71 completed, 30 active not recruiting, 26 recruiting, 15 terminated. 99 Phase 2, 70 Phase 1, 21 Phase 3, 4 Early Phase 1, 3 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combination ADI-PEG 20, TMZ, and RT for Treatment of Newly Diagnosed High-grade Glioma (HGG) ADI-PEG 20 (Arginine deiminase pegylated), Temozolomide (TMZ), Standard of Care Radiation Therapy (RT) - Glioblastoma, High-Grade Glioma (WHO III-IV) | Phase 1 / Phase 2 | Not yet recruiting | Sabine Mueller, MD, PhD | 97 | 2027-06-01 | 2026-09-15 |
| Temozolomide and Survivin Long Peptide Vaccine (SurVaxM) for the Treatment of Patients With Progressing Metastatic Neuroendocrine Carcinomas Biospecimen Collection, Computed Tomography, Incomplete Freund''s Adjuvant - Digestive System Neuroendocrine Neoplasm, Lung Neuroendocrine Neoplasm | Phase 2 | Not yet recruiting | Roswell Park Cancer Institute | 60 | 2026-12-15 | 2026-10-20 |
| PH Weighted Chemical Exchange Saturation Transfer MRI-Based Surgical Resection to Improve Survival in Patients With Glioblastoma Chemical Exchange Saturation Transfer Magnetic Resonance Imaging, Contrast-enhanced Magnetic Resonance Imaging, Magnetic Resonance Imaging - Glioblastoma | Phase 3 | Not yet recruiting | Jonsson Comprehensive Cancer Center | 60 | 2026-12-01 | 2026-07-07 |
| Temozolomide, With or Without WSD0922-FU, for the Treatment of EGFR-Mutant, IDH-Wildtype Glioblastoma Archive Sample Retrieval, Biospecimen Collection, Chest Radiography - Glioblastoma, IDH-Wildtype | Phase 2 | Recruiting | Mayo Clinic | 60 | 2026-08-28 | 2026-10-26 |
| Liothyronine in Combination With BIT Regimen for Medulloblastoma With or Without Minimal Residual Disease Liothyronine (L-T3), Bevacizumab, Irinotecan - Medulloblastoma, Medulloblastoma, Childhood | Phase 1 / Phase 2 | Recruiting | Sabine Mueller, MD, PhD | 69 | 2026-08-21 | 2026-09-28 |
| Temporally-Modulated Pulsed Radiation Therapy Versus Standard Radiation Therapy for the Treatment of Newly Diagnosed, IDH Wildtype, MGMT-Unmethylated Glioblastoma Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging - Glioblastoma, IDH-Wildtype, MGMT-Unmethylated Glioblastoma | Phase 3 | Recruiting | NRG Oncology | 398 | 2026-07-16 | 2026-09-10 |
| Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII silevertinib in combination with temozolomide, temozolomide (TMZ) - Glioblastoma (GBM), Newly Diagnosed Glioblastoma | Phase 2 | Recruiting | Black Diamond Therapeutics, Inc. | 162 | 2026-05-05 | 2026-11-02 |
| A Rollover Study of NBM-BMX in Combination With Temozolomide in Patients With Newly Diagnosed Glioblastoma NBM-BMX Capsule, Temozolomide - Malignant Neoplasm of Brain | Phase 1 / Phase 2 | Recruiting | Novelwise Pharmaceutical Corporation | 15 | 2026-04-20 | 2026-05-06 |
| Beginning Radiation Immediately With GammaTile at GBM Excision Versus Standard of Care GammaTile®, External Beam Radiation Therapy, Temozolomide - Glioblastoma | Phase 3 | Recruiting | GT Medical Technologies, Inc. | 766 | 2025-12-10 | 2026-10-05 |
| Trial of Glioblastoma Immunotherapy Advancement With Nivolumab and Relatlimab Nivolumab, Relatlimab, TMZ - Newly Diagnosed Glioblastoma | Phase 2 | Recruiting | Duke University | 92 | 2025-11-28 | 2026-09-17 |
| Neoadjuvant Chemoradiotherapy With or Without Concurrent Azeliragon in Patients With Newly Diagnosed Glioblastoma Azeliragon, Temozolomide, Radiation therapy - Glioblastoma | Early Phase 1 | Recruiting | Washington University School of Medicine | 12 | 2025-11-06 | 2026-05-29 |
| Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation Cytarabine IT, hydrocortisone, Cisplatin - CNS Embryonal Tumor, CNS, Medulloblastoma | Early Phase 1 | Recruiting | C17 Council | 15 | 2025-09-23 | 2026-11-02 |
| Medication Combinations of Dasatinib, Quercetin, Fisetin, Temozolomide, LMP744, and Autologous TLPO Vaccine for the Treatment of Previously Treated Glioma With Residual Disease Biospecimen Collection, Dasatinib, Fisetin - Glioma | Early Phase 1 | Recruiting | Mayo Clinic | 30 | 2025-08-12 | 2026-10-01 |
| STARLITE for Unresectable High-Grade Gliomas Magnetic Resonance (MR)-guided Laser Interstitial Thermal Therapy (LITT), Abacavir, Lamivudine - High Grade Glioma | Phase 1 | Recruiting | University of Miami | 24 | 2025-04-15 | 2026-06-25 |
| Implantable Microdevice for the Delivery of Drugs and Their Effect on Tumors in Patients With Metastatic or Recurrent Sarcoma Doxorubicin, Doxorubicin Hydrochloride, Drug Delivery Microdevice - Metastatic Sarcoma, Recurrent Sarcoma | Not applicable | Recruiting | M.D. Anderson Cancer Center | 20 | 2025-02-25 | 2026-08-11 |
| Study of Senaparib in Combination With Temozolomide in ARID1A Mutation Associated Ovarian Cancer Senaparib, Temozolomide - Ovary Cancer, Fallopian Tube Cancer | Phase 2 | Active not recruiting | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 18 | 2025-02-06 | 2026-10-28 |
| Lomustine in Addition to Standard of Care in Patients With MGMT Methylated Glioblastoma Temozolomide, Lomustine - Glioblastoma, IDH-wildtype, MGMT-Methylated Glioblastoma | Phase 3 | Recruiting | Vastra Gotaland Region | 200 | 2025-02-01 | 2026-04-13 |
| Comparing Telehealth and In-person Assessments in Glioma Patients Receiving Oral Chemotherapy Assessment, Questionnaire Administration, Telemedicine Visit - Astrocytoma, IDH-Mutant, Glioblastoma | Phase 4 | Completed | Mayo Clinic | 30 | 2024-10-07 | 2026-04-29 |
| Triapine in Combination With Temozolomide for the Treatment of Patients With Recurrent Glioblastoma Biospecimen Collection, Magnetic Resonance Imaging, Questionnaire Administration - Recurrent Glioblastoma, IDH-Wildtype, Recurrent WHO Grade 2 Glioma | Phase 1 | Recruiting | Northwestern University | 22 | 2024-07-23 | 2026-09-09 |
| PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma PEP-CMV, Temozolomide, Tetanus Diphtheria Vaccine - High Grade Glioma, Diffuse Intrinsic Pontine Glioma | Phase 2 | Recruiting | Nationwide Children's Hospital | 120 | 2024-07-18 | 2026-08-24 |
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Glioblastoma (84) · Gliosarcoma (30) · Brain Neoplasms (27) · Glioma (27) · Astrocytoma (23) · Oligodendroglioma (13) · Medulloblastoma (11) · Central Nervous System Neoplasms (9) · Melanoma (8) · Neoplasms (7) · Neuroblastoma (7) · Familial ependymoma (4) · Neuroectodermal Tumors, Primitive (4) · Optic Nerve Glioma (4) · Small Cell Lung Carcinoma (4)
National Cancer Institute (NCI) (38) · Mayo Clinic (8) · Children's Oncology Group (6) · Northwestern University (6) · Jonsson Comprehensive Cancer Center (5) · M.D. Anderson Cancer Center (5) · NRG Oncology (5) · Memorial Sloan Kettering Cancer Center (3) · Second Affiliated Hospital, Zhejiang University, School of Medicine (3) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (3) · AbbVie (2) · European Organisation for Research and Treatment of Cancer - EORTC (2) · Isarna Therapeutics GmbH (2) · Laminar Pharmaceuticals (2) · Mustafa Khasraw, MBChB, MD, FRCP, FRACP (2)
United States (133) · Canada (22) · Australia (15) · China (13) · France (11) · Spain (11) · United Kingdom (10) · Switzerland (9) · Netherlands (8) · Austria (7) · Germany (7) · Italy (7) · Puerto Rico (7) · New Zealand (6) · Belgium (4)
A P Chen (2) · Jeffrey Raizer, MD (2) · Timothy Cloughesy (2) · Adam S Levy (1) · Aerang Kim, M.D. (1) · Alok Kothari, M.D. (1) · Amar Gajjar (1) · Ami V Desai (1) · Andrew B Lassman (1) · Andrew Beelen, MD (1) · Annick Desjardins, MD, FRCPC (1) · Annie Huang (1)
PMID 32691060, PMID 39571596, PMID 18775433, PMID 18955445, PMID 20725730, PMID 20921459, PMID 21149254, PMID 22517399, PMID 22656234, PMID 23554030, PMID 24101040, PMID 24552317, PMID 24991840, PMID 25055291, PMID 26602013, PMID 26615020, PMID 27098749, PMID 28039367, PMID 28497258, PMID 28549783, PMID 29077941, PMID 29490632, PMID 29906251, PMID 29982805, PMID 30854456, PMID 30996008, PMID 31386061, PMID 31724813, PMID 31747009, PMID 31795071, PMID 32270710, PMID 32343642, PMID 32548285, PMID 32652442, PMID 33170593, PMID 33284237, PMID 33601293, PMID 33927108, PMID 34417675, PMID 35031547, PMID 35468680, PMID 35511454, PMID 36274161, PMID 36705597, PMID 36822669, PMID 37218946, PMID 37467452, PMID 38200233, PMID 38874333, PMID 38970256
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