27 completed, 7 unknown, 4 recruiting, 2 not yet recruiting. 33 Not applicable, 7 Phase 2, 4 Phase 3, 1 Phase 1, 1 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Precision Modulation of Gut Microbiome Enteropathogen Colonization in Critical Illness Synbiotic, Standard of Care (SOC) - Critical Illness | Phase 1 / Phase 2 | Not yet recruiting | University of Calgary | 64 | 2027-01-01 | 2026-09-10 |
| The Effect of a Synbiotic on Intestinal Barrier Function and Microbiota Modulation in Middle-aged to Elderly Individuals With Excessive Body Weight Synbiotic, Placebo - Gastrointestinal Microbiome (Focus), Gastrointestinal Symptoms | Not applicable | Recruiting | Chr Hansen - part of Novonesis | 90 | 2026-03-18 | 2026-04-15 |
| Probiotic and Prebiotic Supplementation in Peritoneal Dialysis Patients Synbiotic, Placebo - Chronic Kidney Disease (Stages 4 and 5), Peritoneal Dialysis (PD) | Not applicable | Recruiting | Hospital Universitario Dr. Jose E. Gonzalez | 60 | 2025-10-03 | 2026-07-10 |
| The Effects of a Commercially Available Synbiotic on the Gut Microbiome and Cardiometabolic Health Synbiotic, Placebo - Hypertension, Gut Dysbiosis | Not applicable | Completed | Southern Utah University | 47 | 2025-09-01 | 2026-07-29 |
| Therapeutic Potential of a Synbiotic to Improve Mental Health in Subjects With Obesity. Synbiotic, Placebo - Obese Patients (BMI ≥ 30 kg/m²), Anxiety | Not applicable | Recruiting | Celia Bañuls | 120 | 2025-04-15 | 2026-09-08 |
| NapBiome: Targeting Gut Microbiota and Sleep Rhythm to Improve Developmental and Behavioral Outcomes in Early Childhood Synbiotic, Placebo - Sleep Problem, Neurobehavioral Manifestations | Not applicable | Not yet recruiting | Petra Zimmermann | 380 | 2025-03-01 | 2025-02-20 |
| Evaluating the Impact of Synbiotic Supplementation on Infants and Toddlers Synbiotic Supplement, Lactose (inactive placebo) - Gastrointestinal Tolerance of Probiotics in Infants | Not applicable | Completed | Persephone Biosciences | 110 | 2025-01-01 | 2026-08-25 |
| Synbiotic Supplementation in Cyclists Synbiotic, Placebo - Exercise Endurance | Not applicable | Completed | University of Calgary | 22 | 2024-07-15 | 2026-05-01 |
| Impact of Nutritional Intervention With Probiotics and Prebiotics on Obesity. Probiotic, Prebiotic, Synbiotic - Obesity and Overweight, Obesity, Morbid | Not applicable | Enrolling by invitation | Fundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental | 230 | 2024-02-01 | 2025-04-11 |
| The Effects of Synbiotic on Cardiovascular and Bone Metabolism Markers in Transplanted Kidney Patients synbiotic, placebo - Transplanted Kidney | Not applicable | Unknown | National Nutrition and Food Technology Institute | 44 | 2023-12-01 | 2023-12-07 |
| Efficacy of Synbiotic Supplementation on IL-10, TGF-B and Disease Activity in Systemic Lupus Erythematosus Patients Synbiotic, Placebo - Systemic Lupus Erythematosus | Not applicable | Completed | Universitas Sriwijaya | 36 | 2023-12-01 | 2025-07-02 |
| The Role of Synbiotics in Modulating Host Physiology Via the Gut Microbiome Synbiotic - Healthy | Not applicable | Completed | Elizabeth Simpson | 40 | 2023-07-24 | 2025-05-15 |
| Effect of Synbiotic as an Adjuvant Therapy in the Treatment of Parkinson's Disease Lactobacillus acidophilus 10 billion colony forming unit (CFU) and prebiotic fibers - Parkinson's Disease | Phase 3 | Recruiting | Tanta University | 66 | 2022-06-30 | 2025-04-10 |
| Mitigating Infectious Morbidity and Growth Deficits in HIV Exposed Uninfected infanTs With Human Milk Oligosaccharides Synbiotic, Maltodextrin - HIV, Infant Morbidity | Not applicable | Completed | Columbia University | 140 | 2022-06-02 | 2026-07-01 |
| SEPSIS: L. Plantarum Trial Synbiotic, Probiotic, Placebo - Microbial Colonization, Tolerance | Phase 2 | Completed | The Hospital for Sick Children | 519 | 2022-01-07 | 2023-04-13 |
| Combined Gut-brain Therapy for Children With Autism Synbiotic, Gut-directed Hypnotherapy - Autism Spectrum Disorder, Functional Gastrointestinal Disorders | Not applicable | Completed | The University of Queensland | 40 | 2021-12-01 | 2023-09-06 |
| Synbiotics and Post-op Crohn's Disease Synbiotic, Digestible Maltodextrin - Crohn's Disease | Not applicable | Terminated | University of Alberta | 4 | 2021-07-15 | 2024-01-19 |
| Effect of Synbiotic L. Fermentum Strains on Body Fat Mass synbiotic, probiotic, placebo - Weight, Body | Not applicable | Unknown | Slimbiotics GmbH | 180 | 2021-06-08 | 2022-06-06 |
| Synbiotic Dietary Supplement and Gut Microbiota Synbiotic - Healthy | Completed | The Cleveland Clinic | 34 | 2020-11-10 | 2024-12-09 | |
| The Effect of Synbiotics on the Upper Respiratory Tract Infection Synbiotic, Placebo - Upper Respiratory Tract Infection, Gut Microbiota | Not applicable | Completed | Huazhong University of Science and Technology | 58 | 2020-10-05 | 2021-07-14 |
Showing 20 of 43. Sign in to see all of them.
Obesity (8) · Inflammation (4) · Metabolic Syndrome (4) · Insulin Resistance (3) · Non-alcoholic Fatty Liver Disease (3) · Overweight (3) · Renal Insufficiency, Chronic (3) · Anxiety Disorders (2) · Body Weight (2) · Obesity, Morbid (2) · Autism Spectrum Disorder (1) · Autistic Disorder (1) · Breast Feeding (1) · Communicable Diseases (1) · Connective Tissue Diseases (1)
National Nutrition and Food Technology Institute (4) · University of Reading (3) · Federico II University (2) · Slimbiotics GmbH (2) · The University of Texas Health Science Center at San Antonio (2) · Universidade Federal de Santa Catarina (2) · University of Calgary (2) · Celia Bañuls (1) · Chr Hansen - part of Novonesis (1) · Columbia University (1) · Elizabeth Simpson (1) · Eskisehir Osmangazi University (1) · Fakultas Kedokteran Universitas Indonesia (1) · Fundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental (1) · Hospital Universitario Dr. Jose E. Gonzalez (1)
United States (8) · United Kingdom (5) · Brazil (3) · Canada (3) · Germany (2) · Indonesia (2) · Italy (2) · Spain (2) · Australia (1) · Austria (1) · Bangladesh (1) · Chile (1) · China (1) · Egypt (1) · Iran (1)
Bruna Guida, MD (2) · Nicolas Musi, MD. (2) · Amrita Vijay, PhD (1) · Azita Hekmatdoost, MD, PhD (1) · Christiane Laue, Dr. med. (1) · Christine T Peterson, PhD (1) · Christopher D Byrne, MBBCh, PhD (1) · Cleber Kruel, Doctor (1) · Daniel Roth, MD, PhD (1) · Ener C Dinleyici, MD (1) · Erasmo Trindade, PhD (1) · Gail Cresci (1) · Glenn R Gibson, BSc, PhD (1) · Helmut Essl (1)
PMID 36126902, PMID 24401715, PMID 24743428, PMID 24929795, PMID 25909598, PMID 26602219, PMID 29787859, PMID 31987796, PMID 35845797, PMID 36585139, PMID 37293067, PMID 37474971, PMID 37870148, PMID 39992135, PMID 40032396, PMID 40434674, PMID 41094562, PMID 42066676, PMID 42141362
R01HD105492 (1)