28 completed, 4 unknown, 3 recruiting, 2 active not recruiting. 17 Phase 2, 9 Phase 4, 8 Phase 3, 7 Not applicable, 4 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| VITAL-IMPACT: Improving Cardiometabolic Health in Black Individuals Through Therapeutic Augmentation of Cyclic Guanosine Mono-Phosphate Signaling Pathway Vericiguat 10 MG, Placebo, Insulin Sensitivity Test - Cardiovascular Diseases, Insulin Sensitivity/Resistance | Phase 2 | Not yet recruiting | University of Alabama at Birmingham | 200 | 2026-12-01 | 2026-01-23 |
| Probiotics Use and Preventing Gastrointestinal Symptoms in People Living With Overweight and Obesity. Probiotic Arm, Placebo Arm - Gut Inflammation, Overweight and Obese Volunteers | Not applicable | Enrolling by invitation | University of Ulster | 100 | 2025-10-14 | 2025-11-28 |
| Investigating the Impact of Probiotics on Wellbeing in a Community Probiotic Arm, Placebo Arm - Healthy Adult | Not applicable | Completed | Loughborough University | 85 | 2025-09-28 | 2026-09-10 |
| The Role of Acetazolamide in Mitigating Inflammation and Innate Immune Activation at High Altitude ACETAZOLAMIDE oral capsule, Placebo Arm - Hypoxemia, Acute Mountain Sickness (AMS) | Early Phase 1 | Active not recruiting | University of California, Riverside | 19 | 2025-09-17 | 2026-04-08 |
| COMFORT Trial: Complex Obstetric Management With Focused Regional Transversus Abdominis Plane Block Bupivicaine intervention arm, Placebo arm - Complex Obstetric Surgery, Perioperative Pain Management | Phase 4 | Recruiting | University of Tennessee | 120 | 2025-07-15 | 2026-10-21 |
| Green Tea Extract and Ginger Placebo Arm, Green Tea Extract, Ginger - Nutritional Supplementation, Exercise Physiology | Not applicable | Completed | Erzurum Technical University | 16 | 2025-03-01 | 2025-09-02 |
| Low-dose IL-2 in Established T1D - The "PROREG" Study ILT-101 (Aldesleukin; IL-2), Treatment-Placebo Arm, Placebo Arm - Diabetes Mellitus, Type 1, Diabetes | Phase 1 / Phase 2 | Withdrawn | Jay S. Skyler | 2023-06-01 | 2024-05-22 | |
| Rituximab in Patients With ST-elevation Myocardial Infarction Active arm 1000 mg, Placebo arm - ST Elevated Myocardial Infarction | Phase 2 | Recruiting | Assistance Publique - Hôpitaux de Paris | 372 | 2022-06-01 | 2026-08-12 |
| Study to Evaluate Efficacy, Safety, and Tolerability of IMU-838 in Patients With Progressive Multiple Sclerosis IMU-838, Placebo matching IMU-838 - Multiple Sclerosis | Phase 2 | Unknown | Immunic AG | 450 | 2021-09-30 | 2024-04-29 |
| Hydroxychloroquine for COVID-19 Post-exposure Prophylaxis (PEP) Hydroxychloroquine Sulfate, Ascorbic Acid - COVID-19, Corona Virus Infection | Phase 2 / Phase 3 | Completed | University of Washington | 943 | 2020-03-31 | 2021-12-16 |
| Safety and Immunogenicity of a Novel Vaccine Formulation MV-ZIKA-RSP (V187-001) Two MV-ZIKA-RSP vaccinations (high dose), Two MV-ZIKA-RSP vaccination (low dose), One MV-ZIKA-RSP vaccination (high dose) and one placebo - Zika Virus Infection | Phase 1 | Completed | Themis Bioscience GmbH | 48 | 2019-08-02 | 2021-12-06 |
| This Was a Dose-finding Study to Evaluate Efficacy and Safety of LOU064 in Patients With CSU Inadequately Controlled by H1-antihistamines LOU064 Arm 1, LOU064 Arm 2, LOU064 Arm 3 - Chronic Spontaneous Urticaria | Phase 2 | Completed | Novartis Pharmaceuticals | 311 | 2019-06-06 | 2022-04-29 |
| Preventing Asthma in High Risk Kids Omalizumab, Placebo - Asthma | Phase 2 | Active not recruiting | Boston Children's Hospital | 200 | 2018-11-27 | 2025-12-04 |
| The Effect of Intrauterine Lidocaine Infusion and Oral Tramadol on Pain During Diagnostic Office Hysteroscopy Lidocaine, Tramadol, placebo - Hysteroscopy | Phase 4 | Completed | Cairo University | 156 | 2018-10-15 | 2019-11-18 |
| A Study In Adults With Moderate To Severe Dermatomyositis PF-06823859 low, Placebo Arm, PF-06823859 high - Dermatomyositis | Phase 2 | Completed | Pfizer | 75 | 2018-01-23 | 2023-09-14 |
| The Safety and Efficacy of Naltrexone and Scopolamine Utilized in the Treatment of Major Depression Scopolamine and naltrexone, placebo arm - Depression | Phase 4 | Completed | The Taub Group | 14 | 2018-01-01 | 2019-05-20 |
| Add-on Methotrexate for the Treatment of Schizophrenia Methotrexate, Placebo Arm - Schizophrenia | Phase 2 | Unknown | Sheba Medical Center | 100 | 2017-12-15 | 2017-12-12 |
| Use of Platelet-enriched Plasma During Auricular Reconstruction Platelet enriched plasma administration, Placebo Arm - Ear Cartilage, Platelets | Not applicable | Unknown | Hospital General Dr. Manuel Gea González | 36 | 2017-06-29 | 2018-02-22 |
| Taper Or Abrupt Steroid Stop: TOASSTtrial Prednisone, Placebo Arm - Inflammatory Disorder, Autoimmune | Phase 4 | Recruiting | University Hospital, Basel, Switzerland | 530 | 2017-05-31 | 2026-04-22 |
| N-Acetyl-Cysteine (NAC) for Healing of Amputation Stumps in the Setting of Diabetes Active Arm N-acetyl cysteine (NAC), Placebo Arm - Diabetes Mellitus, Critical Limb Ischemia | Early Phase 1 | Completed | Washington University School of Medicine | 33 | 2017-03-01 | 2024-08-16 |
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Diabetes Mellitus (4) · Cardiovascular Diseases (2) · Diabetes Mellitus, Type 1 (2) · Lymphoma, Follicular (2) · Obesity (2) · Schizophrenia (2) · Altitude Sickness (1) · Angioedema (1) · Angioedemas, Hereditary (1) · Asthma (1) · Autoimmune Diseases (1) · Body Temperature Changes (1) · Bone Neoplasms (1) · Bruxism (1) · COVID-19 (1)
Assistance Publique - Hôpitaux de Paris (1) · Basque Health Service (1) · Baylor College of Medicine (1) · Boston Children's Hospital (1) · Boston Medical Center (1) · CD Pharma India Pvt. Ltd. (1) · Cairo University (1) · Chulalongkorn University (1) · Clayton Sleep Insititute (1) · Dartmouth-Hitchcock Medical Center (1) · Duke University (1) · Erzurum Technical University (1) · Hospital General Dr. Manuel Gea González (1) · Immunic AG (1) · Infinity Pharmaceuticals, Inc. (1)
United States (23) · Germany (6) · Canada (4) · Poland (4) · United Kingdom (4) · France (3) · Netherlands (3) · Spain (3) · Austria (2) · Czechia (2) · Hungary (2) · Russia (2) · Turkey (Türkiye) (2) · Argentina (1) · Australia (1)
Alberto Pugliese, M.D. (1) · Chris Gill, PhD (1) · David A Baidal, M.D. (1) · Donald Cutlip, MD (1) · Doralina Anghelescu, MD (1) · Douglas Grossman, MD, PhD (1) · Emmanuel B Walter, MD, MPH (1) · Eric Powell, PhD (1) · Harold Dauerman, MD (1) · J. Pieter Noordzij, MD (1) · Jay S Skyler, M.D. (1) · Jeffrey A Bluestone, PhD (1)
PMID 10404452, PMID 15867027, PMID 18545744, PMID 20520283, PMID 21458737, PMID 21684825, PMID 21723357, PMID 22384005, PMID 22403223, PMID 22997178, PMID 23086558, PMID 23423576, PMID 23582727, PMID 23941314, PMID 24115337, PMID 25367164, PMID 25703885, PMID 26409291, PMID 30954166, PMID 31053842, PMID 32299254, PMID 32493478, PMID 33242697, PMID 33284679, PMID 35129469, PMID 37018188, PMID 39798982, PMID 40986007, PMID 41010475, PMID 41874840, PMID 42273013, PMID 42542380
2009 (1), 2016 (1), 2018 (1), 2019 (1), R01DK057846 (1), U01AI179563 (1)