16 completed, 7 unknown, 4 terminated, 3 withdrawn. 16 Phase 2, 7 Phase 1, 6 Phase 4, 3 Phase 3, 2 Not applicable.
Follow sodium valproate: new trials by email Literature Review of sodium valproate trials Research Report on sodium valproate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of Intravenous Sodium Valproate on Interleukin-6 Levels in Patients With TMJ Disc Displacement sodium valproate, TMJ Arthrocentesis - Temporomandibular Joint Internal Derangement (ADWR) | Phase 2 | Active not recruiting | Tanta University | 10 | 2024-09-29 | 2026-03-23 |
| Bioavailability and Food Effect of Sodium Valproate Minitablets in Healthy Subjects. Sodium valproate - Food-drug Interaction | Phase 1 | Completed | Desitin Arzneimittel GmbH | 28 | 2023-09-11 | 2024-01-22 |
| Sodium Valproate in Patients With Acute Ischemic Stroke Sodium valproate, Normal saline - Acute Ischemic Stroke | Phase 2 | Unknown | RenJi Hospital | 40 | 2023-09-01 | 2024-02-21 |
| Combining Sodium Valproate With Standard-of-care EGFR (Epidermal Growth Factor Receptor) Monoclonal Antibody Treatment in Patients With Metastatic Colorectal Cancer Sodium Valproate, Panitumumab, Cetuximab - Metastatic Colorectal Cancer | Phase 2 | Active not recruiting | Australasian Gastro-Intestinal Trials Group | 38 | 2023-01-23 | 2026-05-08 |
| Pharmacogenetics-Based Study on Individualized Use of Sodium Valproate sodium valproate - Epilepsy | Phase 4 | Recruiting | The First Affiliated Hospital of University of South China | 312 | 2022-12-01 | 2025-07-10 |
| Levetiracetam Versus Valproate in Idiopathic Generalized Epilepsy Levetiracetam, Sodium valproate - Treatment of Idiopathic Generalized Epilepsy | Completed | Mazandaran University of Medical Sciences | 169 | 2022-09-03 | 2024-05-02 | |
| Efficacy and Safety Trial of Sodium Valproate, in Paediatric and Adult Patients With Wolfram Syndrome Sodium Valproate 200Mg E/C Tablet, Sodium Valproate matched placebo - Wolfram Syndrome | Phase 2 | Completed | University of Birmingham | 63 | 2018-12-28 | 2026-05-05 |
| The Val-CARD Trial Sodium Valproate - Cardiac Valve Disease, Coronary Artery Disease | Phase 1 / Phase 2 | Terminated | University of Leicester | 45 | 2018-11-06 | 2026-08-17 |
| Study of Excretion Balance and Pharmacokinetics of [14C]-Sodium Valproate (3.7 MBq) in Healthy Postmenopausal or Permanently Sterile Female Subjects sodium valproate - Epilepsy | Phase 1 | Completed | Sanofi | 5 | 2018-10-05 | 2022-04-25 |
| Valproic Acid in Treating Cyanotic Breath Holding Spells Valproic Acid - Breathhold | Phase 1 | Completed | Assiut University | 150 | 2017-01-30 | 2020-07-23 |
| Stereotactic Radiosurgery With Nivolumab and Valproate in Patients With Recurrent Glioblastoma Stereotactic Radiosurgery, Nivolumab, Valproate - Glioblastoma | Phase 1 | Terminated | University of Virginia | 4 | 2016-05-24 | 2017-05-31 |
| Treatment of Nodding Syndrome - A Randomized Blinded Placebo-Controlled Crossover Trial of Oral Pyridoxine and Conventional Anti-Epileptic Therapy, in Northern Uganda - 2012 Pyridoxine, Sodium Valproate, Phenytoin - Nodding Syndrome | Phase 2 | Withdrawn | Centers for Disease Control and Prevention | 2016-02-01 | 2022-05-18 | |
| Sodium Valproate for GSDV Sodium Valproate - Glycogen Storage Disease Type V, McArdle Disease | Phase 2 | Completed | University College, London | 8 | 2015-01-01 | 2018-02-05 |
| Ketogenic Diet in Infants With Epilepsy (KIWE) Ketogenic diet, Antiepileptic drug therapy - Epilepsy | Phase 4 | Unknown | University College, London | 160 | 2015-01-01 | 2017-05-04 |
| Levetiracetam Versus Sodium Valproate in Children With Refractory Generalized Convulsive Status Epilepticus Intravenous levetiracetam, Sodium valproate - Grand Mal Status Epilepticus | Phase 2 | Completed | Banaras Hindu University | 80 | 2015-01-01 | 2016-09-30 |
| Treatment of Children With Autism Spectrum Disorders and Epileptiform EEG With Divalproex Sodium divalproex sodium, Placebo - Autism | Phase 2 | Withdrawn | Boston Children's Hospital | 2014-04-01 | 2016-10-21 | |
| Traumatic Neuroprotection and Epilepsy Prevention of Valproate Acid valproate acid - Traumatic Brain Injury | Phase 1 | Unknown | Xijing Hospital | 160 | 2013-10-01 | 2014-01-06 |
| Valproic Acid and Platinum-based Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma Valproic Acid - Head and Neck Cancer, Oral Cavity Cancer | Phase 2 | Completed | Instituto do Cancer do Estado de São Paulo | 14 | 2012-09-01 | 2016-02-23 |
| Rubinstein-Taybi Syndrome: Functional Imaging and Therapeutic Trial sodium valproate, Placebo - Rubinstein-Taybi Syndrome | Phase 2 | Completed | University Hospital, Bordeaux | 41 | 2012-04-01 | 2026-05-14 |
| Valproic Acid With Chemoradiotherapy for Non-Small-Cell Lung Cancer Valproic acid - Locally Advanced Inoperable Non-small-lung Cancer | Phase 1 / Phase 2 | Unknown | Soroka University Medical Center | 20 | 2011-02-01 | 2011-03-29 |
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Epilepsy (7) · Bipolar Disorder (4) · Brain Neoplasms (2) · Glioblastoma (2) · Alcoholism (1) · Amyotrophic Lateral Sclerosis (1) · Asthma (1) · Astrocytoma (1) · Autistic Disorder (1) · Brain Injuries, Traumatic (1) · Carcinoma, Non-Small-Cell Lung (1) · Colorectal Neoplasms (1) · Coronary Artery Disease (1) · Cyanosis (1) · Diffuse Intrinsic Pontine Glioma (1)
Desitin Arzneimittel GmbH (2) · University College, London (2) · University Hospital, Bordeaux (2) · All India Institute of Medical Sciences (1) · Assiut University (1) · AstraZeneca (1) · Australasian Gastro-Intestinal Trials Group (1) · Banaras Hindu University (1) · Baylor College of Medicine (1) · Beth Israel Medical Center (1) · Boston Children's Hospital (1) · Centers for Disease Control and Prevention (1) · Centre of Chinese Medicine, Georgia (1) · Chinese University of Hong Kong (1) · Eisai Limited (1)
United Kingdom (5) · United States (5) · China (4) · France (3) · Denmark (2) · Egypt (2) · Australia (1) · Austria (1) · Brazil (1) · Canada (1) · Chile (1) · Finland (1) · Hong Kong (1) · India (1) · Iran (1)
Ahmed A Mosleh, Ph.D. (1) · Andrew Yeates (1) · Benjamin Purow, MD (1) · Dr. Rasmus Wenzer Licht (1) · Fei Zhou, M.D., Ph.D. (1) · Gavin Murphy, MD (1) · Helen Cross, FRCP(UK) (1) · Igor Galynker, MD, PhD (1) · Ihsan M Salloum, MD, MPH (1) · Jack Su, MD (1) · Janice Faulknor, MD (1)
PMID 15630071, PMID 19743466, PMID 28446244, PMID 28748333, PMID 32285998, PMID 32969724, PMID 33574900, PMID 40010822
2017 (1), 2018 (1)