20 completed, 4 not yet recruiting, 2 terminated, 2 unknown. 24 Not applicable, 3 Phase 1, 3 Phase 2, 1 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Glycemic Impact of NNS Via the Gut Microbiome Sucralose - Prediabetes | Not applicable | Enrolling by invitation | Tufts University | 10 | 2026-10-01 | 2026-10-09 |
| Impact of Sweeteners on the Addictive Threshold of Nicotine Nicotine 0.05 mg/pulse and 0.1 mg/pulse, Saline Placebo (0.5mL injection), sucralose - Smoking ( Cigarette) | Phase 1 | Not yet recruiting | Yale University | 36 | 2026-09-01 | 2026-08-31 |
| Short-Term Effects of Sucralose and Saccharin on Blood Sugar and Gut Microbiota in Type 2 Diabetes Sucralose, Saccharin, Placebo (Calcium Carbonate) - Type 2 Diabetes Mellitus (T2DM) | Not applicable | Not yet recruiting | National University of Malaysia | 33 | 2026-01-30 | 2025-12-10 |
| Effects of Sweetener Consumption on Risk Factors for Heart Disease in Prediabetic Subjects Saccharin, Sucralose, Erythritol - Prediabetic State, Metabolic Syndrome | Not applicable | Not yet recruiting | Charite University, Berlin, Germany | 80 | 2026-01-05 | 2026-01-29 |
| Sucralose as a Way to Enhance Regulatory T Cells sucralose, Placebo - Healthy Volunteer | Not applicable | Not yet recruiting | Caroline Lamarche | 10 | 2025-09-01 | 2025-06-05 |
| Effect of Within-Meal Consumption of Allulose on Diet-induced Thermogenesis Allulose, Stevia, Sucralose - Diet Induced Thermogenesis | Not applicable | Completed | Toronto Metropolitan University | 12 | 2025-05-06 | 2025-11-17 |
| Effects of Sucralose in Gut Intestinal Microbiota and Postprandial GLP-1 sucralose, placebo - GLP-1, Gut Microbiota | Not applicable | Completed | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | 40 | 2023-06-01 | 2025-04-04 |
| Brain and Glycemic Responses to Sweet Soft Drinks Water (reference), Sucrose, Sucralose - Normal Physiological Response to Sweet Drinks | Not applicable | Completed | Wageningen University | 35 | 2023-01-09 | 2024-04-01 |
| Acute Impact of Non-Sugar Sweeteners (Sucralose and Aspartame) non-sugar sweeteners - Sucralose, non-sugar sweetener - aspartame, Non-sugar sweetener - control - Prediabetes | Not applicable | Completed | Virginia Polytechnic Institute and State University | 14 | 2022-08-01 | 2026-04-01 |
| Assessment of Reward Responses to Erythritol Using Flavor Preference Learning Erythritol, Sucrose, Sucralose - Reward Responses, Gastrointestinal Hormones | Not applicable | Completed | University Hospital, Basel, Switzerland | 20 | 2022-03-17 | 2022-10-12 |
| Effects of Oral Pre-loads on Subsequent Energy Intake Erythritol, Sucrose, Sucralose - Energy Intake, Gastrointestinal Hormones | Not applicable | Completed | University Hospital, Basel, Switzerland | 20 | 2021-02-05 | 2021-12-16 |
| Effects of Artificial Sweeteners on Glucose Metabolism in Patients With Type 2 Diabetes sucralose - Diabetes Mellitus, Type 2 | Not applicable | Unknown | RenJi Hospital | 120 | 2019-12-01 | 2019-12-04 |
| Effects of Sucralose in Insulin Sensitivity Sucralose, Placebo - Insulin Sensitivity/Resistance | Not applicable | Completed | Paloma Almeda-Valdés | 24 | 2019-11-01 | 2023-10-19 |
| Effect of the Administration of L-Carnitine on Body Weight in Women in Crossfit Training L-Carnitine, Sucralose - Body Weight Changes | Phase 2 | Unknown | University of Guadalajara | 24 | 2018-12-17 | 2018-02-20 |
| Effects of Sucralose on Drug Absorption and Metabolism (The SweetMeds Study) Sucralose, Placebo - Healthy Volunteers, Overweight | Phase 2 | Recruiting | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | 150 | 2018-04-05 | 2026-10-13 |
| Investigation of Thermal Injury on Intestinal Permeability in Both Thermal Injury and Healthy Participants Lactulose and Mannitol solution, Sucralose - Burns | Phase 1 | Terminated | GlaxoSmithKline | 18 | 2018-01-29 | 2019-08-19 |
| Microbiome and Non-caloric Sweeteners in Humans Glucose, Aspartame, Sucralose - Glucose Intolerance, Glucose, Low Blood | Not applicable | Completed | Weizmann Institute of Science | 120 | 2017-02-19 | 2021-08-04 |
| Sucralose, Stevia, Gut Microbiome and Glucose Metabolism Sucralose, Stevia - Impaired Glucose Tolerance | Not applicable | Completed | University of Minnesota | 40 | 2017-01-03 | 2018-03-22 |
| RS-fMRI to Nutrient Shakes Glucose, Fructose, Sucralose - Pleasure | Not applicable | Completed | Unilever R&D | 20 | 2016-03-01 | 2016-11-21 |
| Sucralose Effects on Glucose Metabolism and Gut Microbiota Sucralose, Placebo - Healthy | Not applicable | Completed | Ramathibodi Hospital | 15 | 2016-01-01 | 2017-04-27 |
Showing 20 of 30. Sign in to see all of them.
Insulin Resistance (8) · Diabetes Mellitus, Type 2 (4) · Obesity (4) · Prediabetic State (3) · Glucose Intolerance (2) · Overweight (2) · Body Weight (1) · Body Weight Changes (1) · Burns (1) · Cardiovascular Diseases (1) · Cigarette Smoking (1) · Diabetes Mellitus (1) · Eosinophilic Esophagitis (1) · Feeding Behavior (1) · Glucose Metabolism Disorders (1)
Yale University (4) · Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (2) · Unilever R&D (2) · University Hospital, Basel, Switzerland (2) · Caroline Lamarche (1) · Charite University, Berlin, Germany (1) · GlaxoSmithKline (1) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1) · National Institute on Alcohol Abuse and Alcoholism (NIAAA) (1) · National University of Malaysia (1) · Paloma Almeda-Valdés (1) · Ramathibodi Hospital (1) · RenJi Hospital (1) · Toronto Metropolitan University (1) · Tufts University (1)
United States (12) · Mexico (4) · Netherlands (3) · Canada (2) · Switzerland (2) · China (1) · Israel (1) · Malaysia (1) · Thailand (1) · United Kingdom (1)
Anne Christin Meyer-Gerspach, PD, PhD (2) · Dana M Small (2) · Paloma Almeda-Valdes, MD, PhD (2) · Chutintorn Sriphrapradang, M.D. (1) · Dana M Small, PhD (1) · Eran Elinav (1) · Evan S Dellon, MD, MPH (1) · Jeroen van der Grond, Dr (1) · Jeroen van der Grond, Dr. (1) · Jing Ma, professor (1) · Lyn M Steffen, PhD (1) · Marta Y Pepino, PhD (1)
PMID 23633524, PMID 20078374, PMID 25231862, PMID 27777606, PMID 29806553, PMID 30535090, PMID 30602577, PMID 30872104, PMID 31258108, PMID 31288630, PMID 31499249, PMID 32449201, PMID 32875733, PMID 33009060, PMID 33171964, PMID 33346905, PMID 33431052, PMID 35208888, PMID 35242721, PMID 35987213, PMID 40907790, PMID 41370820, PMID 41694241, PMID 42323164
P30DK020579 (1), R01DK101856 (1), U54DA036151 (1)