6 completed, 3 unknown. 5 Not applicable, 2 Phase 3, 1 Early Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Completed 3, Unknown 2 |
| Phase 3 | 2 | Completed 1, Unknown 1 |
| Early Phase 1 | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
Follow Physostigmine: new trials by email Literature Review of Physostigmine trials Research Report on Physostigmine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Treatment of Adolescent Antimuscarinic (Anticholinergic) Toxidrome Physostigmine, Lorazepam - Anticholinergics Toxicity | Phase 4 | Completed | University of Colorado, Denver | 19 | 2017-03-30 | 2021-08-23 |
| Anticholium® Per Se Physostigmine, Isotonic Saline - Shock, Septic, Sepsis | Not applicable | Completed | University Hospital Heidelberg | 20 | 2015-01-28 | 2018-01-29 |
| Evaluation if Physostigmine Reduces Symptoms in Patients Who Has Developed a Delirium in Intensive Care After a Surgery Physostigmine, Sodium Chloride solution - Suspected Delirium After Elective or Emergency Heart Surgery, CAM-ICU Diagnosed Delirium | Phase 3 | Unknown | PD Dr. Bertram Scheller | 120 | 2014-04-01 | 2017-03-10 |
| Acetylcholine, Tobacco Smoking, Genes and Nicotinic Receptors Physostigmine - Smoking, Schizophrenia | Not applicable | Completed | Yale University | 80 | 2013-09-01 | 2023-10-25 |
| Pilot Study of Physostigmine-Enhanced Opioid Analgesia Physostigmine, Placebo - Postoperative Pain | Phase 3 | Completed | Medical University of Graz | 20 | 2011-06-01 | 2012-02-22 |
| The Effect of Physostigmine on Cognitive Functioning in the Immediate Period After Sedation for Colonoscopy Physostigmine - Cognitive Dysfunction | Not applicable | Unknown | Rabin Medical Center | 160 | 2010-07-01 | 2010-05-12 |
| Physostigmine After General Anesthesia physostigmine, Isotonic sodium chloride solution - Postoperative Nausea and Vomiting, Anesthesia Recovery Period | Not applicable | Unknown | Bispebjerg Hospital | 50 | 2009-12-01 | 2010-05-27 |
| Phamacological Reversal of Airway Instability During Sedation Physostigmine, Oxygen, Placebo - Upper Airway Obstruction | Not applicable | Completed | University of Rochester | 10 | 2009-08-01 | 2015-04-27 |
| Pharmacological Intervention in Insulin Resistance Targeting Autonomic Nerve Activity Atropine, Physostigmine, Placebo Sodium - Insulin Resistance | Early Phase 1 | Completed | AstraZeneca | 12 | 2007-05-01 | 2009-03-13 |
Airway Obstruction (1) · Cognitive Dysfunction (1) · Delirium (1) · Insulin Resistance (1) · Pain, Postoperative (1) · Postoperative Nausea and Vomiting (1) · Respiratory Aspiration (1) · Schizophrenia (1) · Sepsis (1) · Shock, Septic (1) · Smoking (1)
AstraZeneca (1) · Bispebjerg Hospital (1) · Medical University of Graz (1) · PD Dr. Bertram Scheller (1) · Rabin Medical Center (1) · University Hospital Heidelberg (1) · University of Colorado, Denver (1) · University of Rochester (1) · Yale University (1)
United States (3) · Germany (2) · Austria (1) · Denmark (1) · Israel (1) · Sweden (1)
Bertram Scheller, MD (1) · Bezion Beilin, MD (1) · Frank Pott, MD (1) · George S Wang, MD (1) · Gudrun Rumpold-Seitlinger, MD (1) · Jan Eriksson, MSD (1) · Johannes B Zimmermann, MD, MSc (1) · Kelly Cosgrove, PhD (1) · Per-Anders Jansson, prof (1) · Suzanne B Karan, Medical (1)
PMID 29126416, PMID 31035187, PMID 31398669
K23DA045957 (1), R01DA015577 (1), R01DA038832 (1)