71 completed, 14 unknown, 13 terminated, 9 recruiting. 116 Phase 1, 42 Phase 2.
Follow Therapeutics: new trials by email Literature Review of Therapeutics trials Research Report on Therapeutics
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Defibrio AED Study treatment with Defibrio AED - VF, VT | Phase 1 / Phase 2 | Not yet recruiting | Defibrio, LLC | 25 | 2026-11-01 | 2026-10-19 |
| A Study of [225Ac]Ac-AKY-2519 in Patients With B7-H3 Expressing Solid Tumors [225Ac]Ac-AKY-2519 (therapeutic), [64Cu]Cu-AKY-2519 (imaging) - NSCLC, NSCLC (Advanced Non-small Cell Lung Cancer) | Phase 1 | Recruiting | Aktis Oncology, Inc. | 152 | 2026-11-01 | 2026-10-22 |
| Acceleration of Tooth Movement Using PRP and Photobiomodulation With Clear Aligners Platelet Rich Plasma (PRP) injection, photobiomodulation (PBM) Therapy, clear aligner(12-hour wear protocol) - Orthodontic Tooth Movement | Phase 1 / Phase 2 | Not yet recruiting | Sana'a University | 42 | 2026-09-01 | 2026-08-31 |
| A Study of [225Ac]Ac-AKY-2519 in Patients With Metastatic Castration-Resistant Prostate Cancer [225Ac]Ac-AKY-2519 (therapeutic), [64Cu]Cu-AKY-2519 (imaging) - Castration Resistant Metastatic Prostate Cancer, Prostate Cancer | Phase 1 | Recruiting | Aktis Oncology, Inc. | 138 | 2026-06-17 | 2026-09-15 |
| ASCERV Study: MRG003 Combined With QL1706 in Recurrent or Metastatic Cervical Cancer Treatment - Recurrent or Metastatic Cervical Cancer | Phase 1 / Phase 2 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 41 | 2026-04-10 | 2026-04-21 |
| Chinese Herbal Therapy (Qiqi Shengmai Formula) for Moyamoya Vasculopathy: The CHIMES Trial Traditional Chinese Medicine (TCM) Treatment, Conventional medical treatment, TCM Placebo - Moyamoya Disease, Moyamoya Syndrome | Phase 1 | Not yet recruiting | Fudan University | 66 | 2025-12-30 | 2025-12-22 |
| Exploratory Study of Intranasal Administration of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles for the Treatment of Ischemic Stroke Intranasal Administration of Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles (hUC-MSC-sEV-001) Therapy - Ischemic Stroke | Phase 1 | Not yet recruiting | Zhujiang Hospital | 9 | 2025-12-01 | 2025-11-18 |
| A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors [225Ac]Ac-AKY-1189 (therapeutic), [64Cu]Cu-AKY-1189 (imaging) - Urothelial Carcinoma Bladder, Triple Negative Breast Cancer (TNBC) | Phase 1 | Recruiting | Aktis Oncology, Inc. | 150 | 2025-08-22 | 2026-09-17 |
| Feasibility of a Digital Therapeutic for Adults With Posttraumatic Stress Disorder (PTSD) OTX-601 Digital Therapeutic - Version 1, OTX-601 Digital Therapeutic - Version 2, Treatment as Usual (TAU) - PTSD, Post Traumatic Stress Disorder | Phase 1 | Completed | Oui Therapeutics, Inc. | 40 | 2025-06-30 | 2026-07-27 |
| CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D) CNP-103, Placebo - Type 1 Diabetes Mellitus, T1D | Phase 1 / Phase 2 | Recruiting | COUR Pharmaceutical Development Company, Inc. | 72 | 2025-05-12 | 2026-09-11 |
| Study on the Safety, Tolerability, and Pharmacokinetics of PA9159 Nasal Spray in Healthy Adult Subjects PA9159 nasal spray solution, 80 μg one day treatment, PA9159 nasal spray solution, 160 μg one day treatment, PA9159 nasal spray solution, 320 μg one day treatment - Allergic Rhinitis | Phase 1 | Completed | Anhui Palo Alto Pharmaceuticals, Inc. | 36 | 2025-03-14 | 2026-01-15 |
| Psychological Effects of Methylenedioxymethamphetamine (MDMA) When Administered to Healthy Volunteers (MT-2) Midomafetamine HCl, Therapy - Psychological Effects of Study Drug | Phase 1 | Withdrawn | Resilient Pharmaceuticals | 2024-12-01 | 2024-10-31 | |
| Non-invasive Electrical Spinal Cord Stimulation To Restore Upper Extremity Function in Multiple Sclerosis Transcutaneous electrical spinal cord stimulation + therapy, Occupational Therapy - Multiple Sclerosis | Phase 1 | Unknown | University of Washington | 4 | 2024-08-08 | 2024-08-14 |
| Safety, Tolerability, and Pharmacokinetics of PA9159 Inhalation Aerosol in Healthy Adult Subjects PA9159 Inhalation aerosol, 60 μg one day treatment, PA9159 Inhalation aerosol, 120 μg one day treatment, PA9159 Inhalation aerosol, 240 μg one day treatment - Bronchial Asthma | Phase 1 | Completed | Anhui Palo Alto Pharmaceuticals, Inc. | 40 | 2024-07-22 | 2025-12-30 |
| Padeliporfin VTP Using Robotic Assisted Bronchoscopy in Peripheral Lung Cancer Padeliporfin Vascular Targeted Photodynamic (VTP) therapy - Peripheral Lung Tumor | Phase 1 | Active not recruiting | Impact Biotech Ltd | 36 | 2024-05-28 | 2026-10-08 |
| Padeliporfin VTP Treatment for Unresectable Pancreatic Adenocarcinoma Padeliporfin Vascular Targeted Photodynamic (VTP) therapy - Locally Advanced Unresectable Pancreatic Adenocarcinoma | Phase 1 | Recruiting | Impact Biotech Ltd | 30 | 2024-05-15 | 2026-10-08 |
| CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG/DIPG in Children and Young Adults Treatment with CD200AR-L - Diffuse Midline Glioma, H3 K27M-Mutant, Recurrent High Grade Glioma | Phase 1 | Recruiting | OX2 Therapeutics | 24 | 2024-03-15 | 2024-03-12 |
| Study of CTO1681 for the Prevention and Treatment of CRS in Patients Receiving CAR T-Cell Therapy CTO1681 10 µg, CTO1681 20 μg, CTO1681 30 μg - Cytokine Release Syndrome | Phase 1 / Phase 2 | Recruiting | CytoAgents, Inc. | 54 | 2023-12-28 | 2026-08-31 |
| A Study to Assess the Effects of Epetraborole on the QT Interval in Healthy Adult Subjects Epetraborole and matching placebo, Epetraborole, Placebo - Healthy Volunteers | Phase 1 | Completed | AN2 Therapeutics, Inc | 24 | 2023-06-05 | 2023-12-21 |
| Safety and Tolerability of Intravenous Administration of ICVB-1042 Treatment with ICVB-1042 administered intravenously - Patients With Advanced Solid Tumors | Phase 1 | Terminated | IconOVir Bio | 17 | 2023-06-01 | 2025-04-08 |
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Depression (11) · Substance-Related Disorders (7) · Stress Disorders, Post-Traumatic (6) · Depressive Disorder, Major (5) · Neoplasms (5) · Multiple Myeloma (4) · Alcoholism (3) · Carcinoma, Non-Small-Cell Lung (3) · Prostatic Neoplasms (3) · Anxiety Disorders (2) · Bipolar Disorder (2) · Breast Neoplasms (2) · Burkitt Lymphoma (2) · COVID-19 (2) · Carcinoma, Ovarian Epithelial (2)
University of Pittsburgh (4) · Aktis Oncology, Inc. (3) · Anhui Palo Alto Pharmaceuticals, Inc. (3) · ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA) (3) · Brown University (3) · University of California, Los Angeles (3) · University of North Carolina, Chapel Hill (3) · University of Washington (3) · Yale University (3) · Assaf-Harofeh Medical Center (2) · Impact Biotech Ltd (2) · OX2 Therapeutics (2) · Orvida Pharma (formerly Kamari Pharma) (2) · Resilient Pharmaceuticals (2) · University of Medicine and Dentistry of New Jersey (2)
United States (76) · China (12) · Brazil (4) · Israel (4) · United Kingdom (3) · Canada (2) · Germany (2) · Spain (2) · Switzerland (2) · Australia (1) · Denmark (1) · France (1) · Hong Kong (1) · Italy (1) · New Zealand (1)
David J. Kolko, PhD (2) · Aaron H. Wolfson, MD (1) · Ada C. Gastaldi, doctor (1) · Alejandro Interian, PhD (1) · Andrea Bezjak, MD (1) · Angus Gidely-Baird, PhD (1) · Anna R. Brandon, PhD, MSCS (1) · Annabelle Rodriguez, MD (1) · Anthony Spirito, Ph.D. (1) · Anthony Spirito, PhD (1) · Arij L Abdulmajid, MSc (1) · Barbara O. Rothbaum, PhD (1) · Beny Lafer, Professor (1) · Blanchard Anne, MD,PhD (1) · Brenda Wiederhold, PhD (1)
PMID 11978924, PMID 1280928, PMID 18762591, PMID 19454920, PMID 19736358, PMID 21190403, PMID 21812908, PMID 21995329, PMID 22766415, PMID 22775772, PMID 22951358, PMID 23098171, PMID 23300127, PMID 23800483, PMID 23990896, PMID 24491070, PMID 24577287, PMID 24647726, PMID 24664093, PMID 24737778, PMID 25188543, PMID 25982006, PMID 26977137, PMID 27089154, PMID 27459503, PMID 27658192, PMID 27965864, PMID 28351410, PMID 28733314, PMID 29903051, PMID 30021457, PMID 30240978, PMID 31231276, PMID 31304887, PMID 31328281, PMID 31798447, PMID 32368793, PMID 32379581, PMID 33107592, PMID 33268029, PMID 33607509, PMID 33677832, PMID 34238628, PMID 34515338, PMID 34658014, PMID 35792831, PMID 37716893, PMID 38459156, PMID 39271928, PMID 40533265
5SC1MH090599 (1), K23DA021512 (1), K23MH074860 (1), K23MH082824 (1), P20MH090318 (1), P30CA043703 (1), P50DA009241 (1), P50DA009262 (1), R01AA015419 (1), R01AA020705 (1), R01AI025136 (1), R01AR053732 (1), R01DA020852 (1), R01DA025764 (1), R01MH061512 (1)