9 unknown, 5 completed, 4 recruiting, 3 active not recruiting. 10 Phase 2, 7 Phase 4, 5 Phase 3, 2 Phase 1, 1 Early Phase 1.
Follow Simvastatin 40mg: new trials by email Literature Review of Simvastatin 40mg trials Research Report on Simvastatin 40mg
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Drug-Drug Interaction (DDI) Study of Leramistat in Healthy Adult Subjects leramistat 40mg, Itraconazole 200 mg, Phenytoin 100 Mg Oral Capsule - Pharmacokinetics | Phase 1 | Unknown | Modern Biosciences Ltd | 48 | 2024-04-08 | 2024-08-09 |
| T-reg Function Changes: a Novel Immune Regulatory Effect Underlying Benefit of Statin Use on Lethal Prostate Cancer Simvastatin 40mg - Prostate Cancer | Phase 2 | Recruiting | Medical University of South Carolina | 36 | 2024-03-11 | 2026-03-04 |
| The Role of Simvastatin in The Epithelial-Mesenchymal Transition Process of Breast Cancer Simvastatin 40mg, Placebo - Triple Negative Breast Cancer, Chemotherapy Effect | Phase 2 | Recruiting | Universitas Indonesia | 26 | 2022-08-19 | 2026-09-21 |
| To Study the Safety and Efficacy of Simvastatin in Patients With Hepatopulmonary Syndrome in Cirrhosis. Simvastatin 40mg, Placebo, Standard medical Treatment - Liver Cirrhosis | Not applicable | Unknown | Institute of Liver and Biliary Sciences, India | 45 | 2022-02-26 | 2022-03-15 |
| Efficacy of Simvastatin in Alcoholic Liver Fibrosis Simvastatin 40mg - Liver Fibrosis, Alcohol Abuse | Phase 2 / Phase 3 | Recruiting | Anna Cruceta | 90 | 2022-02-22 | 2024-12-04 |
| Combined Simvastatin and Irinotecan in Treating ES-SCLC Patients Relapsed From 1st Chemotherapy Irinotecan, Simvastatin - Small Cell Lung Cancer | Phase 2 | Unknown | Shanghai Pulmonary Hospital, Shanghai, China | 40 | 2021-11-01 | 2021-08-09 |
| Statin Therapy to Reduce Progression in Women With Platinum Sensitive Ovarian Cancer Simvastatin 40mg - Recurrent Ovarian Cancer, Platinum-sensitive Ovarian Cancer | Early Phase 1 | Completed | Marc Goodman | 18 | 2021-01-25 | 2026-02-04 |
| Multi-Center Study of the Effects of Simvastatin on Hepatic Decompensation and Death in Subjects Presenting With High-Risk Compensated Cirrhosis Placebo Oral Tablet, Simvastatin 40mg - Cirrhosis | Phase 3 | Active not recruiting | VA Office of Research and Development | 142 | 2020-10-02 | 2026-01-07 |
| Effect of Simvastatin on the Prognosis of Primary Primary Sclerosing Cholangitis (PSC) Simvastatin 40mg, Placebo oral tablet - Primary Sclerosing Cholangitis | Phase 3 | Active not recruiting | Annika Bergquist | 571 | 2020-10-01 | 2025-09-05 |
| Simvastatin add-on Treatment to Standard Antidepressant Therapy in Patients With Comorbid Obesity and Major Depression Simvastatin 40mg, Placebo oral tablet - Depressive Disorder, Major, Obesity | Phase 2 | Completed | Charite University, Berlin, Germany | 161 | 2020-08-13 | 2024-12-09 |
| Effect of Lipid Lowering Agents on Diabetic Retinopathy and Cardiovascular Risk of Diabetic Patients Simvastatin 40mg, Fenofibrate 200mg, Omega 3 fatty acid - Diabetic Retinopathy | Phase 4 | Unknown | Alaa Hassan ElBaz | 80 | 2020-02-01 | 2020-01-18 |
| Impact of Bariatric Surgery on Pharmacokinetic Study of Simvastatin and Carvedilol Digestive biopsy, Carvedilol 25mg, Serial blood sampling for PK analysis - Obesity, Bariatric Surgery | Phase 4 | Unknown | Natalia Valadares de Moraes | 120 | 2019-06-01 | 2022-02-08 |
| Effects of Simvastatin on Uterine Leiomyoma Size Simvastatin 40mg, Placebo 40 mg - Fibroid Uterus, Fibroid Tumor | Phase 2 | Active not recruiting | Johns Hopkins University | 60 | 2018-08-20 | 2026-07-21 |
| 7T Magnetic Resonance Spectroscopy and Skeletal Muscle Biopsy Findings in Statin Associated Adverse Muscle Events Simvastatin 40mg - Muscle Cramp, Ache | Phase 4 | Terminated | University of Texas Southwestern Medical Center | 3 | 2018-08-17 | 2023-02-14 |
| Lipid-lowering Therapies in Vietnamese Chronic Kidney Disease Population Simvastatin 40mg, Ezetimibe/simvastatin 10/20 mg/day, Ezetimibe/simvastatin 10/40 mg/day - Hypercholesterolemia, Chronic Kidney Diseases | Phase 4 | Unknown | Hue University of Medicine and Pharmacy | 30 | 2018-06-15 | 2019-08-13 |
| Central Nervous System Vascular Changes in Adult Sickle Cell Disease and the Effect of Treatment With Simvastatin Simvastatin 40mg - Sickle Cell Disease, Stroke | Phase 1 / Phase 2 | Unknown | University of Campinas, Brazil | 28 | 2018-03-05 | 2020-10-12 |
| Treatment of Graves´ophthalmopathy with Simvastatin (GO-S) Simvastatin 40mg - Graves Ophthalmopathy, Thyroid Associated Ophthalmopathy | Phase 3 | Recruiting | Lund University | 80 | 2018-01-26 | 2024-09-25 |
| Simvastatin Effect in Combination With Neoadjuvant Chemotherapy to Clinical Response and Tumor-Free Margin in Locally Advanced Breast Cancer Simvastatin 40mg, Placebo oral capsule - Breast Cancer, Chemotherapy Effect | Phase 2 | Completed | Universitas Indonesia | 60 | 2018-01-15 | 2020-06-05 |
| Simvastatin in the Prevention of Recurrent Pancreatitis Simvastatin 40mg, Placebo - Pancreatitis Relapsing | Phase 3 | Terminated | Enrique de-Madaria | 83 | 2017-09-29 | 2025-03-20 |
| Simvastatin Plus Rifaximin in Decompensated Cirrhosis Simvastatin 20 mg, Simvastatin 40mg, Rifaximin 400 mg - Cirrhoses, Liver | Phase 2 | Completed | Judit Pich | 44 | 2017-07-26 | 2019-03-28 |
Showing 20 of 24. Sign in to see all of them.
Hypercholesterolemia (2) · Hypertension (2) · Liver Cirrhosis (2) · Obesity (2) · Alcoholism (1) · Anemia, Sickle Cell (1) · Atherosclerosis (1) · Breast Neoplasms (1) · Carcinoma, Hepatocellular (1) · Cholangitis, Sclerosing (1) · Depressive Disorder, Major (1) · Diabetes Mellitus (1) · Diabetic Retinopathy (1) · Fibrosis (1) · Graves Ophthalmopathy (1)
Universitas Indonesia (2) · Alaa Hassan ElBaz (1) · Amsterdam UMC, location VUmc (1) · Anna Cruceta (1) · Annika Bergquist (1) · Charite University, Berlin, Germany (1) · Enrique de-Madaria (1) · Federal State Budgetary Scientific Institution, Research Institute of Fundamental and Clinical Immunology (1) · Hospital de Clinicas de Porto Alegre (1) · Hue University of Medicine and Pharmacy (1) · Institute of Liver and Biliary Sciences, India (1) · Johns Hopkins University (1) · Judit Pich (1) · Lund University (1) · Marc Goodman (1)
United States (7) · Spain (3) · Brazil (2) · Germany (2) · Indonesia (2) · Netherlands (2) · Sweden (2) · United Kingdom (2) · China (1) · France (1) · India (1) · Italy (1) · Russia (1) · Vietnam (1)
Annika Bergquist, MD PhD (1) · Baju Adji (1) · Bobbie Jo Rimel, MD (1) · Bruno Benites, MD (1) · Christian Otte, MD (1) · David E. Kaplan, MD MSc (1) · Duong Thi Ngoc Lan, Master (1) · Erwin D Yulian, MD (1) · Filipus Dasawala, MD (1) · Hanifah Hasan, MD (1) · Jose S dos Santos, PhD (1) · Michael Marrone, PhD (1) · Miguel Gus, MD (1) · Mostafa Borahay, MD, PhD (1)
PMID 12467231, PMID 16170339, PMID 30641276, PMID 31607677, PMID 32346071, PMID 32377822, PMID 33262189, PMID 33285097, PMID 33644082, PMID 38018702, PMID 38043603, PMID 39601354, PMID 40465256, PMID 40824526, PMID 41482454
2016 (1), 2018 (1), R01HD094380 (1)