11 completed, 3 unknown, 3 withdrawn, 2 not yet recruiting. 8 Phase 2, 7 Not applicable, 5 Phase 3, 3 Phase 1, 3 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| NO AD: Use of Nitric Oxide (NO) Donors for the Prevention of Autonomic Dysreflexia (AD) During Bowel Care Following SCI Glyceryl Trinitrate Only Product in Oromucosal Dose Form, Placebo sublingual spray - Spinal Cord Injuries, Autonomic Dysreflexia | Phase 2 | Not yet recruiting | Simon Fraser University | 26 | 2026-12-01 | 2026-04-23 |
| Superoxide Dismutase Skin Spray for the Prevention of Acute Radiation Dermatitis in Head and Neck Cancer A topical superoxide dismutase skin spray, Placebo Spray - Radiation-induced Dermatitis | Phase 2 | Recruiting | West China Hospital | 140 | 2026-09-28 | 2026-10-29 |
| Adia Med of Winter Park LLC Chronic Kidney Disease Research Study Umbilical Cord Blood-Derived Stem Cells and Exosomes, Glutathione IV, Glutathione Spray - Chronic Kidney Disease, Kidney Disease | Phase 1 | Recruiting | Adia Med of Winter Park LLC | 100 | 2026-05-18 | 2026-06-17 |
| Topical Lidocaine for Digital Nerve Block Pain Topical Lidocaine Spray, Placebo Spray - Finger Injuries, Procedural Pain | Phase 4 | Completed | Ankara City Hospital Bilkent | 240 | 2026-04-01 | 2026-09-22 |
| Efficacy of Superoxide Dismutase Spray in Preventing Radiation Dermatitis in Patients With Head and Neck Cancer . Placebo Spray, SOD spray - Radiation Dermatitis | Not applicable | Withdrawn | West China Hospital | 2026-02-10 | 2026-06-23 | |
| Comparison of Outcomes Between Topical Minoxidil Versus Oral Minoxidil for the Treatment of Androgenetic Alopecia Minoxidil 5 % Topical Spray, minoxidil, Placebo Spray - Androgenic Alopecia | Phase 3 | Not yet recruiting | Sheikh Zayed Federal Postgraduate Medical Institute | 200 | 2025-12-20 | 2025-12-10 |
| NanaBis™ an Oro-buccal Administered delta9-Tetrahydrocannabinol (d9-THC) & Cannabidiol (CBD) Medicine for the Management of Bone Pain From Metastatic Cancers NanaBis™, Oxycodone CR, Placebo Spray - Cancer Related Pain | Phase 3 | Unknown | Medlab Clinical | 360 | 2023-11-01 | 2022-04-12 |
| Evaluate Efficacy and Safety of X0002 in Treatment of Knee Osteoarthritis X0002 Spray, Celecoxib capsules, placebo - KNEE OSTEOARTHRITIS | Phase 3 | Completed | Jiangsu XinChen-Techfields Pharma Co., LTD. | 180 | 2021-09-29 | 2023-03-07 |
| COVID-19 Methylene Blue Antiviral Treatment Methylene Blue, Saline nasal spray - Covid19 | Phase 2 | Completed | Irkutsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences | 24 | 2021-08-06 | 2022-02-09 |
| Microbiome Therapy in Covid-19 Primary Care Support Microbiome spray, Placebo spray - SARS-CoV Infection, Corona Virus Infection | Not applicable | Suspended | University Hospital, Antwerp | 150 | 2021-02-01 | 2021-06-03 |
| "Effect of Central Insulin Administration on Whole-body Insulin Sensitivity in Women" intranasal insulin, Placebo spray - Insulin Sensitivity | Not applicable | Completed | University Hospital Tuebingen | 29 | 2019-04-21 | 2021-09-05 |
| Faces: Choices Study Oxytocin Spray, Placebo Spray - Socioemotional Aging | Phase 2 / Phase 3 | Withdrawn | University of Florida | 2019-01-01 | 2018-11-26 | |
| Evaluate Efficacy and Safety of X0002 in Treatment of Knee Osteoarthritis X0002 Spray, Ibuprofen Tablet, Ibuprofen Placebo Tab - KNEE OSTEOARTHRITIS | Phase 2 | Completed | Tianjin XinChen-Techfields Pharma Co., LTD. | 353 | 2018-07-16 | 2020-01-13 |
| Spray vs EMLA Cream on Pain During Intra-articular Injection Walter Ritter Ethyl Chloride Spray, Placebo Spray, Placebo Cream - Adhesive Capsulitis of the Shoulder | Phase 4 | Unknown | Soonchunhyang University Hospital | 63 | 2018-03-14 | 2019-04-08 |
| A Study to Evaluate Changes in Nasal Airflow of Loratadine/Pseudoephedrine Tablet and Fluticasone Propionate Nasal Spray in Subjects Following Allergen Exposure loratadine + pseudoephedrine sulfate (BAY818725/Claritin-D), Placebo tablet, Fluticasone Propionate - Rhinitis, Allergic | Phase 4 | Completed | Bayer | 82 | 2018-02-21 | 2019-12-20 |
| Xylitol for Otitis Media Intranasal xylitol spray, Intranasal saline spray - Otitis Media With Effusion | Phase 2 / Phase 3 | Withdrawn | Duke University | 2017-11-20 | 2017-12-22 | |
| Intranasal Oxytocin in Antiosocial Personality Disorder and Psychopathy Oxytocin nasal spray, Placebo spray - Antisocial Personality Disorder | Not applicable | Completed | King's College London | 72 | 2017-05-01 | 2022-05-20 |
| Effect of Weight Loss on Brain Insulin Sensitivity in Humans nasal insulin, placebo spray - Insulin Resistance | Not applicable | Unknown | University Hospital Tuebingen | 40 | 2016-12-01 | 2024-02-02 |
| Oxytocin's Effect on Socioemotional Aging Oxytocin spray, Placebo spray - Aging | Not applicable | Completed | University of Florida | 106 | 2013-07-01 | 2016-08-25 |
| Sativex and Behavioral-relapse Prevention Strategy in Cannabis Dependence Motivational Enhancement/Cognitive Behavioral Therapy, Sativex, Placebo spray - Cannabis Dependence | Phase 2 | Completed | Centre for Addiction and Mental Health | 45 | 2013-03-01 | 2017-10-02 |
Showing 20 of 24. Sign in to see all of them.
Insulin Resistance (2) · Osteoarthritis, Knee (2) · Radiodermatitis (2) · Rhinitis, Allergic (2) · Alopecia (1) · Anosmia (1) · Antisocial Personality Disorder (1) · Autonomic Dysreflexia (1) · Bursitis (1) · COVID-19 (1) · Cancer Pain (1) · Coronavirus Infections (1) · Finger Injuries (1) · Head and Neck Neoplasms (1) · Kidney Diseases (1)
University Hospital Tuebingen (2) · University of Florida (2) · West China Hospital (2) · Adia Med of Winter Park LLC (1) · Ankara City Hospital Bilkent (1) · Bayer (1) · Boehringer Ingelheim (1) · Centre for Addiction and Mental Health (1) · Duke University (1) · Irkutsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences (1) · Jiangsu XinChen-Techfields Pharma Co., LTD. (1) · King's College London (1) · Medlab Clinical (1) · Pennington Biomedical Research Center (1) · Sheikh Zayed Federal Postgraduate Medical Institute (1)
United States (6) · China (3) · Canada (2) · Germany (2) · Belgium (1) · Russia (1) · South Africa (1) · South Korea (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Natalie C Ebner, PhD (2) · Andreas Fritsche, MD (1) · Bernard Le Foll, MD, PhD (1) · Frank L. Greenway, MD (1) · Marissa Ryan, MD (1) · Nigel Blackwood, MB MD (1) · Patrick R Brain, DDS (1) · Richard Edwards, DO (1) · Robert M Naclerio, MD (1) · Victoria Claydon, PhD (1) · Xingchen Peng (1) · Zeng Xiaofeng (1)
PMID 32445850, PMID 34000435, PMID 37692969, PMID 37735274
R21DA031906 (1), UL1TR000064 (1)