6 completed, 2 recruiting, 2 terminated, 2 unknown. 6 Not applicable, 3 Phase 4, 2 Phase 2, 1 Early Phase 1, 1 Phase 1.
Follow Senna: new trials by email Literature Review of Senna trials Research Report on Senna
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Senna vs. Polyethylene Glycol 3350 for the Treatment of Retentive Encopresis in Children PEG 3350, Senna - Encopresis With Constipation and Overflow Incontinence | Early Phase 1 | Not yet recruiting | Shaare Zedek Medical Center | 80 | 2026-07-01 | 2026-06-18 |
| PEG3350 vs Senna After Urogyn Surgery Senna, Polyethylene glycol 3350 - Obstructive Defecation Syndrome, Postoperative Constipation | Phase 4 | Recruiting | St. Joseph's Health, New York | 254 | 2025-04-23 | 2025-05-28 |
| Study Assessing CLENPIQ as Bowel Preparation for Pediatric Colonoscopy CLENPIQ, MIRALAX, SENNA - Bowel Preparation | Phase 1 / Phase 2 | Recruiting | Ferring Pharmaceuticals | 39 | 2022-06-23 | 2026-09-04 |
| Bowel Preparation in Elective Pediatric Colorectal Surgery Senna, Sodium Picosulfate, Magnesium Oxide and Citric Acid, Metronidazole Oral - Colostomy, Hirschsprung Disease - Pull Through | Not applicable | Unknown | McMaster University | 81 | 2022-01-01 | 2021-12-09 |
| RELISTOR's Effects on Opioid-Induced Constipation Relistor Injectable Product, Docusate Calcium, Bisacodyl - OIC | Withdrawn | Methodist Health System | 2021-07-01 | 2026-03-23 | ||
| Peritoneal Dialysis Pilot Study: Evaluating Polyethylene Glycol (PEG) for Constipation Current Bowel Protocol (senna/lactulose), PEG Bowel Protocol (PEG/lactulose) - Constipation, Peritoneal Dialysis Complication | Phase 4 | Completed | Nova Scotia Health Authority | 25 | 2017-07-07 | 2024-08-21 |
| Gut Transit Effect on Enterohepatic Circulation Loperamide, Senna - Intestinal Transit | Not applicable | Completed | University Hospital Plymouth NHS Trust | 19 | 2017-04-10 | 2022-09-30 |
| An Interdisciplinary Approach to the Treatment of Encopresis in Children With Autism Spectrum Disorders Glycerin Suppository, Bisacodyl suppository, Senna - Encopresis, Autistic Disorder | Not applicable | Completed | Emory University | 22 | 2015-02-01 | 2018-07-02 |
| Efficacy of Linaclotide to Senna for CIC Senna, Linzess - Chronic Idiopathic Constipation | Not applicable | Terminated | TriHealth Inc. | 9 | 2014-09-01 | 2019-07-02 |
| A Double-blinded,Double-dummy Clinical Trial of Chinese Herbal Medicine (MaZiRenWan) for Functional Constipation MZRW, Senna, placebo - Functional Constipation, Gastrointestinal Disorders | Phase 2 | Completed | Hong Kong Baptist University | 291 | 2013-06-01 | 2020-05-12 |
| Evaluating the Effect of Senna in Uremic Pruritus Senna, Placebo - End Stage Renal Disease, Pruritus | Not applicable | Completed | Shiraz University of Medical Sciences | 60 | 2011-08-01 | 2015-04-01 |
| Bowel Preparation for Colonoscopy in Children polyethylene glycol, senna - Colonoscopy Preparation | Phase 4 | Terminated | Children's Hospital of Philadelphia | 33 | 2010-09-01 | 2013-04-12 |
| Lubiprostone (Amitiza®) Vs. Standard Care in Opioid-induced Constipation After Surgery in Inpatient Rehabilitation Lubiprostone, Senna - Constipation | Not applicable | Completed | Shirley Ryan AbilityLab | 64 | 2008-04-01 | 2013-03-06 |
| Bowel Preparation and Prokinetics in Capsule Endoscopy Senna, Citramag powder, Metoclopramide - Small Bowel Disease, Gastrointestinal Hemorrhage | Phase 3 | Unknown | London North West Healthcare NHS Trust | 150 | 2006-01-01 | 2007-09-24 |
Constipation (4) · Anemia, Refractory (1) · Autistic Disorder (1) · Behavioral Symptoms (1) · Child Development Disorders, Pervasive (1) · Encopresis (1) · Enterocolitis, Necrotizing (1) · Fecal Incontinence (1) · Gastrointestinal Diseases (1) · Gastrointestinal Hemorrhage (1) · Inflammatory Bowel Diseases (1) · Intestinal Obstruction (1) · Kidney Failure, Chronic (1) · Meconium Ileus (1) · Pruritus (1)
Children's Hospital of Philadelphia (1) · Emory University (1) · Ferring Pharmaceuticals (1) · Hong Kong Baptist University (1) · London North West Healthcare NHS Trust (1) · McMaster University (1) · Methodist Health System (1) · Nova Scotia Health Authority (1) · Shaare Zedek Medical Center (1) · Shiraz University of Medical Sciences (1) · Shirley Ryan AbilityLab (1) · St. Joseph's Health, New York (1) · TriHealth Inc. (1) · University Hospital Plymouth NHS Trust (1)
United States (7) · United Kingdom (2) · Canada (1) · China (1) · Israel (1)
Abdolali Mohagheghzadeh, PhD (1) · Arian Kamali-Sarvestani, Pharm D (1) · Christina M Marciniak, MD (1) · Christopher Fraser, MB BCH, MD, FRCP (1) · Jaclyn Y Tran, BScPharm (1) · Jamshid Roozbeh, MD (1) · Keila S Muniz, MD (1) · Lisa VanHouwelingen, MD, MPH, FRCSC (1) · Mohammad Mehdi Sagheb, MD (1) · Mohd A AlSamman, MD (1) · Petar Mamula, MD (1) · Pouya Faridi, PhD (1) · Richard Meyrat, MD (1)
PMID 22699838, PMID 24180235, PMID 25473191, PMID 29654915, PMID 33283264, PMID 38796500