34 completed. 34 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 34 | Completed 34 |
Follow Phenylephrine: new trials by email Literature Review of Phenylephrine trials Research Report on Phenylephrine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Norepinephrine vs. Phenylephrine for Hypotension in Low-Dose Spinal Anesthesia for Cesarean Delivery Norepinephrine, Phenylephrine - Anesthesia, Spinal | Phase 4 | Completed | Tam Anh Research Institute | 100 | 2024-06-06 | 2026-01-21 |
| Hemodynamics During Induction of General Anesthesia After Prophylactic Ephedrine, Phenylephrine or Norepinephrine. Ephedrine, Phenylephrine, Norepinephrine - Hemodynamic Instability, Anesthesia, General | Phase 4 | Completed | Helse Fonna | 128 | 2022-03-15 | 2024-10-04 |
| Effect of Three Weight-adjusted Vasopressors for Elective Cesarean Delivery metaraminol, Phenylephrine, Norepinephrine - Cesarean Section Complications | Phase 4 | Completed | Xuzhou Medical University | 78 | 2021-10-10 | 2021-12-30 |
| Norepinephrine vs Phenylephrine During General Anesthesia Norepinephrine, Phenylephrine - Anesthesia, Surgery | Phase 4 | Completed | University of California, San Francisco | 3626 | 2021-07-01 | 2026-09-01 |
| Evaluation of Patients After Cardiac Surgery: Novel Ultrasound Parameters for Quantification of Renal Perfusion & Analysis of Phenylephrines' Effect on Invasive Haemodynamics and Echocardiographic Measures Phenylephrine, Combination of PEEP and positioning - Ultrasonography, Renal, Cardiac Surgery | Phase 4 | Completed | Aarhus University Hospital | 30 | 2020-05-25 | 2021-08-06 |
| Efficacy and Safety of Mydriatic Microdrops Compared With Standard Drops for Retinopathy of Prematurity (ROP) Screening: a Pilot Randomized Clinical Trial Microdrop administration [phenylephrine 1.67% + tropicamide 0.33% (drop volume: 6-7 μL)], Standard drop administration [phenylephrine 1.67% + tropicamide 0.33% (drop volume: 28-34 μL)] - Retinopathy of Prematurity | Phase 4 | Completed | Aristotle University Of Thessaloniki | 25 | 2020-03-24 | 2022-04-04 |
| Norepinephrine Versus Phenylephrine for Preventing Spinal Anesthesia Induced Hypotension in Elderly Norepinephrine, phenylephrine - Spinal Induced Hypotension, Elderly | Phase 4 | Completed | Kasr El Aini Hospital | 62 | 2020-01-01 | 2021-09-01 |
| Intramuscular Phenylephrine HCL for Prevention of Spinal Anesthesia Induced Hypotension Phenylephrine Hydrochloride 4 mg, Phenylephrine Hydrochloride 8 mg - Hypotension, Anesthesia | Phase 4 | Completed | Rehman Medical Institute - RMI | 60 | 2020-01-01 | 2022-04-27 |
| Influence of Continuous Administration of Phenylephrine Versus Dobutamine on Spinal Oxygen Saturation, Measured With Near-infrared Spectroscopy (NIRS). Phenylephrine, Dobutamine - Nfuence of Vasoactive Medication on Spinal Oxygenation | Phase 4 | Completed | University Hospital, Ghent | 36 | 2019-07-04 | 2022-12-12 |
| Phenylephrine Versus Norepinephrine for Maintenance of Hemodynamic During Cesarean Section Under Spinal Anesthesia Norepinephrine, Phenylephrine - Cesarean Section Complications, Spinal Anesthesia | Phase 4 | Completed | Centre Hospitalier Régional d'Orléans | 124 | 2019-02-27 | 2021-05-27 |
| Norepinephrine Versus Phenylephrine Continuous Variable Infusion in Cesarean Delivery Phenylephrine, Norepinephrine, Bupivacaine - Cesarean Section Complications, Spinal Anesthesia | Phase 4 | Completed | Cairo University | 123 | 2017-11-10 | 2018-07-17 |
| Three Protocols for Phenylephrine Administration in Cesarean Delivery Single shot phenylephrine, Fixed infusion phenylephrine., Variable infusion phenylephrine. - Cesarean Section Complications, Spinal Anesthesia | Phase 4 | Completed | Cairo University | 217 | 2017-10-06 | 2018-12-17 |
| Effect of Vasopressors on Spinal Anaesthesia Induced Hypotension Epinephrine, Norepinephrine, Phenylephrine - Spinal Anesthesia | Phase 4 | Completed | Cukurova University | 160 | 2017-07-19 | 2019-10-24 |
| Cardiac Index Changes With Ephedrine, Phenylephrine, Ondansetron and Norepinephrine During Spinal Anesthesia cardiac output changes with "ephedrine", cardiac output changes with "phenylephrine", cardiac output changes with "ondansetron" - Cardiac Output, Low | Phase 4 | Completed | University Tunis El Manar | 120 | 2017-02-23 | 2018-08-29 |
| Influence of a Bolus Administration of Ephedrine and Phenylephrine on the Spinal Oxygen Saturation, Measured With NIRS. Ephedrine Hydrochloride 3 MG/ML, Phenylephrine - Influence of Vasoactive Medication on Spinal Oxygenation | Phase 4 | Completed | University Hospital, Ghent | 33 | 2017-02-06 | 2018-12-07 |
| Effectiveness of Phenylefrine in Prevention of Hypotension During Spinal Anesthesia for Cesarean Delivery Phenylephrine - Hypotension Drug-Induced | Phase 4 | Completed | Universidad Industrial de Santander | 140 | 2017-01-17 | 2017-02-24 |
| Intravenous Bolus of Phenylephrine vs. Norepinephrine in Preventing Hypotension After Spinal Anesthesia Phenylephrine, Norepinephrine - Anesthesia, Spinal and Epidural, Adverse Effect | Phase 4 | Completed | University Tunis El Manar | 120 | 2016-05-01 | 2017-10-26 |
| Nebulized Epoprostenol (FLOLAN) and Phenylephrine on One Lung Ventilation (OLV) Inhaled Epoprostenol and phenylephrine, Sevoflurane, Propofol - Oxygenation During One Lung Ventilation | Phase 4 | Completed | University Health Network, Toronto | 8 | 2016-03-01 | 2019-05-17 |
| Effects of Phenylephrine on Cardiac Preload Phenylephrine - Arterial Hypotension, Anaesthesia | Phase 4 | Completed | Algemeen Ziekenhuis Maria Middelares | 26 | 2016-02-01 | 2016-12-09 |
| Effects of Vasopressors on Immune Response Norepinephrine, Phenylephrine, Vasopressins - Endotoxemia | Phase 4 | Completed | Radboud University Medical Center | 40 | 2016-01-01 | 2016-10-13 |
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Hypotension (12) · Mydriasis (3) · Retinopathy of Prematurity (2) · Brain Ischemia (1) · Brain Neoplasms (1) · Cardiac Output, Low (1) · Common Cold (1) · Diabetes Insipidus (1) · Diabetes Mellitus (1) · Endotoxemia (1) · Influenza, Human (1) · Pulmonary Arterial Hypertension (1) · Shock, Septic (1) · Stroke (1)
Cairo University (2) · Khon Kaen University (2) · University Hospital, Ghent (2) · University Tunis El Manar (2) · Aarhus University Hospital (1) · Algemeen Ziekenhuis Maria Middelares (1) · American University of Beirut Medical Center (1) · Aristotle University Of Thessaloniki (1) · Central Hospital, Nancy, France (1) · Centre Hospitalier Régional d'Orléans (1) · Cukurova University (1) · GlaxoSmithKline (1) · Helse Fonna (1) · Kasr El Aini Hospital (1) · Naestved Hospital (1)
Belgium (3) · Denmark (3) · Egypt (3) · United States (3) · Canada (2) · France (2) · Norway (2) · Thailand (2) · Tunisia (2) · China (1) · Colombia (1) · Greece (1) · Netherlands (1) · Pakistan (1) · South Korea (1)
Yosanan Yospaiboon, M.D. (2) · Ahmed M Mukhtar, Professor (1) · Ahmed Mukhtar, Professor (1) · Alain F Kalmar, MD, PhD (1) · Caroline Vanpeteghem (1) · Caroline Vanpeteghem, MD (1) · Chandra Ramamoorthy, MD (1) · Feng Yi, MD (1)
PMID 18946298, PMID 20462091, PMID 22368443, PMID 24624090, PMID 24920942, PMID 25635593, PMID 27144689, PMID 27733286, PMID 29090733, PMID 29151054, PMID 30335625, PMID 30389535, PMID 30639574, PMID 30687737, PMID 31008870, PMID 31165350, PMID 32581577, PMID 32619039, PMID 33109924, PMID 33267787, PMID 33483132, PMID 34654903, PMID 35230558, PMID 36279409, PMID 36925330, PMID 37186094, PMID 38242802, PMID 41144827
2019 (1)