70 completed, 10 terminated, 9 withdrawn, 7 recruiting. 43 Not applicable, 32 Phase 2, 17 Phase 4, 5 Phase 1, 5 Phase 3.
Follow Pitocin: new trials by email Literature Review of Pitocin trials Research Report on Pitocin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Intravenous Oxytocin to Speed Recovery After THA intravenous administration of oxytocin, Placebo - Total Hip Arthroplasty | Phase 2 | Enrolling by invitation | Wake Forest University Health Sciences | 80 | 2026-12-01 | 2026-10-23 |
| Intranasal and Intravenous Oxytocin for Analgesia to Noxious Heat Pain Intravenous oxytocin, Intravenous placebo, Intranasal oxytocin - Pain, Acute | Phase 2 | Completed | Wake Forest University Health Sciences | 24 | 2025-11-05 | 2026-06-30 |
| Induction of Labor After Cesarean Using Foley Alone vs. Concurrent Foley and Oxytocin Foley balloon, Oxytocin - Labor Induction, Cesarean Delivery | Not applicable | Active not recruiting | University of Pennsylvania | 100 | 2025-07-10 | 2026-09-03 |
| Intravenous Oxytocin for Post Operative Pain After Minimally Invasive Hysterectomy Oxytocin, Placebo - Postoperative Pain | Phase 2 | Recruiting | Brigham and Women's Hospital | 152 | 2025-06-01 | 2026-08-13 |
| Comparative Efficacy of Carbetocin and Oxytocin in Parturients at Risk of Atonic Postpartum Hemorrhage Undergoing Elective Cesarean Delivery Oxytocin, Carbetocin - Post Partum Hemorrhage | Not applicable | Recruiting | Samuel Lunenfeld Research Institute, Mount Sinai Hospital | 160 | 2025-01-14 | 2026-04-01 |
| Apply the PD Model of Peripheral Oxytocin Action to a Multimodal Stimulus Oxytocin, Placebo - Pain, Chronic | Phase 2 | Withdrawn | Wake Forest University Health Sciences | 2025-01-01 | 2024-10-26 | |
| Validate a Pharmacodynamic Model of Oxytocin for Peripheral Analgesic Effects Oxytocin - Osteoarthritis, Knee | Phase 2 | Withdrawn | Wake Forest University Health Sciences | 2025-01-01 | 2024-09-19 | |
| Examining Intranasal Oxytocin Augmentation of Brief Couples Therapy for Veterans With PTSD Oxytocin nasal spray, Saline nasal spray, Brief Cognitive-Behavioral Conjoint Therapy - Post-Traumatic Stress Disorder (PTSD) | Phase 2 | Recruiting | VA Office of Research and Development | 240 | 2024-10-28 | 2026-05-04 |
| Different Medications to Induce Labor Misoprostol, Pitocin - Pregnancy, Labor | Phase 3 | Completed | Icahn School of Medicine at Mount Sinai | 303 | 2024-07-02 | 2026-08-18 |
| Comparing the Dose-response Profiles of Uterotonics After Initial Carbetocin Administration - an Ex-vivo Study in Desensitized Human Myometrium Carbetocin, Oxytocin, Ergonovine - Postpartum Hemorrhage | Not applicable | Recruiting | Samuel Lunenfeld Research Institute, Mount Sinai Hospital | 32 | 2024-04-04 | 2026-04-06 |
| Effect of Ephedrine, Phenylepinephrine, and Norepinephrine on Myometrial Contractility in Pregnant People With Type II and Gestational Diabetes During Cesarean Section: An In-vitro Study Ephedrine, Phenylephrine, Norepinephrine - Postpartum Hemorrhage | Not applicable | Recruiting | Samuel Lunenfeld Research Institute, Mount Sinai Hospital | 96 | 2024-03-18 | 2026-04-06 |
| A Pilot Feasibility Study of IM OXT on Fear of Pain and Trust in Physical Therapist During OP Rehabilitation After TKA Oxytocin, Placebo - Osteoarthritis, Knee | Phase 2 | Withdrawn | Wake Forest University Health Sciences | 2024-01-01 | 2021-06-02 | |
| Estimate Serum Oxytocin PD Range in the Periphery Oxytocin - Osteoarthritis, Knee | Phase 2 | Withdrawn | Wake Forest University Health Sciences | 2023-12-01 | 2022-12-30 | |
| Time of Oxytocin Initiation at 2nd Stage of Labor and Adverse Outcomes Oxytocin - Delivery Complication, Cesarean Delivery Affecting Fetus | Not applicable | Recruiting | Rambam Health Care Campus | 120 | 2023-10-01 | 2023-12-26 |
| Defining a PK and PD Model for Peripheral Analgesia After IV Oxytocin Oxytocin - Acute Pain, Chronic Pain | Phase 2 | Completed | Wake Forest University Health Sciences | 25 | 2023-08-17 | 2025-10-28 |
| IV Oxytocin for Post Operative Pain After Minimally Invasive Hysterectomy Oxytocin, Placebo - Pain, Postoperative, Analgesia | Phase 4 | Withdrawn | Beth Israel Deaconess Medical Center | 2023-06-01 | 2023-08-14 | |
| Low-Dose Versus High-Dose Oxytocin Dosing for Induction and Augmentation of Labor Oxytocin (Low dose), Oxytocin (High dose) - Labor Long | Phase 4 | Completed | The University of Texas Medical Branch, Galveston | 170 | 2023-04-17 | 2026-01-09 |
| Peripheral Oxytocin and Touch Pitocin - Healthy Adults | Phase 2 | Completed | University of California, San Diego | 20 | 2023-04-05 | 2024-12-31 |
| A Pharmacokinetic Study of Intravenous and Intranasal Oxytocin in Healthy Subjects intravenous oxytocin, intranasal oxytocin - Healthy Volunteer Study | Phase 1 | Completed | Wake Forest University Health Sciences | 25 | 2023-02-27 | 2025-02-17 |
| A Study of Oxytocin PK After IV Administration in Healthy Subjects and Advanced Knee Arthritis Subjects Oxytocin - Osteoarthritis, Knee | Phase 2 | Withdrawn | Wake Forest University Health Sciences | 2023-01-01 | 2025-08-12 |
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Postpartum Hemorrhage (27) · Osteoarthritis, Knee (7) · Chronic Pain (6) · Stress Disorders, Post-Traumatic (6) · Fetal Membranes, Premature Rupture (4) · Pain, Postoperative (4) · Acute Pain (3) · Substance-Related Disorders (3) · Uterine Inertia (3) · Agnosia (2) · Alcoholism (2) · Cocaine-Related Disorders (2) · Dystocia (2) · Marijuana Abuse (2) · Obesity (2)
Samuel Lunenfeld Research Institute, Mount Sinai Hospital (20) · Wake Forest University Health Sciences (17) · Medical University of South Carolina (10) · Rambam Health Care Campus (3) · Icahn School of Medicine at Mount Sinai (2) · Montefiore Medical Center (2) · NYU Langone Health (2) · Northwestern University (2) · Sheba Medical Center (2) · VA Office of Research and Development (2) · Yale University (2) · Al-Kindy College of Medicine (1) · American University of Beirut Medical Center (1) · Anagnostou, Evdokia, M.D. (1) · Ataturk University (1)
United States (58) · Canada (20) · Israel (6) · India (1) · Iran (1) · Iraq (1) · Lebanon (1) · Malaysia (1) · Panama (1) · Turkey (Türkiye) (1) · Uganda (1)
Mrinalini Balki, MD (18) · James C Eisenach, MD (15) · Aimee L McRae-Clark, PharmD (2) · Aimee McRae-Clark, Pharm.D. (2) · Angela Bianco, MD (2) · Jose Carvalho, MD (2) · Linda Mayes, MD (2) · Ahmed S Alnuaimi, PhD (1) · Alaa A Hussein, FICOG, MD (1) · Alan Peaceman, MD (1) · Alan T Tita, MD, PhD (1) · Amanda Wang, MD (1) · Amir Weissman, MD (1) · Anat Berkovitch, resident (1) · Andrew D Weeks, FRCOG (1)
PMID 36996264, PMID 40121179, PMID 8598837, PMID 9704771, PMID 10472877, PMID 10811917, PMID 11687101, PMID 1554660, PMID 15802392, PMID 16125041, PMID 16437525, PMID 16753768, PMID 17138963, PMID 18515515, PMID 19384121, PMID 19858734, PMID 20012748, PMID 20417240, PMID 21087166, PMID 21152844, PMID 21793769, PMID 21981277, PMID 22105253, PMID 22105254, PMID 22227638, PMID 22387929, PMID 22406244, PMID 23047939, PMID 24297389, PMID 24485867, PMID 24906304, PMID 27588932, PMID 28361390, PMID 28651258, PMID 28707488, PMID 29215519, PMID 29294429, PMID 29401080, PMID 32189217, PMID 32561468, PMID 33169839, PMID 33957657, PMID 34288223, PMID 34325670, PMID 34455213, PMID 35358738, PMID 36480452, PMID 36649339, PMID 37759174, PMID 38614447
P01NS119159 (4), K12HD001258 (1), K12HD055885 (1), P20GM130414 (1), P50MH082999 (1), R01AA027212 (1), R21HD078778 (1)