerland (4) · Germany (3) · Italy (3) · Netherlands (3) · Spain (3) · United Kingdom (3) · Austria (2) · Israel (2)
A P Chen (2) · Jeffrey Raizer, MD (2) · Adam S Levy (1) · Ami V Desai (1) · Andrew B Lassman (1) · Andrew Beelen, MD (1) · Annick Desjardins, MD, FRCPC (1) · Brian Shuch, MD (1) · Charles Conrad, MD (1) · Charles M Rudin (1) · Dabiao Zhou, MD (1) · Daniel Landi, MD (1) · David R Grosshans (1)
PMID 39571596, PMID 18775433, PMID 18955445, PMID 20725730, PMID 20921459, PMID 21149254, PMID 22517399, PMID 22656234, PMID 24101040, PMID 24552317, PMID 24991840, PMID 26602013, PMID 26615020, PMID 27098749, PMID 28039367, PMID 28549783, PMID 29077941, PMID 29906251, PMID 29982805, PMID 30854456, PMID 30996008, PMID 31386061, PMID 31724813, PMID 31747009, PMID 31795071, PMID 32270710, PMID 32343642, PMID 32548285, PMID 32652442, PMID 32691060, PMID 33170593, PMID 33284237, PMID 33601293, PMID 33927108, PMID 34417675, PMID 35031547, PMID 35468680, PMID 36705597, PMID 36822669, PMID 37218946, PMID 37467452, PMID 38200233, PMID 39480453, PMID 39560182, PMID 40016450, PMID 40779733, PMID 40906325, PMID 41544350, PMID 41554272
U10CA180886 (6), U10CA180821 (5), U10CA180868 (5), U10CA098543 (4), U10CA031946 (3), U01CA062475 (2), U10CA025224 (2), 2014 (1), 2017 (1), N01CM00039 (1), P30CA008748 (1), P30CA060553 (1), P30CA124435 (1), P30CA138292 (1), P50CA108961 (1)