16 completed, 7 unknown, 6 recruiting, 2 terminated. 11 Phase 4, 7 Not applicable, 6 Phase 2, 5 Phase 3, 2 Phase 1.
Follow Proton Pump Inhibitor: new trials by email Literature Review of Proton Pump Inhibitor trials Research Report on Proton Pump Inhibitor
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Randomized, Three-Arm Study Comparing Vonaprazan 10 mg, Vonaprazan 20 mg, and Esomeprazole 40 mg for the Healing of LA Grade B or Higher Reflux Esophagitis at 8 Weeks Vonoprazan, Esomeprazole 40mg - GERD | Not applicable | Recruiting | Asian Institute of Gastroenterology, India | 414 | 2025-12-20 | 2026-03-06 |
| Prophylactic Proton Pump Inhibition for Esophageal Protection in Lung Radiation Therapy Experimental (Health Canada Approved Proton Pump Inhibitors) - Primary Lung Cancer, Non Small Cell Lung Cancer | Phase 2 | Not yet recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 58 | 2025-10-02 | 2025-07-22 |
| Potassium-Competitive Acid Blocker Versus Proton Pump Inhibitor as A Part of Bismuth Based Quadruple Therapy for Treatment of Helicobacter Pylori Infection Potassium-Competitive Acid Blocker, Proton Pump Inhibitor - Potassium-Competitive Acid Blocker, Proton Pump Inhibitor | Not applicable | Recruiting | Tanta University | 320 | 2025-09-11 | 2025-09-12 |
| Tegoprazan And Lansoprazole Effectiveness in Bleeding Peptic Ulcer Treatment Tegoprazan, Lansoprazole - Peptic Ulcer Bleeding | Not applicable | Recruiting | Mario Steffanus | 162 | 2025-05-01 | 2025-05-29 |
| The PRO-SOma COla (PROSOCO) Study Proton Pump inhibitor, Placebo - Healthy | Not applicable | Unknown | University of Copenhagen | 11 | 2023-09-13 | 2023-11-07 |
| PROTon Pump Inhibitors and Stent OCclusion Rate Of Lumen Apposing Metal Stents Proton pump inhibitor, LAMS-implantation - Acute Pancreatitis | Completed | University Medical Center Goettingen | 893 | 2023-05-05 | 2025-06-15 | |
| Preoperative Use of Pantoprazole for Prevention of Post Operative Nausea and Vomiting in Gynecologic Surgery pantoprazole, Placebo - Postoperative Nausea and Vomiting | Phase 2 | Recruiting | United States Naval Medical Center, Portsmouth | 132 | 2022-08-26 | 2025-05-21 |
| Risk Factors and Machine Learning Model for Proton Pump Inhibitor Related Acute Kidney Injury Proton pump inhibitor - Proton Pump Inhibitor, Acute Kidney Injury | Completed | Qianfoshan Hospital | 30000 | 2022-07-01 | 2023-11-18 | |
| Stop of Proton-pump Inhibitor Treatment in Patients With Liver Cirrhosis - a Double-blind, Placebo-controlled Trial Placebo, Esomeprazole 20mg - Liver Cirrhosis | Phase 4 | Recruiting | Universitätsklinikum Hamburg-Eppendorf | 476 | 2021-04-22 | 2025-04-24 |
| Study of Nitazoxanide (NTZ) for Helicobacter Pylori in Children Nitazoxanide, Clarithromycin, Metronidazole - Helicobacter Pylori Infection | Phase 3 | Recruiting | Tanta University | 100 | 2020-06-01 | 2020-06-04 |
| Nordic Gastric and Esophageal Tumor Study Proton pump inhibitor - Cancer of Stomach, Cancer of the Esophagus | Completed | Karolinska Institutet | 900000 | 2019-01-01 | 2024-06-24 | |
| Implementation of PPI Medication PGX Testing Genotype Guided PPI Dosing - Gastroesophageal Reflux | Phase 4 | Completed | Nemours Children's Clinic | 28 | 2016-07-21 | 2018-11-21 |
| IRX-2 Regimen in Patients With Newly Diagnosed Stage II, III, or IVA Squamous Cell Carcinoma of the Oral Cavity IRX-2, Cyclophosphamide, Indomethacin - Squamous Cell Carcinoma of the Oral Cavity | Phase 2 | Completed | Brooklyn ImmunoTherapeutics, LLC | 105 | 2016-01-11 | 2024-01-30 |
| Oral Steroids for Regorafenib-induced Fatigue/Malaise in Unresectable mCRC (KSCC1402/HGCSG1402) General condition, Blood pressure, Patient Reported Outcome - Rectal Cancer | Phase 2 | Unknown | Clinical Research Support Center Kyush | 74 | 2014-10-01 | 2014-11-13 |
| Amoxicillin/Metronidazole Based Quadruple Therapy for Helicobacter Pylori Eradication Lansoprazole, Bismuth Potassium Citrate, Amoxicillin - Dyspepsia, Peptic Ulcer | Phase 4 | Completed | Shanghai Jiao Tong University School of Medicine | 215 | 2014-07-01 | 2015-02-03 |
| High Dose Amoxicillin Versus Tetracycline as Second-line Treatment of Resistant Helicobacter Pylori Infection Lansoprazole, Bismuth Potassium Citrate, Metronidazole - Helicobacter Pylori Treatment Failure | Phase 4 | Completed | Shanghai Jiao Tong University School of Medicine | 312 | 2014-07-01 | 2016-03-01 |
| Effects of PQ912 on the Pharmacokinetics of Midazolam and Omeprazole PQ912, Midazolam, Omeprazole - Healthy Volunteers, Pharmacologic Action | Phase 1 | Completed | Vivoryon Therapeutics N.V. | 18 | 2014-06-01 | 2015-10-21 |
| The Changes of Ryodoraku and HRV After PPI Treatment in GERD Patients Ryodoraku, ANSWatch, UGI endoscopy - Non-erosive Reflux Disease, Barrett's Esophagus | Not applicable | Unknown | Taichung Tzu Chi Hospital | 120 | 2014-05-01 | 2014-11-20 |
| PPI's and SSRI's Therapy for the Management of NCCP Citalopram - Chest Pain Rule Out Myocardial Infarction | Phase 4 | Terminated | Evangelismos Hospital | 60 | 2014-03-01 | 2019-12-02 |
| Levofloxacin and Bismuth-containing Therapy Versus Quadruple Therapy as Second-line Treatment of Resistant Helicobacter Pylori Infection Proton pump inhibitor, Bismuth subsalicylate, Metronidazole - Cure Rate of Helicobacter Pylori Infection | Phase 4 | Completed | Shanghai Jiao Tong University School of Medicine | 200 | 2012-11-01 | 2014-08-29 |
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Gastroesophageal Reflux (8) · Peptic Ulcer (4) · Stomach Neoplasms (4) · Dyspepsia (2) · Lymphoma, Non-Hodgkin (2) · Neoplasms (2) · Non-Erosive Reflux Disease (2) · Acute Kidney Injury (1) · Barrett Esophagus (1) · Brain Neoplasms (1) · Breast Neoplasms (1) · Carcinoma, Non-Small-Cell Lung (1) · Carcinoma, Squamous Cell (1) · Community-Acquired Pneumonia (1) · Cough (1)
Shanghai Jiao Tong University School of Medicine (6) · Tanta University (2) · AVM Biotechnology Inc (1) · Advanced Center for Specialty Care (1) · Asian Institute of Gastroenterology, India (1) · Brooklyn ImmunoTherapeutics, LLC (1) · Canadian Network for Observational Drug Effect Studies, CNODES (1) · Clinical Research Support Center Kyush (1) · Evangelismos Hospital (1) · Gangnam Severance Hospital (1) · Karolinska Institutet (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · Mario Steffanus (1) · Massachusetts Eye and Ear Infirmary (1) · National Cancer Center, Korea (1)
China (7) · United States (7) · Canada (4) · Germany (3) · Egypt (2) · South Korea (2) · Taiwan (2) · United Kingdom (2) · Brazil (1) · Denmark (1) · Greece (1) · India (1) · Indonesia (1) · Japan (1) · Sweden (1)
Hong Lu, M.D. (3) · Abeer Salamah, Lecturer (1) · Andrea Morgner-Miehlke, MD, PhD (1) · Ansgar W Lohse, MD (1) · Casey Timmerman, DO (1) · Chen-Chi Wu, MD (1) · Christoph Ammer-Herrmenau, MD (1) · Christopher J Hartnick, MD (1) · Chuan-Jen Hsu, MD (1) · Edward Loniewski, D.O. (1) · George B Smallfield, MD, MSPH (1) · Gregory T Wolf, MD, FACS (1) · Gwang Ha Kim, M.D., Ph.D. (1) · Hong Lu (1) · Il Ju Choi, M.D., Ph.D. (1)
PMID 23376004, PMID 23721547, PMID 23856153, PMID 26165736, PMID 26338726, PMID 28680717, PMID 30327875, PMID 32738599, PMID 40164133
2023 (2), 2014 (1), 2019 (1)